Influencing Factors of Diabetic Patients of on Oral Health-Related Quality of Life: A Scoping Review
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Abstract
Background: The oral health-related quality of life in diabetic patients is regarded as a significant factor for assessing their dental health. This study aimed to examine the current research state, frequently utilized research instruments, and factors impacting the oral health quality of life in individuals with diabetes.
Methods: Our review was conducted according to the PRISMA extended guidelines for scoping review. We conducted a literature review on the oral health and quality of life of diabetic patients using PubMed, Embase, and additional databases. This research proposal has been formally submitted to the Open Science Framework.
Results: Out of 3827 materials, merely 17 publications satisfied the review requirements for our study. The search period extended from the inception of the library until Feb 5, 2024. The research encompassed seven countries, including China, the United States, and Iran, utilizing the Oral Health Evaluation Index for the Elderly and the Oral Health Impact Scale as prevalent assessment instruments. The quality of life connected to oral health was predominantly low among diabetic patients, influenced by socio-demographic characteristics, oral health status, biochemical indicators, psychosocial elements, lifestyle choices, and oral-related factors.
Conclusion: The oral health-related quality of life among diabetic patients is typically diminished. Oral health care professionals must devise strategies to promptly identify, assess, and manage the factors influencing the oral health-related quality of life in diabetic patients, while incorporating necessary preventive measures and screenings to enhance oral disease prevention in routine evaluations.
1. Sun H, Saeedi P, Karuranga S, et al (2022). IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract, 183:109119.
2. Lin X, Xu Y, Pan X, et al (2020). Global, re-gional, and national burden and trend of diabetes in 195 countries and territo-ries: an analysis from 1990 to 2025. Sci Rep, 10(1):14790.
3. Hills AP, Arena R, Khunti K, et al (2018). Epidemiology and determinants of type 2 diabetes in south Asia. Lancet Diabetes Endocrinol, 6(12):966-78.
4. Goldney J, Barker MM, Thomas M, et al (2024). Age at onset of type 2 diabetes and prevalence of vascular disease and heart failure: Systematic review and dose-response meta-analysis. J Diabetes Complications, 38(10):108849.
5. Molania T, Alimohammadi M, Akha O, et al (2017). The effect of xerostomia and hyposalivation on the quality of life of patients with type II diabetes mellitus. Electron Physician, 9(11):5814-5819.
6. Nascimento GG, Leite F, Vestergaard P, et al (2018). Does diabetes increase the risk of periodontitis? A systematic review and meta-regression analysis of longitu-dinal prospective studies. Acta Diabetol, 55(7):653-67.
7. Pérez-Vielma NM, Gómez-López M, Mar-tínez-Godínez M, et al (2024). Candida Variety in the Oral Cavity of Mexican Subjects with Type 2 Diabetes Mellitus and TLR2 Gene Expression. Clin Pract, 14(2):417-25.
8. Ahmadinia AR, Rahebi D, Mohammadi M, et al (2022). Association between type 2 diabetes (T2D) and tooth loss: a system-atic review and meta-analysis. Bmc Endocr Disord, 22(1):100.
9. Mauri-Obradors E, Estrugo-Devesa A, Jané-Salas E, et al (2017). Oral manifestations of Diabetes Mellitus. A systematic re-view. Med Oral Patol Oral Cir Bucal, 22(5): e586-e594.
10. Sánchez GI, Ramírez L, Muñoz CM, et al(2024). Xerostomia and Salivary Dys-function in Patients With Diabetes Mellitus. A Cross-Sectional Study. J Oral Pathol Med, 53(10):622-36.
11. Hsu YJ, Lin KD, Chen JH, et al (2019). Per-iodontal Treatment Experience Associ-ated with Oral Health-Related Quality of Life in Patients with Poor Glycemic Control in Type 2 Diabetes: A Case-Control Study. Int J Environ Res Public Health, 16(20): 4011.
12. Santonocito S, Polizzi A, Marchetti E, et al (2022). Impact of Periodontitis on Gly-cemic Control and Metabolic Status in Diabetes Patients: Current Knowledge on Early Disease Markers and Thera-peutic Perspectives. Mediators Inflamm, 2022:4955277.
13. Henni SH, Skudutyte-Rysstad R, Ansteins-son V, et al (2023). Oral health and oral health-related quality of life among old-er adults receiving home health care services: A scoping review. Gerodontology, 40(2):161-71.
