Effect of Isolation Measures on Nosocomial Infection Rates in Nursing Practice during COVID-19: A Meta-Analysis
Abstract
Background: Nosocomial infections represent a critical challenge in nursing practice, particularly during the COVID-19 pandemic. Isolation measures have been implemented widely to curb the spread of infections within healthcare settings. We aimed to evaluate the effectiveness of isolation measures in reducing nosocomial infection rates in nursing practice during the COVID-19 pandemic.
Methods: A systematic search was conducted using keywords such as "isolation measures," "nosocomial infection," and "COVID-19" and their combinations in international databases, focusing on articles published between 2020 and 2024. Data were analyzed using meta-analysis and a random effects model. Heterogeneity between studies was assessed with the I² test, and analyses were performed using STATA software.
Results: The analysis of 8 selected articles with a total sample size of 10,532 individuals showed that the implementation of isolation measures significantly reduced nosocomial infection rates, with an average effect size of 0.58 (95% CI: 42.1-74.5).
Conclusion: Isolation measures are effective in reducing nosocomial infection rates in nursing practice during the COVID-19 pandemic. The findings support the continued use of these measures to enhance patient safety and control infection spread within healthcare facilities.
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12. Hajian MH, Alvandi M, Rezaei G, et al (2022). Investigation of the dynamic sys-tem of providing medical services in the hospital for COVID-19 disease patients. Acad J Health Sci, 37(3):29-34.
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14. Guven DC, Eroglu I, Ismayilov R, et al (2022). Lessons learned from the pan-demic: Isolation and hygiene measures for COVID-19 could reduce nosocomial infection rates in oncology wards. J On-col Pharm Pract, 28(8):1807-1811.
15. Zubiri L, Rosovsky RP, Mooradian MJ, et al (2021). Temporal trends in inpatient on-cology census before and during the COVID-19 pandemic and rates of nos-ocomial COVID-19 among patients with cancer at a large academic center. Oncol-ogist, 26(8):e1427-e1433.
16. Harada S, Uno S, Ando T, et al (2020). Con-trol of a nosocomial outbreak of COVID-19 in a university hospital. Open Forum Infect Dis, 7(12):ofaa512.
17. Mohamed Farghaly Ali A, Mostafa Fahmy Isamil A (2020). Comparative study: Nurses' attitude, psychological response, and practices compliance with infection control measures during COVID-19 outbreak. Egypt J Health Care, 11(4):775-791.
18. Silverberg SL, Puchalski Ritchie LM, Gobat N, Murthy S (2021). COVID-19 infection prevention and control procedures and institutional trust: Perceptions of Cana-dian intensive care and emergency de-partment nurses. Can J Anaesth, 68(8):1165-1175.
19. Montero MM, Hidalgo Lopez C, Lopez Montesinos I, et al (2021). Impact of a nosocomial COVID-19 outbreak on a non-COVID-19 nephrology ward during the first wave of the pandemic in Spain. Antibiotics (Basel), 10(6):619.
20. Chen S, Chen Q, Yang J, et al (2021). Curb-ing the COVID-19 pandemic with facili-ty-based isolation of mild cases: A mathematical modeling study. J Travel Med, 28(2):taaa226.
21. Wee LE, Venkatachalam I, Sim XYJ, et al (2021). Containment of COVID-19 and reduction in healthcare-associated res-piratory viral infections through a multi-tiered infection control strategy. Infect Dis Health, 26(2):123-131.
22. Bai X (2022). Nursing risk management of COVID-19 pneumonia isolation wards using HFMEA method. Int J Life Sci Res Arch, 03(01):039–053.
23. Doyen D, Morand L, Jozwiak M, et al (2022). Impact of isolation time of COVID-19 patients in intensive care units on healthcare workers' contamina-tion and nursing care intensity. Front Med (Laussane), 9:824563.
24. Yang W, Zhang M, Rong L, et al (2022). Analysis of the effect of systematic pre-job training for nurses in isolation wards during the COVID-19 pandemic. Open J Nurs, 12(4):279-289.
25. Zhao Z, Lan X, Chen Q, et al (2021). Nurs-ing care management strategies in isola-tion wards during the COVID-19 out-break. Open Journal of Nursing, 11(4):249-257.
