Turmeric for Treatment of Irritable Bowel Syndrome: A Systematic Review of Population-Based Evidence
-
Emad Jafarzadeh
,
Shahram Shoeibi
,
Yaser Bahramvand
,
Elham Nasrollahi
,
Armin Salek Maghsoudi
,
Fatemeh Yazdi
,
Sepideh KarkonShayan
,
Shokoufeh Hassani
Abstract
Background: Irritable bowel syndrome (IBS) is a highly prevalent disorder of the gut interaction characterized by abdominal discomfort and pain associated with altered bowel habits in the absence of structural abnormalities. In spite of IBS' high prevalence and disease burden across the globe, no explanations have been given as to its underlying pathophysiology. As for the treatment of IBS, there is no specific medication, and the most beneficial treatment is usually supportive therapy. Recent animal and human studies have demonstrated the therapeutic potential of curcumin or turmeric in the treatment of IBS.
Methods: We systematically reviewed all available evidence supporting curcumin and turmeric's therapeutic potential in relieving IBS symptoms in the present study. For this purpose, a database search was performed using curcumin, turmeric, and IBS and all their equivalents as of the search terms in Web of Science, PubMed, Scopus, Ovid, Embase, and Google Scholar from1990 up to Feb 2021. The investigation was then limited to clinical trials, and then nine articles were collected for data analysis.
Results: The findings of the included literature showed that curcumin and turmeric alone or in combination with other medications could improve the severity of IBS as well as the quality of life among people who suffer from IBS symptoms.
Conclusion: Overall, medications containing curcumin and turmeric extract due to these compounds' anti-inflammatory effects may improve IBS symptoms, particularly abdominal pain and life quality.
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2. Pellissier S, Bonaz B. The place of stress and emotions in the irritable bowel syndrome. Vitamins and hormones. 2017;103:327-54. doi: 10.1016/bs.vh.2016.09.005.
3. Coss-Adame E, Rao SS. Brain and gut interactions in irritable bowel syndrome: new paradigms and new understandings. Current gastroenterology reports. 201.2016.379. doi: 10.1007/s11894-014-0379-z.
4. Sisay M, Bussa N, Gashaw T, Mengistu G. Investigating In Vitro Antibacterial Activities of Medicinal Plants Having Folkloric Repute in Ethiopian Traditional Medicine. Journal of evidence-based integrative medicine. 2019;24:2515690X19886276. doi: 10.1177/2515690X19886276
5. Kopczyńska M, Mokros Ł, Pietras T, Małecka-Panas E. Quality of life and depression in patients with irritable bowel syndrome. Przeglad gastroenterologiczny. 2018;13(2):102. doi:10.5114/pg.2018.75819.
6. Wang L, Alammar N, Singh R, Nanavati J, Song Y, Chaudhary R, et al. Gut microbial dysbiosis in the irritable bowel syndrome: a systematic review and meta-analysis of case-control studies. Journal of the Academy of Nutrition and Dietetics. 2020;120(4):565-86. doi: 10.1016/j.jand.2019.05.015
7. Mari A, Abu Baker F, Mahamid M, Sbeit W, Khoury T. The evolving role of gut microbiota in the management of irritable bowel syndrome: An overview of the current knowledge. Journal of clinical medicine. 2020;9(3):685. doi: 10.3390/jcm9030685.
8. Bonaz B, Lane RD, Oshinsky ML, Kenny PJ, Sinha R, Mayer EA, et al. Diseases, disorders, and comorbidities of interoception. Trends in Neurosciences. 2021;44(1):39-51. doi: 10.1016/j.tins.2020.09.009.
9. Panzarini E, Mariano S, Tacconi S, Carata E, Tata AM, Dini L. Novel Therapeutic Delivery of Nanocurcumin in Central Nervous System Related Disorders. Nanomaterials. 2021;11(1):2. doi: 10.3390/nano11010002.
10. Ghorani‐Azam A, Sepahi S, Khodaverdi E, Mohajeri SA. Herbal medicine as a promising therapeutic approach for the management of vascular dementia: A systematic literature review. Phytotherapy Research. 2018;32(9):1720-8. doi: 10.1002/ptr.6120.
