Graft and Patient Survival Rates in Kidney Transplantation, and Their Associated Factors: A Systematic Review and Meta-Analysis
-
Mousa Ghelichi-Ghojogh
,
Haleh Ghaem
,
Fateme Mohammadizadeh
,
Mouhebat Vali
,
Faisal Ahmed
,
Soheil Hassanipour
,
Hossein-Ali Nikbakht
,
Fateme rezaei
,
Mohammad Fararouei
Abstract
Background: End-Stage Renal Disease (ESRD) is an irreversible impairment of kidney function that leads to permanently dependent on alternative therapies such as hemodialysis, peritoneal dialysis, and renal transplantation. This study aimed to systematically investigate the survival rate of patients with renal transplantation, graft, and its related factors in Iran.
Methods: This systematic review and meta-analysis drew on articles indexed in six international and one internal databases (Medline/PubMed, ProQuest, Scopus, Embase, SID, and Web of knowledge) until Nov 2020. The reporting of the present study was performed in terms of PRISMA statement. All analyzes were performed using the STATA software.
Results: Overall, 367 titles from 6 databases were evaluated of which 86 articles met the inclusion criteria. According to the random model, the graft survival rate at one, three, five, and 10 years were 92.48%, 85.08%, 79.96% and 68.15% respectively. Additionally, the patient survival rates at one, three, five, and 10 years were 91.27%, 86.46%, 81.17% and 78.15% respectively. There was a significant relationship between the age recipient and three-year graft survival rate (P=0.021). Additionally, there was an inverse and significant relationship between the donor age and 10-year patient survival rate (P=0.011).
Conclusion: The patient and graft survival in transplanted kidney patients is comparable with most developed countries.
1. Ghelichi Ghojogh M, Taghizadeh Afshari A, et al (2017). The Effect of Body Mass Index on Patient and Graft Survival Rate in Kidney Transplanted Patients in Iran. Nephro-Urol Mon, 9(4): e14386.
2. El Nahas AM, Bello AK (2005). Chronic kidney disease: the global challenge. The lancet, 365:331-340.
3. Florit E, Diekmann F, Budde K, et al (2015). Living Donor Transplantation: Long-Term Evolution Related to Age Matching. Transplantation proceedings, Elsevier, pp. 2346-2350.
4. Einollahi B (2004). Iranian experience with the non-related renal transplantation. Saudi J Kidney Dis Transpl, 15:421-428.
5. Jahromi SE, Ahmed F, Pourahmad S, et al (2019). Predictors of peritoneal dialysis associated peritonitis; application of the zero-inflated negative binomial model. J Nephropathol, 8:e36.
6. Zeraati AA, Nazemian F, Takalloo L, et al (2016). The relationship between serology of hepatitis E virus with liver and kidney function in kidney transplant patients. EXCLI J, 15:343-9.
7. Mahdavi-Mazdeh M, Rouchi AH, Norouzi S, et al (2007). Renal replacement therapy in Iran. Urol J, 4:66-70.
8. Ghojogh MG, Salarilak S, Afshari AT, et al (2018). Impact of type of donor on graft and patient survival rate in kidney transplanted patients in Iran. J Renal Inj Prev, 7:264-268.
9. Heldal K, Hartmann A, Grootendorst DC, et al (2010). Benefit of kidney transplantation beyond 70 years of age. Nephrol Dial Transplant, 25:1680-1687.
10. Jawoniyi O, Gormley K, McGleenan E, Noble HR (2018). Organ donation and transplantation: awareness and roles of healthcare professionals—a systematic literature review. J Clin Nurs, 27:e726-e738.
11. Tekin S, Yavuz H, Yuksel Y, et al (2015). Kidney transplantation from elderly donor. Transplant Proc, 47(5):1309-11.
12. Abbaszadeh S, Nourbala MH, Taheri S, et al (2008). Renal transplantation from deceased donors in Iran. Saudi J Kidney Dis Transpl, 19:664-8.
13. Hassanzadeh J, Hashiani A, Rajaeefard A, et al (2010). Long-term survival of living donor renal transplants: A single center study. Indian J Nephrol, 20:179-184.
