Case-Control Trials on Risk Factors for Pancreatic Cancer: A Systematic Review and Meta-Analysis
-
Yan Yang
,
Jianwei Shi
,
Jiaoling Huang
,
Mingwang Cheng
,
Shasha Geng
,
Wenya Yu
,
Ning Chen
,
Chen Chen
,
Zhaoxin Wang
Abstract
Background: The single risk factors of pancreatic cancer (PC) has been extensively studied. We aimed to synthesize results from such studies to identify and estimate multiple independent risk factors of PC.
Methods: Articles published up to Feb 28, 2020 in English or Chinese reporting risk factors of PC were reviewed. The fixed-effects model with 95% confidence interval (CI) were used to calculate the pooled Odds Ratio (OR). Data were analyzed using RevMan 5.3.
Results: PC was significantly associated with smoking (OR: 1.76, 95% CI: 1.61–1.92, P < 0.00001, I2 = 6%), diabetes (OR: 2.69, 95% CI: 2.52-2.88, P < 0.00001, I2 = 0%), family history of PC (OR: 2.58, 95% CI: 2.13-3.11, P < 0.00001, I2 = 0%), and chronic pancreatitis (OR: 5.84, 95% CI: 3.63-9.41, P < 0.00001, I2 = 0%).
Conclusion: Smoking, diabetes, family history of PC, and chronic pancreatitis were independent risk factors for PC. These independent risk factors have an important role in identifying high-risk groups, which is of great significance to reduce the incidence of PC and improve the quality of life and prognosis of patients.
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17. Yang MW, Zhang DD (2017). Analysis of the prevalence and risk factors of pan-creatic cancer. Chin J Frontiers Med Sci (Electronic Version), 9(4):122-124.
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22. Ben Q, Cai Q, Li Z, et al (2011). The rela-tionship between new-onset diabetes mellitus and pancreatic cancer risk: a case-control study. Eur J Cancer, 47(2):248-54.
23. Talamini R, Polesel J, Gallus S, et al (2010). Tobacco smoking, alcohol consumption and pancreatic cancer risk: a case-control study in Italy. Eur J Cancer, 46(2):370-6.
24. Maisonneuve P, Lowenfels AB, Bueno-de-Mesquita HB, et al (2010). Past medical history and pancreatic cancer risk: Re-sults from a multicenter case-control study. Ann Epidemiol, 20(2):92-8.
25. Pang T, Ding G, Wu Z, et al (2017). A novel scoring system to analyze combined ef-fect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study. Sci Rep, 7(1):13657.
26. Hassan MM, Bondy ML, Wolff RA, et al (2007). Risk factors for pancreatic can-cer: case-control study. Am J Gastroenterol, 102(12):2696-707.
27. Rahman F, Cotterchio M, Cleary SP, et al (2015). Association between alcohol consumption and pancreatic cancer risk: a case-control study. PLoS One, 10(4):e0124489.
28. Becker AE, Hernandez YG, Frucht H, et al (2014). Pancreatic ductal adenocarcino-ma: risk factors, screening, and early de-tection. World J Gastroenterol, 20(32):11182-98.
29. Kuzmickiene I, Everatt R, Virviciute D, et al (2013). Smoking and other risk factors for pancreatic cancer: a cohort study in men in Lithuania. Cancer Epidemiol, 37(2):133-9.
30. Inoue M, Tajima K, Takezaki T, et al (2003). Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Re-search Program at Aichi Cancer Center (HERPACC). Int J Epidemiol, 32(2):257-62.
31. Lowenfels AB, Maisonneuve P (2004). Epi-demiology and prevention of pancreatic cancer. Jpn J Clin Oncol, 34(5):238-44.
32. Wang XL, Wang J (2005). Smoking-gene in-teraction and disease development: rel-evance to pancreatic cancer and athero-sclerosis. World J Surg, 29(3):344-53.
33. Giovannucci E, Michaud D (2007). The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology, 132(6):2208-25.
34. Cullen JJ, Mitros FA, Oberley LW (2003). Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer. Pancreas, 26(1):23-7.
35. Tersmette AC, Petersen GM, Offerhaus GJ, et al (2001). Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pan-creatic cancer. Clin Cancer Res, 7(3):738-44.
36. Yadav D, Lowenfels AB (2013). The epi-demiology of pancreatitis and pancreat-ic cancer. Gastroenterology, 144(6):1252-1261.
2. Rahib L, Smith BD, Aizenberg R, et al (2014). Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States.Cancer Res, 74(11):2913-21.
3. Hausmann S, Kong B, Michalski C, et al (2014). The role of inflammation in pancreatic cancer. Adv Exp Med Biol, 816:129-51.
4. Grubb MCM, Kilbourne B, Kilbourne K, et al (2017). Socioeconomic, environmental, and geographic factors and us lung can-cer mortality, 1999–2009. Family Med & Community Health, 5(1):3-12.
5. Lin Y, Tamakoshi A, Kawamura T, et al (2002). A prospective cohort study of cigarette smoking and pancreatic cancer in Japan. Cancer Causes Control, 13(3):249-54.
6. Zhang XH, Gao YT, Shao CX, et al (2006). Epidemiological study on the relation-ship between past disease history and 2 pancreatic cancer. Tumor, 26(1): 37-41.
7. Qiu DY, Yang RM, Zhang J (2004).167 cases of elderly pancreatic cancer and their relationship with diabetes mellitus and chronic pancreatitis. Chin J Clin Med, 11(5): 753-755.
8. Zhou GZ, Li ZS, Yu ZL, et al (2002). Study on the relationship between diabetes, family history and pancreatic cancer. Med J Chin PLA, 27 (4): 298-301.