11. Farzaei MH, Zobeiri M, Parvizi F, El-Senduny FF, Marmouzi I, Coy-Barrera E, et al. Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients. 2018;10(7):855. doi: 10.3390/nu10070855.
12. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Journal of clinical epidemiology. 2009;62(10):e1-e34. doi: 10.1136/bmj.b2700
13. Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. Bmj. 2015;349. doi: 10.1136/bmj.g7647
14. Lacy BE, Patel NK. Rome criteria and a diagnostic approach to irritable bowel syndrome. Journal of clinical medicine. 2017;6(11):99. doi: 10.3390/jcm6110099.
15. Bundy R, Walker AF, Middleton RW, Booth J. Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. Journal of Alternative & Complementary Medicine. 2004;10(6):1015-8. doi: 10.1089/acm.2004.10.1015.
16. Alt F, Chong PW, Teng E, Uebelhack R. Evaluation of benefit and tolerability of IQP‐CL‐101 (xanthofen) in the symptomatic improvement of irritable bowel syndrome: A double‐blinded, randomised, placebo‐controlled clinical trial. Phytotherapy Research. 2017;31(7):1056-62. doi: 10.1002/ptr.5826.
17. Portincasa P, Bonfrate L, Scribano ML, Kohn A, Caporaso N, Festi D, et al. Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome. Journal of Gastrointestinal & Liver Diseases. 2016;25(2). doi: 10.15403/jgld.2014.1121.252.ccm.
18. Di Ciaula A, Portincasa P, Maes N, Albert A. Efficacy of bio-optimized extracts of turmeric and essential fennel oil on the quality of life in patients with irritable bowel syndrome. Annals of gastroenterology. 2018;31(6):685. doi: 10.20524/aog.2018.0304
19. Ried K, Travica N, Dorairaj R, Sali A. Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. Nutrition Research. 2020;76:37-51 doi: 10.1016/j.nutres.2020.02.008..
20. Lior O, Sklerovsy-Benjaminov F, Lish I, Konokoff F, Naftali T. Treatment of Irritable Bowel Syndrome with a Combination of Curcumin, Green Tea and Selenomethionine Has a Positive Effect on Satisfaction with Bowel Habits. Journal of Biosciences and Medicines. 2019;7(5):170 doi: 10.4236/jbm.2019.75018 –
21. Lauche R, Kumar S, Hallmann J, Lüdtke R, Rampp T, Dobos G, et al. Efficacy and safety of Ayurvedic herbs in diarrhoea-predominant irritable bowel syndrome: A randomised controlled crossover trial. Complementary therapies in medicine. 2016;26:171-7. doi: 10.1016/j.ctim.2016.04.002.
22. Lopresti AL, Smith SJ, Rea A, Michel S. Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study. BMC complementary medicine and therapies. 2021;21(1):1-17. doi: 10.1186/s12906-021-03220-6.
23. Pilipenko V, Teplyuk D, Shakhovskaya A, Isakov V, Vorobyova V, Vorobyova I, et al. Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study. Voprosy pitaniia. 2015;84(6):83-91. doi: 10.1177/1756283X09104794.
24. Hulisz D. The burden of illness of irritable bowel syndrome: current challenges and hope for the future. Journal of Managed Care Pharmacy. 2004;10(4):299-309. doi: 10.18553/jmcp.2004.10.4.299.
25. Dulbecco P, Savarino V. Therapeutic potential of curcumin in digestive diseases. World journal of gastroenterology: WJG. 2013;19(48):9256. doi: 10.3748/wjg.v19.i48.9256.
26. Hewlings SJ, Kalman DS. Curcumin: a review of its effects on human health. Foods. 2017;6(10):92. doi: 10.3390/foods6100092.
27. Hassani S, Tavakoli F, Amini M, Kobarfard F, Nili-Ahmadabadi A, Sabzevari O. Occurrence of melamine contamination in powder and liquid milk in market of Iran. Food Additives & Contaminants: Part A. 2013;30(3):413-20. doi: 10.1080/19440049.2012.761730.