14. Vester U, Kranz B, Testa G, et al (2004). Medical and surgical aspects of pediatric renal transplantation using living donors. Transplant Proc, 36(5):1308-10.
15. Lee C-Y, Yang C-Y, Lin W-C, et al (2020). Prognostic factors for renal transplant graft survival in a retrospective cohort of 1000 cases: The role of desensitization therapy. J Formos Med Assoc, 119(4):829-837.
16. Chhabra D, Grafals M, Skaro AI, Parker M, Gallon L et al (2008). Impact of anemia after renal transplantation on patient and graft survival and on rate of acute rejection. Clin J Am Soc Nephrol, 3:1168-1174.
17. de Weerd AE, Betjes MG (2018). ABO-incompatible kidney transplant outcomes: a meta-analysis. Clin J Am Soc Nephrol, 13:1234-1243.
18. Moher D, Shamseer L, Clarke M, et al (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev, 4(1):1.
19. Penson D, Krishnaswami S, Jules A. Evaluation and treatment of cryptorchidism. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012 Dec. Report No.: 13-EHC001-EF.
20. Bagos PG, Nikolopoulos GK (2009). Mixed-effects Poisson regression models for meta-analysis of follow-up studies with constant or varying durations. The International Journal of Biostatistics, 5(1):21.
21. Harris RJ, Deeks JJ, Altman DG, et al (2008). Metan: fixed-and random-effects meta-analysis. The Stata Journal, 8:3-28.
22. Lin L, Chu H (2018). Quantifying publication bias in meta‐analysis. Biometrics, 74:785-794.
23. Hassani Z, Emami N (2018). Prediction of the Survival of Kidney Transplantation with imbalanced Data Using Intelligent Algorithms. Computer Science Journal of Moldova, 26(2):77.
24. Wang D, Xu Tz, Chen Jh, et al (2009). Factors influencing second renal allograft survival: a single center experience in China. Transpl Immunol, 20:150-154.
25. Dinis P, Nunes P, Marconi L, et al (2014). Kidney retransplantation: removal or persistence of the previous failed allograft? Transplant Proc, 46(6):1730-4.
26. Segoloni G, Messina M, Basso E, et al (2009). Kidney retransplantation: indications and limits. G Ital Nefrol, 26(2):191-200.
27. Kazemeyni S, Aghighi M (2012). Organ procurement from deceased donors and its impact on organ transplantation in Iran during the first ten years of cadaveric transplantation. Int J Organ Transplant Med, 3(3):125-9.
28. Vergoulas G, Ioannidis I, Nikodimopoulou M, et al (2008). Outcomes of kidney transplantation in Greek and Albanian patients: a single centre experience. Hippokratia, 12(3):176-80.
29. Wang JH, Skeans MA, Israni AK (2016). Current status of kidney transplant outcomes: dying to survive. Adv Chronic Kidney Dis, 23:281-286.
30. Pallet N, Thervet E, Alberti C, et al (2005). Kidney transplant in black recipients: are African Europeans different from African Americans? Am J Transplant, 5:2682-2687.
31. Tang Y, Zhang Y, Jia B (2001). Analysis of 2200 kidney transplantations. Zhonghua Yi Xue Za Zhi, 81:82-85.
32. Adams J, Mehls O, Wiesel M (2004). Pediatric renal transplantation and the dysfunctional bladder. Transpl Int, 17:596-602.
33. Loucaidou M, Prasad S, Van Tromp J, et al (2004). Outcome of renal transplantation in South Asian recipients is similar to that in non-Asians. Transplantation, 78:1021-1024.
34. Chen JH, Shen W, He Q, et al (2004). [Pediatric renal transplantation: clinical analysis of 23 cases]. Zhonghua Wai Ke Za Zhi, 42:1100-3.
35. Higgins R, West N, Edmunds M, et al (1997). Effect of a strict HLA matching policy on distribution of cadaveric kidney transplants to Indo-Asian and white European recipients: regional study. BMJ, 315:1354-1355.
36. Richardson C, Butterworth P, Feehally J, Nicholson M (1998). Results of renal transplantation in Indo-Asian recipients. Br J Surg, 85(5):653-4.
