The Effect of Helicobacter pylori Infection on Overweight: A Systematic Review and Meta-Analysis
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Abstract
Background: The association between Helicobacter pylori infection and overweight, as one of the most common health issues, remains controversial. In this study, we systematically reviewed the effect of H. pylori infection and overweight to get a reliable answer.
Methods: We used the Preferred Reporting Items for the Systematic Review and Meta-Analysis statement. We searched the association between H. pylori and overweight infection in international databases including Medline, Web of knowledge and Scopus, without any limitations of language, publication type, and publication status in search step of this systematic review from 2000 to 2020. We surveyed the title, abstract and full text of each research studies, and we used Newcastle-Ottawa quality for assessing the quality of each paper. A random effects model was used to calculate the pooled odd ratio with 95% confidence intervals.
Results: Fifteen papers were eligible for this review. The selected studies reported different Odd Ratio between overweight and H. pylori infection but Odds Ratio (95% confidence interval) in our systematic and meta-analysis study was estimated at 1.42 (95%CI; 1.12, 1.81) and it was statistically significant (P: 0.003).
Conclusion: H. pylori infection is significantly associated with overweight, therefore, the eradication of H. pylori infection is suggested because this infectious might be resulted in overweight.
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4. Abreo A, Gebretsadik T, Stone CA, Hartert TV (2018). The impact of modifiable risk factor reduction on childhood asthma development. Clin Transl Med, 7(1):15.
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7. Hooi JK, Lai WY, Ng WK, et al (2017). Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology,153(2):420-9.
8. Wotherspoon A, Ortiz-Hidalgo C, Falzon M, Isaacson P (1991). Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet, 338(8776):1175-6.
9. Aydemir S, Bayraktaroglu T, Sert M, et al (2005). The effect of Helicobacter pylori on insulin resistance. Dig Dis Sci, 50(11):2090-3.
10. Bener A, Micallef R, Afifi M, et al (2007). Association between type 2 diabetes mellitus and Helicobacter pylori infection. Turk J Gastroenterol, 18(4):225-9.
11. Al-Akwaa AM (2010). Prevalence of Helicobacter pylori infection in a group of morbidly obese Saudi patients undergoing bariatric surgery: a preliminary report. Saudi J Gastroenterol, 16(4):264-7.
12. Arslan E, Atilgan H, Yavasoglu I (2009). The prevalence of Helicobacter pylori in obese subjects. Eur J Intern Med, 20(7):695-7.
13. Kamada T, Hata J, Kusunoki H, et al (2005). Eradication of Helicobacter pylori increases the incidence of hyperlipidaemia and obesity in peptic ulcer patients. Dig Liver Dis, 37(1):39-43.
14. Lender N, Talley NJ, Enck P, et al (2014). Review article: Associations between Helicobacter pylori and obesity--an ecological study. Aliment Pharmacol Ther, 40(1):24-31.
15. Imada T, Mizuno M, Take S, et al (2016). Helicobacter pylori eradication may increase body mass index, but the effect may not last long. A 10-year observation. J Transl Med Res, 21(2):143-7.
16. Al-Zubaidi AM, Alzobydi AH, Alsareii SA, et al (2018). Body Mass Index and Helicobacter pylori among Obese and Non-Obese Patients in Najran, Saudi Arabia: A Case-Control Study. Int J Environ Res Public Health, 15(11):2586.
17. Abdullahi M, Annibale B, Capoccia D, et al (2008). The Eradication of Helicobacter pylori is Affected by Body Mass Index (BMI). Obes Surg,18(11):1450-4.
18. Peixoto A, Silva M, Gaspar R, et al (2016). Loose ends in the eradication of Helicobacter pylori infection. J Transl Int Med, 4(4):178-81.
19. Moher D LA, Tetzlaff J, Altman DG, The PRISMA Group (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med, 6(7): e1000097.
20. World Health Organization (2000). Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser, 894:i-xii, 1-253.
21. Stang A (2010). Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 25(9):603-5.
22. Wu MS, Lee WJ, Wang HH, Huang SP, Lin JT (2005). A case-control study of association of Helicobacter pylori infection with morbid obesity in Taiwan. Arch Intern Med, 165(13):1552-5.
23. Siddiqui B, Yakoob J, Abbas Z, et al (2018). Distribution of Helicobacter pylori infection and abnormal body-mass index (BMI) in a developing country. J Infect Dev Ctries, 12(5):342-6.
24. Chen LW, Kuo SF, Chen CH, et al (2018). A community-based study on the association between Helicobacter pylori Infection and obesity. Sci Rep, 8(1):10746.
25. Blaser MJ, Atherton JC (2004). Helicobacter pylori persistence: biology and disease. J Clin Invest, 113(3):321-33.
26. Azuma T, Suto H, Ito Y, et al (2001). Gastric leptin and Helicobacter pylori infection. Gut, 49(3):324-9.
27. Thalmaier U, Lehn N, Pfeffer K, et al (2002). Role of tumor necrosis factor alpha in Helicobacter pylori gastritis in tumor necrosis factor receptor 1-deficient mice. Infect Immun, 70(6):3149-55.
