Original Article

Upregulation of miRNA-155 in Nasopharyngeal Carcinoma Patients

Abstract

Background: The upregulation of miRNA-155 (miR-155) has been associated with oncogenesis of many human tumors, including nasopharyngeal carcinoma (NPC). However, the profile of miR-155 in Vietnamese NPC patients has not been investigated. The current study aimed to evaluate the miR-155 expression and assess whether miR-155 is a potential biomarker for diagnosis of NPC in Vietnamese patients.

Methods: In current case-control study, total of RNA was isolated from 60 biopsy NPC samples and 60 non-cancerous swab samples were analyzed by Reverse-transcription PCR, qualitative Real-time PCR.

Results: The frequency of miR-155 detection were 78.33%, 15.0% in NPC and non-cancerous samples (P<0.05), respectively. The miR-155 expression level was 4.92 times higher in tumor samples than non-cancerous sample.

Conclusion: Taken together, miR-155 in NPC was upregulated. It may serve as a potential biomarker for NPC in the Vietnamese population.

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IssueVol 50 No 8 (2021) QRcode
SectionOriginal Article(s)
Published2021-07-22
DOI https://doi.org/10.18502/ijph.v50i8.6810
Keywords
Mirn155 microRNA Nasopharyngeal carcinoma Vietnamese

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How to Cite
1.
Lao T, Nguyen M, Nguyen D, Le T. Upregulation of miRNA-155 in Nasopharyngeal Carcinoma Patients. Iran J Public Health. 2021;50(8):1642-1647.