Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 51 6 2022 06 08 1223 1231 Emad Jafarzadeh Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Shahram Shoeibi Food and Drug Laboratory Research Center, Iran Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran Yaser Bahramvand Students’ Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran Elham Nasrollahi Students’ Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran Armin Salek Maghsoudi Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Fatemeh Yazdi Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Sepideh KarkonShayan Student Research Committee, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran Shokoufeh Hassani Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences, Tehran Uni-versity of Medical Sciences, Tehran, Iran 2021 09 29 2022 02 06 Background: Irritable bowel syndrome (IBS) is a highly prevalent disorder of the gut interaction characterized by abdominal discomfort and pain associated with altered bowel habits in the absence of structural abnormalities. In spite of IBS' high prevalence and disease burden across the globe, no explanations have been given as to its underlying pathophysiology. As for the treatment of IBS, there is no specific medication, and the most beneficial treatment is usually supportive therapy. Recent animal and human studies have demonstrated the therapeutic potential of curcumin or turmeric in the treatment of IBS. Methods: We systematically reviewed all available evidence supporting curcumin and turmeric's therapeutic potential in relieving IBS symptoms in the present study. For this purpose, a database search was performed using curcumin, turmeric, and IBS and all their equivalents as of the search terms in Web of Science, PubMed, Scopus, Ovid, Embase, and Google Scholar from1990 up to Feb 2021. The investigation was then limited to clinical trials, and then nine articles were collected for data analysis. Results: The findings of the included literature showed that curcumin and turmeric alone or in combination with other medications could improve the severity of IBS as well as the quality of life among people who suffer from IBS symptoms. Conclusion: Overall, medications containing curcumin and turmeric extract due to these compounds' anti-inflammatory effects may improve IBS symptoms, particularly abdominal pain and life quality.   https://ijph.tums.ac.ir/index.php/ijph/article/view/26430 https://ijph.tums.ac.ir/index.php/ijph/article/download/26430/7616