Trends in Aflatoxin M1 Global Research: A Bibliometric Analysis Study
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Abstract
Background: Fungal metabolites known as aflatoxin M1 (AFM1) are linked to contaminated milk and milk products. Consuming food contaminated with AFM1 poses major health risks and may even be fatal.
Methods: The retrieved publications were categorized in this bibliometric study using the Web of Science (WoS) database Jan 1, 1970 to Nov 30, 2022 based on a variety of factors, including the time of publication of articles, citation totals, languages, research areas, countries, affiliations, funding agencies, journals, and keywords analysis to identify any hot and developing subjects. Additionally, VOSviewer software version 1.6.18 provided the bibliometric analysis of the global collaboration network and hot research themes.
Results: Overall, 679 published documents were detected. Food Control was the top-line journal in publications on AFM1 research with 540 published articles, while the USA was the best productive country in AFM1 publications as well as the major country with the maximum co-authorship collaboration. This study ensures quantitative and qualitative analyses of the top 25 journals, most cited published articles, most relevant authors and title word occurrences in published documents on AFM1 publications. Over the past two decades, there has been an enormous rise for research conducted on global AFM1.
Conclusion: The assessment of the historical state and development trend in AFM1 scientific research can serve as a roadmap for future research and eventually, serve as a foundation for bettering management practices for territorial decisions, healthcare, and dairy industries.
1. Marchese S, Polo A, Ariano A, et al (2018). Aflatoxin B1 and M1: Biological proper-ties and their ınvolvement in cancer de-velopment. Toxins (Basel), 10(6):214.
2. Daou R, Afif C, Joubrane K, et al (2020). Occurrence of aflatoxin M1 in raw, pas-teurized, UHT cows’ milk, and dairy products in Lebanon. Food Control, 111:107055.
3. Giovati L, Magliani W, Ciociola T, et al (2015). AFM₁ in Milk: Physical, biologi-cal, and prophylactic methods to miti-gate contamination. Toxins (Basel), 7(10):4330-49.
4. International Agency for Research on Cancer Monograph 100F aflatox-ins.(2010), pp. 225-248.
5. Assaf JC, El Khoury A, Atoui A, et al (2018). A novel technique for aflatoxin M1 de-toxification using chitin or treated shrimp shells: In vitro effect of physical and kinetic parameters on the binding stability. Appl Microbiol Biotechnol, 102(15):6687-6697.
6. Zinedine A, Ben Salah-Abbes J, Abbès S, Tantaoui-Elaraki A, et al (2021). Aflatox-in M1 in Africa: Exposure assessment, regulations, and prevention strategies - a review. Rev Environ Contam Toxicol, 258:73-108.
7. Zhou W, Chen J, Huang Y, (2019). Co-Citation analysis and burst detection on financial bubbles with scientometrics approach. Economic Research-Ekonomska Istraživanja, 32(1): 2310-2328.
8. Donthu N, Kumar S, Mukherjee D, et al (2021). How to conduct a bibliometric analysis: An overview and guidelines. J Bus Res, 133:285-296.
9. Hou Y, Wang Q, et al (2021). A bibliometric study about energy, environment, and climate change. Environ Sci Pollut Res Int, 28(26):34187-34199.
10. Ekici A, Alkan S, Aydemir S, et al (2022). Trends in Naegleria fowleri global re-search: A bibliometric analysis study. Ac-ta Trop, 234:106603.
11. Alkan-Çeviker S, Öntürk H, Alıravcı ID, Sıddıkoğlu D (2021). Trends of COVID 19 vaccines: International collaboration and visualized analysis. Infect Dis Clin Mi-crobiol, 2021; 3: 129-136.
12. Cinpolat HY (2022). A bibliometric analysis of global research trends on biomarker studies in Alzheimer’s disease. D J Med Sci, 8(1):5-10.
13. Gökçe ON, Alkan S (2022). Contribution of Turkey in Liver Transplant Research: A Scopus Database Search. Exp Clin Trans-plant, 21(5):415-421.
