Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 44 6 2015 10 11 797 803 EN Farzad SHIDFAR Dept. of Nutrition, Iran University of Medical Sciences, Tehran, Iran. Shima JAZAYERI Dept. of Nutrition, Iran University of Medical Sciences, Tehran, Iran. Seyedeh Neda MOUSAVI Dept. of Cellular & Molecular Nutrition, Tehran University of Medical Sciences, Tehran, Iran. Mojtaba MALEK Research Center for Endocrinology and Metabolism, Institute of Endocrinology in Firouzgar Hospital, Iran University of Medical Sciences, Iran. Aghafateme HOSSEINI Dept. of Statistics, School of Health Management and Information Sciences, Tehran University of Medical Sciences, Tehran, Iran. Basmeh KHOSHPEY Dept. of Nutrition, Iran University of Medical Sciences, Tehran, Iran. 2015 10 10 2015 10 10 Background: Animal studies have shown antioxidant effects of Royal Jelly (RJ) and its effect on insulin resistance as the most common complication of Type 2 diabetes. This study was conducted to determine the effect of RJ intake on serum total antioxidant capacity, Malondialdehyde and insulin resistance in T2DM. Methods: In this randomized controlled trial, forty-six type 2 diabetic patients, aged 25-65 years, with BMI of 20-30 kg/m2, and HbA1c of 6-8% were included. The patients were randomly assigned to receive 1000 mg of RJ supplement or placebo, 3 times daily for 8 weeks. HOMA-IR, anthropometric measurements, fasting blood glucose, serum insulin, total antioxidant capacity and malondialdehyde level were measured. Results: In comparison with placebo, HOMA-IR decreased (P=0.015) while serum total antioxidant capacity in-creased significantly in RJ group (P=0.016). No significant difference was detected for serum insulin and MDA in two groups. Conclusions: RJ intake may have favorable effects on serum TAC and HOMA-IR in diabetic patients. https://ijph.tums.ac.ir/index.php/ijph/article/view/3300 https://ijph.tums.ac.ir/index.php/ijph/article/download/3300/3028