Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 5 2016 05 25 596 605 Qicai CHEN Dept. of Prevention and Health Care, Dongying Shengli Oilfield Central Hospital, Dongying, China Juan XIAO Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China Pengpeng ZHANG Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China AND Tianjin Entry-Exit Inspections and Quarantine Bureau, Tianjin, China Lili CHEN Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China AND Dept. of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou, China Xiaoxiao CHEN Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China Shumei WANG Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China 2016 05 25 2016 05 25 Background: Increasing serum levels of uric acid (SUA) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate SUA. Estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. The study aimedtoexplore SUA among patients suffering from these diseases to enhance the hypothesis. Methods: Overall, 1349 female participants were selected into three cases: CaseⅠhaving uterine fibroids (n=568), CaseⅡ having fibrocycstic breast disease (n=608) and CaseⅢ having uterine fibroids combining with fibrocycstic breast disease (n=173); 4206 participants without these diseases were selected as controls. Based on health check-up data from 2011 to 2012, in Dongying Shengli Oilfield Central Hospital, a cross-sectional study was conducted to examine the difference in SUA between the case and control. We adjusted covariates by generalized linear regression mode. Results: From 19 to 44 yr, SUA of CaseⅠ to CaseⅢ were lower than controls by 8.46 umol/L (P=0.011), 5.88umol/L (P=0.014) and 9.39 umol/L (P=0.059), respectively. From 45-54 yr, no significant differences were between three cases and controls. In CaseⅠand its control: from 54-59 yr, differences were not significant; from 60 to 72 yr, SUA in CaseⅠwas lower than the control by 32.02umol/L (P=0.003). Conclusion: Participants of uterine fibroids and fibrocystic breast disease had a lower SUA except the stage of menopause, which indirectly supported that estrogenic effect, may protectively decrease SUA.     https://ijph.tums.ac.ir/index.php/ijph/article/view/6795 https://ijph.tums.ac.ir/index.php/ijph/article/download/6795/5409