26. Allande-Cussó R, Fernández-García E, Ba-rrientos-Trigo S, et al (2021). Implement-ing holistic care in isolated patients dur-ing the COVID-19 pandemic: A case study using nursing outcomes (NOC) and interventions (NIC) classifications. Holist Nurs Pract, 35(6):326-331.
27. Park MJ, Lee YM (2022). The effect on COVID-19 infection control practice of nurses who work in sites with negative pressure isolation rooms. J Korean Crit Care Nurs, 15(1):35-46.
28. Pavić J, Vučko M, Liška F (2022). Implica-tions of work in the COVID isolation ward and the central emergency de-partment on the life and work of nurses. Croat Nurs J, 6(1):71-81.
29. Abd-elkader TM, Aref SM, Ali AF, Ali AA (2023). Nursing staff compliance regard-ing infection control measures with COVID-19 patients at isolation hospi-tals. Minia Sci Nurs J, 13(1):103-110.
30. Akcoban S, Yava A, Koyuncu A, Tosun B (2023). Evaluation of the relationship be-tween individual workload perception and compliance with isolation measures of emergency and critical care nurses. Work. 75(2):679-688.
31. Niu W, Ma X, Zhang Y, Sun Z (2021). The psychological effects of nursing inter-ventions on patients with suspected COVID-19 during isolation. Ann Palliat Med, 10(6):6344-6350.
2. Rozploch M, Giza A, Kaminska M, et al (2022). Impact of the COVID-19 pan-demic on the prevalence of nosocomial infections in patients hospitalized in the clinical department of hematology in Cracow, Poland. Blood, 140(Suppl 1):11197-11199.
3. Jung J, Kim SK, Lee Y, et al (2022). Rates of COVID-19 infection among healthcare workers in designated COVID-19 wards and general wards. J Korean Med Sci, 37(43):e308.
4. Kang M, Henry S, Thomas E, et al (2021). The impact of coronavirus disease 2019 (COVID-19) pandemic on device-associated healthcare-associated infec-tion. Antimicrob Steward Healthc Epidemiol, 1(Suppl 1):s54.
5. Anderson RM, Heesterbeek H, Klinkenberg D, et al (2020). How will country-based mitigation measures influence the course of the COVID-19 epidemic? Lan-cet, 395(10228):931-934.
6. Huang H, Wu K, Chen H, et al (2023). The impact of the COVID-19 pandemic on nosocomial infections: A retrospective analysis in a tertiary maternal and child healthcare hospital. Front Public Health, 11:1132323.
7. Mimura K, Oka H, Sawano M (2021). A per-spective on hospital-acquired (nosocom-ial) infection control of COVID-19: Usefulness of spatial separation between wards and airborne isolation unit. J Breath Res, 15(4): 10.1088/1752-7163/ac1721.
8. Bakhshi M, Karkehabadi A, Razavian SB (2024). Revolutionizing medical diagno-sis with novel teaching-learning-based optimization. 2024 Int Conf Emerg Smart Comput Inform (ESCI):1-6.
9. Tsai CY, Chang NC, Fang HC, et al (2020). A novel non-contact self-injection-locked radar for vital sign sensing and body movement monitoring in COVID-19 isolation ward. J Med Syst, 44 (10): 177.
10. Lyu X, Hu J, Xu X, et al (2021). Factors in-fluencing risk perception and nosocom-ial infection prevention practices of frontline nurses during the COVID-19 pandemic. BMC Nurs, 20(1):78.
11. Corbett RW, Blakey S, Nitsch D, et al (2020). Epidemiology of COVID-19 in an urban dialysis center. J Am Soc Neph-rol, 31(8):1815-1823.
12. Hajian MH, Alvandi M, Rezaei G, et al (2022). Investigation of the dynamic sys-tem of providing medical services in the hospital for COVID-19 disease patients. Acad J Health Sci, 37(3):29-34.
13. Karkehabadi A, Sasan A (n.d.). SMOOT: Sa-liency guided mask optimized online training.
14. Guven DC, Eroglu I, Ismayilov R, et al (2022). Lessons learned from the pan-demic: Isolation and hygiene measures for COVID-19 could reduce nosocomial infection rates in oncology wards. J On-col Pharm Pract, 28(8):1807-1811.