14. Zyoud SH (2019) Global scientific trends on aflatoxin research during 1998-2017: bibliometric and visualized study. J Oc-cup Med Toxicol, 14:27.
15. Kim Y, Seo J, Croft WB (2011). Automatic boolean query suggestion for profes-sional search. In Proceedings of the 34th in-ternational ACM SIGIR conference on Re-search and development in Information Retriev-al, 825-834.
16. Aria M, Cuccurullo C (2017). Bibliometrix: An R-tool for comprehensive science mapping analysis. Journal of Informetrics, 11:959–975.
17. Wild CP (2007). Aflatoxin exposure in de-veloping countries: the critical interface of agriculture and health. Food Nutr Bull, 28(2 Suppl):S372–80.
18. Yalcin SS, Güneş B, Yalcin S (2022). Influ-ence of season and lactational stage on aflatoxin M1 and ochratoxin A in hu-man milk in a cohort study from south-eastern region of Turkey. Int J Environ Health Res, 32(6):1192-1203.
19. Madali B, Gulec A, Ayaz A (2018). A survey of aflatoxin M1 in different milk types in Turkey: risk assessment of children’s exposure. Progress in Nutrition, 20(4):659-664.
20. Gurbuz S, Altun SK (2019). Aflatoxın M1 in Traditional Homemade Yoghurts Mar-keted in Southeastern Turkey. FEB-Fresenıus Envıronmental Bulletın, 2802.
21. Pour SH, Mahmoudi S, Masoumi S, et al (2020). Aflatoxin M1 contamination level in Iranian milk and dairy products: A systematic review and meta-analysis. World Mycotoxin Journal, 13(1):67-82.
22. Campbell TC, Caedo JP Jr, Bulatao-Jayme J, et al (1970). Aflatoxin M1 in human urine. Nature, 227(5256):403-4.
23. Sinnhube Ro, Lee DJ, Wales, et al (1970). Aflatoxin-M1, a potent liver carcinogen for rainbow trout. In Federation Proceedings, 29(2):A568.
24. Sun Z, Lu P, Gail MH, et al (1999). In-creased risk of hepatocellular carcino-ma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology, 30(2): 379-383.
25. Diaz DE, Hagler WM, Blackwelder JT, et al (2004). Aflatoxin binders II: Reduction of aflatoxin M1 in milk by sequestering agents of cows consuming aflatoxin in feed. Mycopathologia, 157:233-241.
26. Micheli L, Grecco R, Badea M, Moscone D, et al (2005). An electrochemical im-munosensor for aflatoxin M1 determi-nation in milk using screen-printed elec-trodes. Biosens Bioelectron, 21(4):588-596.
27. Klingelhöfer D, Zhu Y, Braun M, et al (2018). Aflatoxin – publication analysis of a global health threat. Food Control, 89:280–90.
28. Zyoud SH, Al-Jabi SW, Sweileh WM, et al (2015). Bibliometric profile of the global scientific research on methanol poison-ing (1902-2012). J Occup Med Toxicol, 10:17.
29. Zyoud SH, Al-Jabi SW, Sweileh WM, et al (2015). Global research productivity of N-acetylcysteine use in paracetamol overdose: a bibliometric analysis (1976-2012). Hum Exp Toxicol, 34(10):1006–16.
30. Zyoud SH, Waring WS, Al-Jabi SW, Sweileh WM, (2017). Global research production in glyphosate intoxication from 1978 to 2015: a bibliometric analysis. Hum Exp Toxicol, 36(10):997–1006.
31. Briganti M, Delnevo CD, Brown L, et al (2019). Bibliometric Analysis of Elec-tronic Cigarette Publications: 2003(−)2018. Int J Environ Res Public Health, 16(3):320.
32. Zyoud SH (2016). Global research trends of Middle East respiratory syndrome coronavirus: a bibliometric analysis. BMC Infect Dis, 16:255.
