Finding a Link between Obesity and Senescence: A Systematic Review and Meta-Analysis
-
Sry Suryani Widjaja
,
Rusdiana Rusdiana
,
Tengku Mardani Helvi
,
Rostime Hermayeni Simanullang
,
Vito Filbert Jayalie
,
Rina Amelia
,
Jessie Arisa
Abstract
Background: Cell aging is associated with changes in telomeres due to DNA damage arising from chronic inflammation in obese patients. The aim of the systematic review and meta-analysis was to find the relationship between obesity and aging or senescence.
Methods: The systematic review was conducted through PRISMA guideline, beginning with literature search within 2012-2022 in several databases (PubMed, EBSCOHost, Science Direct, Scopus, and Cochrane) followed by screening process using predetermined PICO criteria. Original studies on the topic of obesity and senescence (aging), from preclinical studies to clinical research (cohort or cross-sectional studies) that were published within the last ten years. All studies were appraised using SYRCLE risk of bias tool for preclinical studies and Newcastle-Ottawa Scale (NOS) for cross-sectional and cohort studies. The data extraction on the studies’ characteristic and outcome on aging or senescence were followed by quantitative analysis using MetaXL process on prevalence ratio and hazard ratio of obesity to comorbidities and mortality.
Results: Fifteen studies were enrolled. Obesity and white adipose tissue cause increased levels of pro-inflammatory and pro-senescence cytokine and macrophage whilst the aging process lowers metabolism with increased insulin resistance and linked to increased risk of obesity. Obesity occurs in 22% (95% CI 18%-26%) of elderly population with higher prevalence rate in the women population. Obesity is associated with significant increased risk of multimorbidity by 56% (OR = 1.58 [95% CI 1.48-1.96]).
Conclusion: The obesity and aging or senescence has reciprocal relationship between each other.
1. Ghanemi A, Yoshioka M, St-Amand J (2018). Broken Energy Homeostasis and Obesity Pathogenesis: The Surrounding Concepts. J Clin Med, 7(11):453-65.
2. Goossens GH (2017). The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function. Obes Facts,10(3):207–15.
3. Jura M, Kozak LP (2016). Obesity and related consequences to ageing. Age, 38(1):23
4. DiLoreto R, Murphy CT (2015). The cell biology of aging. Mol Biol Cell, 26(25) :4524–31.
5. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013). The Hallmarks of Aging. Cell, 153(6):1194–217.
6. Mundstock E, Sarria EE, Zatti H, et al (2015). Effect of obesity on telomere length: Systematic review and meta-analysis. Obesity (Silver Spring), 23(11):2165–74.
7. Aravinthan A (2023). Cellular senescence: a hitchhiker’s guide. Hum Cel, 28(2):51–64.
8. Bitto A, Crowe EP, Lerner C, Torres C, Sell C (2014). The senescence arrest program and the cell cycle. Methods Mol Biol, 1170:145–54.
9. Page MJ, McKenzie JE, Bossuyt PM, et al (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372: n71
10. GA Wells D O’Connell, J Peterson, V Welch, M Losos, P Tugwell BS (2014). Newcastle-Ottawa quality assessment scale. Ottawa Hosp Res Institute, (3):2–4.
11. Puzianowska-Kuznicka M, Kuryłowicz A, Walkiewicz D, et al (2019). Obesity Paradox in Caucasian Seniors: Results of the PolSenior Study. J Nutr Health Aging, 23(9):796–804.
12. Bowman K, Atkins JL, Delgado J, et al (2017). Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants. Am J Clin Nutr,106(1):130–5.
13. Apalasamy YD, Awang H, Mansor N, AbRashid N, Kamarulzaman ND, Lih Yoong T (2021). Factors Associated With Obesity and Abdominal Obesity Among Malaysian Older Adults. Asia-Pacific J Public Heal,33(5):547–54.
14. Romano E, Ma R, Vancampfort D, et al (2021). Multimorbidity and obesity in older adults from six low- and middle-income countries. Prev Med,153: 106816.
15. Choi S, Chon J, Lee SA, et al (2022). Central obesity is associated with lower prevalence of sarcopenia in older women, but not in men: a cross-sectional study. BMC Geriatr, 22(1):406.
16. Muhammad T, Boro B, Kumar M, Srivastava S (2022). Gender differences in the association of obesity-related measures with multi-morbidity among older adults in India: evidence from LASI, Wave-1. BMC Geriatr,22(1):171.
