Association of ADIPOQ Single Nucleotide Polymorphisms (SNPs) with Obesity Risk in Different Populations: A Systematic Review and Analysis
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Abstract
Background: Thirty-two single nucleotide polymorphisms (SNPs) are commonly found in ADIPOQ. APN levels are decreased in obesity, and SNPs of the ADIPOQ gene affecting APN have varying associations with the development of obesity in different populations. This systematic review and meta-analysis aimed to investigate the association of SNPs in ADIPOQ with the risk of obesity development in various populations.
Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist date up to Feb 2023. We used the Newcastle–Ottawa scale to find out if a study fit the main criteria for submission and to assess the data quality of the articles included in the systematic review and meta-analysis. Odds ratios (OR) and 95% confidence intervals (CI) were calculated via Review Manager (RM) V.5.4 to estimate the connection between ADIPOQ polymorphic qualities of a gene and the risk of developing obesity.
Results: The present study analysed the association between ADIPOQ polymorphisms (rs1501299, rs2241766, rs266729, rs822393, and rs822396) and obesity risk and suggested that APN is partially responsible for the emergence of obesity and increases its risk.
Conclusion: It is important to take into account several limitations of this meta-analysis when evaluating the findings. First off, even though we looked through numerous databases for all relevant papers, there is a chance we overlooked some. Our capacity to arrive at more firm conclusions was further hampered by the small number of papers that made up our meta-analysis. The most current data, however, are presented in this study since it used newly published data to perform a meta-analysis and evaluate the relationship between ADIPOQ polymorphisms and obesity.
2. García Pacheco AV, Arévalo Peláez CE, Ortiz Benavides RE (2022). The pharmacological treatment of obesity: A historical perspective. Gac Méd Caracas, 130(3S). Recuperado a partir de http://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/24172
3. Selvakumaran S, Lin CY, Hadgraft N, Chandrabose M, Owen N, Sugiyama T (2023). Area-level socioeconomic ine-qualities in overweight and obesity: Sys-tematic review on moderation by built-environment attributes. Health Place, 83: 103101.
4. Jadhav AD, Chobe SV (2022). Risk assess-ment of cardiovascular diseases using kNN and decision tree classifier. Revue d'Intelligence Artificielle, 36(1): 155-161.
5. Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects), Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm EB, Danaei G (2014). Metabol-ic mediators of the effects of body-mass index, overweight, and obesity on coro-nary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants. Lancet, 383 (9921): 970-83.
6. Alnuaimi J, Al-Za’abi A, Yousef IA, Belghali M, Liftawi SM, Shraim ZF, Tayih EAM (2023). Effect of a health-based physical activity intervention on university stu-dents’ physically active behaviors and perception. Int J Sustain Dev Plan, 18(5): 1451-1456.
7. Ergören MC, Söyler G, Sah H, et al (2019). Investigation of potential genomic bi-omarkers for obesity and personalized medicine. Int J Biol Macromol, 122: 493-8.
8. Wu J, Liu Z, Meng K, et al (2014). Associa-tion of adiponectin gene (ADIPOQ) rs2241766 polymorphism with obesity in adults: a meta-analysis. PLoS One, 9 (4): e95270.
9. Palit SP, Patel R, Jadeja SD, et al (2020). A genetic analysis identifies a haplotype at adiponectin locus: association with obe-sity and type 2 diabetes. Sci Rep, 10 (1): 2904.
10. Alharbi MS, Khabour OF, Alomari MA (2023). The association between adi-ponectin plasma level and rs1501299 ADIPOQ polymorphism with atrial fi-brillation. J King Saud Univ Sci, 35(4): 102655.
11. Wang ZV, Scherer PE (2016). Adiponectin, the past two decades. J Mol Cell Biol, 8 (2):93-100.
12. Al-Harithy RN, Al-Zahrani MH (2012). The adiponectin gene, ADIPOQ, and genet-ic susceptibility to colon cancer. Oncol Lett, 3 (1): 176-80.
13. Moher D, Liberati A, Tetzlaff J, et al (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med, 6 (7): e1000097.
14. Hasni D, Ilmiawati C, Firdawati F, Lipoeto NI (2023). Possible correlations between SH2B3 rs2078863 gene polymorphism, lifestyle, food habits, and nutritional in-take of Minangkabau females with hy-pertension. Adv Life Sci, 10(4):609-618.
