The Role of Osteocalcin in Patients with Osteoporosis: A Systematic Review
-
Seyed Mohammad Mohammadi
,
Nadia Saniee
,
Sajedeh Mousaviasl
,
Esmat Radmanesh
,
Amir Hossein Doustimotlagh
Abstract
Background: Osteoporosis is the most common systemic skeletal disease worldwide. We aimed to review the latest studies related to osteocalcin and osteoporosis to clarify this relationship more precisely.
Methods: A systematic literature search was performed to review studies on the effects of osteocalcin on osteoporosis, on studied published between January 2013 and January 2023. We systematically reviewed Web of Science, PubMed, ProQuest, Scopus, and Google Scholar.
Results: The search yielded 4903 records, including 1063 from PubMed, 2307 from Scopus, 1084 from Web of Science, 408 from ProQuest, and 41 from Google Scholar, and twelve articles were included for data extraction and quality assessment. A significant increase in the serum level of osteocalcin was observed in postmenopausal women with osteoporosis (P<0.05), and there was a negative correlation between bone mineral density and the serum level of osteocalcin.
Conclusion: Osteocalcin could be a promising marker for the diagnosis and screening of patients with osteoporosis.
1. Stumpf U, Kraus M, Ladurner R, Neuerburg C, Böcker W (2022). Osteoporosis: diagnostics and treatment. Z Gerontol Geriatr, 55:703-14.
2. Lorentzon M, Abrahamsen B (2022). Osteoporosis epidemiology using international cohorts. Curr Opin Rheumatol, 34:280-288.
3. Lorentzon M, Johansson H, Harvey NC, et al (2022). Osteoporosis and fractures in women: the burden of disease. Climacteric, 25:4-10.
4. Parveen B, Parveen A, Vohora D (2019). Biomarkers of Osteoporosis: An Update. Endocr Metab Immune Disord Drug Targets,19:895-912.
5. Wang JS, Mazur CM, Wein MN (2021). Sclerostin and Osteocalcin: Candidate Bone-Produced Hormones. Front Endocrinol (Lausanne), 12:584147.
6. Komori T (2020). Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle. Int J Mol Sci, 21.
7. Rammelt S, Neumann M, Hanisch U, et al (2005). Osteocalcin enhances bone remodeling around hydroxyapatite/collagen composites. J Biomed Mater Res A, 73:284-94.
8. Neve A, Corrado A, Cantatore FP (2013). Osteocalcin: skeletal and extra-skeletal effects. J Cell Physiol, 228:1149-53.
9. Singh S, Kumar D, Lal AK (2015). Serum Osteocalcin as a Diagnostic Biomarker for Primary Osteoporosis in Women. J Clin Diagn Res, 9(8): RC04–7.
10. Hamdi RA (2013). Evaluation of Serum Osteocalcin Level in Iraqi Postmenopausal Women with Primary Osteoporosis. J Fac Med Baghdad, 55:166-9.
11. Bhadricha H, Khatkhatay MI, Desai M (2019). Development of an in house ELISA for human intact osteocalcin and its utility in diagnosis and management of osteoporosis. Clin Chim Acta, 489:117-23.
12. Page MJ, McKenzie JE, Bossuyt PM, et al (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372: n71.
13. Health NIf (2021). Study quality assessment tool for observational cohort and cross-sectional studies. https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools
14. Roomi AB, Mahdi Salih AH, Noori SD, Nori W, Tariq S (2022). Evaluation of Bone Mineral Density, Serum Osteocalcin, and Osteopontin Levels in Postmenopausal Women with Type 2 Diabetes Mellitus, with/without Osteoporosis. J Osteoporos, 2022:1437061.
15. Mulbah RG, Sitati FC, Gakuya EM, Mutiso VM (2018). Elevated serum osteocalcin levels as a surrogate marker of primary osteoporosis in postmenopausal women. East Afr Med J, 95:1865-9.
