Safety and Efficacy of Shaoyao Decoction with Anti-Inflammatory Effect in the Treatment of Ulcerative Colitis: A Meta-Analysis
Abstract
Background: We aimed to evaluate the effectiveness and safety of Shaoyao Tang in treating ulcerative colitis (UC) through a randomized controlled meta-analysis.
Methods: Computer searches were conducted between Jan 2000 and Mar 2023 using the databases of CNKI, VIP, PubMed, the Cochrane Library, Wanfang and Web of Science in search of trials with randomization and control including Shaoyao decoction in UC. After quality assessment, The Revman 5.3 was applied.
Results: Overall, 23 articles were selected for the study totally. Shaoyao decoction improved clinical effective rate (P<0.001) and effective rate of syndrome (P<0.001), IBDQ (P<0.001), interleukin-4 (P<0.001) and interleukin-10 (P<0.001), reduced adverse reactions (P=0.004), recurrence rate (P=0.03), DAI (P<0.001), tumour necrosis component α (P<0.001), interleukin-1β (P<0.001), interleukin-6 (P<0.001), and extremely sensitive C-reactive protein (P=0.02).
Conclusion: Shaoyao decoction has certain advantages and good safety in the treatment of UC; however the findings still need to be supported by excellent studies.
1. Henry C, Bassignani A, Berland M, et al (2022). Modern Metaproteomics: A Unique Tool to Characterize the Active Microbiome in Health and Diseases, and Pave the Road towards New Bi-omarkers-Example of Crohn's Disease and Ulcerative Colitis Flare-Ups. Cells, 11(8):1340.
2. Zuo W, Wang B, Bai X, et al (2022). 16S rRNA and metagenomic shotgun se-quencing data revealed consistent pat-terns of gut microbiome signature in pediatric ulcerative colitis. Sci Rep, 12(1):6421.
3. Cui LJ, Yuan W, Chen FY, et al (2022). Pec-tic polysaccharides ameliorate the pa-thology of ulcerative colitis in mice by reducing pyroptosis. Ann Transl Med, 10(6):347.
4. Kikut J, Mokrzycka M, Drozd A, et al (2022). Involvement of Proinflammatory Arachidonic Acid (ARA) Derivatives in Crohn's Disease (CD) and Ulcerative Colitis (UC). J Clin Med, 11(7):1861.
5. Meza-Ortiz CJ, Martínez-Vázquez SE, Yamamoto-Furusho JK (2022). Associa-tion of dietary fiber consumption with disease activity in ulcerative colitis: An exploratory study in the Mexican popu-lation. Gac Med Mex, 158(1):41-47.
6. Hao L, Wang HJ (2022). Treatment of ul-cerative colitis of large intestine damp-heat type with light method and fre-quency. Guoji Zhongyi Zhongyao Zazhi, 44(3):347-349.
7. Hou PG, Lv CH, Wang HQ (2014). Obser-vation on effect of Salicylic Acid Sul-fasalazine combined with Shaoyao de-coction in treatment of ulcerative colitis. Qiqihaer Yixueyuan Xuebao, 35(2):168-169.
8. Yin P, Li W, Yang HM, et al (2021). Clinical study on retention enema with Jiawei Shaoyao decoction and Kangfuxin Liq-uid combined with oral administration of mesalazine enteric-coated tables in the treatment of ulcerative colitis of large intestine damp-heat type. Hebei Zhongyi, 43(2):278-282.
9. Salehi-Pourmehr H, Naseri A, Mostafaei A, et al (2021). Misconduct in research in-tegrity: Assessment the quality of sys-tematic reviews in Cochrane urological cancer review group. Turk J Urol, 47(5):392-419.
10. Chao JF (2018). Effects of modified Shaoyao decoction combined with mesalazine on the levels of inflammato-ry factors in patients with ulcerative co-litis. Guangming Zhongyi, 33(2):254-256.
