Effect of Lavender Aromatherapy on Anxiety and Fatigue in Hemodialysis Patients: A Systematic Review and Meta-Analysis
,
Abstract
Background: Several studies have evaluated the effects of lavender essential oil on the anxiety of hemodialysis (HD) patients, but most of them did not estimate the pooled effect size. The current systematic review and meta-analysis was conducted to evaluate the effects of lavender on anxiety and fatigue among HD patients.
Methods: Eligible studies were selected based on the PRISMA steps and protocol. Literature was retrieved from PubMed, Web of Science, Scopus databases, Cochrane, ClinicalTrials.gov, and Google Scholar Search Engines until Sep 2022. The risk of bias and analysis were evaluated using version 2 of the Cochrane risk-of-bias tool and STATA v.14 software, respectively. Effect sizes were pooled using random effect models.
Results: Nine studies were included. Lavender oil significantly reduced the average anxiety of HD patients compared to the control group (SMD: -2.51, 95% CI: [-3.56, -1.45], Z=4.67, P<0.001, I2 :89.9%). Also, it significantly reduced the average fatigue compared to the control group (SMD: -1.56, 95% CI: [-2.49, -0.63], Z=3.29, P=0.001, I2:92.2%). Subgroup analysis indicated controversial results regarding session frequency and drop number of lavender oil.
Conclusion: Using Lavender oil significantly reduced fatigue and anxiety in HD patients.
1. Meng Y, Wu HT, Niu JL, et al (2022). Prevalence of depression and anxiety and their predictors among patients undergoing maintenance hemodialysis in Northern China: a cross-sectional study. Ren Fail, 44 (1):933-944.
2. Htay H, Bello AK, Levin A, et al (2021). Hemodialysis Use and Practice Patterns: An International Survey Study. Am J Kidney Dis, 77 (3):326-335.e1.
3. Korkut S (2022). Evaluation of psychopathological symptoms, death anxiety, coronavirus anxiety, suicide risk, and associated risk factors among hemodialysis patients in the COVID-19 pandemic. Ther Apher Dial, 26 (5):941-949.
4. Sarboozi-Hoseinabadi T, Askari M, Miri K, et al (2020). Depression, Anxiety, and Stress of Nurses' Family Members in Covid–19 Pandemic; a Case Study of Torbat-e Heydariyeh Hospitals. Iran J War Public Health, 12 (4):241-248.
5. Lehto R, Stein KF (2009). Death anxiety: An analysis of an evolving concept. Res Theory Nurs Pract, 23(1):23-41.
6. Nia MN, Mohajer S, Bagheri N, Sarboozi-Hoseinabadi T (2022). The effects of family-centered empowerment model on depression, anxiety, and stress of the family caregivers of patients with COVID-19: a randomized clinical trial. BMC Prim Care, 23 (1):185.
7. Nadort E, van Geenen NJK, Schouten RW, et al (2022). Validation of Two Screening Tools for Anxiety in Hemodialysis Patients. J Pers Med, 12(7):1077.
8. Fathi M, Sanagoo A, Jouybari L, et al (2016). Death anxiety in hemodialysis patients admitted to Panj-Azar teaching hospital, 2013. J Res Dev Nursing Midwifery, 12(3):48_55.
9. Dean A (2019). The holistic management of fatigue within palliative care. Int J Palliat Nurs, 25 (8):368-376.
10. Mazloum SR, Rajabzadeh M, Mohajer S, et al (2023). Comparing the Effects of Warm Footbath and Foot Reflexology on the Fatigue of Patients Undergoing Radiotherapy: A Randomized Clinical Trial. Integr Cancer Ther, 22: 15347354231172940
11. Malini H, Forwaty E, Cleary M, et al (2022). The Effect of Intradialytic Range of Motion Exercise on Dialysis Adequacy and Fatigue in Hemodialysis Patients. J Nurs Res, 30 (4):e221.
12. Lee G, Lee J-S, Kim JH, et al (2019). Impact of patient’s pain and fatigue on decision of discharge after laparoscopic surgery for colorectal cancer. Ann Coloproctol, 35(4):209-215.
