Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1476 1484 Qingquan REN Department of Labor and Environmental Hygiene, Shenyang Medical College, Liaoning 110034, P.R. China AND Key Laboratory of Environmental Pollution and Microecology of Liaoning Province, Shenyang Medical College, Shenyang, Liaoning 110034, P.R. China Shuyin LI Key Laboratory of Environmental Pollution and Microecology of Liaoning Province, Shenyang Medical College, Shenyang, Liaoning 110034, P.R. China AND Department of Pathogenic Biology, Shenyang Medical College, Shenyang, Liaoning 110034, P.R. China Chunling XIAO Key Laboratory of Environmental Pollution and Microecology of Liaoning Province, Shenyang Medical College, Shenyang, Liaoning 110034, P.R. China AND Department of Pathogenic Biology, Shenyang Medical College, Shenyang, Liaoning 110034, P.R. China Jiazhi ZHANG Shenyang Environmental Monitoring Center Station, Shenyang, Liaoning 110016, P.R. China Hong LIN Shenyang Environmental Monitoring Center Station, Shenyang, Liaoning 110016, P.R. China Shuai WANG Shenyang Environmental Monitoring Center Station, Shenyang, Liaoning 110016, P.R. China 2020 04 17 2020 05 29 Background: The aim of this study was to investigate the overall impact of PM2.5, PM10, NO2, SO2, CO, and O3 on the admission of cardiovascular and cerebrovascular disease. Methods: We collected data on cardiovascular and cerebrovascular disease admissions from two hospitals in Shenyang Liaoning, China from Jan 2014 to Dec 2017, as well as daily measurements of six pollutants at 11 sites in Shenyang. The generalized additive model was used to assess the association between daily contaminants and admission to cardiovascular and cerebrovascular disease. Results: The single-contamination model showed a significant correlation between NO2, O3, PM10 and cardiovascular and cerebrovascular diseases at lag0 day. Air pollutants had lag effects on different gender groups. Excess relative risks (ERs) associated with a 10 μg/m3 increase were 1.522(1.057, 1.988) on lag02 for NO2, 0.547% (0.367%, 0.728%), 0.133% (0.061%, 0.205%) on lag3 for O3 and PM10. The dual pollutant model showed that the effects of NO2, O3, and PM10 after adjusting the influence of other pollutants were still statistically significant. Conclusion: Short-term exposure to ambient air pollution (NO2, O3, and PM10) may be associated with an increased risk of daily cardiovascular and cerebrovascular admission, which may provide reliable evidence for further understanding of the potential adverse effects of air pollution on cardiovascular and cerebrovascular diseases. https://ijph.tums.ac.ir/index.php/ijph/article/view/20390 https://ijph.tums.ac.ir/index.php/ijph/article/download/20390/6941