11. Chen JL, Chen JF, Han YB, et al (2018). Ef-fect of retention enema with Chinese herbaceous peony decoction on in-flammatory factors of patients with damp-heat ulcerative colitis .Zhongguo Zhongxiyi Jiehe Xiaohua Zazhi, 26(11):938-940.
12. Ding HH (2019). Curative effect of Shaoyao decoction modification combined with mesalazine in the treatment of ulcera-tive colitis with damp-heat intrinsic type. Zhongguo Zhongyiyao Keji, 26(5):744-745.
13. He RA, Yan HY (2020). Effects of Shaoyao decoction combined with acupuncture on clinical manifestations, colonoscopy and colon pathological changes in pa-tients with active ulcerative colitis. Gui-zhou Yiyao, 44(10):1589-1590.
14. Huang HJ, Fei SY (2019). Acupuncture combined with Peony Decoction in the treatment of ulcerative colitis. Jilin Zhongyiyao, 39(03):389-392.
15. Huang HL (2018). Clinical observation on 34 cases of ulcerative colitis treated by Shaoyao decoction combined with Bupi Yichang Pills. Zhongguo Minzu Minjian Yiyao , 27(09):100-102.
16. Jia ZJ, Yang PQ, Ge LL (2011). Damp-heat intrinsic ulcerative colitis treated with Shaoyao decoction and Chinese medi-cine enema in 70 Cases. Zhongguo Yaoye, 20(01):73.
17. Li HB, Cheng LL (2018). Shaoyao decoction combined with acupuncture in the treatment of active ulcerative colitis. Ji-lin Zhongyiyao, 38(03):331-334.
18. Liang ZM, Zhang GL, Cai YM (2005). Clini-cal observation on treatment of ulcera-tive colitis with Shaoyao decoction re-tention enema. Jilin Zhongyiyao, 11:30-31.
19. Lou W, Wang WD, Cao SH (2022). Study on effect of Shaoyao decoction on YKL-40 and IL-17 in patients with ulcerative co-litis(J/OL). Zhonghua Zhongyiyao Xue Kan, 4;8.
20. Lu LS, He YH, Luo M, et al (2010). Shaoyao decoction in the treatment of ulcerative colitis with damp heat accumulation in 30 cases. Zhongguo Zhongyiyao Xiandai Yuancheng Jiaoyu, 8(19):11-12.
21. Qi XY, Zhang QS, Zhang CY (2016). Clini-cal effect of modified treatment of Shaoyao Tang retention enema com-bined with mesalazine on ulcerative co-litis with large intestine damp-heat. Zhongguo Shiyan Fangjixue Zazhi, 22(19):149-153.
22. Sun XJ (2017). Observation on the curative effect of modified Shaoyao decoction combined with western medicine in the treatment of ulcerative colitis. Xiandai Zhongxiyi Jiehe Zazhi, 26(04):436-438.
23. Tan GZ, Sun J, Qu YZ, et al (2020). Clinical observation of Shaoyao decoction and infliximab on moderate or severe ulcer-ative colitis. Shanxi Zhongyi, 36(07):23-26.
24. Tian GD (2017). Clinical effect of modi-fied Shaoyao decoction in the treatment of ulcerative colitis. Neimenggu Zhongyiyao, 36(17):3-4.
25. Wa HF, Qi CJ (2019). Clinical effect of modified Shaoyao decoction combined with conventional western medicine in the treatment of patients with ulcerative colitis. Zhongguo Gangchangbing Za-zhi, 39(05):77.
26. Wang K, Wei M (2020). Observation on the curative effect of modified Shaoyao de-coction combined with acupuncture in the treatment of ulcerative colitis with damp-heat accumulation in active stage. Xiandai Zhongxiyi Jiehe Zazhi, 29(07):763-766.
27. Xu JJ, Ji F, Chen JY, et al (2007). Clinical Observation on Chronic Ulcerative Co-litis Treated by Modified Peony Decoc-tion. Zhejiang Zhongyi Zazhi,(06):323-324.
28. Yang JK (2019). Clinical observation on 30 cases of ulcerative colitis treated by Shaoyao decoction with retention ene-ma combined with moxibustion .Zhongguo Minzu Minjian Yiyao, 28(03):106-108.