13. Wang QT, Wei L, Luo YM, et al (2022). Effectiveness of Aromatherapy on Ameliorating Fatigue in Adults: A Meta-Analysis. Evid Based Complement Alternat Med, 2022: 1141411.
14. Bourbonnais FF, Tousignant KF (2012). The pain experience of patients on maintenance hemodialysis. Nephrol Nurs J, 39(1):13-9.
15. Song Y-y, Hu R-j, Diao Y-s, et al (2018). Effects of Exercise Training on Restless Legs Syndrome, Depression, Sleep Quality, and Fatigue Among Hemodialysis Patients: A Systematic Review and Meta-analysis. J Pain Symptom Manage, 55 (4):1184-1195.
16. Bouya S, Ahmadidarehsima S, Badakhsh M, et al (2018). Effect of aromatherapy interventions on hemodialysis complications: A systematic review. Complement Ther Clin Pract, 32: 130-138.
17. Song X, Peng J, Jiang W, et al (2021). Effects of aromatherapy on sleep disorders: A protocol for systematic review and meta-analysis. Medicine (Baltimore), 100(17):e25727.
18. Aliasgharpour M, Abbaszadeh R, Mohammadi N,et al (2016). Effect of lavender aromatherapy on the pain of arteriovenous fistula puncture in patients on hemodialysis. NPT, 3(1):26-30.
19. Taşan E, Ovayolu O, Ovayolu N (2019). The effect of diluted lavender oil inhalation on pain development during vascular access among patients undergoing haemodialysis. Complement Ther Clin Pract, 35:177-182.
20. Farrar AJ, Farrar FC (2020). Clinical aromatherapy. Nurs Clin North Am, 55 (4):489-504.
21. Bagheri-Nesami M, Shorofi SA, Nikkhah A, et al (2016). The effects of aromatherapy with lavender essential oil on fatigue levels in haemodialysis patients: A randomized clinical trial. Complement Ther Clin Pract, 22:33-37.
22. Karadag E, Samancioglu Baglama S (2019). The Effect of Aromatherapy on Fatigue and Anxiety in Patients Undergoing Hemodialysis Treatment: A Randomized Controlled Study. Holist Nurs Pract, 33 (4):222-229.
23. Ahmady S, Rezaei M, Khatony A (2019). Comparing effects of aromatherapy with lavender essential oil and orange essential oil on fatigue of hemodialysis patients: A randomized trial. Complement Ther Clin Pract, 36:64-68.
24. Bayulgen MY, Gun M (2022). Effect of Complementary and Integrative Treatments on Fatigue Symptoms in Hemodialysis Patients A Systematic Review. Holist Nurs Pract, 36 (1):17-27.
25. Zhao W, Cai Y, Xie N, et al (2021). The effect of aromatherapy on fatigue of maintenance hemodialysis patients: a Meta-analysis. Ren Fail, 37 (34):2715-2721.
26. Moher D, Liberati A, Tetzlaff J, et al (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ, 339:b2535.
27. Corlett RT (2011). Trouble with the gray literature. Biotropica, 43 (1):3-5.
28. Higgins JPT, (editors) GS (2011). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. ed. The Cochrane Collaboration.
29. Ahn E, Kang H (2018). Introduction to systematic review and meta-analysis. Korean J Anesthesiol, 71 (2):103-112.
30. Tawfik GM, Dila KAS, Mohamed MYF, et al (2019). A step by step guide for conducting a systematic review and meta-analysis with simulation data. Trop Med Health, 47:46 .
31. Ozen N, Sayilan AA, Ok E, et al (2023). Effects of Long-term Administration of Inhaled Lavender During Hemodialysis on Patients' Invasive Pain, Anxiety, and Comfort During Cannulation: A Single-blind Randomized Controlled Trial. Altern Ther Health Med, 29 (2) :6-12.
32. Şahin S, Tokgöz B, Demir G (2021). Effect of Lavender Aromatherapy On Arteriovenous Fistula Puncture Pain and the Level of State and Trait Anxiety in Hemodialysis Patients: A Randomized Controlled Trial. Pain Manag Nurs, 22 (4):509-515.
