Original Article

Breast Cancer in Megapolises of Kazakhstan: Epidemiological Assessment of Incidence and Mortality


Background: Breast cancer is the most common malignant disease among the female population of Kazakhstan like in many developed countries of the world (Canada, UK, US, Western Europe), and it accounts for every 5th tumor. We aimed to assess the epidemiological aspects of breast cancer incidence and mortality among Almaty and Astana (Now Nur-Sultan), Kazakhstan residents in 2009-2018.

Methods: A retrospective study using modern descriptive and analytical methods of epidemiology was conducted to evaluate the breast cancer incidence and mortality in megapolises of Kazakhstan.

Results: The average annual age-standardized incidence rate of breast cancer amounted to 61.90/0000 (95% CI=56.2-67.6) in Almaty and 61.20/0000 (95% CI=56.765.7) in Astana. The average age-standardized mortality was 19.20/0000 (95% CI=17.3-21.1) in Almaty and 19.30/0000 (95% CI=17.1-21.4) in Astana. The standardized incidence in the megapolises tended to increase (Тgr=+0.8% in Almaty and Тgr=+1.4% in Astana), while the mortality was decreasing (Тdec=−4.2% in Almaty and Тdec=−1.1% in Astana). According to the component analysis, the growth in the number of breast cancer cases was due to a population increase (ΔP=+130.4% in Almaty and ΔP=+93.2% in Astana), with a notable decrease of factors related to the risk of getting sick (ΔR=−27.9% in Almaty, ΔR=−6.1% in Astana).

Conclusion: This is the first epidemiological study to assess the changes in incidence and mortality from breast cancer in megapolises of Kazakhstan because of screening. The results of this study can be used to improve the government program to combat breast cancer.



