Trends in Melanoma Mortality in Serbia: A 22-Year Population-Based Study
-
Zorana Babic
,
Nemanja Rancic
,
Sanja Ilic
,
Snezana Corovic
,
Vesna Milicic
,
Gordana Djordjevic
,
Ognjen Djordjevic
,
Sladjana Ilic
,
Svetlana Radevic
Abstract
Background: We aimed to investigating the sex-specific and age-specific melanoma mortality trends observed on the territory of Serbia between 2000 and 2021.
Methods: This population-based study used data from the Statistical Office of the Republic of Serbia database during the period 2000–2021. The calculation of the gender and age-standardized rates (ASR) was performed. We used a regression analysis complete with linear trend model.
Results: The mean ASR was 1.77 per 100,000 people, meaning that male mortality rates (2.24 per 100,000) was higher than female mortality rates (1.34 per 100,000). During the observation period, a rising trend in mortality from melanoma skin cancer was reported. Observed by gender, the change of melanoma mortality trend was significant in men (P=0.021), but not in women (P=0.747). The annual growth rate of ASRs values was 1.43%. A increase in the melanoma mortality rate was observed since 2000 by 2.44% annually in males and by 2.79% annually in females. Mortality rates were increasing in both sexes as they aged, and the greatest number of deaths was recorded in the group of those aged 80 yr or above (16.25 per 100,000 for men; 10.45 per 100,000 for women).
Conclusion: Our study findings underline the importance of launching more effective public health awareness campaigns to educate people about the dangers of melanoma and its symptoms’ detection along with establishing a diagnosis at an early stage of the disease, especially among male patients and those at an advanced age.
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2. Dziankowska-Zaborszczyk E, Maniecka-Bryła I, Pikala M (2022). Mortality Trends Due to Skin Melanoma in Poland in the Years 2000-2020. Int J Environ Res Public Healt, 19 (23): 16118.
3. Erdei E, Torres SM (2010). A new under-standing in the epidemiology of mela-noma. Exp Rev Anticancer Ther, 10 (11): 1811–23.
4. Erdmann F, Lortet-Tieulent J, Schüz J, et al (2013). International trends in the inci-dence of malignant melanoma 1953-2008--are recent generations at higher or lower risk? Int J Cancer, 132 (2): 385-400.
5. Lopes J, Rodrigues CMP, Gaspar MM, Reis CP (2022). Melanoma Management: From Epidemiology to Treatment and Latest Advances. Cancers (Basel), 14 (19): 4652.
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8. Saginala K, Barsouk A, Aluru JS, Rawla P, Barsouk A (2021). Epidemiology of mel-anoma. Med Sci (Basel), 9 (4): 63.
9. International Agency for Research on Can-cer. Cancer Tomorrow. Estimated Num-ber of Deaths from 2020 to 2040 of Melanoma of Skin. Available from: https://gco.iarc.fr/tomorrow/en/dataviz/isotype?cancers=16_17&single_unit=5000&group_cancers=1&multiple_cancers=1&types=1 [cited August 2023].
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11. Gandini S, Sera F, Cattaruzza MS, et al (2005). Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi. Eur J Cancer, 41 (1): 28-44.
12. Memon A, Bannister P, Rogers I, et al (2021). Changing epidemiology and age-specific incidence of cutaneous malignant melanoma in England: An analysis of the national cancer registration data by age, gender and anatomical site, 1981-2018. Lancet Reg Health Eur, 2: 100024.
13. Segi M (1960). Cancer Mortality for Selected Sites in 24 Countries (1950–1957). Sendai: Department of Public Health, Tohoku University of Medicine. https://search.worldcat.org/title/36669244
14. Yang DD, Salciccioli JD, Marshall DC, Sheri A, Shalhoub J (2020). Trends in malig-nant melanoma mortality in 31 countries from 1985 to 2015. Br J Dermatol, 183: 1056–1064.
15. Eriksson H, Lyth J, Månsson-Brahme E, et al (2014). Later stage at diagnosis and worse survival in cutaneous malignant melanoma among men living alone: a na-tionwide population-based study from Sweden. J Clin Oncol, 32 (13): 1356-64.
16. Berk-Krauss J, Stein JA, Weber J, Polsky D, Geller AC (2020). New Systematic Thera-pies and Trends in Cutaneous Melanoma Deaths among US Whites, 1986-2016. Am J Public Health, 110 (5): 731-733.
17. Gutiérrez-González E, López-Abente G, Aragonés N, et al (2019). Trends in Mor-tality from Cutaneous Malignant Mela-noma in Spain (1982-2016): Sex-Specific Age-Cohort-Period Effects. J Eur Acad Dermatol Venereol, 33 (8): 1522–8.