33. Şentürk A, Tekinsoy Kartin P (2018). The effect of lavender oil application via inhalation pathway on hemodialysis patients' anxiety level and sleep quality. Holist Nurs Pract, 32 (6):324-335.
34. Kiani F, Shahrakipour M, Zadeh MAH (2016). The effect of inhaling lavender on hemodialysis patient’s anxiety. International Journal of Pharmacy and Technology, 8 (2):13853-13865.
35. Rahimi E, Sedighi Chafjiri A, Hasavari F, et al (2022). Evaluation of the Effect of Lavender Aroma on Fatigue among Hemodialysis Patients. Holist Nurs Pract, 36 (2):76-84.
36. Hassanzadeh M, Kiani F, Bouya S, et al (2018). Comparing the effects of relaxation technique and inhalation aromatherapy on fatigue in patients undergoing hemodialysis. Complement Ther Clin Pract, 31:210-214.
37. Zhang C, Mu H, Yang Y-F, et al (2023). Effect of aromatherapy on quality of life in maintenance hemodialysis patients: a systematic review and meta-analysis. Ren Fail, 45 (1):2164202.
38. Wahida AZ, Rumahorbo H, Murtiningsih (2022). The effectiveness of intradialytic exercise in ameliorating fatigue symptoms in patients with chronic kidney failure undergoing hemodialysis: A systematic literature review and meta-analysis. J Taibah Univ Med Sci, 18 (3):512-525.
39. Kim M, Nam ES, Lee Y, et al (2021). Effects of Lavender on Anxiety, Depression, and Physiological Parameters: Systematic Review and Meta-Analysis. Asian Nurs Res (Korean Soc Nurs Sci), 15(5):279-290 .
40. Boutron I PM, Higgins JPT, Altman DG, et al (updated August 2023). Cochrane, 2023. Available from: www.training.cochrane.org/handbook
41. Morrison A, Polisena J, Husereau D, et al (2012). The effect of English-language restriction on systematic review-based meta-analyses: a systematic review of empirical studies. Int J Technol Assess Health Care, 28 (2):138-44.
42. Mehrabian S, Tirgari B, Forouzi MA, et al (2022). Effect of Aromatherapy Massage on Depression and Anxiety of Elderly Adults: a Randomized Controlled Trial. Int J Ther Massage Bodywork, 15 (1):37-45.
43. Burns PB, Rohrich RJ, Chung KC (2011). The Levels of Evidence and Their Role in Evidence-Based Medicine. Plast Reconstr Surg, 128 (1):305-310.
44. Senturk A, Kartin PT (2018). The Effect of Lavender Oil Application via Inhalation Pathway on Hemodialysis Patients' Anxiety Level and Sleep Quality. Holist Nurs Pract, 32(6):324-335.
2. Htay H, Bello AK, Levin A, et al (2021). Hemodialysis Use and Practice Patterns: An International Survey Study. Am J Kidney Dis, 77 (3):326-335.e1.
3. Korkut S (2022). Evaluation of psychopathological symptoms, death anxiety, coronavirus anxiety, suicide risk, and associated risk factors among hemodialysis patients in the COVID-19 pandemic. Ther Apher Dial, 26 (5):941-949.
4. Sarboozi-Hoseinabadi T, Askari M, Miri K, et al (2020). Depression, Anxiety, and Stress of Nurses' Family Members in Covid–19 Pandemic; a Case Study of Torbat-e Heydariyeh Hospitals. Iran J War Public Health, 12 (4):241-248.
5. Lehto R, Stein KF (2009). Death anxiety: An analysis of an evolving concept. Res Theory Nurs Pract, 23(1):23-41.
6. Nia MN, Mohajer S, Bagheri N, Sarboozi-Hoseinabadi T (2022). The effects of family-centered empowerment model on depression, anxiety, and stress of the family caregivers of patients with COVID-19: a randomized clinical trial. BMC Prim Care, 23 (1):185.
7. Nadort E, van Geenen NJK, Schouten RW, et al (2022). Validation of Two Screening Tools for Anxiety in Hemodialysis Patients. J Pers Med, 12(7):1077.
8. Fathi M, Sanagoo A, Jouybari L, et al (2016). Death anxiety in hemodialysis patients admitted to Panj-Azar teaching hospital, 2013. J Res Dev Nursing Midwifery, 12(3):48_55.
