Assessing the Impact of Multidisciplinary Team (MDT) Care on Patients with Liver Cancer/Cirrhosis: A Systematic Review and Meta-Analysis
-
Qin Peng
,
Lin Li
,
Jing Yang
,
Kaishan Tao
,
Xian Zhao
,
Lin Wang
,
Xiaosong Jiang
Abstract
Background: Liver cancer and cirrhosis are significant public health challenges with a high global burden. Multidisciplinary Team (MDT) care has gained recognition as a promising approach to improve the management and outcomes of patients with liver cancer and cirrhosis. We aimed to evaluate the effectiveness of MDT care in improving the clinical outcomes, including survival rates, quality of life, and disease progression, in patients with liver cancer and cirrhosis.
Methods: The search was performed using the keywords of liver cancer and MDT and their combinations in international databases with a time limit for publishing articles from 2010 and 2023. The data were evaluated using a technique of meta-analysis as well as a model called random effects. The I2 test was used to examine the degree of heterogeneity between the studies. STATA was used to analyze the data.
Results: The analysis of 13 different papers with a total sample size of 8641 individuals revealed that the average scores of the MDT and liver cancer were identical to (0.64), with a confidence interval ranging from (95% 48.5-81.7).
Conclusion: MDT is effective in the length of treatment and reduction of risk and mortality rates. The negative prognostic factors of not following the MDT decision were not observed.
1. Milana F, Famularo S, Luberto A, et al (2022). Multidisciplinary tumor board in the management of patients with colorectal liver metastases: a single-center review of 847 patients. Cancers (Basel), 14(16):3952.
2. Mammas CS, Mamma AS (2022). E-multidisciplinary oncology conference for liver cancer as a technology and method to optimize personalization and outcomes in the peripheries. Stud Health Technol Inform, 289:313-316.
3. Cao JJ, Kwon DH, Ghaziani TT, et al (2023). Accuracy of information provided by ChatGPT regarding liver cancer surveillance and diagnosis. AJR Am J Roentgenol, 221(4):556-9.
4. Bahardoust M, Dehkharghani MZ, Ebrahimi P, et al (2023). Effect of ABO blood group on postoperative overall survival and recurrence-free survival rate in patients with hepatocellular carcinoma after hepatectomy: a multi-center retrospective cohort study. BMC Surg, 23(1):324.
5. Mintz KJ, Leblanc RM (2021). The use of nanotechnology to combat liver cancer: Progress and perspectives. Biochim Biophys Acta Rev Cancer, 1876(2):188621.
6. Chan L-K, Tsui Y-M, Ho DW-H, et al (2022). Cellular heterogeneity and plasticity in liver cancer. Semin Cancer Biol, 82:134-149.
7. Huang L, Sun H, Sun L, et al (2023). Rapid, label-free histopathological diagnosis of liver cancer based on Raman spectroscopy and deep learning. Nat Commun, 14(1):48.
8. Bakhshi M, Karkehabadi A, Razavian SB, editors. Revolutionizing Medical Diagnosis with Novel Teaching-Learning-Based Optimization. 2024 International Conference on Emerging Smart Computing and Informatics (ESCI).
9. Juez I, Rubio C, Figueras J (2011). Multidisciplinary approach of colorectal liver metastases. Clin Transl Oncol, 13(10):721-7.
10. Gish RG, Lencioni R, Di Bisceglie AM, et al (2012). Role of the multidisciplinary team in the diagnosis and treatment of hepatocellular carcinoma. Expert Rev Gastroenterol Hepatol, 6(2):173-85.
11. Ye Y-J, Shen Z-L, Sun X-t, et al (2012). Impact of multidisciplinary team working on the management of colorectal cancer. Chin Med J, 125(2):172-7.
12. Miguet M, Adam J, Blanc J, et al (2019). Multidisciplinary meetings specific to hepatocellular carcinoma: How to proceed? J Visc Surg, 156(3):217-27.