33. Hou J, Wang G, Wang F, et al (2017). Guideline of prevention and treatment for chronic hepatitis B (2015 update). J Clin Transl Hepatol, 5(4):297–318.
34. Oil Crops Research Institute of Chinese Academy of Agricultural Sciences (2014). NSFC-CGIAR cooperative project on groundnut aflatoxin resistance support-ed. [Cited 2022 December 01]; Available from: http://ocri.caas.cn/en/news/intlcooperation/90801.htm
35. Selim MI, Popendorf W, Ibrahim MS, et al (1996). Aflatoxin B1 in common Egyp-tian foods. J AOAC Int, 79(5):1124–9.
36. Hamid AS, Tesfamariam IG, Zhang Y, Zhang ZG (2013). Aflatoxin B1-induced hepatocellular carcinoma in developing countries: geographical distribution, mechanism of action and prevention. Oncol Lett, 5(4):1087–92.
37. Fakhri Y, Ghorbani R, Taghavi M, et al (2019). Concentration and prevalence of aflatoxin M1 in human breast milk in Iran: Systematic review, meta-analysis, and carcinogenic risk assessment: A re-view. J Food Prot, 82(5): 785-795.
38. Sharma H, Jadhav VJ, Garg SR (2020). Afla-toxin M1 in milk in Hisar city, Haryana, India and risk assessment. Food Addit Contam Part B Surveill, 13(1): 59-63.
39. Pandey AK, Shakya S, Patyal A, et al (2021). Detection of aflatoxin M1 in bovine milk from different agro-climatic zones of Chhattisgarh, India, using HPLC-FLD and assessment of human health risks. Mycotoxin Res, 37(3):265-273.
40. Gummadidala PM, Omebeyinje MH, Burch, JA, et al (2019). Complementary feeding may pose a risk of simultaneous exposures to aflatoxin M1 and deoxyni-valenol in Indian infants and toddlers: Lessons from a mini-survey of food samples obtained from Kolkata, India. Food Chem Toxicol, 123:9-15.
41. Magnussen A, Parsi MA (2013). Aflatoxins, hepatocellular carcinoma and public health. World J Gastroenterol, 19(10):1508–12.
42. Kumar P, Mahato DK, Kamle M, Mohanta TK, Kang SG (2017). Aflatoxins: a global concern for food safety, Human Health and Their Management. Front Microbiol, 7:2170.
43. Turna NS, Wu F (2021). Aflatoxin M1 in milk: A global occurrence, intake, & ex-posure assessment. Trends in Food Science & Technology, 110:183-192.
2. Daou R, Afif C, Joubrane K, et al (2020). Occurrence of aflatoxin M1 in raw, pas-teurized, UHT cows’ milk, and dairy products in Lebanon. Food Control, 111:107055.
3. Giovati L, Magliani W, Ciociola T, et al (2015). AFM₁ in Milk: Physical, biologi-cal, and prophylactic methods to miti-gate contamination. Toxins (Basel), 7(10):4330-49.
4. International Agency for Research on Cancer Monograph 100F aflatox-ins.(2010), pp. 225-248.
5. Assaf JC, El Khoury A, Atoui A, et al (2018). A novel technique for aflatoxin M1 de-toxification using chitin or treated shrimp shells: In vitro effect of physical and kinetic parameters on the binding stability. Appl Microbiol Biotechnol, 102(15):6687-6697.
6. Zinedine A, Ben Salah-Abbes J, Abbès S, Tantaoui-Elaraki A, et al (2021). Aflatox-in M1 in Africa: Exposure assessment, regulations, and prevention strategies - a review. Rev Environ Contam Toxicol, 258:73-108.
7. Zhou W, Chen J, Huang Y, (2019). Co-Citation analysis and burst detection on financial bubbles with scientometrics approach. Economic Research-Ekonomska Istraživanja, 32(1): 2310-2328.
