Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 8 2021 07 22 1642 1647 EN Thuan Lao Department of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, Vietnam Minh Nguyen Cho Ray Hospital, Ho Chi Minh City, Vietnam Dung Nguyen University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam Thuy Le Department of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, Vietnam 2020 03 03 2020 05 29 Background: The upregulation of miRNA-155 (miR-155) has been associated with oncogenesis of many human tumors, including nasopharyngeal carcinoma (NPC). However, the profile of miR-155 in Vietnamese NPC patients has not been investigated. The current study aimed to evaluate the miR-155 expression and assess whether miR-155 is a potential biomarker for diagnosis of NPC in Vietnamese patients. Methods: In current case-control study, total of RNA was isolated from 60 biopsy NPC samples and 60 non-cancerous swab samples were analyzed by Reverse-transcription PCR, qualitative Real-time PCR. Results: The frequency of miR-155 detection were 78.33%, 15.0% in NPC and non-cancerous samples (P<0.05), respectively. The miR-155 expression level was 4.92 times higher in tumor samples than non-cancerous sample. Conclusion: Taken together, miR-155 in NPC was upregulated. It may serve as a potential biomarker for NPC in the Vietnamese population. https://ijph.tums.ac.ir/index.php/ijph/article/view/19929 https://ijph.tums.ac.ir/index.php/ijph/article/download/19929/7322