29. Yao CJ, Li YL, Luo LH, et al (2021). Study on mechanism of Shaoyao decoction in regulating balance of Th17/Treg cells to improve inflammatory response of ul-cerative colitis with damp heat syn-drome of large intestine. Shijie Kexue Jishu – Zhongyiyao Xiandaihua, 23(08):2635-2642.
30. Zhang WH (2021). Clinical efficacy and adverse reaction analysis of modified Shaoyao decoction combined with mesalazine in the treatment of ulcera-tive colitis with large intestine damp-heat syndrome. Heilongjiang Zhongyiyao, 50(05):180-181.
31. Zhao FC (2019). Curative effect observation of Shaoyao decoction combined with mesalazine in the treatment of ulcera-tive colitis. Shiyong Zhongyiyao Zazhi, 35(03):311-312.
32. Zhong YM (2010). A summary of 64 cases of ulcerative colitis treated with Shaoyao decoction combined with traditional Chinese medicine retention enema. Hu-nan Zhongyi Zazhi, 26(05):31-33.
33. Agraib LM, Yamani MI, Rayyan YM, et al (2021). The probiotic supplementation role in improving the immune system among people with ulcerative colitis: a narrative review. Drug Metab Pers Ther, 10.1515/dmdi-2021-0150.
34. Rohani P, Alimadadi H, Abdollah Gorji F, et al (2021). Efficacy of infliximab and adalimumab therapy in very early onset, severe ulcerative colitis. Gastroenterol Hepatol Bed Bench, 14(Suppl1):S75-S81.
35. Wang Y, Zhang YX, Yang XR, et al (2022). Efficacy of Shaoyao Sijun Jianpi Decoc-tion combined with traditional Chinese medicine enema on hormone-dependent ulcerative colitis of spleen-deficiency damp-heat type and its effect on inflammatory factors and withdrawal of hormones. Xiandai Zhongxiyi Jiehe Zazhi, 31(06):753-757+774.
36. Xiong Q, Li TL, Xie FJ, et al (2022). Expe-rience of professor FENG Peimin in treating ulcerative colitis with separating dampness-heat. Sichuan Zhongyi, 40(02):4-6.
37. Cao SQ, Wang FY, Tang SN, et al (2021). Effect of Shaoyaotang on Expressions of CD14,FADD and Caspase-8 in Co-lonic Tissues of Rats with Large Intesti-nal Damp-heat Syndrome of Ulcerative Colitis. Zhongguo Shiyan Fangjixue Za-zhi, 27(05):1-7.
2. Zuo W, Wang B, Bai X, et al (2022). 16S rRNA and metagenomic shotgun se-quencing data revealed consistent pat-terns of gut microbiome signature in pediatric ulcerative colitis. Sci Rep, 12(1):6421.
3. Cui LJ, Yuan W, Chen FY, et al (2022). Pec-tic polysaccharides ameliorate the pa-thology of ulcerative colitis in mice by reducing pyroptosis. Ann Transl Med, 10(6):347.
4. Kikut J, Mokrzycka M, Drozd A, et al (2022). Involvement of Proinflammatory Arachidonic Acid (ARA) Derivatives in Crohn's Disease (CD) and Ulcerative Colitis (UC). J Clin Med, 11(7):1861.
5. Meza-Ortiz CJ, Martínez-Vázquez SE, Yamamoto-Furusho JK (2022). Associa-tion of dietary fiber consumption with disease activity in ulcerative colitis: An exploratory study in the Mexican popu-lation. Gac Med Mex, 158(1):41-47.
6. Hao L, Wang HJ (2022). Treatment of ul-cerative colitis of large intestine damp-heat type with light method and fre-quency. Guoji Zhongyi Zhongyao Zazhi, 44(3):347-349.
7. Hou PG, Lv CH, Wang HQ (2014). Obser-vation on effect of Salicylic Acid Sul-fasalazine combined with Shaoyao de-coction in treatment of ulcerative colitis. Qiqihaer Yixueyuan Xuebao, 35(2):168-169.