8. Donthu N, Kumar S, Mukherjee D, et al (2021). How to conduct a bibliometric analysis: An overview and guidelines. J Bus Res, 133:285-296.
9. Hou Y, Wang Q, et al (2021). A bibliometric study about energy, environment, and climate change. Environ Sci Pollut Res Int, 28(26):34187-34199.
10. Ekici A, Alkan S, Aydemir S, et al (2022). Trends in Naegleria fowleri global re-search: A bibliometric analysis study. Ac-ta Trop, 234:106603.
11. Alkan-Çeviker S, Öntürk H, Alıravcı ID, Sıddıkoğlu D (2021). Trends of COVID 19 vaccines: International collaboration and visualized analysis. Infect Dis Clin Mi-crobiol, 2021; 3: 129-136.
12. Cinpolat HY (2022). A bibliometric analysis of global research trends on biomarker studies in Alzheimer’s disease. D J Med Sci, 8(1):5-10.
13. Gökçe ON, Alkan S (2022). Contribution of Turkey in Liver Transplant Research: A Scopus Database Search. Exp Clin Trans-plant, 21(5):415-421.
14. Zyoud SH (2019) Global scientific trends on aflatoxin research during 1998-2017: bibliometric and visualized study. J Oc-cup Med Toxicol, 14:27.
15. Kim Y, Seo J, Croft WB (2011). Automatic boolean query suggestion for profes-sional search. In Proceedings of the 34th in-ternational ACM SIGIR conference on Re-search and development in Information Retriev-al, 825-834.
16. Aria M, Cuccurullo C (2017). Bibliometrix: An R-tool for comprehensive science mapping analysis. Journal of Informetrics, 11:959–975.
17. Wild CP (2007). Aflatoxin exposure in de-veloping countries: the critical interface of agriculture and health. Food Nutr Bull, 28(2 Suppl):S372–80.
18. Yalcin SS, Güneş B, Yalcin S (2022). Influ-ence of season and lactational stage on aflatoxin M1 and ochratoxin A in hu-man milk in a cohort study from south-eastern region of Turkey. Int J Environ Health Res, 32(6):1192-1203.
19. Madali B, Gulec A, Ayaz A (2018). A survey of aflatoxin M1 in different milk types in Turkey: risk assessment of children’s exposure. Progress in Nutrition, 20(4):659-664.
20. Gurbuz S, Altun SK (2019). Aflatoxın M1 in Traditional Homemade Yoghurts Mar-keted in Southeastern Turkey. FEB-Fresenıus Envıronmental Bulletın, 2802.
21. Pour SH, Mahmoudi S, Masoumi S, et al (2020). Aflatoxin M1 contamination level in Iranian milk and dairy products: A systematic review and meta-analysis. World Mycotoxin Journal, 13(1):67-82.
22. Campbell TC, Caedo JP Jr, Bulatao-Jayme J, et al (1970). Aflatoxin M1 in human urine. Nature, 227(5256):403-4.
23. Sinnhube Ro, Lee DJ, Wales, et al (1970). Aflatoxin-M1, a potent liver carcinogen for rainbow trout. In Federation Proceedings, 29(2):A568.
24. Sun Z, Lu P, Gail MH, et al (1999). In-creased risk of hepatocellular carcino-ma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology, 30(2): 379-383.
25. Diaz DE, Hagler WM, Blackwelder JT, et al (2004). Aflatoxin binders II: Reduction of aflatoxin M1 in milk by sequestering agents of cows consuming aflatoxin in feed. Mycopathologia, 157:233-241.
26. Micheli L, Grecco R, Badea M, Moscone D, et al (2005). An electrochemical im-munosensor for aflatoxin M1 determi-nation in milk using screen-printed elec-trodes. Biosens Bioelectron, 21(4):588-596.
27. Klingelhöfer D, Zhu Y, Braun M, et al (2018). Aflatoxin – publication analysis of a global health threat. Food Control, 89:280–90.