14. Khalifa N, Rahman B, Gaintantzopoulou MD, et al (2020). Oral health status and oral health-related quality of life among patients with type 2 diabetes mellitus in the United Arab Emirates: a matched case-control study. Health Qual Life Out-comes, 18(1):182.
15. Slade GD, Spencer AJ (1994). Development and evaluation of the Oral Health Im-pact Profile. Community Dent Health, 11(1):3-11.
16. Atchison KA, Dolan TA (1990). Develop-ment of the Geriatric Oral Health As-sessment Index. J Dent Educ, 54(11):680-7.
17. Rohani B (2019). Oral manifestations in pa-tients with diabetes mellitus. World J Di-abetes, 10(9):485-9.
18. Tricco AC, Lillie E, Zarin W, et al (2018). PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explana-tion. Ann Intern Med, 169(7):467-73.
19. Zeng X, Zhang Y, Kwong JS, et al (2015). The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med, 8(1):2-10.
20. Lin W, Wang F, Chen W (2023). Current sta-tus and influencing factors of oral self-care behavior and oral health quality of life in elderly patients with type 2 diabe-tes mellitus. China Modern Doctor, 61(18):52-56.
21. Ma J, Tang X, Liu M (2023). Multivariate Linear Regression Analysis of Influen-tial Factors of Oral Health-Related Quality of Life in Older Patients with Diabetes Mellitus. International Journal of Geriatrics, 44(1):49-52.
22. Zheng M, Zhang M, Hou X, et al (2022). Oral health status and its related factors influencing the quality of life among geriatric patients with type 2 diabetes mellitus. Practical Preventive Medicine, 29(4):487-490.
23. Wen Z, Zhang X, Wang H, et al (2022). In-vestigation of the Oral Health-Related Quality of Life in Elderly Patients with Type 2 Diabetes in Community Based on Andersen Model. Military Nursing, 39(5):1-4.
24. Wang C, Jiang J, Hu A, et al (2021). Analysis of oral health-related quality of life and influencing factors in diabetic patients. Journal of Medical Science Yanbian University, 44(2):106-110.
25. Ding L, Chen P, Xiao L, et al (2021). Analy-sis of Current Status and Influencing Factors of Oral Health Literacy and Oral Health Quality of Life in Elderly Diabetic Patients. China Continuing Medi-cal Education, 13(19):139-142.
26. Jia J, Jia N, Chen L (2017). Analysis and In-vestigation on Oral Health Quality of Life and Influencing Factors in Elderly Patients with Type 2 Diabetes Mellitus. Journal of Qilu Nursing, 23(1):20-22.
27. Duan X, Jin C, Yan J (2015). The level and influence factors of oral health-related quality of life in elderly patients with di-abetes. Chinese Journal of Nursing, 50(3):313-317.
28. Liu C (2018). Oral Health Quality Assess-ment and Influencing Factors in Mid-dle-aged and Elderly Patients with Dia-betes. Smart Healthcare, 4(26):28-30.
29. Lu D, Wang C, Huang S, et al (2021). Effects of Hemoglobin A1c on the Oral Health-Related Quality of Life in Type 2 Dia-betes Patients. World Latest Medicine Infor-mation, 21(32):57-60.
30. Chen H, Lin Y, Lin J, et al (2023). Rural-urban disparities in Oral Health-related Quality of Life for middle-aged and older adults with diabetes in Taiwan. Front Public Health, 11:1162201.
31. Vu GT, Little BB, Esterhay RJ, et al (2022). Oral health-related quality of life in US adults with type 2 diabetes. J Public Health Dent, 82(1):79-87.
32. Tabesh A, Mahmood M, Sirous S (2023). Oral health-related quality of life and xerostomia in type 2 diabetic patients. Dent Med Probl, 60(2):227-31.
33. Azogui-Lévy S, Dray-Spira R, Attal S, et al (2018). Factors associated with oral health-related quality of life in patients with diabetes. Aust Dent J, 63(2):163-9.
34. de Sousa RV, Pinho RCM, Vajgel BDCF, et al (2019). Evaluation of oral health-related quality of life in individuals with type 2 diabetes mellitus. Brazilian Journal of Oral Sciences, 18:1-16.
35. Thirunavukkarasu A, Alharbi MS, Salahud-din M, et al (2023). Evaluation of oral health-related quality of life and its as-sociation with mental health status of patients with type 2 diabetes mellitus in the post-COVID-19 pandemic era: A study from Central Saudi Arabia. Front Public Health, 11:1158979.
