The Impact of Air Pollution on Hospitalization for Cardiovascular and Cerebrovascular Disease in Shenyang, China
Background: The aim of this study was to investigate the overall impact of PM2.5, PM10, NO2, SO2, CO, and O3 on the admission of cardiovascular and cerebrovascular disease.
Methods: We collected data on cardiovascular and cerebrovascular disease admissions from two hospitals in Shenyang Liaoning, China from Jan 2014 to Dec 2017, as well as daily measurements of six pollutants at 11 sites in Shenyang. The generalized additive model was used to assess the association between daily contaminants and admission to cardiovascular and cerebrovascular disease.
Results: The single-contamination model showed a significant correlation between NO2, O3, PM10 and cardiovascular and cerebrovascular diseases at lag0 day. Air pollutants had lag effects on different gender groups. Excess relative risks (ERs) associated with a 10 μg/m3 increase were 1.522(1.057, 1.988) on lag02 for NO2, 0.547% (0.367%, 0.728%), 0.133% (0.061%, 0.205%) on lag3 for O3 and PM10. The dual pollutant model showed that the effects of NO2, O3, and PM10 after adjusting the influence of other pollutants were still statistically significant.
Conclusion: Short-term exposure to ambient air pollution (NO2, O3, and PM10) may be associated with an increased risk of daily cardiovascular and cerebrovascular admission, which may provide reliable evidence for further understanding of the potential adverse effects of air pollution on cardiovascular and cerebrovascular diseases.
2. CDC, National Center for Health Statistics (2017). Health, United States, 2016: with chart book on long-term trends in health: Hyattsville, MD: National Center for Health Statistics, CDC, US Department of Health and Human Services.
3. Chen R, Yin P, Meng X, et al (2019). Asso-ciations between Coarse Particulate Mat-ter Air Pollution and Cause-Specific Mor-tality: A Nationwide Analysis in 272 Chi-nese Cities. Environ Health Perspect, 127: 017008.
4. Chen X, Zhang L, Chen J, et al (2018). Res-piratory and Cardiovascular Diseases Mortality and Long-Term Exposure to Ambient Air Pollution: A 12-Year Cohort Study in Northern China. ISEE Conference Abstracts, 2018. DOI: 10.1289/isesisee.2018.O02.01.09
5. He T, Yang Z, Liu T, Shen Y, et al (2016). Ambient air pollution and years of life lost in Ningbo, China. Sci Rep 6: 22485.
6. Bergstra A D, Brunekreef B, Burdorf A (2018). The effect of industry-related air pollution on lung function and respirato-ry symptoms in schoolchildren. Environ Health, 17: 30.
7. Chen R, Chu C, Tan J, et al (2010). Ambient air pollution and hospital admission in Shanghai, China. J Hazard Mater, 181: 234-240.
8. Vidale S, Arnaboldi M, Bosio V, et al (2017). Short-term air pollution exposure and cardiovascular events: A 10-year study in the urban area of Como, Italy. Int J Cardi-ol, 248: 389-393.
9. Dastoorpoor M, Sekhavatpour Z, Masoumi K, et al (2019). Air pollution and hospital admissions for cardiovascular diseases in Ahvaz, Iran. Sci Total Environ, 652: 1318-1330.
10. Mauderly JL, Samet JM (2008). Is there evi-dence for synergy among air pollutants in causing health effects? Environ Health Per-spect, 117: 1-6.
11. Burnett R T, Stieb D, Brook J R, et al (2004). Associations between short-term changes in nitrogen dioxide and mortality in Ca-nadian cities. Arch Environ Health, 59: 228-236.
12. Qian Z, He Q, Lin H M, et al (2007). Asso-ciation of daily cause-specific mortality with ambient particle air pollution in Wu-han, China. Environ Res, 105: 380-389.
13. Stockfelt L, Andersson E M, Molnár P, et al (2017). Long-term effects of total and source-specific particulate air pollution on incident cardiovascular disease in Gothenburg, Sweden. Environ Res, 158: 61-71.
14. Hsu W H, Hwang S A, Kinney P L, et al (2017). Seasonal and temperature modifi-cations of the association between fine particulate air pollution and cardiovascular hospitalization in New York State. Sci To-tal Environ, 578: 626-632.
15. Li H, Wu J, Wang A, et al (2018). Effects of ambient carbon monoxide on daily hos-pitalizations for cardiovascular disease: a time-stratified case-crossover study of 460,938 cases in Beijing, China from 2013 to 2017. Environ Health,17: 82.
16. Atkinson R W, Samoli E, Analitis A, et al (2016). Short-term associations between particle oxidative potential and daily mor-tality and hospital admissions in London. Int J Hyg Environ Health, 219: 566-572.
17. Bennett WD, Zeman KL, Kim C (1996). Variability of fine particle deposition in healthy adults: effect of age and gender. Am J Respir Crit Care Med, 153: 1641-1647.
18. Diver WR, Teras LR, Gaudet MM, et al (2014). Exposure to Environmental To-bacco Smoke and Risk of Non-Hodgkin Lymphoma in Nonsmoking Men and Women . Am J Epidemiol, 179: 987-995.
19. Zhao L, Liang HR, Chen FY, et al (2017). Association between air pollution and cardiovascular mortality in China: a sys-tematic review and meta-analysis. Oncotar-get, 8: 66438-66448.
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