15. Stang A (2010). Critical evaluation of the Newcastle-Ottawa scale for the assess-ment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 25 (9): 603-5.
16. Beebe-Dimmer JL, Zuhlke KA, Ray AM, et al (2010). Genetic variation in adiponec-tin (ADIPOQ) and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans. Prostate Cancer Pros-tatic Dis, 13 (4): 362-8.
17. de Luis DA, Primo D, Izaola O, et al (2019). Role of the variant in adiponectin gene rs266729 on weight loss and cardiovas-cular risk factors after a hypocaloric di-et with the Mediterranean pattern. Nutri-tion, 60: 1–5.
18. Boumaiza I, Omezzine A, Rejeb J, et al (2011). Association between eight adi-ponectin polymorphisms, obesity, and metabolic syndrome parameters in Tu-nisian volunteers. Metab Syndr Relat Dis-ord, 9 (6): 419-26.
19. Elghazy AM, Elsaeid AM, Refaat M, et al (2022). Biochemical studies of adiponec-tin gene polymorphism in patients with obesity in Egyptians. Arch Physiol Biochem, 128 (1): 43-50.
20. Hsiao TJ, Lin E (2016). A validation study of adiponectin rs266729 gene variant with type 2 diabetes, obesity, and meta-bolic phenotypes in a Taiwanese popu-lation. Biochem Genet, 54 (6): 830-41.
21. Kaur H, Badaruddoza B, Bains V, et al (2018). Genetic association of ADIPOQ gene variants (-3971A>G and +276G>T) with obesity and metabolic syndrome in North Indian Punjabi population. PLoS One, 13 (9): e0204502.
22. Ramya K, Ayyappa KA, Ghosh S, et al (2013). Genetic association of ADIPOQ gene variants with type 2 diabetes, obesi-ty and serum adiponectin levels in south Indian population. Gene, 532 (2): 253-62.
23. Peralta Romero JJ, Karam Araujo R, Bur-guete García AI, et al (2015). ADIPOQ and ADIPOR2 gene polymorphisms: as-sociation with overweight/obesity in Mexican children. Bol Med Hosp Infant Mex, 72 (1): 26-33.
24. Vankova D, Radanova M, Kiselova-Kaneva Y, et al (2015). The FTO rs9939609, AD-IPOQ rs1501299, rs822391, and ADI-POR2 rs16928662 polymorphisms rela-tionship to obesity and metabolic syn-drome in Bulgarian sample. Biotechnol Bi-otechnol Equip, 26: 65.
25. Zaki ME, El-Salam M, Hassan NA, et al (2014). Association of adiponectin gene polymorphisms 276 G>T with obesity and biochemical parameters in adoles-cents. Int J Pharm Pharm Sci, 6 (5): 226-9.
26. Zayani N, Omezzine A, Boumaiza I, et al (2017). Association of ADIPOQ, leptin, LEPR, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul heart study. J Clin Lab Anal, 31 (6): e22148.
27. Alimi M, Goodarzi MT, Nekoei M (2021). Association of ADIPOQ rs266729 and rs1501299 gene polymorphisms and cir-culating adiponectin level with the risk of type 2 diabetes in a population of Iran: a case-control study. J Diabetes Me-tab Disord, 20 : 87-93.
28. Ogundele OE, Adekoya KO, Osinubi AAA, et al (2018). Association of adiponectin gene (ADIPOQ) polymorphisms with measures of obesity in Nigerian young adults. Egypt J Medical Hum Genet, 19 (2): 123-7.
29. López DJE, Urbaneja H (2020). Tolerancia a la glucosa e insulinemia en hermanos asintomáticos de pacientes diabéticos tipo 2. Gaceta Médica De Caracas, 114(4): 305–317.
30. Abuhendi N, Qush A, Naji F, Abunada H, Al Buainain R, Shi Z, Zayed H (2019). Genetic polymorphisms associated with type 2 diabetes in the Arab world: A sys-tematic review and meta-analysis. Diabe-tes Res Clin Pract, 151: 198–208.
| Files | ||
| Issue | Vol 53 No 10 (2024) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v53i10.16696 | |
| Keywords | ||
| Obesity risk Single nucleotide polymorphisms ADIPOQ gene | ||
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