13. Cutolo C, Dell’Aversana F, Fusco R, et al (2022). Combined hepatocellular-cholangiocarcinoma: What the multidisciplinary team should know. Diagnostics (Basel), 12(4):890.
14. Dyson J, Jaques B, Chattopadyhay D, et al (2014). Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team. J Hepatol, 60(1):110-7.
15. Adam R, De Gramont A, Figueras J, et al (2012). The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus. Oncologist, 17(10):1225-39.
16. Zhang Y-R, Wang H, Zhou N, et al (2021). A multidisciplinary team approach to the treatment of liver cirrhosis. J Inflamm Res, 14:5443-5450.
17. Naugler WE, Alsina AE, Frenette CT, et al (2015). Building the multidisciplinary team for management of patients with hepatocellular carcinoma. Clin Gastroenterol Hepatol, 13(5):827-35.
18. Adam R, de Gramont A, Figueras J, et al (2015). Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev, 41(9):729-41.
19. Engstrand J, Kartalis N, Strömberg C, et al (2017). The impact of a hepatobiliary multidisciplinary team assessment in patients with colorectal cancer liver metastases: a population‐based study. Oncologist, 22(9):1067-74.
20. Corallo S, Calegari MA, Zurlo IV, et al (2019). The impact of multidisciplinary team (MDT) management on outcome of hepatic resection in liver-limited colorectal metastases. American Society of Clinical Oncology.
21. Hellingman T, de Swart M, Joosten J, et al (2020). The value of a dedicated multidisciplinary expert panel to assess treatment strategy in patients suffering from colorectal cancer liver metastases. Surg Oncol, 35:412-7.
22. Lhewa D, Green EW, Naugler WE (2020). Multidisciplinary Team Management of Hepatocellular Carcinoma Is Standard of Care. Clin Liver Dis, 24(4):771-87.
23. Karkehabadi A, Homayoun H, Sasan A, editors. SMOOT: Saliency guided mask optimized online training. 2024 IEEE 17th Dallas Circuits and Systems Conference (DCAS); 2024: IEEE.
24. Byrd K, Alqahtani S, Yopp AC, et al(2021). Role of multidisciplinary care in the management of hepatocellular carcinoma. Semin Liver Dis, 41(1):1-8.
25. Bahardoust M, Mousavi S, Dehkharghani MZ, et al (2024). Association of Tramadol Versus Codeine Prescriptions with all-cause mortality and cardiovascular diseases among patients with osteoarthritis: a systematic review and meta-analysis of propensity score-matched population-based cohort studies. Adv Rheumatol, 64(1):80.
26. Nieuwenhuizen S, Puijk RS, van den Bemd B, et al (2020). Resectability and ablatability criteria for the treatment of liver only colorectal metastases: multidisciplinary consensus document from the COLLISION trial group. Cancers (Basel), 12(7):1779.
27. Li X, Chen Q, Bi X, et al (2020). Effects of multidisciplinary team on the outcomes of colorectal cancer patients with liver metastases. Ann Palliat Med, 9(5):2741748-2748.
28. Taberna M, Gil Moncayo F, Jané-Salas E, et al (2020). The multidisciplinary team (MDT) approach and quality of care. Front Oncol, 10:85.
29. Chow FC-L, Chok KS-H (2019). Colorectal liver metastases: An update on multidisciplinary approach. World J Hepatol, 11(2):150-172.
30. Adam R, Kitano Y (2019). Multidisciplinary approach of liver metastases from colorectal cancer. Ann Gastroenterol Surg, 3(1):50-6.
31. Duininck G, Lopez‐Aguiar AG, Lee RM, et al (2019). Optimizing cancer care for hepatocellular carcinoma at a safety‐net hospital: The value of a multidisciplinary disease management team. J Surg Oncol, 120(8):1365-70.
