2023 Impact Factor: 1.3
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pISSN: 2251-6085
eISSN: 2251-6093
Chairman & Editor-in-Chief:
Dariush D. Farhud, MD, Ph.D., MG.
This journal is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE). 
Vol 11 No 1-2 (1982)
Articles
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A total of 1500 infected liver with F. hepatica and F. gigantica from slaughtered cattle in different parts of Iran were studied. Grossly the livers were usually irregular in shape, with prominent bile ducts on the visceral surface as grayish-white, firm-branching streaks. The atrophy of the left lobe due to fibrosis and ischemia were noticed. On the cut surface the main bile ducts wall consisted of hard fibrotic tissue with pipe-stem appearance and calcium deposition on the inner layer of the ducts in F.hepatica infection. In the livers infected with F.gigantica, grossly seemed to be of a more normal consistency with much less calcium deposition in the ducts. In histopathological changes there was evidence of different stages of parenchymal damages, varying from fresh burrow with young flukes inside to old and healed nodules due to migration of the young flukes. A large number of eosinophils, lymphocytes plasma cells, disintegration of hepatocytes and coagulation necrosis were seen. The thickening of the bile ducts wall and the intense fibrous tissue proliferation in the portal areas compressed the adjacent liver cells, causing pressure atrophy of the liver. In very chronic cases glandular hyperplasia of ducts wall which lined by columnar epithelial cells with vacuolated cytoplasm were marked. In some ducts compact aggregation of fibroblasts which gave a smooth appearance to the bile ducts wall were noticed. The monolobular fibrosis in both F.hepatica and F.gigantica infections were a typical feature.
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In a survey of 148 subjects (72 females and 76 males) in 3 villages and one city in Isfahan province, plasma vitamin A, hemoglobin concentration and hematocrit were determined in all subjects, and serum iron was measured in 19 persons, in order to investigate the possible relationship between vitamin A and hematopoietic factors. A positive correlation existed between plasma vitamin A and hemoglobin concentration. People with acceptable hemoglobin values had significantly higher plasma vitamin A levels compared to those with less-than-acceptable hemoglobin values. A direct correlation between plasma vitamin A and serum iron was also observed. The evidence gathered in this study supports the hypothesis that there is a direct relationship between anemia and vitamin A status of the subjects.
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Based on the evaluation of two human cell lines, Hela and Chang, abeuploidy and several marker chromosomes were found in both cells. The morphological characteristic of marker chromosomes of Chang cells was distinctly different from HeLa. Certain submetacentric marker chromosome was frequently present among 80% of marker chromosomes of Chang cells which distinguished this line from HeLa, which showed the various identifiable marker chromosomes. This evidence clearly established the different etiology of these two human cell lines.