16. Hutomo DI, Masulili SLC, Tadjoedin FM, Kusdhany LS (2017). Correlation of serum osteocalcin level and periodontal attachment loss with osteoporosis risk status in postmenopausal women. Int J Appl Pharm, 9(2):92-4.
17. Xu Y, Shen L, Liu LY, Zhang ZL, Hu WW (2022). Undercarboxylated Osteocalcin and Its Associations With Bone Mineral Density, Bone Turnover Markers, and Prevalence of Osteopenia and Osteoporosis in Chinese Population: A Cross-Sectional Study. Front Endocrinol (Lausanne),13:843912.
18. Kamel MA, Helmy MH, Abou Rayah AN, Mohand N, Hania HM (2013). Insulin-like growth factor-1 and osteocalcin are correlated with markers of osteoporosis in postmenopausal women with type-2 diabetes. Open J Endocr Metab Dis, 3(5):245-251.
19. Naeem ST, Hussain R, Raheem A, Siddiqui I, Ghani F, Khan AH (2016). Bone Turnover Markers for Osteoporosis Status Assessment at Baseline in Postmenopausal Pakistani Females. J Coll Physicians Surg Pak, 26(5):408-12.
20. Alam MF, Rana MA, Alam MS (2019). Osteocalcin, a promising marker of osteoporosis: evaluation in post-menopausal females with osteoporosis. Int J Adv Pharm Med, 6 (6): 1746-1749
21. Chidre YV, Shaikh AB (2017). Association of vitamin D and osteocalcin levels in post-menopausal women with osteoporosis. Int J Reprod Contracept Obstet Gynecol, 6(4):1244-8.
22. Rai M, Rai T, D'sa J, Rai S (2018). Bone Turnover Markers: An Emerging Tool to Detect Primary Osteoporosis. Journal of Clinical and Diagnostic Research, 12(12): BC04-BC07.
23. Jain BK, Patne SS, Bindra M (2013). Serum osteocalcin levels in postmenopausal osteoporosis women-a cross sectional study. International Journal of Pharma and Bio Sciences, 4:B299-B302.
24. Fasihi L, Tartibian B, Eslami R (2021). Evaluation of osteoporosis using serum osteocalcin and alkaline phosphatase in active middle-aged women. Yafteh, 23:112-25.
25. Chi PJ, Hung SY, Hsiao FT, Liou HH, Tsai JP (2022). Serum osteocalcin concentration as an independent biomarker of osteoporosis in patients with chronic kidney disease. Clin Nephrol, 98(1):1-9.
26. Ji Y, Gao H, Wang Y, Jiang X (2022). Diagnostic Significance of β;-Collagen Degradation Products and Osteocalcin in Chronic Obstructive Pulmonary Disease Complicated with Osteoporosis. Current Topics in Nutraceutical Research, 20(2):288-292.
27. Vadivalagan C, Krishnan A, Chen SJ, et al (2022). The Warburg effect in osteoporosis: Cellular signaling and epigenetic regulation of energy metabolic events to targeting the osteocalcin for phenotypic alteration. Cell Signal, 100:110488
28. Ishida M, Amano S (2004). Osteocalcin fragment in bone matrix enhances osteoclast maturation at a late stage of osteoclast differentiation. J Bone Miner Metab, 22:415-29.
29. Tian L, Yang R, Wei L, et al (2017). Prevalence of osteoporosis and related lifestyle and metabolic factors of postmenopausal women and elderly men: A cross-sectional study in Gansu province, Northwestern of China. Medicine (Baltimore), 96(43):e8294.
30. Wada S, Fukawa T, Kamiya S (2007). Osteocalcin and bone. Clin Calcium, 17(11):1673-7.
31. Chen HY, Tsai HD, Chen WC, Wu JY, Tsai FJ, Tsai CH (2001). Relation of polymorphism in the promotor region for the human osteocalcin gene to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan. J Clin Lab Anal, 15(5):251-5.