32. Flores A, Ho CK, Asrani SK (2018). Innovative care models in liver disease: the role of multidisciplinary teams. Curr Hepatol Rep, 17:193-9.
33. Sinn DH, Choi G-S, Park HC, et al (2019). Multidisciplinary approach is associated with improved survival of hepatocellular carcinoma patients. PLoS One, 14(1):e0210730.
34. Munro A, Brown M, Niblock P, et al (2015). Do Multidisciplinary Team (MDT) processes influence survival in patients with colorectal cancer? A population-based experience. BMC Cancer, 15: 686.
35. Charriere B, Muscari F, Maulat C, et al (2017). Outcomes of patients with hepatocellular carcinoma are determined in multidisciplinary team meetings. J Surg Oncol, 115(3):330-336.
36. Fiorentini G, Sarti D, Aliberti C, et al (2017). Multidisciplinary approach of colorectal cancer liver metastases. World J Clin Oncol, 8(3):190-202.
37. Foda ZH, Annapragada AV, Boyapati K, et al (2023). Detecting liver cancer using cell-free DNA fragmentomes. Cancer Discov, 13(3):616-31.
38. An L, Zeng H, Zheng R, et al (2019). [Liver cancer epidemiology in China, 2015]. Zhonghua Zhong Liu Za Zhi, 41(10):721-727.
39. Calderaro J, Ziol M, Paradis V, et al (2019). Molecular and histological correlations in liver cancer. J Hepatol, 71(3):616-30.
40. Saitta C, Pollicino T, Raimondo G (2019). Obesity and liver cancer. Ann Hepatol, 18(6):810-5.
41. Wang C, Vegna S, Jin H, et al (2019). Inducing and exploiting vulnerabilities for the treatment of liver cancer. Nature, 574(7777):268-72.
42. Basso M, Corallo S, Calegari MA, et al (2020). The impact of multidisciplinary team management on outcome of hepatic resection in liver-limited colorectal metastases. Scientific Reports, 10(1):10871.
43. De Greef K, Rolfo C, Russo A, et al (2016). Multisciplinary management of patients with liver metastasis from colorectal cancer. World J Gastroenterol, 22(32):7215-25.
44. Anwanwan D, Singh SK, Singh S, et al (2020). Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer, 1873(1):188314.
45. Pillay B, Wootten AC, Crowe H, et al(2016). The impact of multidisciplinary team meetings on patient assessment, management and outcomes in oncology settings: a systematic review of the literature. Cancer Treat Rev, 42:56-72.
2. Mammas CS, Mamma AS (2022). E-multidisciplinary oncology conference for liver cancer as a technology and method to optimize personalization and outcomes in the peripheries. Stud Health Technol Inform, 289:313-316.
3. Cao JJ, Kwon DH, Ghaziani TT, et al (2023). Accuracy of information provided by ChatGPT regarding liver cancer surveillance and diagnosis. AJR Am J Roentgenol, 221(4):556-9.
4. Bahardoust M, Dehkharghani MZ, Ebrahimi P, et al (2023). Effect of ABO blood group on postoperative overall survival and recurrence-free survival rate in patients with hepatocellular carcinoma after hepatectomy: a multi-center retrospective cohort study. BMC Surg, 23(1):324.
5. Mintz KJ, Leblanc RM (2021). The use of nanotechnology to combat liver cancer: Progress and perspectives. Biochim Biophys Acta Rev Cancer, 1876(2):188621.
6. Chan L-K, Tsui Y-M, Ho DW-H, et al (2022). Cellular heterogeneity and plasticity in liver cancer. Semin Cancer Biol, 82:134-149.
7. Huang L, Sun H, Sun L, et al (2023). Rapid, label-free histopathological diagnosis of liver cancer based on Raman spectroscopy and deep learning. Nat Commun, 14(1):48.