9. Dean A (2019). The holistic management of fatigue within palliative care. Int J Palliat Nurs, 25 (8):368-376.
10. Mazloum SR, Rajabzadeh M, Mohajer S, et al (2023). Comparing the Effects of Warm Footbath and Foot Reflexology on the Fatigue of Patients Undergoing Radiotherapy: A Randomized Clinical Trial. Integr Cancer Ther, 22: 15347354231172940
11. Malini H, Forwaty E, Cleary M, et al (2022). The Effect of Intradialytic Range of Motion Exercise on Dialysis Adequacy and Fatigue in Hemodialysis Patients. J Nurs Res, 30 (4):e221.
12. Lee G, Lee J-S, Kim JH, et al (2019). Impact of patient’s pain and fatigue on decision of discharge after laparoscopic surgery for colorectal cancer. Ann Coloproctol, 35(4):209-215.
13. Wang QT, Wei L, Luo YM, et al (2022). Effectiveness of Aromatherapy on Ameliorating Fatigue in Adults: A Meta-Analysis. Evid Based Complement Alternat Med, 2022: 1141411.
14. Bourbonnais FF, Tousignant KF (2012). The pain experience of patients on maintenance hemodialysis. Nephrol Nurs J, 39(1):13-9.
15. Song Y-y, Hu R-j, Diao Y-s, et al (2018). Effects of Exercise Training on Restless Legs Syndrome, Depression, Sleep Quality, and Fatigue Among Hemodialysis Patients: A Systematic Review and Meta-analysis. J Pain Symptom Manage, 55 (4):1184-1195.
16. Bouya S, Ahmadidarehsima S, Badakhsh M, et al (2018). Effect of aromatherapy interventions on hemodialysis complications: A systematic review. Complement Ther Clin Pract, 32: 130-138.
17. Song X, Peng J, Jiang W, et al (2021). Effects of aromatherapy on sleep disorders: A protocol for systematic review and meta-analysis. Medicine (Baltimore), 100(17):e25727.
18. Aliasgharpour M, Abbaszadeh R, Mohammadi N,et al (2016). Effect of lavender aromatherapy on the pain of arteriovenous fistula puncture in patients on hemodialysis. NPT, 3(1):26-30.
19. Taşan E, Ovayolu O, Ovayolu N (2019). The effect of diluted lavender oil inhalation on pain development during vascular access among patients undergoing haemodialysis. Complement Ther Clin Pract, 35:177-182.
20. Farrar AJ, Farrar FC (2020). Clinical aromatherapy. Nurs Clin North Am, 55 (4):489-504.
21. Bagheri-Nesami M, Shorofi SA, Nikkhah A, et al (2016). The effects of aromatherapy with lavender essential oil on fatigue levels in haemodialysis patients: A randomized clinical trial. Complement Ther Clin Pract, 22:33-37.
22. Karadag E, Samancioglu Baglama S (2019). The Effect of Aromatherapy on Fatigue and Anxiety in Patients Undergoing Hemodialysis Treatment: A Randomized Controlled Study. Holist Nurs Pract, 33 (4):222-229.
23. Ahmady S, Rezaei M, Khatony A (2019). Comparing effects of aromatherapy with lavender essential oil and orange essential oil on fatigue of hemodialysis patients: A randomized trial. Complement Ther Clin Pract, 36:64-68.
24. Bayulgen MY, Gun M (2022). Effect of Complementary and Integrative Treatments on Fatigue Symptoms in Hemodialysis Patients A Systematic Review. Holist Nurs Pract, 36 (1):17-27.
25. Zhao W, Cai Y, Xie N, et al (2021). The effect of aromatherapy on fatigue of maintenance hemodialysis patients: a Meta-analysis. Ren Fail, 37 (34):2715-2721.
26. Moher D, Liberati A, Tetzlaff J, et al (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ, 339:b2535.
27. Corlett RT (2011). Trouble with the gray literature. Biotropica, 43 (1):3-5.
28. Higgins JPT, (editors) GS (2011). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. ed. The Cochrane Collaboration.
