No Evidence of Human Herpesvirus 8 among Iranian Patients Infected with HIV
-
Amitis RAMEZANI
,
Elham SABOORI
,
Kayhan AZADMANESH
,
Minoo MOHRAZ
,
Monireh KAZEMIMANESH
,
Afsaneh KARAMI
,
Mohammad BANIFAZL
,
Hanieh GOLCHEHREGAN
,
Arezoo AGHAKHANI
Abstract
Background: Kaposi’s sarcoma is a vascular malignancy, which frequently occurs among immunocompromised individuals such as transplant recipients and patients with acquired immunodeficiency syndrome. Human herpesvirus 8 (HHV-8) is considered the etiological agent of all forms of Kaposi’s sarcoma. Though some seroepidemiological studies conducted on the prevalence of HHV-8 in Iran, there are insufficient data on the prevalence of HHV-8 viremia in HIV infected patients. We therefore, aimed to determine the prevalence of HHV-8 viremia in general population and HIV infected patients without Kaposi’s sarcoma in Tehran, Iran.
Methods: We conducted a cross sectional survey on 99 patients with HIV infection referred to Iranian Research Center for HIV/AIDS and 40 healthy controls in Tehran, Iran from January to April 2014. The presence of HHV-8 DNA was detected in buffy coat samples of enrolled subjects using nested PCR assay.
Results: A total of 99 HIV infected patients with mean age of 37.9±10 yr and 40 healthy controls with mean age of 39±11.5 yr were enrolled in the study. The mean CD4 count was 410.3± 211.4 cells/mm3. HHV-8 DNA was not detected in both healthy control and HIV patient groups.
Conclusion: This survey showed low rate of HHV-8 DNA in healthy controls and HIV patients. Considering our findings HHV-8 infection does not seem to be widespread in our population. Further studies focusing on different regions of Iran appear to be required to have a more accurate estimation.
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| Issue | Vol 45 No 7 (2016) | |
| Section | Original Article(s) | |
| Keywords | ||
| Human immunodeficiency virus (HIV) Human herpesvirus 8 (HHV-8) Prevalence Viremia Iran | ||
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