8. Bakhshi M, Karkehabadi A, Razavian SB, editors. Revolutionizing Medical Diagnosis with Novel Teaching-Learning-Based Optimization. 2024 International Conference on Emerging Smart Computing and Informatics (ESCI).
9. Juez I, Rubio C, Figueras J (2011). Multidisciplinary approach of colorectal liver metastases. Clin Transl Oncol, 13(10):721-7.
10. Gish RG, Lencioni R, Di Bisceglie AM, et al (2012). Role of the multidisciplinary team in the diagnosis and treatment of hepatocellular carcinoma. Expert Rev Gastroenterol Hepatol, 6(2):173-85.
11. Ye Y-J, Shen Z-L, Sun X-t, et al (2012). Impact of multidisciplinary team working on the management of colorectal cancer. Chin Med J, 125(2):172-7.
12. Miguet M, Adam J, Blanc J, et al (2019). Multidisciplinary meetings specific to hepatocellular carcinoma: How to proceed? J Visc Surg, 156(3):217-27.
13. Cutolo C, Dell’Aversana F, Fusco R, et al (2022). Combined hepatocellular-cholangiocarcinoma: What the multidisciplinary team should know. Diagnostics (Basel), 12(4):890.
14. Dyson J, Jaques B, Chattopadyhay D, et al (2014). Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team. J Hepatol, 60(1):110-7.
15. Adam R, De Gramont A, Figueras J, et al (2012). The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus. Oncologist, 17(10):1225-39.
16. Zhang Y-R, Wang H, Zhou N, et al (2021). A multidisciplinary team approach to the treatment of liver cirrhosis. J Inflamm Res, 14:5443-5450.
17. Naugler WE, Alsina AE, Frenette CT, et al (2015). Building the multidisciplinary team for management of patients with hepatocellular carcinoma. Clin Gastroenterol Hepatol, 13(5):827-35.
18. Adam R, de Gramont A, Figueras J, et al (2015). Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev, 41(9):729-41.
19. Engstrand J, Kartalis N, Strömberg C, et al (2017). The impact of a hepatobiliary multidisciplinary team assessment in patients with colorectal cancer liver metastases: a population‐based study. Oncologist, 22(9):1067-74.
20. Corallo S, Calegari MA, Zurlo IV, et al (2019). The impact of multidisciplinary team (MDT) management on outcome of hepatic resection in liver-limited colorectal metastases. American Society of Clinical Oncology.
21. Hellingman T, de Swart M, Joosten J, et al (2020). The value of a dedicated multidisciplinary expert panel to assess treatment strategy in patients suffering from colorectal cancer liver metastases. Surg Oncol, 35:412-7.
22. Lhewa D, Green EW, Naugler WE (2020). Multidisciplinary Team Management of Hepatocellular Carcinoma Is Standard of Care. Clin Liver Dis, 24(4):771-87.
23. Karkehabadi A, Homayoun H, Sasan A, editors. SMOOT: Saliency guided mask optimized online training. 2024 IEEE 17th Dallas Circuits and Systems Conference (DCAS); 2024: IEEE.
24. Byrd K, Alqahtani S, Yopp AC, et al(2021). Role of multidisciplinary care in the management of hepatocellular carcinoma. Semin Liver Dis, 41(1):1-8.
25. Bahardoust M, Mousavi S, Dehkharghani MZ, et al (2024). Association of Tramadol Versus Codeine Prescriptions with all-cause mortality and cardiovascular diseases among patients with osteoarthritis: a systematic review and meta-analysis of propensity score-matched population-based cohort studies. Adv Rheumatol, 64(1):80.
26. Nieuwenhuizen S, Puijk RS, van den Bemd B, et al (2020). Resectability and ablatability criteria for the treatment of liver only colorectal metastases: multidisciplinary consensus document from the COLLISION trial group. Cancers (Basel), 12(7):1779.
27. Li X, Chen Q, Bi X, et al (2020). Effects of multidisciplinary team on the outcomes of colorectal cancer patients with liver metastases. Ann Palliat Med, 9(5):2741748-2748.