32. Lateef M, Baig M, Azhar A (2010). Estimation of serum osteocalcin and telopeptide-C in postmenopausal osteoporotic females. Osteoporos Int, 21(5):751-5.
33. Lumachi F, Ermani M, Camozzi V, Tombolan V, Luisetto G (2009). Changes of bone formation markers osteocalcin and bone-specific alkaline phosphatase in postmenopausal women with osteoporosis. Ann N Y Acad Sci,1173 Suppl 1:E60-3.
2. Lorentzon M, Abrahamsen B (2022). Osteoporosis epidemiology using international cohorts. Curr Opin Rheumatol, 34:280-288.
3. Lorentzon M, Johansson H, Harvey NC, et al (2022). Osteoporosis and fractures in women: the burden of disease. Climacteric, 25:4-10.
4. Parveen B, Parveen A, Vohora D (2019). Biomarkers of Osteoporosis: An Update. Endocr Metab Immune Disord Drug Targets,19:895-912.
5. Wang JS, Mazur CM, Wein MN (2021). Sclerostin and Osteocalcin: Candidate Bone-Produced Hormones. Front Endocrinol (Lausanne), 12:584147.
6. Komori T (2020). Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle. Int J Mol Sci, 21.
7. Rammelt S, Neumann M, Hanisch U, et al (2005). Osteocalcin enhances bone remodeling around hydroxyapatite/collagen composites. J Biomed Mater Res A, 73:284-94.
8. Neve A, Corrado A, Cantatore FP (2013). Osteocalcin: skeletal and extra-skeletal effects. J Cell Physiol, 228:1149-53.
9. Singh S, Kumar D, Lal AK (2015). Serum Osteocalcin as a Diagnostic Biomarker for Primary Osteoporosis in Women. J Clin Diagn Res, 9(8): RC04–7.
10. Hamdi RA (2013). Evaluation of Serum Osteocalcin Level in Iraqi Postmenopausal Women with Primary Osteoporosis. J Fac Med Baghdad, 55:166-9.
11. Bhadricha H, Khatkhatay MI, Desai M (2019). Development of an in house ELISA for human intact osteocalcin and its utility in diagnosis and management of osteoporosis. Clin Chim Acta, 489:117-23.
12. Page MJ, McKenzie JE, Bossuyt PM, et al (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372: n71.
13. Health NIf (2021). Study quality assessment tool for observational cohort and cross-sectional studies. https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools
14. Roomi AB, Mahdi Salih AH, Noori SD, Nori W, Tariq S (2022). Evaluation of Bone Mineral Density, Serum Osteocalcin, and Osteopontin Levels in Postmenopausal Women with Type 2 Diabetes Mellitus, with/without Osteoporosis. J Osteoporos, 2022:1437061.
15. Mulbah RG, Sitati FC, Gakuya EM, Mutiso VM (2018). Elevated serum osteocalcin levels as a surrogate marker of primary osteoporosis in postmenopausal women. East Afr Med J, 95:1865-9.
16. Hutomo DI, Masulili SLC, Tadjoedin FM, Kusdhany LS (2017). Correlation of serum osteocalcin level and periodontal attachment loss with osteoporosis risk status in postmenopausal women. Int J Appl Pharm, 9(2):92-4.
17. Xu Y, Shen L, Liu LY, Zhang ZL, Hu WW (2022). Undercarboxylated Osteocalcin and Its Associations With Bone Mineral Density, Bone Turnover Markers, and Prevalence of Osteopenia and Osteoporosis in Chinese Population: A Cross-Sectional Study. Front Endocrinol (Lausanne),13:843912.
18. Kamel MA, Helmy MH, Abou Rayah AN, Mohand N, Hania HM (2013). Insulin-like growth factor-1 and osteocalcin are correlated with markers of osteoporosis in postmenopausal women with type-2 diabetes. Open J Endocr Metab Dis, 3(5):245-251.