28. Pan H GJ, Su Z (2014). Advances in understanding the interrelations between leptin resistance and obesity. Physiol Behav, 130: 157–69.
29. Roper J, Francois F, Shue PL, et al (2008). Leptin and ghrelin in relation to Helicobacter pylori status in adult males. J Clin Endocrinol Metab, 93(6):2350-7.
30. Cornejo-Pareja I, Martín-Núñez GM, Roca-Rodríguez M, et al (2019). H. pylori Eradication Treatment Alters Gut Microbiota and GLP-1 Secretion in Humans. J Clin Med, 8(4):451.
31. Salim MA, Eftekharian MM, Taheri M, Alikhani MY (2017). Determining the IgM and IgG antibody titer against CMV and Helicobacter pylori in the serum of multiple sclerosis patients comparing to the control group in Hamadan. Hum Antibodies, 26(1):23-28.
32. Nouri F, Kamarehei F, Asghari B, et al (2022). Prevalence and drug resistance patterns of bacteria isolated from wound and bloodstream nosocomial infections in Hamadan, West of Iran. All Life, 15: 174-182.
33. Kamarehei F, Khabiri A, Saidijam M, et al (2018). Designing a novel ELISA method based on CagA, NapA recombinant antigens to increase sensitivity and specificity of Helicobacter pylori whole cell antigen detection. Gastroenterol Hepatol Bed Bench, 11(4):333-342.
34. Alikhani MY, Arebestani MR, Sayedin Khorasani M, Majlesi A, Jaefari M (2014). Evaluation of Helicobacter pylori vacA and cagA Genotypes and Correlation With Clinical Outcome in Patients With Dyspepsia in Hamadan Province, Iran. Iran Red Crescent Med J, 16(11):e19173.
35. Kamarehei F, Taheri M, Mohammadi Y, et al (2020). Prevalence of Helicobacter pylori virulence genes among Iranian infected patients: a systematic review and meta-analysis. Rev Med Microbiol, 31(4):191-200.
36. Bazmamoun H RZ, Esfahani H, Arefian (2014). Evaluation of Iron deficiency anemia and BMI in children suffering from Helicobacter pylori infection. Iran J Ped Hematol Oncol, 4(4):167-71.
37. Ghasemi Basir HR, Ghobakhlou M, Akbari P, et al (2017). Correlation between the Intensity of Helicobacter pylori Colonization and Severity of Gastritis. Gastroenterol Res Pract, 2017:8320496.
2. Damcott C. M. SP, Shuldiner AR (2003). The genetics of obesity. Endocrinol Metab Clin North Am, 32: 761–786.
3. Kyrou I, Randeva HS, Tsigos C, Kaltsas G, Weickert MO (2018). Clinical problems caused by obesity. Endotext [Internet]: MDText. com, Inc.
4. Abreo A, Gebretsadik T, Stone CA, Hartert TV (2018). The impact of modifiable risk factor reduction on childhood asthma development. Clin Transl Med, 7(1):15.
5. Hruby A, Hu FB (2015). The epidemiology of obesity: a big picture. Pharmacoeconomics, 33(7):673-89.
6. Chu NF, Wang SC, Chang HY, Wu DM (2010). Medical services utilization and expenditure of obesity-related disorders in Taiwanese adults. Value Health, 13(6):829-36.
7. Hooi JK, Lai WY, Ng WK, et al (2017). Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology,153(2):420-9.
8. Wotherspoon A, Ortiz-Hidalgo C, Falzon M, Isaacson P (1991). Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet, 338(8776):1175-6.
9. Aydemir S, Bayraktaroglu T, Sert M, et al (2005). The effect of Helicobacter pylori on insulin resistance. Dig Dis Sci, 50(11):2090-3.
10. Bener A, Micallef R, Afifi M, et al (2007). Association between type 2 diabetes mellitus and Helicobacter pylori infection. Turk J Gastroenterol, 18(4):225-9.
11. Al-Akwaa AM (2010). Prevalence of Helicobacter pylori infection in a group of morbidly obese Saudi patients undergoing bariatric surgery: a preliminary report. Saudi J Gastroenterol, 16(4):264-7.
12. Arslan E, Atilgan H, Yavasoglu I (2009). The prevalence of Helicobacter pylori in obese subjects. Eur J Intern Med, 20(7):695-7.
13. Kamada T, Hata J, Kusunoki H, et al (2005). Eradication of Helicobacter pylori increases the incidence of hyperlipidaemia and obesity in peptic ulcer patients. Dig Liver Dis, 37(1):39-43.
14. Lender N, Talley NJ, Enck P, et al (2014). Review article: Associations between Helicobacter pylori and obesity--an ecological study. Aliment Pharmacol Ther, 40(1):24-31.
15. Imada T, Mizuno M, Take S, et al (2016). Helicobacter pylori eradication may increase body mass index, but the effect may not last long. A 10-year observation. J Transl Med Res, 21(2):143-7.