8. Yin P, Li W, Yang HM, et al (2021). Clinical study on retention enema with Jiawei Shaoyao decoction and Kangfuxin Liq-uid combined with oral administration of mesalazine enteric-coated tables in the treatment of ulcerative colitis of large intestine damp-heat type. Hebei Zhongyi, 43(2):278-282.
9. Salehi-Pourmehr H, Naseri A, Mostafaei A, et al (2021). Misconduct in research in-tegrity: Assessment the quality of sys-tematic reviews in Cochrane urological cancer review group. Turk J Urol, 47(5):392-419.
10. Chao JF (2018). Effects of modified Shaoyao decoction combined with mesalazine on the levels of inflammato-ry factors in patients with ulcerative co-litis. Guangming Zhongyi, 33(2):254-256.
11. Chen JL, Chen JF, Han YB, et al (2018). Ef-fect of retention enema with Chinese herbaceous peony decoction on in-flammatory factors of patients with damp-heat ulcerative colitis .Zhongguo Zhongxiyi Jiehe Xiaohua Zazhi, 26(11):938-940.
12. Ding HH (2019). Curative effect of Shaoyao decoction modification combined with mesalazine in the treatment of ulcera-tive colitis with damp-heat intrinsic type. Zhongguo Zhongyiyao Keji, 26(5):744-745.
13. He RA, Yan HY (2020). Effects of Shaoyao decoction combined with acupuncture on clinical manifestations, colonoscopy and colon pathological changes in pa-tients with active ulcerative colitis. Gui-zhou Yiyao, 44(10):1589-1590.
14. Huang HJ, Fei SY (2019). Acupuncture combined with Peony Decoction in the treatment of ulcerative colitis. Jilin Zhongyiyao, 39(03):389-392.
15. Huang HL (2018). Clinical observation on 34 cases of ulcerative colitis treated by Shaoyao decoction combined with Bupi Yichang Pills. Zhongguo Minzu Minjian Yiyao , 27(09):100-102.
16. Jia ZJ, Yang PQ, Ge LL (2011). Damp-heat intrinsic ulcerative colitis treated with Shaoyao decoction and Chinese medi-cine enema in 70 Cases. Zhongguo Yaoye, 20(01):73.
17. Li HB, Cheng LL (2018). Shaoyao decoction combined with acupuncture in the treatment of active ulcerative colitis. Ji-lin Zhongyiyao, 38(03):331-334.
18. Liang ZM, Zhang GL, Cai YM (2005). Clini-cal observation on treatment of ulcera-tive colitis with Shaoyao decoction re-tention enema. Jilin Zhongyiyao, 11:30-31.
19. Lou W, Wang WD, Cao SH (2022). Study on effect of Shaoyao decoction on YKL-40 and IL-17 in patients with ulcerative co-litis(J/OL). Zhonghua Zhongyiyao Xue Kan, 4;8.
20. Lu LS, He YH, Luo M, et al (2010). Shaoyao decoction in the treatment of ulcerative colitis with damp heat accumulation in 30 cases. Zhongguo Zhongyiyao Xiandai Yuancheng Jiaoyu, 8(19):11-12.
21. Qi XY, Zhang QS, Zhang CY (2016). Clini-cal effect of modified treatment of Shaoyao Tang retention enema com-bined with mesalazine on ulcerative co-litis with large intestine damp-heat. Zhongguo Shiyan Fangjixue Zazhi, 22(19):149-153.
22. Sun XJ (2017). Observation on the curative effect of modified Shaoyao decoction combined with western medicine in the treatment of ulcerative colitis. Xiandai Zhongxiyi Jiehe Zazhi, 26(04):436-438.
23. Tan GZ, Sun J, Qu YZ, et al (2020). Clinical observation of Shaoyao decoction and infliximab on moderate or severe ulcer-ative colitis. Shanxi Zhongyi, 36(07):23-26.