29. Ahn E, Kang H (2018). Introduction to systematic review and meta-analysis. Korean J Anesthesiol, 71 (2):103-112.
30. Tawfik GM, Dila KAS, Mohamed MYF, et al (2019). A step by step guide for conducting a systematic review and meta-analysis with simulation data. Trop Med Health, 47:46 .
31. Ozen N, Sayilan AA, Ok E, et al (2023). Effects of Long-term Administration of Inhaled Lavender During Hemodialysis on Patients' Invasive Pain, Anxiety, and Comfort During Cannulation: A Single-blind Randomized Controlled Trial. Altern Ther Health Med, 29 (2) :6-12.
32. Şahin S, Tokgöz B, Demir G (2021). Effect of Lavender Aromatherapy On Arteriovenous Fistula Puncture Pain and the Level of State and Trait Anxiety in Hemodialysis Patients: A Randomized Controlled Trial. Pain Manag Nurs, 22 (4):509-515.
33. Şentürk A, Tekinsoy Kartin P (2018). The effect of lavender oil application via inhalation pathway on hemodialysis patients' anxiety level and sleep quality. Holist Nurs Pract, 32 (6):324-335.
34. Kiani F, Shahrakipour M, Zadeh MAH (2016). The effect of inhaling lavender on hemodialysis patient’s anxiety. International Journal of Pharmacy and Technology, 8 (2):13853-13865.
35. Rahimi E, Sedighi Chafjiri A, Hasavari F, et al (2022). Evaluation of the Effect of Lavender Aroma on Fatigue among Hemodialysis Patients. Holist Nurs Pract, 36 (2):76-84.
36. Hassanzadeh M, Kiani F, Bouya S, et al (2018). Comparing the effects of relaxation technique and inhalation aromatherapy on fatigue in patients undergoing hemodialysis. Complement Ther Clin Pract, 31:210-214.
37. Zhang C, Mu H, Yang Y-F, et al (2023). Effect of aromatherapy on quality of life in maintenance hemodialysis patients: a systematic review and meta-analysis. Ren Fail, 45 (1):2164202.
38. Wahida AZ, Rumahorbo H, Murtiningsih (2022). The effectiveness of intradialytic exercise in ameliorating fatigue symptoms in patients with chronic kidney failure undergoing hemodialysis: A systematic literature review and meta-analysis. J Taibah Univ Med Sci, 18 (3):512-525.
39. Kim M, Nam ES, Lee Y, et al (2021). Effects of Lavender on Anxiety, Depression, and Physiological Parameters: Systematic Review and Meta-Analysis. Asian Nurs Res (Korean Soc Nurs Sci), 15(5):279-290 .
40. Boutron I PM, Higgins JPT, Altman DG, et al (updated August 2023). Cochrane, 2023. Available from: www.training.cochrane.org/handbook
41. Morrison A, Polisena J, Husereau D, et al (2012). The effect of English-language restriction on systematic review-based meta-analyses: a systematic review of empirical studies. Int J Technol Assess Health Care, 28 (2):138-44.
42. Mehrabian S, Tirgari B, Forouzi MA, et al (2022). Effect of Aromatherapy Massage on Depression and Anxiety of Elderly Adults: a Randomized Controlled Trial. Int J Ther Massage Bodywork, 15 (1):37-45.
43. Burns PB, Rohrich RJ, Chung KC (2011). The Levels of Evidence and Their Role in Evidence-Based Medicine. Plast Reconstr Surg, 128 (1):305-310.
44. Senturk A, Kartin PT (2018). The Effect of Lavender Oil Application via Inhalation Pathway on Hemodialysis Patients' Anxiety Level and Sleep Quality. Holist Nurs Pract, 32(6):324-335.
| Files | ||
| Issue | Vol 53 No 3 (2024) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v53i3.15135 | |
| Keywords | ||
| Lavender Aromatherapy Anxiety Fatigue Hemodialysis Meta-analysis | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Firooz M, Mahmoodi shan GR, Jouybari L, Yazdi K, Osuji J. Effect of Lavender Aromatherapy on Anxiety and Fatigue in Hemodialysis Patients: A Systematic Review and Meta-Analysis. Iran J Public Health. 2024;53(3):539-552.