16. Al-Zubaidi AM, Alzobydi AH, Alsareii SA, et al (2018). Body Mass Index and Helicobacter pylori among Obese and Non-Obese Patients in Najran, Saudi Arabia: A Case-Control Study. Int J Environ Res Public Health, 15(11):2586.
17. Abdullahi M, Annibale B, Capoccia D, et al (2008). The Eradication of Helicobacter pylori is Affected by Body Mass Index (BMI). Obes Surg,18(11):1450-4.
18. Peixoto A, Silva M, Gaspar R, et al (2016). Loose ends in the eradication of Helicobacter pylori infection. J Transl Int Med, 4(4):178-81.
19. Moher D LA, Tetzlaff J, Altman DG, The PRISMA Group (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med, 6(7): e1000097.
20. World Health Organization (2000). Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser, 894:i-xii, 1-253.
21. Stang A (2010). Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 25(9):603-5.
22. Wu MS, Lee WJ, Wang HH, Huang SP, Lin JT (2005). A case-control study of association of Helicobacter pylori infection with morbid obesity in Taiwan. Arch Intern Med, 165(13):1552-5.
23. Siddiqui B, Yakoob J, Abbas Z, et al (2018). Distribution of Helicobacter pylori infection and abnormal body-mass index (BMI) in a developing country. J Infect Dev Ctries, 12(5):342-6.
24. Chen LW, Kuo SF, Chen CH, et al (2018). A community-based study on the association between Helicobacter pylori Infection and obesity. Sci Rep, 8(1):10746.
25. Blaser MJ, Atherton JC (2004). Helicobacter pylori persistence: biology and disease. J Clin Invest, 113(3):321-33.
26. Azuma T, Suto H, Ito Y, et al (2001). Gastric leptin and Helicobacter pylori infection. Gut, 49(3):324-9.
27. Thalmaier U, Lehn N, Pfeffer K, et al (2002). Role of tumor necrosis factor alpha in Helicobacter pylori gastritis in tumor necrosis factor receptor 1-deficient mice. Infect Immun, 70(6):3149-55.
28. Pan H GJ, Su Z (2014). Advances in understanding the interrelations between leptin resistance and obesity. Physiol Behav, 130: 157–69.
29. Roper J, Francois F, Shue PL, et al (2008). Leptin and ghrelin in relation to Helicobacter pylori status in adult males. J Clin Endocrinol Metab, 93(6):2350-7.
30. Cornejo-Pareja I, Martín-Núñez GM, Roca-Rodríguez M, et al (2019). H. pylori Eradication Treatment Alters Gut Microbiota and GLP-1 Secretion in Humans. J Clin Med, 8(4):451.
31. Salim MA, Eftekharian MM, Taheri M, Alikhani MY (2017). Determining the IgM and IgG antibody titer against CMV and Helicobacter pylori in the serum of multiple sclerosis patients comparing to the control group in Hamadan. Hum Antibodies, 26(1):23-28.
32. Nouri F, Kamarehei F, Asghari B, et al (2022). Prevalence and drug resistance patterns of bacteria isolated from wound and bloodstream nosocomial infections in Hamadan, West of Iran. All Life, 15: 174-182.
33. Kamarehei F, Khabiri A, Saidijam M, et al (2018). Designing a novel ELISA method based on CagA, NapA recombinant antigens to increase sensitivity and specificity of Helicobacter pylori whole cell antigen detection. Gastroenterol Hepatol Bed Bench, 11(4):333-342.
34. Alikhani MY, Arebestani MR, Sayedin Khorasani M, Majlesi A, Jaefari M (2014). Evaluation of Helicobacter pylori vacA and cagA Genotypes and Correlation With Clinical Outcome in Patients With Dyspepsia in Hamadan Province, Iran. Iran Red Crescent Med J, 16(11):e19173.
35. Kamarehei F, Taheri M, Mohammadi Y, et al (2020). Prevalence of Helicobacter pylori virulence genes among Iranian infected patients: a systematic review and meta-analysis. Rev Med Microbiol, 31(4):191-200.
36. Bazmamoun H RZ, Esfahani H, Arefian (2014). Evaluation of Iron deficiency anemia and BMI in children suffering from Helicobacter pylori infection. Iran J Ped Hematol Oncol, 4(4):167-71.
37. Ghasemi Basir HR, Ghobakhlou M, Akbari P, et al (2017). Correlation between the Intensity of Helicobacter pylori Colonization and Severity of Gastritis. Gastroenterol Res Pract, 2017:8320496.
| Files | ||
| Issue | Vol 51 No 11 (2022) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v51i11.11159 | |
| Keywords | ||
| Helicobacter pylori Overweight Meta-analysis | ||
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How to Cite
1.
Kamarehei F, Mohammadi Y. The Effect of Helicobacter pylori Infection on Overweight: A Systematic Review and Meta-Analysis. Iran J Public Health. 2022;51(11):2417-2424.