15. Zubiri L, Rosovsky RP, Mooradian MJ, et al (2021). Temporal trends in inpatient on-cology census before and during the COVID-19 pandemic and rates of nos-ocomial COVID-19 among patients with cancer at a large academic center. Oncol-ogist, 26(8):e1427-e1433.
16. Harada S, Uno S, Ando T, et al (2020). Con-trol of a nosocomial outbreak of COVID-19 in a university hospital. Open Forum Infect Dis, 7(12):ofaa512.
17. Mohamed Farghaly Ali A, Mostafa Fahmy Isamil A (2020). Comparative study: Nurses' attitude, psychological response, and practices compliance with infection control measures during COVID-19 outbreak. Egypt J Health Care, 11(4):775-791.
18. Silverberg SL, Puchalski Ritchie LM, Gobat N, Murthy S (2021). COVID-19 infection prevention and control procedures and institutional trust: Perceptions of Cana-dian intensive care and emergency de-partment nurses. Can J Anaesth, 68(8):1165-1175.
19. Montero MM, Hidalgo Lopez C, Lopez Montesinos I, et al (2021). Impact of a nosocomial COVID-19 outbreak on a non-COVID-19 nephrology ward during the first wave of the pandemic in Spain. Antibiotics (Basel), 10(6):619.
20. Chen S, Chen Q, Yang J, et al (2021). Curb-ing the COVID-19 pandemic with facili-ty-based isolation of mild cases: A mathematical modeling study. J Travel Med, 28(2):taaa226.
21. Wee LE, Venkatachalam I, Sim XYJ, et al (2021). Containment of COVID-19 and reduction in healthcare-associated res-piratory viral infections through a multi-tiered infection control strategy. Infect Dis Health, 26(2):123-131.
22. Bai X (2022). Nursing risk management of COVID-19 pneumonia isolation wards using HFMEA method. Int J Life Sci Res Arch, 03(01):039–053.
23. Doyen D, Morand L, Jozwiak M, et al (2022). Impact of isolation time of COVID-19 patients in intensive care units on healthcare workers' contamina-tion and nursing care intensity. Front Med (Laussane), 9:824563.
24. Yang W, Zhang M, Rong L, et al (2022). Analysis of the effect of systematic pre-job training for nurses in isolation wards during the COVID-19 pandemic. Open J Nurs, 12(4):279-289.
25. Zhao Z, Lan X, Chen Q, et al (2021). Nurs-ing care management strategies in isola-tion wards during the COVID-19 out-break. Open Journal of Nursing, 11(4):249-257.
26. Allande-Cussó R, Fernández-García E, Ba-rrientos-Trigo S, et al (2021). Implement-ing holistic care in isolated patients dur-ing the COVID-19 pandemic: A case study using nursing outcomes (NOC) and interventions (NIC) classifications. Holist Nurs Pract, 35(6):326-331.
27. Park MJ, Lee YM (2022). The effect on COVID-19 infection control practice of nurses who work in sites with negative pressure isolation rooms. J Korean Crit Care Nurs, 15(1):35-46.
28. Pavić J, Vučko M, Liška F (2022). Implica-tions of work in the COVID isolation ward and the central emergency de-partment on the life and work of nurses. Croat Nurs J, 6(1):71-81.
29. Abd-elkader TM, Aref SM, Ali AF, Ali AA (2023). Nursing staff compliance regard-ing infection control measures with COVID-19 patients at isolation hospi-tals. Minia Sci Nurs J, 13(1):103-110.
30. Akcoban S, Yava A, Koyuncu A, Tosun B (2023). Evaluation of the relationship be-tween individual workload perception and compliance with isolation measures of emergency and critical care nurses. Work. 75(2):679-688.
31. Niu W, Ma X, Zhang Y, Sun Z (2021). The psychological effects of nursing inter-ventions on patients with suspected COVID-19 during isolation. Ann Palliat Med, 10(6):6344-6350.
| Files | ||
| Issue | Vol 54 No 2 (2025) | |
| Section | Review Article(s) | |
| Keywords | ||
| COVID-19 Pandemic Isolation measures Nursing practice | ||
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How to Cite
1.
Ma L, Ye F. Effect of Isolation Measures on Nosocomial Infection Rates in Nursing Practice during COVID-19: A Meta-Analysis. Iran J Public Health. 2025;54(2):297-308.