36. Sadeghi R, Taleghani F, Farhadi S (2014). Oral health related quality of life in di-abetic patients. J Dent Res Dent Clin Dent Prospects, 8(4):230-4.
37. Huang Z, Pei X, Graves DT(2020). The In-terrelationship between Diabetes, IL-17 and Bone Loss. Curr Osteoporos Rep, 18(1):23-31.
38. Preshaw PM, Alba AL, Herrera D, et al (2012). Periodontitis and diabetes: a two-way relationship. Diabetologia, 55(1):21-31.
39. Knorst JK, Sfreddo CS, de F MG, et al (2021). Socioeconomic status and oral health-related quality of life: A systemat-ic review and meta-analysis. Community Dent Oral Epidemiol, 49(2):95-102.
40. Hoseini A, Mirzapour A, Bijani A, et al (2017). Salivary flow rate and xerostomia in patients with type I and II diabetes mellitus. Electron Physician, 9(9):5244-9.
41. Lima D, Carneiro S, Barbosa F, et al (2017). Salivary flow and xerostomia in older patients with type 2 diabetes mellitus. PLoS One, 12(8): e180891.
42. Latti BR, Kalburge JV, Birajdar SB, et al (2018). Evaluation of relationship be-tween dental caries, diabetes mellitus and oral microbiota in diabetics. J Oral Maxillofac Pathol, 22(2):282.
43. Almusawi MA, Gosadi I, Abidia R, et al (2018). Potential risk factors for dental caries in Type 2 diabetic patients. Int J Dent Hyg, 16(4):467-75.
44. Sanz M, Ceriello A, Buysschaert M, et al (2018). Scientific evidence on the links between periodontal diseases and diabe-tes: Consensus report and guidelines of the joint workshop on periodontal dis-eases and diabetes by the International diabetes Federation and the European Federation of Periodontology. Diabetes Res Clin Pract, 137:231-41.
45. Alwithanani N (2023). Periodontal Diseases and Diabetes Mellitus: A Systematic Re-view. J Pharm Bioallied Sci, 15(Suppl 1):S54-S63.
46. Stoicescu M, Calniceanu H, Țig I, et al (2021). Significant aspects and correla-tion between glycemic control and gen-eralized chronic periodontitis in type 2 diabetes mellitus patients. Exp Ther Med, 22(1):671.
47. Preeja C, Ambili R, Nisha KJ, et al (2013). Archana V. Unveiling the role of stress in periodontal etiopathogenesis: an evi-dence-based review. J Investig Clin Dent, 4(2):78-83.
48. Alqahtani SM, Gokhale ST, Elagib M, et al (2023). Assessment and Correlation of Salivary Ca, Mg, and pH in Smokers and Non-Smokers with Generalized Chronic Periodontitis. Medicina (Kaunas), 59(4):765.
2. Lin X, Xu Y, Pan X, et al (2020). Global, re-gional, and national burden and trend of diabetes in 195 countries and territo-ries: an analysis from 1990 to 2025. Sci Rep, 10(1):14790.
3. Hills AP, Arena R, Khunti K, et al (2018). Epidemiology and determinants of type 2 diabetes in south Asia. Lancet Diabetes Endocrinol, 6(12):966-78.
4. Goldney J, Barker MM, Thomas M, et al (2024). Age at onset of type 2 diabetes and prevalence of vascular disease and heart failure: Systematic review and dose-response meta-analysis. J Diabetes Complications, 38(10):108849.
5. Molania T, Alimohammadi M, Akha O, et al (2017). The effect of xerostomia and hyposalivation on the quality of life of patients with type II diabetes mellitus. Electron Physician, 9(11):5814-5819.
6. Nascimento GG, Leite F, Vestergaard P, et al (2018). Does diabetes increase the risk of periodontitis? A systematic review and meta-regression analysis of longitu-dinal prospective studies. Acta Diabetol, 55(7):653-67.
7. Pérez-Vielma NM, Gómez-López M, Mar-tínez-Godínez M, et al (2024). Candida Variety in the Oral Cavity of Mexican Subjects with Type 2 Diabetes Mellitus and TLR2 Gene Expression. Clin Pract, 14(2):417-25.
8. Ahmadinia AR, Rahebi D, Mohammadi M, et al (2022). Association between type 2 diabetes (T2D) and tooth loss: a system-atic review and meta-analysis. Bmc Endocr Disord, 22(1):100.
9. Mauri-Obradors E, Estrugo-Devesa A, Jané-Salas E, et al (2017). Oral manifestations of Diabetes Mellitus. A systematic re-view. Med Oral Patol Oral Cir Bucal, 22(5): e586-e594.