19. Naeem ST, Hussain R, Raheem A, Siddiqui I, Ghani F, Khan AH (2016). Bone Turnover Markers for Osteoporosis Status Assessment at Baseline in Postmenopausal Pakistani Females. J Coll Physicians Surg Pak, 26(5):408-12.
20. Alam MF, Rana MA, Alam MS (2019). Osteocalcin, a promising marker of osteoporosis: evaluation in post-menopausal females with osteoporosis. Int J Adv Pharm Med, 6 (6): 1746-1749
21. Chidre YV, Shaikh AB (2017). Association of vitamin D and osteocalcin levels in post-menopausal women with osteoporosis. Int J Reprod Contracept Obstet Gynecol, 6(4):1244-8.
22. Rai M, Rai T, D'sa J, Rai S (2018). Bone Turnover Markers: An Emerging Tool to Detect Primary Osteoporosis. Journal of Clinical and Diagnostic Research, 12(12): BC04-BC07.
23. Jain BK, Patne SS, Bindra M (2013). Serum osteocalcin levels in postmenopausal osteoporosis women-a cross sectional study. International Journal of Pharma and Bio Sciences, 4:B299-B302.
24. Fasihi L, Tartibian B, Eslami R (2021). Evaluation of osteoporosis using serum osteocalcin and alkaline phosphatase in active middle-aged women. Yafteh, 23:112-25.
25. Chi PJ, Hung SY, Hsiao FT, Liou HH, Tsai JP (2022). Serum osteocalcin concentration as an independent biomarker of osteoporosis in patients with chronic kidney disease. Clin Nephrol, 98(1):1-9.
26. Ji Y, Gao H, Wang Y, Jiang X (2022). Diagnostic Significance of β;-Collagen Degradation Products and Osteocalcin in Chronic Obstructive Pulmonary Disease Complicated with Osteoporosis. Current Topics in Nutraceutical Research, 20(2):288-292.
27. Vadivalagan C, Krishnan A, Chen SJ, et al (2022). The Warburg effect in osteoporosis: Cellular signaling and epigenetic regulation of energy metabolic events to targeting the osteocalcin for phenotypic alteration. Cell Signal, 100:110488
28. Ishida M, Amano S (2004). Osteocalcin fragment in bone matrix enhances osteoclast maturation at a late stage of osteoclast differentiation. J Bone Miner Metab, 22:415-29.
29. Tian L, Yang R, Wei L, et al (2017). Prevalence of osteoporosis and related lifestyle and metabolic factors of postmenopausal women and elderly men: A cross-sectional study in Gansu province, Northwestern of China. Medicine (Baltimore), 96(43):e8294.
30. Wada S, Fukawa T, Kamiya S (2007). Osteocalcin and bone. Clin Calcium, 17(11):1673-7.
31. Chen HY, Tsai HD, Chen WC, Wu JY, Tsai FJ, Tsai CH (2001). Relation of polymorphism in the promotor region for the human osteocalcin gene to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan. J Clin Lab Anal, 15(5):251-5.
32. Lateef M, Baig M, Azhar A (2010). Estimation of serum osteocalcin and telopeptide-C in postmenopausal osteoporotic females. Osteoporos Int, 21(5):751-5.
33. Lumachi F, Ermani M, Camozzi V, Tombolan V, Luisetto G (2009). Changes of bone formation markers osteocalcin and bone-specific alkaline phosphatase in postmenopausal women with osteoporosis. Ann N Y Acad Sci,1173 Suppl 1:E60-3.
| Files | ||
| Issue | Vol 53 No 11 (2024) | |
| Section | Review Article(s) | |
| Keywords | ||
| Bone mineral density Postmenopausal women Osteocalcin Osteoporosis | ||
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How to Cite
1.
Mohammadi SM, Saniee N, Mousaviasl S, Radmanesh E, Doustimotlagh AH. The Role of Osteocalcin in Patients with Osteoporosis: A Systematic Review. Iran J Public Health. 2024;53(11):2432-2439.