37. Jeffrey RF, Woodrow G, Mahler J, et al (2002). Indo-Asian experience of renal transplantation in Yorkshire: results of a 10-year survey. Transplantation, 73:1652-1657.
38. Collins AJ, Foley R, Herzog C, et al (2008). Excerpts from the United States Renal Data System 2007 annual data report. Am J Kidney Dis, 51(1 Suppl 1):S1-320.
39. Abdi E, Savaj S, Nejadgashti H, et al (2006). Renal Transplantation Results in Hashemi Nejad Hospital during 1996-2005 and its Comparison with that of 1986-1996. Razi J Med Sci, 13:113-120.
40. Becker BN, Becker YT, Pintar TJ, et al (2000). Using renal transplantation to evaluate a simple approach for predicting the impact of end-stage renal disease therapies on patient survival: observed/expected life span. Am J Kidney Dis, 35:653-659.
41. Herzog CA, Ma JZ, Collins AJ (2000). Long-term survival of renal transplant recipients in the United States after acute myocardial infarction. Am J Kidney Dis, 36:145-152.
42. Ojo AO, Hanson JA, Wolfe RA, et al (2000). Long-term survival in renal transplant recipients with graft function. Kidney Int, 57:307-313.
43. Rubin RH (1993). Infectious disease complications of renal transplantation. Kidney Int, 44:221-36.
44. Hariharan S, Johnson C P, Bresnahan B A, et al (2000). Prediction of renal allograft function with early doppler ultrasonography. N Engl J Med, 342(9):605-12.
45. Abbud-Filho M, Ramalho H, Barberato J, et al (1998). Factors influencing the outcome of pediatric renal transplantation at a single center. Transplant Proc, 30(6):2871.
46. Briganti EM, Wolfe R, Russ GR, et al (2002). Graft loss following renal transplantation in Australia: is there a centre effect? Nephrol Dial Transplant, 17(6):1099-104.
47. Orsenigo E, Socci C, Carlucci M, et al (2005). Multivariate analysis of factors affecting patient and graft survival after renal transplant. Transplant Proc, 37(6):2461-3.
48. Courtney A, McNamee P, Maxwell A (2008). The evolution of renal transplantation in clinical practice: for better, for worse? QJM, 101:967-978.
49. Feyssa E, Charlotte J-B, Ellison G, et al (2009). Racial/Ethnic Disparity in Kidney Transplantation Outcomes: Influence of Donor andRecipient Characteristics. J Natl Med Assoc, 101:111-115.
50. Pugliese O, Quintieri F, Mattucci DA, et al (2005). Kidney graft survival in Italy and factors influencing it. Prog Transplant, 15:385-391.
51. Almasi Hashiani A, Rajaeefard A, Hassanzade J, Salahi H (2010). Survival analysis of renal transplantation and its relationship with age and sex. Koomesh, 11:302-306.
2. El Nahas AM, Bello AK (2005). Chronic kidney disease: the global challenge. The lancet, 365:331-340.
3. Florit E, Diekmann F, Budde K, et al (2015). Living Donor Transplantation: Long-Term Evolution Related to Age Matching. Transplantation proceedings, Elsevier, pp. 2346-2350.
4. Einollahi B (2004). Iranian experience with the non-related renal transplantation. Saudi J Kidney Dis Transpl, 15:421-428.
5. Jahromi SE, Ahmed F, Pourahmad S, et al (2019). Predictors of peritoneal dialysis associated peritonitis; application of the zero-inflated negative binomial model. J Nephropathol, 8:e36.
6. Zeraati AA, Nazemian F, Takalloo L, et al (2016). The relationship between serology of hepatitis E virus with liver and kidney function in kidney transplant patients. EXCLI J, 15:343-9.
7. Mahdavi-Mazdeh M, Rouchi AH, Norouzi S, et al (2007). Renal replacement therapy in Iran. Urol J, 4:66-70.
8. Ghojogh MG, Salarilak S, Afshari AT, et al (2018). Impact of type of donor on graft and patient survival rate in kidney transplanted patients in Iran. J Renal Inj Prev, 7:264-268.
9. Heldal K, Hartmann A, Grootendorst DC, et al (2010). Benefit of kidney transplantation beyond 70 years of age. Nephrol Dial Transplant, 25:1680-1687.
