The Effect of Conjugated Linoleic Acids, Vitamin E and Their Combination on Lipid Peroxidation in Active Rheumatoid Arthritis

Abstract

Background: Reactive oxygen species (ROS) have important role in the etiology and pathogenesis of Rheumatoid Arthritis (RA). We investigated the effect of conjugated linoleic acids (CLAs) and vitamin E on lipid peroxidation.
Methods: In a randomized, double-blind placebo, controlled, clinical trial 87 patients with active RA were enrolled. They were divided into 4 groups, received one of the following daily supplement for 3 months; 1- group C: 2.5gr CLA, that con­tained 2 gr 50:50 mix of cis 9-trans11 and trans 10-cis 12 CLAs, 2- group E: 400mg Vitamin E, 3- group CE: CLAs  plus vita­min E, 4- group P: placebo. After supplementation Glutathione peroxidase (GSH-Px) level increased in C, E and CE groups, CE group had  lower GSH-Px than P group(P≤ 0.05).
Results: Glutathione reductase (GR) increased in CE, C and P groups. Catalase increased in all groups, but enhancement was significant in C and CE. Superoxide dismutase (SOD) decreased in E and C (P≤ 0.05). Catalase and SOD did not show signifi­cant differences between groups. Malondialdehyde (MDA) decreased significantly in all groups but this decrease was only significant in CE in comparison with other groups.
Conclusion:  CLAs might be useful in reducing oxidative stress in RA