Does Supplementation with Royal Jelly Improve Oxidative Stress and Insulin Resistance in Type 2 Diabetic Patients?
Background: Animal studies have shown antioxidant effects of Royal Jelly (RJ) and its effect on insulin resistance as the most common complication of Type 2 diabetes. This study was conducted to determine the effect of RJ intake on serum total antioxidant capacity, Malondialdehyde and insulin resistance in T2DM.
Methods: In this randomized controlled trial, forty-six type 2 diabetic patients, aged 25-65 years, with BMI of 20-30 kg/m2, and HbA1c of 6-8% were included. The patients were randomly assigned to receive 1000 mg of RJ supplement or placebo, 3 times daily for 8 weeks. HOMA-IR, anthropometric measurements, fasting blood glucose, serum insulin, total antioxidant capacity and malondialdehyde level were measured.
Results: In comparison with placebo, HOMA-IR decreased (P=0.015) while serum total antioxidant capacity in-creased significantly in RJ group (P=0.016). No significant difference was detected for serum insulin and MDA in two groups.
Conclusions: RJ intake may have favorable effects on serum TAC and HOMA-IR in diabetic patients.
|Issue||Vol 44 No 6 (2015)|
|Royal Jelly Type 2 diabetes mellitus Insulin resistance Total antioxidant capacity|
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|This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.|