28. Hosseini A, Abdollahi M, Hassanzadeh G, Rezayat M, Hassani S, Pourkhalili N, et al. Protective effect of magnesium‐25 carrying porphyrin‐fullerene nanoparticles on degeneration of dorsal root ganglion neurons and motor function in experimental diabetic neuropathy. Basic & clinical pharmacology & toxicology. 2011;109(5):381-6. doi: 10.1111/j.1742-7843.2011.00741.x.
29. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. The AAPS journal. 2013;15(1):195-218. doi: 10.1208/s12248-012-9432-8.
30. Hudson A, Lopez E, Almalki AJ, Roe AL, Calderón AI. A review of the toxicity of compounds found in herbal dietary supplements. Planta Medica. 2018;84(09/10):613-26. doi: 10.1055/a-0605-3786.
31. Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. The molecular targets and therapeutic uses of curcumin in health and disease. 2007:105-25. doi: 10.1007/978-0-387-46401-5_3.
32. Marchiani A, Rozzo C, Fadda A, Delogu G, Ruzza P. Curcumin and curcumin-like molecules: from spice to drugs. Current medicinal chemistry. 2014;21(2):204-22. doi:10.2174/092986732102131206115810.
33. Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-κB pathway. Clinical Cancer Research. 2007;13(11): 3423-30.doi: 10.1158/1078-0432.CCR-06-3072
34. Shetty NP, Prabhakaran M, Srivastava AK. Pleiotropic nature of curcumin in targeting multiple apoptotic‐mediated factors and related strategies to treat gastric cancer: A review. Phytotherapy Research. 2021 May 24. doi: 10.1002/ptr.7158.
35. Yu Y, Wu S, Li J, Wang R, Xie X, Yu X, et al. The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. Metabolic brain disease. 2015;30(1):47-55.. doi: 10.1007/s11011-014-9554-z
36. Patel SS, Acharya A, Ray R, Agrawal R, Raghuwanshi R, Jain P. Cellular and molecular mechanisms of curcumin in prevention and treatment of disease. Critical reviews in food science and nutrition. 2020;60(6):887-939. doi: 10.1080/10408398.2018.1552244.
37. Salek-Maghsoudi A, Hassani S, Momtaz S, Shadboorestan A, Ganjali MR, Ghahremani MH, et al. Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon. Toxicology. 2019;411:1-14. doi: 10.1016/j.tox.2018.10.014.
38. Sözen S, Aziret M, Bali I, Emir S, Ülgen Y, Binnetoğlu K, Polat Y, Çetinkünar S. The Effect of Curcumin on an Animal Intestinal Ischemia/Reperfusion Model for Bacterial Translocation and Inflammatory Response. International Surgery. 2015;100(11-12):1352-9. doi: 10.9738/INTSURG-D-15-00004.1.
2. Pellissier S, Bonaz B. The place of stress and emotions in the irritable bowel syndrome. Vitamins and hormones. 2017;103:327-54. doi: 10.1016/bs.vh.2016.09.005.
3. Coss-Adame E, Rao SS. Brain and gut interactions in irritable bowel syndrome: new paradigms and new understandings. Current gastroenterology reports. 201.2016.379. doi: 10.1007/s11894-014-0379-z.
4. Sisay M, Bussa N, Gashaw T, Mengistu G. Investigating In Vitro Antibacterial Activities of Medicinal Plants Having Folkloric Repute in Ethiopian Traditional Medicine. Journal of evidence-based integrative medicine. 2019;24:2515690X19886276. doi: 10.1177/2515690X19886276
5. Kopczyńska M, Mokros Ł, Pietras T, Małecka-Panas E. Quality of life and depression in patients with irritable bowel syndrome. Przeglad gastroenterologiczny. 2018;13(2):102. doi:10.5114/pg.2018.75819.
6. Wang L, Alammar N, Singh R, Nanavati J, Song Y, Chaudhary R, et al. Gut microbial dysbiosis in the irritable bowel syndrome: a systematic review and meta-analysis of case-control studies. Journal of the Academy of Nutrition and Dietetics. 2020;120(4):565-86. doi: 10.1016/j.jand.2019.05.015
7. Mari A, Abu Baker F, Mahamid M, Sbeit W, Khoury T. The evolving role of gut microbiota in the management of irritable bowel syndrome: An overview of the current knowledge. Journal of clinical medicine. 2020;9(3):685. doi: 10.3390/jcm9030685.