10. Sánchez GI, Ramírez L, Muñoz CM, et al(2024). Xerostomia and Salivary Dys-function in Patients With Diabetes Mellitus. A Cross-Sectional Study. J Oral Pathol Med, 53(10):622-36.
11. Hsu YJ, Lin KD, Chen JH, et al (2019). Per-iodontal Treatment Experience Associ-ated with Oral Health-Related Quality of Life in Patients with Poor Glycemic Control in Type 2 Diabetes: A Case-Control Study. Int J Environ Res Public Health, 16(20): 4011.
12. Santonocito S, Polizzi A, Marchetti E, et al (2022). Impact of Periodontitis on Gly-cemic Control and Metabolic Status in Diabetes Patients: Current Knowledge on Early Disease Markers and Thera-peutic Perspectives. Mediators Inflamm, 2022:4955277.
13. Henni SH, Skudutyte-Rysstad R, Ansteins-son V, et al (2023). Oral health and oral health-related quality of life among old-er adults receiving home health care services: A scoping review. Gerodontology, 40(2):161-71.
14. Khalifa N, Rahman B, Gaintantzopoulou MD, et al (2020). Oral health status and oral health-related quality of life among patients with type 2 diabetes mellitus in the United Arab Emirates: a matched case-control study. Health Qual Life Out-comes, 18(1):182.
15. Slade GD, Spencer AJ (1994). Development and evaluation of the Oral Health Im-pact Profile. Community Dent Health, 11(1):3-11.
16. Atchison KA, Dolan TA (1990). Develop-ment of the Geriatric Oral Health As-sessment Index. J Dent Educ, 54(11):680-7.
17. Rohani B (2019). Oral manifestations in pa-tients with diabetes mellitus. World J Di-abetes, 10(9):485-9.
18. Tricco AC, Lillie E, Zarin W, et al (2018). PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explana-tion. Ann Intern Med, 169(7):467-73.
19. Zeng X, Zhang Y, Kwong JS, et al (2015). The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med, 8(1):2-10.
20. Lin W, Wang F, Chen W (2023). Current sta-tus and influencing factors of oral self-care behavior and oral health quality of life in elderly patients with type 2 diabe-tes mellitus. China Modern Doctor, 61(18):52-56.
21. Ma J, Tang X, Liu M (2023). Multivariate Linear Regression Analysis of Influen-tial Factors of Oral Health-Related Quality of Life in Older Patients with Diabetes Mellitus. International Journal of Geriatrics, 44(1):49-52.
22. Zheng M, Zhang M, Hou X, et al (2022). Oral health status and its related factors influencing the quality of life among geriatric patients with type 2 diabetes mellitus. Practical Preventive Medicine, 29(4):487-490.
23. Wen Z, Zhang X, Wang H, et al (2022). In-vestigation of the Oral Health-Related Quality of Life in Elderly Patients with Type 2 Diabetes in Community Based on Andersen Model. Military Nursing, 39(5):1-4.
24. Wang C, Jiang J, Hu A, et al (2021). Analysis of oral health-related quality of life and influencing factors in diabetic patients. Journal of Medical Science Yanbian University, 44(2):106-110.
25. Ding L, Chen P, Xiao L, et al (2021). Analy-sis of Current Status and Influencing Factors of Oral Health Literacy and Oral Health Quality of Life in Elderly Diabetic Patients. China Continuing Medi-cal Education, 13(19):139-142.
26. Jia J, Jia N, Chen L (2017). Analysis and In-vestigation on Oral Health Quality of Life and Influencing Factors in Elderly Patients with Type 2 Diabetes Mellitus. Journal of Qilu Nursing, 23(1):20-22.
27. Duan X, Jin C, Yan J (2015). The level and influence factors of oral health-related quality of life in elderly patients with di-abetes. Chinese Journal of Nursing, 50(3):313-317.
28. Liu C (2018). Oral Health Quality Assess-ment and Influencing Factors in Mid-dle-aged and Elderly Patients with Dia-betes. Smart Healthcare, 4(26):28-30.
29. Lu D, Wang C, Huang S, et al (2021). Effects of Hemoglobin A1c on the Oral Health-Related Quality of Life in Type 2 Dia-betes Patients. World Latest Medicine Infor-mation, 21(32):57-60.
30. Chen H, Lin Y, Lin J, et al (2023). Rural-urban disparities in Oral Health-related Quality of Life for middle-aged and older adults with diabetes in Taiwan. Front Public Health, 11:1162201.
