Efficacy of Shenqi Jiangtang Granules-Assisted Western Medicine in the Treatment of Gestational Diabetes Mellitus (GDM)
-
Juan Tang
,
Li Fan
,
Chunlei Lv
,
Runjie Wan
,
Jianjian Liu
,
Xiaoyan Liu
Abstract
Background: We aimed to investigate the efficacy of Shenqi Jiangtang granules-assisted Western medicine in the treatment of gestational diabetes mellitus (GDM).
Methods: A total of 147 patients with GDM treated in Qilu Hospital of Shandong University from Jan 2018 to Apr 2019 were enrolled. They were randomly divided into traditional Chinese medicine (TCM) combined with Western medicine group, Western medicine group and control group. The control group was treated with exercise combined with diet therapy, and the Western medicine group was additionally treated with metformin tablets. The TCM combined with Western medicine group was additionally treated with Shenqi Jiangtang granules.
Results: After treatment, the levels of 10 indicators in the three groups were lower than those before treatment (P < 0.05). These indicators were the lowest in the TCM combined with Western medicine group. However, high-density lipoprotein cholesterol (HDL-C), glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) after treatment increased in the three groups compared with those before treatment (P < 0.05), which was the most obvious in the TCM combined with Western medicine group. After treatment, the number of patients with natural delivery in the TCM combined with Western medicine group was the largest. The incidences of complications in pregnant women, fetuses and newborns were the lowest in the TCM combined with Western medicine group.
Conclusion: Application of Shenqi Jiangtang granules-assisted Western medicine in patients with GDM can effectively control blood glucose and lipid levels, enhance antioxidant capacity, reduce the levels of inflammatory cytokines and decrease the incidence of adverse pregnancy outcomes.
2. Cambos S, Rigalleau V, Baillet-Blanco L (2017). Comment on: A randomized clin-ical trial of exercise during pregnancy to prevent gestational diabetes mellitus and improve pregnancy outcome in over-weight and obese pregnant women. Am J Obstet Gynecol, 217(3): 380.
3. Dodd JM, Louise J, Deussen AR, et al (2019). Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, place-bo-controlled trial. Lancet Diabetes Endo-crinol, 7(1): 15-24.
4. Brown J, Martis R, Hughes B, et al (2017). Oral anti-diabetic pharmacological thera-pies for the treatment of women with gestational diabetes. Cochrane Database Syst Rev, 1(1): CD011967.
5. Chiswick CA, Reynolds RM, Denison FC, et al (2015). Efficacy of metformin in preg-nant obese women: a randomised con-trolled trial. BMJ Open, 5(1): e006854.
6. Hadar E, Oats J, Hod M (2009). Towards new diagnostic criteria for diagnosing GDM: the HAPO study. J Perinat Med, 37(5): 447-449.
7. Alfadhli EM (2015). Gestational diabetes mellitus. Saudi Med J, 36(4): 399-406.
8. Spaight C, Gross J, Horsch A, Puder JJ (2016). Gestational Diabetes Mellitus. En-docr Dev, 31: 163-178.
9. Lain KY, Catalano PM (2007). Metabolic changes in pregnancy. Clin Obstet Gynecol, 50(4): 938–948.
10. Wang C, Wei Y, Zhang X, et al (2017). A randomized clinical trial of exercise dur-ing pregnancy to prevent gestational dia-betes mellitus and improve pregnancy outcome in overweight and obese preg-nant women. Am J Obstet Gynecol, 216(4): 340-351.
11. Berghella V, Saccone G (2017). Exercise in pregnancy! Am J Obstet Gynecol, 216(4): 335-337.
12. Laredo-Aguilera JA, Gallardo-Bravo M, Ra-banales-Sotos JA, et al (2020). Physical Activity Programs during Pregnancy Are Effective for the Control of Gestational Diabetes Mellitus. Int J Environ Res Public Health, 17(17): 6151.