1. Bilyalova Z, Igissinov N, Moore M, Igissi-nov S, Sarsenova S, Khassenova Z (2012). Epidemiological evaluation of breast cancer in ecological areas of Ka-zakhstan – association with pollution emissions. Asian Pac J Cancer Prev, 13(5):2341-2344.
2. Beysebayev E, Bilyalova Z, Kozhakeeva L, Baissalbayeva A, Abiltayeva A (2015). Spatial and Temporal Epidemiological Assessment of Breast Cancer Incidence and Mortality in Kazakhstan, 1999-2013. Asian Pac J Cancer Prev, 16(15):6795-6798.
3. Bekmukhambetov Y, Imangazina Z, Jarkenov T, Mamyrbayev A (2015). Can-cer incidence and mortality data in Ak-tobe, west Kazakhstan, 2000-2010. Asian Pac J Cancer Prev, 16(6):2379-2383.
4. Botha JL, Bray F, Sankila R, Parkin DM (2003). Breast cancer incidence and mor-tality trends in 16 European countries. Eur J Cancer, 39(12):1718-1729.
5. Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M, Znaor A, Soerjomataram I, Bray F (2018). Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Available from: https://gco.iarc.fr/today/home. Ac-cessed 04 February 2019.
6. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 68(6):394-424.
7. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A, Bray F (2019). Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and meth-ods. Int J Cancer, 144(8):1941-1953.
8. Tautayev A, Toguzbayeva A, Kamzabek A, Bilyalova Z, Igissinov N (2019) Breast cancer in Kazakhstan: Changes in conse-quences of screening? Medicina (Kaunas), 55 (Supplement 1):191.
9. Chissov V, Starinskiy V, Kovalev B (2007). The organization of oncological service in Russia (methodical recommendations, manuals for doc-tors). Мoscow, 663 p. (in Russian).
10. Altobelli E, Lattanzi A (2014). Breast cancer in European Union: an update of screen-ing programmes as of March 2014 (Re-view). Int J Oncol, 45 (5): 1785-1792.
11. Harding C, Pompei F, Burmistrov D, et al (2015) Breast cancer screening, incidence, and mortality across US counties. JAMA Intern Med, 175(9):1483–1489.
12. Nagai H, Kim YH (2017). Cancer preven-tion from the perspective of global can-cer burden patterns. J Thorac Dis, 9(3):448-451.
13. Zou XN (2017). Epidemic trend, screening, and early detection and treatment of can-cer in Chinese population. Cancer Biol Med, 14(1):50-59.
14. da Costa Vieira RA, Biller G, Uemura G, Ruiz CA, Curado MP (2017). Breast can-cer screening in developing countries. Clinics (Sao Paulo), 72(4):244-253.
15. Kolak A, Kamińska M, Sygit K, et al. (2017). Primary and secondary prevention of breast cancer. Ann Agric Environ Med, 24(4):549-553.
16. Colditz GA, Sellers TA, Trapido E (2006). Epidemiology–identifying the causes and preventability of cancer? Nat Rev Cancer, 6:75‐83.
17. American Cancer Society (2011). Global Can-cer Facts & Figures. 2nd ed. Atlanta, GA: American Cancer Society, Inc.; 2011.
18. Colditz GA, Bohlke K (2014). Priorities for the primary prevention of breast cancer. CA Cancer J Clin, 64(3):186-194.
19. Yap YS,Lu YS, Tamura K, et al. (2019). In-sights into Breast Cancer in the East vs the West: A Review. JAMA Oncol, doi: 10.1001/jamaoncol.2019.0620.
20. WHO (2008) Breast cancer: prevention and control. https://www.who.int/topics/cancer/breastcancer/ru/index3.html, accessed 07 February 2019.
21. Merkov АМ, Polyakov LY (1974). Health Statistics. Leningrad: Medicine. p. 384 (in Russian).
22. dos Santos Silva I (1999). Cancer epidemiology: principles and methods. Lion, France: IARC. 441 p.
23. Tango T (2010). Statistical Methods for Disease Clustering. – Springer Science+Business Media, LLC 2010. – 247 с.
24. Merabishvili VM (2015). Oncological statistics (traditional methods, new information technolo-gies): A guide for physicians. Second edition, sup-plemented. Part I., 2015. - 223 p.
25. Omar B. Ahmad, Cynthia Boschi-Pinto, Alan D. Lopez, Christopher JL Murray, Rafael Lozano, Mie Inoue. Age standard-ization of rates: a new who standard. GPE Discussion Paper Series: No.31 EIP/GPE/EBD World Health Organi-zation 2001. Electronic resource: http://www.who.int/healthinfo/paper31.pdf. (accessed 26 June 2015).
26. Recommendations of the National Cancer Institute (USA) on the use of the World Standard (WHO 2000-2025). Electronic resource: http://seer.cancer.gov/stdpopulations/world.who.html
27. Dvoyrin VV. Aksel EM (1987). Component analysis of the dynamics of malignant neoplasms: guidelines. Moscow. Pages: 130 (in Russian)
28. Mermer G, Turk M (2014). Assessment of the Effects of Breast Cancer Training on Women Between the Ages of 50 and 70 in Kemalpasa, Turkey. Asian Pac J Cancer Prev, 15 (24), 10749-10755.
29. Malvia S, Bagadi SA, Dubey US, Saxena S (2017). Epidemiology of breast cancer in Indian women. Asia Pac J Clin Oncol, 13 (4): 289-295.
30. Mukem S, Sriplung H, McNeil E, Tangcharoensathien V (2014). Breast cancer screening among women in Thai-land: analyses of population-based household surveys. J Med Assoc Thai, 97(11): 1106-1118.
31. Yip CH (2009). Breast cancer in Asia. Meth-ods Mol Biol, 471: 51-64.
32. Saika K, Sobue T (2009). Epidemiology of Breast Cancer in Japan and the US. JMAJ, 52(1): 39-44.
33. Eisemann N, Waldmann A, Katalinic A (2013). Epidemiology of Breast Cancer – Current Figures and Trends. Geburtshilfe Frauenheilkd, 73(2): 130-135.
34. Beysebaev EТ (2014). Modern comparative aspects of the epidemiology of breast cancer (Literature review). KazNMU Bulle-tin, 1: 78-83. (In Russian).
35. Klemp JR (2015). Breast cancer prevention across the cancer care continuum. Semin Oncol Nurs, 31(2):89-99.
36. Gray JM, Rasanayagam S, Engel C., Rizzo J (2017). State of the evidence 2017: an up-date on the connection between breast cancer and the environment. Environmental Health, 16:94.
37. Sighoko D, Murphy AM, Irizarry B, et al. (2017). Changes in the racial disparity in breast cancer mortality in the ten US cities with the largest African American popula-tions from 1999 to 2013: The reduction in breast cancer mortality disparity in Chicago. Cancer Causes Control, 28(6):563-568.
38. Sharma R (2019). Breast cancer incidence, mortality and mortality-to-incidence ratio (MIR) are associated with human devel-opment, 1990-2016: evidence from Global Burden of Disease Study 2016. Breast Cancer, 26(4):428-445.
39. Kanavos P (2006). The rising burden cancer in the developing world. Ann Oncol, 17 Suppl 8: 15-23.
40. Coughlin SS, Ekwueme DU (2009). Breast cancer as a global health concern. Cancer Epidemiol, 33 (5): 315-318.
IssueVol 48 No 7 (2019) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijph.v48i7.2948
Breast Cancer Incidence Mortality Kazakhstan

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How to Cite
IGISSINOV N, TOGUZBAYEVA A, TURDALIYEVA B, IGISSINOVA G, BILYALOVA Z, AKPOLATOVA G, VANSVANOV M, TARZHANOVA D, ZHANTUREYEVA A, ZHANALIYEVA M, ALMABAYEVA A, TAUTAYEV A. Breast Cancer in Megapolises of Kazakhstan: Epidemiological Assessment of Incidence and Mortality. Iran J Public Health. 48(7):1257-1264.