28. Zyoud SH, Al-Jabi SW, Sweileh WM, et al (2015). Bibliometric profile of the global scientific research on methanol poison-ing (1902-2012). J Occup Med Toxicol, 10:17.
29. Zyoud SH, Al-Jabi SW, Sweileh WM, et al (2015). Global research productivity of N-acetylcysteine use in paracetamol overdose: a bibliometric analysis (1976-2012). Hum Exp Toxicol, 34(10):1006–16.
30. Zyoud SH, Waring WS, Al-Jabi SW, Sweileh WM, (2017). Global research production in glyphosate intoxication from 1978 to 2015: a bibliometric analysis. Hum Exp Toxicol, 36(10):997–1006.
31. Briganti M, Delnevo CD, Brown L, et al (2019). Bibliometric Analysis of Elec-tronic Cigarette Publications: 2003(−)2018. Int J Environ Res Public Health, 16(3):320.
32. Zyoud SH (2016). Global research trends of Middle East respiratory syndrome coronavirus: a bibliometric analysis. BMC Infect Dis, 16:255.
33. Hou J, Wang G, Wang F, et al (2017). Guideline of prevention and treatment for chronic hepatitis B (2015 update). J Clin Transl Hepatol, 5(4):297–318.
34. Oil Crops Research Institute of Chinese Academy of Agricultural Sciences (2014). NSFC-CGIAR cooperative project on groundnut aflatoxin resistance support-ed. [Cited 2022 December 01]; Available from: http://ocri.caas.cn/en/news/intlcooperation/90801.htm
35. Selim MI, Popendorf W, Ibrahim MS, et al (1996). Aflatoxin B1 in common Egyp-tian foods. J AOAC Int, 79(5):1124–9.
36. Hamid AS, Tesfamariam IG, Zhang Y, Zhang ZG (2013). Aflatoxin B1-induced hepatocellular carcinoma in developing countries: geographical distribution, mechanism of action and prevention. Oncol Lett, 5(4):1087–92.
37. Fakhri Y, Ghorbani R, Taghavi M, et al (2019). Concentration and prevalence of aflatoxin M1 in human breast milk in Iran: Systematic review, meta-analysis, and carcinogenic risk assessment: A re-view. J Food Prot, 82(5): 785-795.
38. Sharma H, Jadhav VJ, Garg SR (2020). Afla-toxin M1 in milk in Hisar city, Haryana, India and risk assessment. Food Addit Contam Part B Surveill, 13(1): 59-63.
39. Pandey AK, Shakya S, Patyal A, et al (2021). Detection of aflatoxin M1 in bovine milk from different agro-climatic zones of Chhattisgarh, India, using HPLC-FLD and assessment of human health risks. Mycotoxin Res, 37(3):265-273.
40. Gummadidala PM, Omebeyinje MH, Burch, JA, et al (2019). Complementary feeding may pose a risk of simultaneous exposures to aflatoxin M1 and deoxyni-valenol in Indian infants and toddlers: Lessons from a mini-survey of food samples obtained from Kolkata, India. Food Chem Toxicol, 123:9-15.
41. Magnussen A, Parsi MA (2013). Aflatoxins, hepatocellular carcinoma and public health. World J Gastroenterol, 19(10):1508–12.
42. Kumar P, Mahato DK, Kamle M, Mohanta TK, Kang SG (2017). Aflatoxins: a global concern for food safety, Human Health and Their Management. Front Microbiol, 7:2170.
43. Turna NS, Wu F (2021). Aflatoxin M1 in milk: A global occurrence, intake, & ex-posure assessment. Trends in Food Science & Technology, 110:183-192.
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| Issue | Vol 53 No 1 (2024) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v53i1.14694 | |
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| Aflatoxin M1 Milk Bibliometric VOSviewer software Publications | ||
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How to Cite
1.
Kılıç Altun S, Aydemir M, Alkan S. Trends in Aflatoxin M1 Global Research: A Bibliometric Analysis Study. Iran J Public Health. 2024;53(1):175-186.