18. Ward-Peterson M, Acuna JM, Alkhalifah MK, et al (2016). Association between race/ethnicity and survival of melanoma patients in the United States over 3 dec-ades: A secondary analysis of SEER data. Medicine, 95 (17): e3315.
19. Sneyd MJ, Cox B (2013). A comparison of trends in melanoma mortality in New Zealand and Australia: The two countries with the highest melanoma incidence and mortality in the world. BMC Cancer, 13: 372.
20. Garbe C, Leiter U (2009). Melanoma epi-demiology and trends. Clin Dermatol, 27 (1): 3–9.
21. Ward WH, Farma JM (2017). Cutaneous Melanoma: Etiology and Therapy. Bris-bane (AU): Codon Publications.
22. Armstrong BK (2004). How sun exposure causes skin cancer: An epidemiological perspective in: Hill D, Elwood JM, Eng-lish D. Prevention of Skin Cancer. Dordrecht, The Netherlands: Kluwer Academic Pub-lishers, pp. 89-116.
23. Watson M, Geller AC, Tucker MA, Guy GP Jr, Weinstock MA (2016). Melanoma burden and recent trends among non-Hispanic whites aged 15-49years, United States. Prev Med, 91: 294-298.
24. Pantovic M, Djordjevic O, Radevic S, Bankovic D, Parezanovic Ilic K, Ra-dovanovic S (2023). Mortality of malig-nant melanoma in Central Serbia, in the period 1999-2015. Dermatol Pract Concept, 13 (1): e202308.
25. Rastrelli M, Tropea S, Rossi CR, Alaibac M (2014). Melanoma: Epidemiology, risk factors, pathogenesis, diagnosis and clas-sification. In Vivo, 28: 1005–1011.
26. Arnold M, de Vries E, Whiteman DC, et al (2018). Global burden of cutaneous mel-anoma attributable to ultraviolet radiation in 2012. Int J Cancer, 143 (6): 1305-1314.
27. Olsen CM, Thompson JF, Pandeya N, Whiteman DC (2020). Evaluation of sex-specific incidence of melanoma. JAMA Dermatol, 156 (5): 553-560.
28. Robsahm TE, Bergva G, Hestvik UE, Møller B (2013). Sex differences in rising trends of cutaneous malignant melanoma in Norway, 1954-2008. Melanoma Res, 23 (1): 70-8.
29. Boniol M, Autier P, Boyle P, Gandini S (2012). Cutaneous melanoma attributable to sunbed use: Systematic review and me-ta‐analysis. BMJ, 345: e4757.
30. Sung H, Siegel RL, Rosenberg PS, Jemal A (2019). Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry. Lancet Public Health, 4 (3): e137-e147.
2. Dziankowska-Zaborszczyk E, Maniecka-Bryła I, Pikala M (2022). Mortality Trends Due to Skin Melanoma in Poland in the Years 2000-2020. Int J Environ Res Public Healt, 19 (23): 16118.
3. Erdei E, Torres SM (2010). A new under-standing in the epidemiology of mela-noma. Exp Rev Anticancer Ther, 10 (11): 1811–23.
4. Erdmann F, Lortet-Tieulent J, Schüz J, et al (2013). International trends in the inci-dence of malignant melanoma 1953-2008--are recent generations at higher or lower risk? Int J Cancer, 132 (2): 385-400.
5. Lopes J, Rodrigues CMP, Gaspar MM, Reis CP (2022). Melanoma Management: From Epidemiology to Treatment and Latest Advances. Cancers (Basel), 14 (19): 4652.
6. Guy GP, Thomas CC, Thompson T, et al (2015). Vital signs: Melanoma incidence and mortality trends and projections – United States, 1982–2030. Morb Mortal Wkly Rep, 64 (21): 591–6.
7. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin, 68, 394–424.
8. Saginala K, Barsouk A, Aluru JS, Rawla P, Barsouk A (2021). Epidemiology of mel-anoma. Med Sci (Basel), 9 (4): 63.
9. International Agency for Research on Can-cer. Cancer Tomorrow. Estimated Num-ber of Deaths from 2020 to 2040 of Melanoma of Skin. Available from: https://gco.iarc.fr/tomorrow/en/dataviz/isotype?cancers=16_17&single_unit=5000&group_cancers=1&multiple_cancers=1&types=1 [cited August 2023].
10. Koczkodaj P, Sulkowska U, Didkowska J, Rutkowski P, Mańczuk M (2023). Mela-noma Mortality Trends in 28 European Countries: A Retrospective Analysis for the Years 1960-2020. Cancers (Basel), 15 (5): 1514.
11. Gandini S, Sera F, Cattaruzza MS, et al (2005). Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi. Eur J Cancer, 41 (1): 28-44.