24. Tian GD (2017). Clinical effect of modi-fied Shaoyao decoction in the treatment of ulcerative colitis. Neimenggu Zhongyiyao, 36(17):3-4.
25. Wa HF, Qi CJ (2019). Clinical effect of modified Shaoyao decoction combined with conventional western medicine in the treatment of patients with ulcerative colitis. Zhongguo Gangchangbing Za-zhi, 39(05):77.
26. Wang K, Wei M (2020). Observation on the curative effect of modified Shaoyao de-coction combined with acupuncture in the treatment of ulcerative colitis with damp-heat accumulation in active stage. Xiandai Zhongxiyi Jiehe Zazhi, 29(07):763-766.
27. Xu JJ, Ji F, Chen JY, et al (2007). Clinical Observation on Chronic Ulcerative Co-litis Treated by Modified Peony Decoc-tion. Zhejiang Zhongyi Zazhi,(06):323-324.
28. Yang JK (2019). Clinical observation on 30 cases of ulcerative colitis treated by Shaoyao decoction with retention ene-ma combined with moxibustion .Zhongguo Minzu Minjian Yiyao, 28(03):106-108.
29. Yao CJ, Li YL, Luo LH, et al (2021). Study on mechanism of Shaoyao decoction in regulating balance of Th17/Treg cells to improve inflammatory response of ul-cerative colitis with damp heat syn-drome of large intestine. Shijie Kexue Jishu – Zhongyiyao Xiandaihua, 23(08):2635-2642.
30. Zhang WH (2021). Clinical efficacy and adverse reaction analysis of modified Shaoyao decoction combined with mesalazine in the treatment of ulcera-tive colitis with large intestine damp-heat syndrome. Heilongjiang Zhongyiyao, 50(05):180-181.
31. Zhao FC (2019). Curative effect observation of Shaoyao decoction combined with mesalazine in the treatment of ulcera-tive colitis. Shiyong Zhongyiyao Zazhi, 35(03):311-312.
32. Zhong YM (2010). A summary of 64 cases of ulcerative colitis treated with Shaoyao decoction combined with traditional Chinese medicine retention enema. Hu-nan Zhongyi Zazhi, 26(05):31-33.
33. Agraib LM, Yamani MI, Rayyan YM, et al (2021). The probiotic supplementation role in improving the immune system among people with ulcerative colitis: a narrative review. Drug Metab Pers Ther, 10.1515/dmdi-2021-0150.
34. Rohani P, Alimadadi H, Abdollah Gorji F, et al (2021). Efficacy of infliximab and adalimumab therapy in very early onset, severe ulcerative colitis. Gastroenterol Hepatol Bed Bench, 14(Suppl1):S75-S81.
35. Wang Y, Zhang YX, Yang XR, et al (2022). Efficacy of Shaoyao Sijun Jianpi Decoc-tion combined with traditional Chinese medicine enema on hormone-dependent ulcerative colitis of spleen-deficiency damp-heat type and its effect on inflammatory factors and withdrawal of hormones. Xiandai Zhongxiyi Jiehe Zazhi, 31(06):753-757+774.
36. Xiong Q, Li TL, Xie FJ, et al (2022). Expe-rience of professor FENG Peimin in treating ulcerative colitis with separating dampness-heat. Sichuan Zhongyi, 40(02):4-6.
37. Cao SQ, Wang FY, Tang SN, et al (2021). Effect of Shaoyaotang on Expressions of CD14,FADD and Caspase-8 in Co-lonic Tissues of Rats with Large Intesti-nal Damp-heat Syndrome of Ulcerative Colitis. Zhongguo Shiyan Fangjixue Za-zhi, 27(05):1-7.
| Files | ||
| Issue | Vol 54 No 3 (2025) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v54i3.18241 | |
| Keywords | ||
| Ulcerative colitis Shaoyao decoction Meta-analysis | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Zhu Y, Liu Q. Safety and Efficacy of Shaoyao Decoction with Anti-Inflammatory Effect in the Treatment of Ulcerative Colitis: A Meta-Analysis. Iran J Public Health. 2025;54(3):478-488.