8. Bonaz B, Lane RD, Oshinsky ML, Kenny PJ, Sinha R, Mayer EA, et al. Diseases, disorders, and comorbidities of interoception. Trends in Neurosciences. 2021;44(1):39-51. doi: 10.1016/j.tins.2020.09.009.
9. Panzarini E, Mariano S, Tacconi S, Carata E, Tata AM, Dini L. Novel Therapeutic Delivery of Nanocurcumin in Central Nervous System Related Disorders. Nanomaterials. 2021;11(1):2. doi: 10.3390/nano11010002.
10. Ghorani‐Azam A, Sepahi S, Khodaverdi E, Mohajeri SA. Herbal medicine as a promising therapeutic approach for the management of vascular dementia: A systematic literature review. Phytotherapy Research. 2018;32(9):1720-8. doi: 10.1002/ptr.6120.
11. Farzaei MH, Zobeiri M, Parvizi F, El-Senduny FF, Marmouzi I, Coy-Barrera E, et al. Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients. 2018;10(7):855. doi: 10.3390/nu10070855.
12. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Journal of clinical epidemiology. 2009;62(10):e1-e34. doi: 10.1136/bmj.b2700
13. Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. Bmj. 2015;349. doi: 10.1136/bmj.g7647
14. Lacy BE, Patel NK. Rome criteria and a diagnostic approach to irritable bowel syndrome. Journal of clinical medicine. 2017;6(11):99. doi: 10.3390/jcm6110099.
15. Bundy R, Walker AF, Middleton RW, Booth J. Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. Journal of Alternative & Complementary Medicine. 2004;10(6):1015-8. doi: 10.1089/acm.2004.10.1015.
16. Alt F, Chong PW, Teng E, Uebelhack R. Evaluation of benefit and tolerability of IQP‐CL‐101 (xanthofen) in the symptomatic improvement of irritable bowel syndrome: A double‐blinded, randomised, placebo‐controlled clinical trial. Phytotherapy Research. 2017;31(7):1056-62. doi: 10.1002/ptr.5826.
17. Portincasa P, Bonfrate L, Scribano ML, Kohn A, Caporaso N, Festi D, et al. Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome. Journal of Gastrointestinal & Liver Diseases. 2016;25(2). doi: 10.15403/jgld.2014.1121.252.ccm.
18. Di Ciaula A, Portincasa P, Maes N, Albert A. Efficacy of bio-optimized extracts of turmeric and essential fennel oil on the quality of life in patients with irritable bowel syndrome. Annals of gastroenterology. 2018;31(6):685. doi: 10.20524/aog.2018.0304
19. Ried K, Travica N, Dorairaj R, Sali A. Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. Nutrition Research. 2020;76:37-51 doi: 10.1016/j.nutres.2020.02.008..
20. Lior O, Sklerovsy-Benjaminov F, Lish I, Konokoff F, Naftali T. Treatment of Irritable Bowel Syndrome with a Combination of Curcumin, Green Tea and Selenomethionine Has a Positive Effect on Satisfaction with Bowel Habits. Journal of Biosciences and Medicines. 2019;7(5):170 doi: 10.4236/jbm.2019.75018 –
21. Lauche R, Kumar S, Hallmann J, Lüdtke R, Rampp T, Dobos G, et al. Efficacy and safety of Ayurvedic herbs in diarrhoea-predominant irritable bowel syndrome: A randomised controlled crossover trial. Complementary therapies in medicine. 2016;26:171-7. doi: 10.1016/j.ctim.2016.04.002.
22. Lopresti AL, Smith SJ, Rea A, Michel S. Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study. BMC complementary medicine and therapies. 2021;21(1):1-17. doi: 10.1186/s12906-021-03220-6.
23. Pilipenko V, Teplyuk D, Shakhovskaya A, Isakov V, Vorobyova V, Vorobyova I, et al. Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study. Voprosy pitaniia. 2015;84(6):83-91. doi: 10.1177/1756283X09104794.