10. Jawoniyi O, Gormley K, McGleenan E, Noble HR (2018). Organ donation and transplantation: awareness and roles of healthcare professionals—a systematic literature review. J Clin Nurs, 27:e726-e738.
11. Tekin S, Yavuz H, Yuksel Y, et al (2015). Kidney transplantation from elderly donor. Transplant Proc, 47(5):1309-11.
12. Abbaszadeh S, Nourbala MH, Taheri S, et al (2008). Renal transplantation from deceased donors in Iran. Saudi J Kidney Dis Transpl, 19:664-8.
13. Hassanzadeh J, Hashiani A, Rajaeefard A, et al (2010). Long-term survival of living donor renal transplants: A single center study. Indian J Nephrol, 20:179-184.
14. Vester U, Kranz B, Testa G, et al (2004). Medical and surgical aspects of pediatric renal transplantation using living donors. Transplant Proc, 36(5):1308-10.
15. Lee C-Y, Yang C-Y, Lin W-C, et al (2020). Prognostic factors for renal transplant graft survival in a retrospective cohort of 1000 cases: The role of desensitization therapy. J Formos Med Assoc, 119(4):829-837.
16. Chhabra D, Grafals M, Skaro AI, Parker M, Gallon L et al (2008). Impact of anemia after renal transplantation on patient and graft survival and on rate of acute rejection. Clin J Am Soc Nephrol, 3:1168-1174.
17. de Weerd AE, Betjes MG (2018). ABO-incompatible kidney transplant outcomes: a meta-analysis. Clin J Am Soc Nephrol, 13:1234-1243.
18. Moher D, Shamseer L, Clarke M, et al (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev, 4(1):1.
19. Penson D, Krishnaswami S, Jules A. Evaluation and treatment of cryptorchidism. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012 Dec. Report No.: 13-EHC001-EF.
20. Bagos PG, Nikolopoulos GK (2009). Mixed-effects Poisson regression models for meta-analysis of follow-up studies with constant or varying durations. The International Journal of Biostatistics, 5(1):21.
21. Harris RJ, Deeks JJ, Altman DG, et al (2008). Metan: fixed-and random-effects meta-analysis. The Stata Journal, 8:3-28.
22. Lin L, Chu H (2018). Quantifying publication bias in meta‐analysis. Biometrics, 74:785-794.
23. Hassani Z, Emami N (2018). Prediction of the Survival of Kidney Transplantation with imbalanced Data Using Intelligent Algorithms. Computer Science Journal of Moldova, 26(2):77.
24. Wang D, Xu Tz, Chen Jh, et al (2009). Factors influencing second renal allograft survival: a single center experience in China. Transpl Immunol, 20:150-154.
25. Dinis P, Nunes P, Marconi L, et al (2014). Kidney retransplantation: removal or persistence of the previous failed allograft? Transplant Proc, 46(6):1730-4.
26. Segoloni G, Messina M, Basso E, et al (2009). Kidney retransplantation: indications and limits. G Ital Nefrol, 26(2):191-200.
27. Kazemeyni S, Aghighi M (2012). Organ procurement from deceased donors and its impact on organ transplantation in Iran during the first ten years of cadaveric transplantation. Int J Organ Transplant Med, 3(3):125-9.
28. Vergoulas G, Ioannidis I, Nikodimopoulou M, et al (2008). Outcomes of kidney transplantation in Greek and Albanian patients: a single centre experience. Hippokratia, 12(3):176-80.
29. Wang JH, Skeans MA, Israni AK (2016). Current status of kidney transplant outcomes: dying to survive. Adv Chronic Kidney Dis, 23:281-286.
30. Pallet N, Thervet E, Alberti C, et al (2005). Kidney transplant in black recipients: are African Europeans different from African Americans? Am J Transplant, 5:2682-2687.
31. Tang Y, Zhang Y, Jia B (2001). Analysis of 2200 kidney transplantations. Zhonghua Yi Xue Za Zhi, 81:82-85.
32. Adams J, Mehls O, Wiesel M (2004). Pediatric renal transplantation and the dysfunctional bladder. Transpl Int, 17:596-602.
