Evaluation of Antimicrobial Resistance of Acinetobacter baumannii to Imipenem, Ciporofloxacin and Ceftazidime using E Test

Abstract

Background: Resistance patterns among nosocomial bacterial pathogens in hospitals may vary widely from country to coun­try at any given point and within the same country over time. Acinetobacter baumannii is one of the most important bacte­rium causes hospital acquired infections. Therefore, surveillance of antibiotic resistance of A. baumannii is necessary, espe­cially in our country which there is no have much data in this field.
Methods: In a prospective study, strain comprised of a total of 191 recent clinical isolates selected consecutively from clini­cal infections of separate patients from three University hospitals in Tehran. Minimum inhibitory concentration (MIC) of these organisms for imipenem, ciprofloxacin and ceftazidime was determined using E test method according to CLSI guide­line. Also, MIC₅₀ and MIC₉₀ percent was calculated for each of these antibiotics.
Results: The percentages of Acinetobacter baumannii isolates susceptible to ciprofloxacin and ceftazidime by E test were 55.5% and 44.5%, respectively. The percentage of bacterium susceptible to imipenem by E test was 72.8%. MIC₅₀ and MIC₉₀ of imipenem in E test were 1.5 and >32, respectively.
Conclusion: High antimicrobial resistance against A. baumannii species has been seen in Iran; therefore, it is necessary to imple­ment some approaches for prevention of bacterial spread.