24. Hulisz D. The burden of illness of irritable bowel syndrome: current challenges and hope for the future. Journal of Managed Care Pharmacy. 2004;10(4):299-309. doi: 10.18553/jmcp.2004.10.4.299.
25. Dulbecco P, Savarino V. Therapeutic potential of curcumin in digestive diseases. World journal of gastroenterology: WJG. 2013;19(48):9256. doi: 10.3748/wjg.v19.i48.9256.
26. Hewlings SJ, Kalman DS. Curcumin: a review of its effects on human health. Foods. 2017;6(10):92. doi: 10.3390/foods6100092.
27. Hassani S, Tavakoli F, Amini M, Kobarfard F, Nili-Ahmadabadi A, Sabzevari O. Occurrence of melamine contamination in powder and liquid milk in market of Iran. Food Additives & Contaminants: Part A. 2013;30(3):413-20. doi: 10.1080/19440049.2012.761730.
28. Hosseini A, Abdollahi M, Hassanzadeh G, Rezayat M, Hassani S, Pourkhalili N, et al. Protective effect of magnesium‐25 carrying porphyrin‐fullerene nanoparticles on degeneration of dorsal root ganglion neurons and motor function in experimental diabetic neuropathy. Basic & clinical pharmacology & toxicology. 2011;109(5):381-6. doi: 10.1111/j.1742-7843.2011.00741.x.
29. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. The AAPS journal. 2013;15(1):195-218. doi: 10.1208/s12248-012-9432-8.
30. Hudson A, Lopez E, Almalki AJ, Roe AL, Calderón AI. A review of the toxicity of compounds found in herbal dietary supplements. Planta Medica. 2018;84(09/10):613-26. doi: 10.1055/a-0605-3786.
31. Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. The molecular targets and therapeutic uses of curcumin in health and disease. 2007:105-25. doi: 10.1007/978-0-387-46401-5_3.
32. Marchiani A, Rozzo C, Fadda A, Delogu G, Ruzza P. Curcumin and curcumin-like molecules: from spice to drugs. Current medicinal chemistry. 2014;21(2):204-22. doi:10.2174/092986732102131206115810.
33. Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-κB pathway. Clinical Cancer Research. 2007;13(11): 3423-30.doi: 10.1158/1078-0432.CCR-06-3072
34. Shetty NP, Prabhakaran M, Srivastava AK. Pleiotropic nature of curcumin in targeting multiple apoptotic‐mediated factors and related strategies to treat gastric cancer: A review. Phytotherapy Research. 2021 May 24. doi: 10.1002/ptr.7158.
35. Yu Y, Wu S, Li J, Wang R, Xie X, Yu X, et al. The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. Metabolic brain disease. 2015;30(1):47-55.. doi: 10.1007/s11011-014-9554-z
36. Patel SS, Acharya A, Ray R, Agrawal R, Raghuwanshi R, Jain P. Cellular and molecular mechanisms of curcumin in prevention and treatment of disease. Critical reviews in food science and nutrition. 2020;60(6):887-939. doi: 10.1080/10408398.2018.1552244.
37. Salek-Maghsoudi A, Hassani S, Momtaz S, Shadboorestan A, Ganjali MR, Ghahremani MH, et al. Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon. Toxicology. 2019;411:1-14. doi: 10.1016/j.tox.2018.10.014.
38. Sözen S, Aziret M, Bali I, Emir S, Ülgen Y, Binnetoğlu K, Polat Y, Çetinkünar S. The Effect of Curcumin on an Animal Intestinal Ischemia/Reperfusion Model for Bacterial Translocation and Inflammatory Response. International Surgery. 2015;100(11-12):1352-9. doi: 10.9738/INTSURG-D-15-00004.1.
| Files | ||
| Issue | Vol 51 No 6 (2022) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v51i6.9656 | |
| Keywords | ||
| Irritable bowel syndrome Curcumin Turmeric Curcuma longa Gastrointestinal disorders | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Jafarzadeh E, Shoeibi S, Bahramvand Y, Nasrollahi E, Salek Maghsoudi A, Yazdi F, KarkonShayan S, Hassani S. Turmeric for Treatment of Irritable Bowel Syndrome: A Systematic Review of Population-Based Evidence. Iran J Public Health. 2022;51(6):1223-1231.