33. Loucaidou M, Prasad S, Van Tromp J, et al (2004). Outcome of renal transplantation in South Asian recipients is similar to that in non-Asians. Transplantation, 78:1021-1024.
34. Chen JH, Shen W, He Q, et al (2004). [Pediatric renal transplantation: clinical analysis of 23 cases]. Zhonghua Wai Ke Za Zhi, 42:1100-3.
35. Higgins R, West N, Edmunds M, et al (1997). Effect of a strict HLA matching policy on distribution of cadaveric kidney transplants to Indo-Asian and white European recipients: regional study. BMJ, 315:1354-1355.
36. Richardson C, Butterworth P, Feehally J, Nicholson M (1998). Results of renal transplantation in Indo-Asian recipients. Br J Surg, 85(5):653-4.
37. Jeffrey RF, Woodrow G, Mahler J, et al (2002). Indo-Asian experience of renal transplantation in Yorkshire: results of a 10-year survey. Transplantation, 73:1652-1657.
38. Collins AJ, Foley R, Herzog C, et al (2008). Excerpts from the United States Renal Data System 2007 annual data report. Am J Kidney Dis, 51(1 Suppl 1):S1-320.
39. Abdi E, Savaj S, Nejadgashti H, et al (2006). Renal Transplantation Results in Hashemi Nejad Hospital during 1996-2005 and its Comparison with that of 1986-1996. Razi J Med Sci, 13:113-120.
40. Becker BN, Becker YT, Pintar TJ, et al (2000). Using renal transplantation to evaluate a simple approach for predicting the impact of end-stage renal disease therapies on patient survival: observed/expected life span. Am J Kidney Dis, 35:653-659.
41. Herzog CA, Ma JZ, Collins AJ (2000). Long-term survival of renal transplant recipients in the United States after acute myocardial infarction. Am J Kidney Dis, 36:145-152.
42. Ojo AO, Hanson JA, Wolfe RA, et al (2000). Long-term survival in renal transplant recipients with graft function. Kidney Int, 57:307-313.
43. Rubin RH (1993). Infectious disease complications of renal transplantation. Kidney Int, 44:221-36.
44. Hariharan S, Johnson C P, Bresnahan B A, et al (2000). Prediction of renal allograft function with early doppler ultrasonography. N Engl J Med, 342(9):605-12.
45. Abbud-Filho M, Ramalho H, Barberato J, et al (1998). Factors influencing the outcome of pediatric renal transplantation at a single center. Transplant Proc, 30(6):2871.
46. Briganti EM, Wolfe R, Russ GR, et al (2002). Graft loss following renal transplantation in Australia: is there a centre effect? Nephrol Dial Transplant, 17(6):1099-104.
47. Orsenigo E, Socci C, Carlucci M, et al (2005). Multivariate analysis of factors affecting patient and graft survival after renal transplant. Transplant Proc, 37(6):2461-3.
48. Courtney A, McNamee P, Maxwell A (2008). The evolution of renal transplantation in clinical practice: for better, for worse? QJM, 101:967-978.
49. Feyssa E, Charlotte J-B, Ellison G, et al (2009). Racial/Ethnic Disparity in Kidney Transplantation Outcomes: Influence of Donor andRecipient Characteristics. J Natl Med Assoc, 101:111-115.
50. Pugliese O, Quintieri F, Mattucci DA, et al (2005). Kidney graft survival in Italy and factors influencing it. Prog Transplant, 15:385-391.
51. Almasi Hashiani A, Rajaeefard A, Hassanzade J, Salahi H (2010). Survival analysis of renal transplantation and its relationship with age and sex. Koomesh, 11:302-306.
| Files | ||
| Issue | Vol 50 No 8 (2021) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v50i8.6801 | |
| Keywords | ||
| Kidney Transplantation End stage renal disease Graft survival Patient survival Meta-analysis | ||
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How to Cite
1.
Ghelichi-Ghojogh M, Ghaem H, Mohammadizadeh F, Vali M, Ahmed F, Hassanipour S, Nikbakht H-A, rezaei F, Fararouei M. Graft and Patient Survival Rates in Kidney Transplantation, and Their Associated Factors: A Systematic Review and Meta-Analysis. Iran J Public Health. 2021;50(8):1555-1563.
