Lower Serum Levels of Uric Acid in Uterine Fibroids and Fibro-cystic Breast Disease Patients in Dongying City, China
Abstract
Background: Increasing serum levels of uric acid (SUA) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate SUA. Estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. The study aimedtoexplore SUA among patients suffering from these diseases to enhance the hypothesis.
Methods: Overall, 1349 female participants were selected into three cases: CaseⅠhaving uterine fibroids (n=568), CaseⅡ having fibrocycstic breast disease (n=608) and CaseⅢ having uterine fibroids combining with fibrocycstic breast disease (n=173); 4206 participants without these diseases were selected as controls. Based on health check-up data from 2011 to 2012, in Dongying Shengli Oilfield Central Hospital, a cross-sectional study was conducted to examine the difference in SUA between the case and control. We adjusted covariates by generalized linear regression mode.
Results: From 19 to 44 yr, SUA of CaseⅠ to CaseⅢ were lower than controls by 8.46 umol/L (P=0.011), 5.88umol/L (P=0.014) and 9.39 umol/L (P=0.059), respectively. From 45-54 yr, no significant differences were between three cases and controls. In CaseⅠand its control: from 54-59 yr, differences were not significant; from 60 to 72 yr, SUA in CaseⅠwas lower than the control by 32.02umol/L (P=0.003).
Conclusion: Participants of uterine fibroids and fibrocystic breast disease had a lower SUA except the stage of menopause, which indirectly supported that estrogenic effect, may protectively decrease SUA.
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| Issue | Vol 45 No 5 (2016) | |
| Section | Original Article(s) | |
| Keywords | ||
| Uric acid Estrogenic effect Leiomyoma and fibrocyst Breast disease | ||
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