Original Article

Anxiety in Patients with Chronic Cor Pulmonale and Its Effect on Exercise Capacity


Background: Chronic cor pulmonale (CCP) is a disease of increasing frequency in Chinese people and profoundly influences their health. CCP is often accompanied by anxiety and other psychological problems, and patients may show signs of motor function decline. However, little attention has been paid to the impact of CCP-related psychological problems on motor function.

Methods: Patients with CCP receiving in- or outpatient treatment in the Respiratory Department of Xiangya Hospital of Central South University and the Second Xiangya Hospital of Central South University in Hunan Province between January and July 2015 were investigated. A total of 167 questionnaires were distributed, with 160 valid questionnaires ultimately collected from 95 male and 65 female participants of mean age (± standard deviation) of 68.2 ± 12.3 yr. Self-Rating Anxiety Scale (SAS) scoring was adopted to evaluate anxiety in the participants, and heart rate, blood pressure, breathing rate, 6-minute walk test and Borg index score were combined to detect the exercise capability of the participants.

Results: Anxiety was present in 48.8% of patients. Heart rate, systolic blood pressure, breathing rate and the Borg score of CCP patients with anxiety were higher than in CCP patients without anxiety (P < 0.05), while mean walking distance was shorter (P < 0.05).

Conclusion: The rate of anxiety in patients with CCP is relatively high. Anxiety reduces motor function in CCP patients; therefore, in the process of treating patients with CCP, effort should be made to engage simultaneously patients in psychotherapy.



Roca M, Mitu O, Roca IC, et al. (2015). Chronic Diseases - Medical and Social Aspects. Rev Cercet Interv So, 49: 257-75.

Yang JH (2016). Discussion on application of Qi, blood and body fluids differentia-tion in the treatment of chronic pulmo-nary heart disease. Clin J Chin Med, 8(12): 13-4.

Roberts WC, Shafii AE, Grayburn PA, et al. (2015). Clinical and morphologic features of acute, subacute and chronic cor pulmonale (pulmonary heart disease). Am J Cardiol, 115(5): 697-703.

Rosenkranz S (2014). Cor pulmonale und pulmonale Hypertonie. Herz, 39(1): 58-65.

Tian MQ (2012). Clinical Analysis of 60 Cases Chronic Pulmonary Heart Disease in Elderly Combined with Coronary Heart Disease. Hebei Med, 18(2): 177-79.

Da Q (2012). Mental disorders and psychological nursing of patients with chronic pulmonary heart disease. Med J Chin People’s Health, 24(12): 1486.

Hassel E, Berre AM, Skjulsvik AJ, Steinshamn S (2014). Effects of exercise training on pulmonary vessel muscularization and right ventricular function in an animal model of COPD. Respir Res, 15(1): 117.

Brønstad E, Tjonna AE, Rognmo Ø, Dalen H, Heggli AM, Wisloff U, et al. (2013). Aerobic exercise training improves right-and left ventricular systolic function in patients with COPD. COPD, 10(3): 300-6.

He XB, Chen ZX, Huang SX, Wu X (2009). A comparative study on cardiopulmonary exercise testing in patients with chronic puhnonary heart disease and chronic obstructive pulmonary disease. Chin J Pr Intern Med, 29(S1): 15-8.

Meena M, Dixit R, Kewlani JP, KumarS, HarishS, SharmaD, et al. (2015). Home-based long-term oxygen therapy and oxygen conservation devices: An updated review. Natl J Physiol Pharm Pharmacol, 5(4): 267-74.

Wang JY, Liao EY, Huang CX, et al. (2010). Medical (2 edition). Beijing: People's Med Pub House, pp.: 43-9.

Zhu XM, Tian H, Tao L, et al. (2012). The study of ECG-parameter change in postoperative congenital heart disease children pre- and post-six-minute walking test. Chin J Evid Based Pediatr, 7(5): 336-40.

Yang DH, Chen L, Xi QC, et al. (2015). Significance of CAT and 6MWT for assessing elderly patients with moderate-severe chronic obstructive pulmonary disease during stable period. J Clin Pulm Med, 20(12): 2193-195.

Zung WW (1971). A rating instrument for anxieties orders. Psychosomatics, 12(6): 371-79.

Borg E, Borg G, Larsson K, et al. (2010). An index for breathlessness and leg fatigue. Scand J Med Sci Sports, 20(4): 644-50.

Chaicharn Pothirat MD, Deesomchok A, Theerakittikul T, et al. (2007). Clinical characteristics, management in real world practice and long-term survival among COPD patients of Northern Thailand COPD club members. J Med Assoc Thai, 90(4): 653-62.

Maurer J, Rebbapragada V, Borson S, et al. (2008). Anxiety and depression in COPD: current understanding, unanswered questions, and research needs. Chest, 134(4_suppl): 43S-56S.

Yu XL (2009). Anxiety and nursing strategies of patients with Chronic Cor Pulmonale. J Xianning Univ (Med Sci), 23(3): 259-60.

Sun YH (2013). Psychological Intervention for Patients Who Suffered Heart Disease from Lung Disorders Psychological Condition and the Influence of Cardiac Function. Med Inf, 26(12): 288-89.

Tang SY, Yan LH, Jiang SH (2009). Effect of Psychotherapy on Aged Outpatients with Depression. Chin J Gen Pract, 7(1): 55-6.

Zhu WH, Lan F, Yan Q, et al. (2012). Analysis of Depression and Anxiety in Patients with Chronic Cor Pulmonale and Their Influencing Factors. Chin J Gen Pract, 10(5): 758-59.

Ma XM (2009). The Professional Feminine Anxious Psychology Illness's Origin Analyzes. J Baoshan Teach Coll, 28(2): 93-7.

Hatzimanolis A, Vitoratou S, Mandelli L, et al. (2013). Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability. J Affect Disord, 148(2-3): 316-22.

Fragkos KC, Frangos CC (2013). Assessing eating disorder risk: the pivotal role of achievement anxiety, depression and female gender in non-clinical samples. Nutrients, 5(3): 811-28.

Zhu MJ (2012). Clinical observation and nursing care of patients with chronic heart failure of pulmonary heart disease. Med Innovat China, 2012, 9(27): 59-60.

Zhao HB, Gou DX (2009). Analysis of the causes of COPD in acute exacerbation stage with conscious disturbance. Guide China Med, 7(4): 52, 25.

Wang LH, Fang ZJ, Wu XT (1999). The investigation of emotional status and influential factors in chronic obstructive pul monary disease patients. Health Psychol J, 7(4): 416-18.

Li Y (2013). Effect of comprehensive nursing care on adverse psychological and the quality of life of patients with cor pulmonale. Hebei J Trad Chin Med, 12: 1880-882.

Li JL (2012). Effect of psychological intervention on negative emotion and quality of life of patients with chronic cor pulmonale. Chin J Pract Nurs, 28(27): 7-8.

Jiang SX, Wang FX (2008). Psychological analysis and psychological nursing of patients with chronic cor pulmonale. China Med Her, 5(8): 142.

Blakemore A, Dickens C, Guthrie E, et al. (2014). Depression and anxiety predict health-related quality of life in chronic obstructive pulmonary disease: systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis, 9(1): 501-12.

IssueVol 45 No 8 (2016) QRcode
SectionOriginal Article(s)
CCP Anxiety Exercise capacity Influence

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
XU W, YAO J, CHEN L. Anxiety in Patients with Chronic Cor Pulmonale and Its Effect on Exercise Capacity. Iran J Public Health. 2016;45(8):1004-1011.