12. Memon A, Bannister P, Rogers I, et al (2021). Changing epidemiology and age-specific incidence of cutaneous malignant melanoma in England: An analysis of the national cancer registration data by age, gender and anatomical site, 1981-2018. Lancet Reg Health Eur, 2: 100024.
13. Segi M (1960). Cancer Mortality for Selected Sites in 24 Countries (1950–1957). Sendai: Department of Public Health, Tohoku University of Medicine. https://search.worldcat.org/title/36669244
14. Yang DD, Salciccioli JD, Marshall DC, Sheri A, Shalhoub J (2020). Trends in malig-nant melanoma mortality in 31 countries from 1985 to 2015. Br J Dermatol, 183: 1056–1064.
15. Eriksson H, Lyth J, Månsson-Brahme E, et al (2014). Later stage at diagnosis and worse survival in cutaneous malignant melanoma among men living alone: a na-tionwide population-based study from Sweden. J Clin Oncol, 32 (13): 1356-64.
16. Berk-Krauss J, Stein JA, Weber J, Polsky D, Geller AC (2020). New Systematic Thera-pies and Trends in Cutaneous Melanoma Deaths among US Whites, 1986-2016. Am J Public Health, 110 (5): 731-733.
17. Gutiérrez-González E, López-Abente G, Aragonés N, et al (2019). Trends in Mor-tality from Cutaneous Malignant Mela-noma in Spain (1982-2016): Sex-Specific Age-Cohort-Period Effects. J Eur Acad Dermatol Venereol, 33 (8): 1522–8.
18. Ward-Peterson M, Acuna JM, Alkhalifah MK, et al (2016). Association between race/ethnicity and survival of melanoma patients in the United States over 3 dec-ades: A secondary analysis of SEER data. Medicine, 95 (17): e3315.
19. Sneyd MJ, Cox B (2013). A comparison of trends in melanoma mortality in New Zealand and Australia: The two countries with the highest melanoma incidence and mortality in the world. BMC Cancer, 13: 372.
20. Garbe C, Leiter U (2009). Melanoma epi-demiology and trends. Clin Dermatol, 27 (1): 3–9.
21. Ward WH, Farma JM (2017). Cutaneous Melanoma: Etiology and Therapy. Bris-bane (AU): Codon Publications.
22. Armstrong BK (2004). How sun exposure causes skin cancer: An epidemiological perspective in: Hill D, Elwood JM, Eng-lish D. Prevention of Skin Cancer. Dordrecht, The Netherlands: Kluwer Academic Pub-lishers, pp. 89-116.
23. Watson M, Geller AC, Tucker MA, Guy GP Jr, Weinstock MA (2016). Melanoma burden and recent trends among non-Hispanic whites aged 15-49years, United States. Prev Med, 91: 294-298.
24. Pantovic M, Djordjevic O, Radevic S, Bankovic D, Parezanovic Ilic K, Ra-dovanovic S (2023). Mortality of malig-nant melanoma in Central Serbia, in the period 1999-2015. Dermatol Pract Concept, 13 (1): e202308.
25. Rastrelli M, Tropea S, Rossi CR, Alaibac M (2014). Melanoma: Epidemiology, risk factors, pathogenesis, diagnosis and clas-sification. In Vivo, 28: 1005–1011.
26. Arnold M, de Vries E, Whiteman DC, et al (2018). Global burden of cutaneous mel-anoma attributable to ultraviolet radiation in 2012. Int J Cancer, 143 (6): 1305-1314.
27. Olsen CM, Thompson JF, Pandeya N, Whiteman DC (2020). Evaluation of sex-specific incidence of melanoma. JAMA Dermatol, 156 (5): 553-560.
28. Robsahm TE, Bergva G, Hestvik UE, Møller B (2013). Sex differences in rising trends of cutaneous malignant melanoma in Norway, 1954-2008. Melanoma Res, 23 (1): 70-8.
29. Boniol M, Autier P, Boyle P, Gandini S (2012). Cutaneous melanoma attributable to sunbed use: Systematic review and me-ta‐analysis. BMJ, 345: e4757.
30. Sung H, Siegel RL, Rosenberg PS, Jemal A (2019). Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry. Lancet Public Health, 4 (3): e137-e147.
| Files | ||
| Issue | Vol 53 No 4 (2024) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v53i4.15559 | |
| Keywords | ||
| Malignant melanoma Mortality Age-standardized rates Population-based study | ||
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How to Cite
1.
Babic Z, Rancic N, Ilic S, Corovic S, Milicic V, Djordjevic G, Djordjevic O, Ilic S, Radevic S. Trends in Melanoma Mortality in Serbia: A 22-Year Population-Based Study. Iran J Public Health. 2024;53(4):828-836.