13. Amaefule CE, Bolou A, Drymoussi Z, et al (2020). Effectiveness and acceptability of metformin in preventing the onset of type 2 diabetes after gestational diabetes in postnatal women: a protocol for a randomised, placebo-controlled, double-blind feasibility trial—Optimising health outcomes with Metformin to prevent di-Abetes After pregnancy (OMAhA). BMJ Open, 10(5): e036198.
14. Brown FM, Isganaitis E, James-Todd T (2019). Much to HAPO FUS About: In-creasing Maternal Glycemia in Pregnancy Is Associated With Worsening Child-hood Glucose Metabolism. Diabetes Care, 42(3): 393-395.
15. Mack LR, Tomich PG (2017). Gestational Diabetes: Diagnosis, Classification, and Clinical Care. Obstet Gynecol Clin North Am, 44(2): 207-217.
16. Yin YN, Li XL, Tao TJ, et al (2014). Physical activity during pregnancy and the risk of gestational diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials. Br J Sports Med, 48(4): 290-295.
17. Bellamy L, Casas JP, Hingorani AD, et al (2009). Type 2 diabetes mellitus after ges-tational diabetes: a systematic review and meta-analysis. Lancet, 373(9677): 1773–1779.
18. Ma RCW (2018). Epidemiology of diabetes and diabetic complications in China. Dia-betologia, 61(6): 1249-1260.
19. Song C, Li J, Leng J, et al (2016). Lifestyle intervention can reduce the risk of gesta-tional diabetes: a meta-analysis of ran-domized controlled trials. Obes Rev, 17(10): 960-969.
20. Tran ND, Hunter SK, Yankowitz J (2004). Oral hypoglycemic agents in pregnancy. Obstet Gynecol Surv, 59(6): 456-463.
21. Chen P, Wang S, Ji J, et al (2015). Risk fac-tors and management of gestational dia-betes. Cell Biochem Biophys, 71(2): 689-694.
22. Lowe WL Jr, Scholtens DM, Kuang A, et al (2019). Hyperglycemia and Adverse Preg-nancy Outcome Follow-up Study (HAPO FUS): Maternal Gestational Diabetes Mellitus and Childhood Glucose Me-tabolism. Diabetes Care, 42(3): 372-380.
23. Qazi WA, Babur MN, Malik AN, et al (2020). Effects of structured exercise re-gime on Glycosylated Hemoglobin and C reactive protein in patients with Gesta-tional Diabetes Mellitus - A randomized controlled trial. Pak J Med Sci, 36(7): 1449-1453.
24. Zhu Y, Zhang C (2016). Prevalence of ges-tational diabetes and risk of progression to type 2 diabetes: a global perspective. Curr Diab Rep, 16(1): 7.
25. Law KP, Zhang H (2017). The pathogenesis and pathophysiology of gestational dia-betes mellitus: Deductions from a three-part longitudinal metabolomics study in China. Clin Chim Acta, 468: 60-70.
26. Xu YXZ, Xi S, Qian X (2019). Evaluating Traditional Chinese Medicine and Herbal Products for the Treatment of Gestation-al Diabetes Mellitus. J Diabetes Res, 2019: 9182595.
27. Zhao HL, Tong PCY, Chan JCN (2006). Traditional Chinese medicine in the treatment of diabetes. Nestle Nutr Work-shop Ser Clin Perform Programme, 11: 15-29.
28. Gui QF, Xu ZR, Xu KY, et al (2016). The Efficacy of Ginseng-Related Therapies in Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-analysis. Medicine (Baltimore), 95(6): e2584.
29. Guo Q, Niu W, Li X, et al (2019). Study on Hypoglycemic Effect of the Drug Pair of Astragalus Radix and Dioscoreae Rhi-zoma in T2DM Rats by Network Phar-macology and Metabonomics. Molecules, 24(22): 4050.
| Files | ||
| Issue | Vol 50 No 11 (2021) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v50i11.7573 | |
| Keywords | ||
| Shenqi Jiangtang granules Gestational diabetes mellitus Clinical efficacy Adverse pregnancy outcome | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