31. Vu GT, Little BB, Esterhay RJ, et al (2022). Oral health-related quality of life in US adults with type 2 diabetes. J Public Health Dent, 82(1):79-87.
32. Tabesh A, Mahmood M, Sirous S (2023). Oral health-related quality of life and xerostomia in type 2 diabetic patients. Dent Med Probl, 60(2):227-31.
33. Azogui-Lévy S, Dray-Spira R, Attal S, et al (2018). Factors associated with oral health-related quality of life in patients with diabetes. Aust Dent J, 63(2):163-9.
34. de Sousa RV, Pinho RCM, Vajgel BDCF, et al (2019). Evaluation of oral health-related quality of life in individuals with type 2 diabetes mellitus. Brazilian Journal of Oral Sciences, 18:1-16.
35. Thirunavukkarasu A, Alharbi MS, Salahud-din M, et al (2023). Evaluation of oral health-related quality of life and its as-sociation with mental health status of patients with type 2 diabetes mellitus in the post-COVID-19 pandemic era: A study from Central Saudi Arabia. Front Public Health, 11:1158979.
36. Sadeghi R, Taleghani F, Farhadi S (2014). Oral health related quality of life in di-abetic patients. J Dent Res Dent Clin Dent Prospects, 8(4):230-4.
37. Huang Z, Pei X, Graves DT(2020). The In-terrelationship between Diabetes, IL-17 and Bone Loss. Curr Osteoporos Rep, 18(1):23-31.
38. Preshaw PM, Alba AL, Herrera D, et al (2012). Periodontitis and diabetes: a two-way relationship. Diabetologia, 55(1):21-31.
39. Knorst JK, Sfreddo CS, de F MG, et al (2021). Socioeconomic status and oral health-related quality of life: A systemat-ic review and meta-analysis. Community Dent Oral Epidemiol, 49(2):95-102.
40. Hoseini A, Mirzapour A, Bijani A, et al (2017). Salivary flow rate and xerostomia in patients with type I and II diabetes mellitus. Electron Physician, 9(9):5244-9.
41. Lima D, Carneiro S, Barbosa F, et al (2017). Salivary flow and xerostomia in older patients with type 2 diabetes mellitus. PLoS One, 12(8): e180891.
42. Latti BR, Kalburge JV, Birajdar SB, et al (2018). Evaluation of relationship be-tween dental caries, diabetes mellitus and oral microbiota in diabetics. J Oral Maxillofac Pathol, 22(2):282.
43. Almusawi MA, Gosadi I, Abidia R, et al (2018). Potential risk factors for dental caries in Type 2 diabetic patients. Int J Dent Hyg, 16(4):467-75.
44. Sanz M, Ceriello A, Buysschaert M, et al (2018). Scientific evidence on the links between periodontal diseases and diabe-tes: Consensus report and guidelines of the joint workshop on periodontal dis-eases and diabetes by the International diabetes Federation and the European Federation of Periodontology. Diabetes Res Clin Pract, 137:231-41.
45. Alwithanani N (2023). Periodontal Diseases and Diabetes Mellitus: A Systematic Re-view. J Pharm Bioallied Sci, 15(Suppl 1):S54-S63.
46. Stoicescu M, Calniceanu H, Țig I, et al (2021). Significant aspects and correla-tion between glycemic control and gen-eralized chronic periodontitis in type 2 diabetes mellitus patients. Exp Ther Med, 22(1):671.
47. Preeja C, Ambili R, Nisha KJ, et al (2013). Archana V. Unveiling the role of stress in periodontal etiopathogenesis: an evi-dence-based review. J Investig Clin Dent, 4(2):78-83.
48. Alqahtani SM, Gokhale ST, Elagib M, et al (2023). Assessment and Correlation of Salivary Ca, Mg, and pH in Smokers and Non-Smokers with Generalized Chronic Periodontitis. Medicina (Kaunas), 59(4):765.
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| Issue | Vol 54 No 3 (2025) | |
| Section | Review Article(s) | |
| Keywords | ||
| Diabetes Oral health-related quality of life Determinants Scoping review Evaluation instrument | ||
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How to Cite
1.
Xian X, Zhang Y, Fu G, Li Z, Chen J, Wang M, Zheng Q. Influencing Factors of Diabetic Patients of on Oral Health-Related Quality of Life: A Scoping Review. Iran J Public Health. 2025;54(3):465-477.