9. Chen M, Liu SS, et al (2014). Case-control study of smoking and risk of pancreatic cancer. China Cancer, 23(003):200-204.
10. Yan D, Wang XY, Xu XX, et al (2010). Analysis of risk factors for pancreatic cancer. Xinjiang Med Univ, 33 (8): 928-930.
11. Zhou GZ. Study on the related factors and prognosis of pancreatic cancer [PhD dissertation]. Second Military Medical Uni-versity; 2002.
12. Xu P, Huang Q, Liu CH, et al (2011). Case-control study on risk factors of pancre-atic cancer. Tumor, 31(007):653-657.
13. Zhao JQ, Xue ZM, Yang JP, et al (2018). Case-control study on risk factors asso-ciated with pancreatic cancer. Modern Oncology Med, 26(8):1229-1232.
14. Yao Y. Case-control study on pancreatic cancer and environmental, disease, psy-chological and behavioral factors and preliminary study on genetic susceptibil-ity [PhD dissertation]. Peking Union Medi-cal College; 2013.
15. Peng LN, Zhai YF, Li Y, et al (2014). 147 cases of pancreatic cancer risk factors were retrospectively analyzed. Henan Med Res, 23(2):105-107.
16. Chen Q. Risk factors and clinical charac-teristics of 916 patients with pancreatic cancer in East China [PhD dissertation]. The Second Military Medical University;2012.
17. Yang MW, Zhang DD (2017). Analysis of the prevalence and risk factors of pan-creatic cancer. Chin J Frontiers Med Sci (Electronic Version), 9(4):122-124.
18. Silverman DT, Schiffman M, Everhart J, et al (1999). Diabetes mellitus, other medi-cal conditions and familial history of cancer as risk factors for pancreatic cancer. Br J Cancer, 80(11):1830-7.
19. Zheng Z, Zheng R, He Y, et al (2016). Risk Factors for Pancreatic Cancer in China: A Multicenter Case-Control Study. J Epi-demiol, 26(2):64-70.
20. Anderson LN, Cotterchio M, Gallinger S (2009). Lifestyle, dietary, and medical history factors associated with pancreat-ic cancer risk in Ontario, Canada. Cancer Causes Control, 20(6):825-34.
21. Bosetti C, Rosato V, Li D, et al (2014). Dia-betes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium. Ann Oncol, 25(10):2065-2072.
22. Ben Q, Cai Q, Li Z, et al (2011). The rela-tionship between new-onset diabetes mellitus and pancreatic cancer risk: a case-control study. Eur J Cancer, 47(2):248-54.
23. Talamini R, Polesel J, Gallus S, et al (2010). Tobacco smoking, alcohol consumption and pancreatic cancer risk: a case-control study in Italy. Eur J Cancer, 46(2):370-6.
24. Maisonneuve P, Lowenfels AB, Bueno-de-Mesquita HB, et al (2010). Past medical history and pancreatic cancer risk: Re-sults from a multicenter case-control study. Ann Epidemiol, 20(2):92-8.
25. Pang T, Ding G, Wu Z, et al (2017). A novel scoring system to analyze combined ef-fect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study. Sci Rep, 7(1):13657.
26. Hassan MM, Bondy ML, Wolff RA, et al (2007). Risk factors for pancreatic can-cer: case-control study. Am J Gastroenterol, 102(12):2696-707.
27. Rahman F, Cotterchio M, Cleary SP, et al (2015). Association between alcohol consumption and pancreatic cancer risk: a case-control study. PLoS One, 10(4):e0124489.
28. Becker AE, Hernandez YG, Frucht H, et al (2014). Pancreatic ductal adenocarcino-ma: risk factors, screening, and early de-tection. World J Gastroenterol, 20(32):11182-98.
29. Kuzmickiene I, Everatt R, Virviciute D, et al (2013). Smoking and other risk factors for pancreatic cancer: a cohort study in men in Lithuania. Cancer Epidemiol, 37(2):133-9.
30. Inoue M, Tajima K, Takezaki T, et al (2003). Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Re-search Program at Aichi Cancer Center (HERPACC). Int J Epidemiol, 32(2):257-62.
31. Lowenfels AB, Maisonneuve P (2004). Epi-demiology and prevention of pancreatic cancer. Jpn J Clin Oncol, 34(5):238-44.
32. Wang XL, Wang J (2005). Smoking-gene in-teraction and disease development: rel-evance to pancreatic cancer and athero-sclerosis. World J Surg, 29(3):344-53.
33. Giovannucci E, Michaud D (2007). The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology, 132(6):2208-25.
34. Cullen JJ, Mitros FA, Oberley LW (2003). Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer. Pancreas, 26(1):23-7.
35. Tersmette AC, Petersen GM, Offerhaus GJ, et al (2001). Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pan-creatic cancer. Clin Cancer Res, 7(3):738-44.
36. Yadav D, Lowenfels AB (2013). The epi-demiology of pancreatitis and pancreat-ic cancer. Gastroenterology, 144(6):1252-1261.
| Files | ||
| Issue | Vol 52 No 8 (2023) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v52i8.13397 | |
| Keywords | ||
| Pancreatic cancer Risk factor Systemic review Meta-analysis Case-control trials | ||
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How to Cite
1.
Yang Y, Shi J, Huang J, Cheng M, Geng S, Yu W, Chen N, Chen C, Wang Z. Case-Control Trials on Risk Factors for Pancreatic Cancer: A Systematic Review and Meta-Analysis. Iran J Public Health. 2023;52(8):1578-1588.