28. Taberna M, Gil Moncayo F, Jané-Salas E, et al (2020). The multidisciplinary team (MDT) approach and quality of care. Front Oncol, 10:85.
29. Chow FC-L, Chok KS-H (2019). Colorectal liver metastases: An update on multidisciplinary approach. World J Hepatol, 11(2):150-172.
30. Adam R, Kitano Y (2019). Multidisciplinary approach of liver metastases from colorectal cancer. Ann Gastroenterol Surg, 3(1):50-6.
31. Duininck G, Lopez‐Aguiar AG, Lee RM, et al (2019). Optimizing cancer care for hepatocellular carcinoma at a safety‐net hospital: The value of a multidisciplinary disease management team. J Surg Oncol, 120(8):1365-70.
32. Flores A, Ho CK, Asrani SK (2018). Innovative care models in liver disease: the role of multidisciplinary teams. Curr Hepatol Rep, 17:193-9.
33. Sinn DH, Choi G-S, Park HC, et al (2019). Multidisciplinary approach is associated with improved survival of hepatocellular carcinoma patients. PLoS One, 14(1):e0210730.
34. Munro A, Brown M, Niblock P, et al (2015). Do Multidisciplinary Team (MDT) processes influence survival in patients with colorectal cancer? A population-based experience. BMC Cancer, 15: 686.
35. Charriere B, Muscari F, Maulat C, et al (2017). Outcomes of patients with hepatocellular carcinoma are determined in multidisciplinary team meetings. J Surg Oncol, 115(3):330-336.
36. Fiorentini G, Sarti D, Aliberti C, et al (2017). Multidisciplinary approach of colorectal cancer liver metastases. World J Clin Oncol, 8(3):190-202.
37. Foda ZH, Annapragada AV, Boyapati K, et al (2023). Detecting liver cancer using cell-free DNA fragmentomes. Cancer Discov, 13(3):616-31.
38. An L, Zeng H, Zheng R, et al (2019). [Liver cancer epidemiology in China, 2015]. Zhonghua Zhong Liu Za Zhi, 41(10):721-727.
39. Calderaro J, Ziol M, Paradis V, et al (2019). Molecular and histological correlations in liver cancer. J Hepatol, 71(3):616-30.
40. Saitta C, Pollicino T, Raimondo G (2019). Obesity and liver cancer. Ann Hepatol, 18(6):810-5.
41. Wang C, Vegna S, Jin H, et al (2019). Inducing and exploiting vulnerabilities for the treatment of liver cancer. Nature, 574(7777):268-72.
42. Basso M, Corallo S, Calegari MA, et al (2020). The impact of multidisciplinary team management on outcome of hepatic resection in liver-limited colorectal metastases. Scientific Reports, 10(1):10871.
43. De Greef K, Rolfo C, Russo A, et al (2016). Multisciplinary management of patients with liver metastasis from colorectal cancer. World J Gastroenterol, 22(32):7215-25.
44. Anwanwan D, Singh SK, Singh S, et al (2020). Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer, 1873(1):188314.
45. Pillay B, Wootten AC, Crowe H, et al(2016). The impact of multidisciplinary team meetings on patient assessment, management and outcomes in oncology settings: a systematic review of the literature. Cancer Treat Rev, 42:56-72.
| Files | ||
| Issue | Vol 54 No 2 (2025) | |
| Section | Review Article(s) | |
| Keywords | ||
| Liver cancer Multidisciplinary Multidisciplinary team Hepatocellular carcinoma Cirrhosis | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Peng Q, Li L, Yang J, Tao K, Zhao X, Wang L, Jiang X. Assessing the Impact of Multidisciplinary Team (MDT) Care on Patients with Liver Cancer/Cirrhosis: A Systematic Review and Meta-Analysis. Iran J Public Health. 2025;54(2):240-251.