17. Muhammad T, Balachandran A, Kumar P, Srivastava S (2022). Obesity-related measures and successful ageing among community-dwelling older adults in India: a cross-sectional study. Sci Rep, 12(1):17186.
18. Santamaría-Ulloa C, Chinnock A, Montero-López M (2022). Association between obesity and mortality in the Costa Rican elderly: a cohort study. BMC Public Health , 22(1):1007.
19. Svärd A, Lahti J, Roos E, et al (2017). Obesity, change of body mass index and subsequent physical and mental health functioning: A 12-year follow-up study among ageing employees. BMC Public Health, 17(1):744.
20. Han TS, Correa E, Lean MEJ, et al (2017). Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS). Endocrine,55(2):456-69.
21. Brunelli DT, Boldrini VO, Bonfante ILP, et al (2022). Obesity Increases Gene Expression of Markers Associated With Immunosenescence in Obese Middle-Aged Individuals. Front Immunol, 12:806400.
22. Espinosa De Ycaza AE, Søndergaard E, Morgan-Bathke M, et al (2021). Senescent cells in human adipose tissue: A cross-sectional study. Obesity (Silver Spring),29(8):1320–7.
23. Rabhi N, Desevin K, Belkina AC, et al (2022). Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors. Life Sci Alliance, 5(5): e202101286.
24. Iizuka Y, Kim H, Nakasatomi M, Matsumoto A, Shimizu J (2021). Phenotypic and genotypic changes in obesity and type 2 diabetes of male KK mice with aging. Exp Anim, 71(1):71–81.
25. Frasca D, Romero M, Diaz A, Garcia D, Thaller S, Blomberg BB (2021). B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity. Int J Mol Sci, 22(4):1839.
26. Garawi F, Devries K, Thorogood N, Uauy R (2014). Global differences between women and men in the prevalence of obesity: is there an association with gender inequality? Eur J Clin Nutr, 68(10):1101–6.
27. Case A, Menendez A (2009). Sex differences in obesity rates in poor countries: Evidence from South Africa. Economics and Human Biology, 7(3): 271-82.
28. Yount KM, Li L (2011). Domestic violence and obesity in Egyptian women. J Biosoc Sci, 43(1):85–99.
29. Af El-Hazmi M, Warsy AS (2002). Relationship between Age and the Prevalence of Obesity and Overweight in Saudi Population. Bahrain Med Bull, 24(2):1-7.
30. Bakhshi E, Seifi B, Biglarian A, Mohammad K (2011). Factors associated with obesity in Iranian elderly people: Results from the national health survey. BMC Res Notes, 4:538.
31. Wang R, Zhang P, Gao C, et al (2016). Prevalence of overweight and obesity and some associated factors among adult residents of northeast China: a cross-sectional study. BMJ Open, 6(7):e010828.
32. Toth MJ, Tchernof A, Sites CK, Poehlman ET (2000). Effect of menopausal status on body composition and abdominal fat distribution. Int J Obes Relat Metab Disord , 24(2):226–31.
33. Ruan XY, Gallagher D, Harris T, et al (2007). Estimating whole body intermuscular adipose tissue from single cross-sectional magnetic resonance images. J Appl Physiol (1985), 102(2):748–54.
34. Lemieux I, Pascot A, Couillard C, et al (2000). Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation , 102(2):179–84.
35. Tchernof A, Lamarche B, Prud’homme D, et al (1996). The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care, 19(6):629–37.
36. Couillard C, Bergeron N, Prud’Homme D, et al (1998). Postprandial triglyceride response in visceral obesity in men. Diabetes , 47(6):953–60.
37. Thorpe RJ, Ferraro KF (2004). Aging, Obesity, and Mortality: Misplaced Concern About Obese Older People? Res Aging, 26(1):108–29.
38. Barbé-Tuana F, Funchal G, Schmitz CRR, Maurmann RM, Bauer ME (2020). The interplay between immunosenescence and age-related diseases. Semin Immunopathol , 42(5):545-57.
39. Rouault C, Marcelin G, Adriouch S, et al (2020). Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity. Diabetologia 54(1):240-254.
40. Fuente M, Miquel J (2009). An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging. Curr Pharm Des, 15(26):3003–26.
41. Solana R, Pawelec G, Tarazona R (2006). Aging and innate immunity. Immunity, 24(5):491–4.
42. Bastard J-P, Maachi M, Lagathu C, et al (2006). Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw, 17(1):4–12.
2. Goossens GH (2017). The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function. Obes Facts,10(3):207–15.
3. Jura M, Kozak LP (2016). Obesity and related consequences to ageing. Age, 38(1):23
4. DiLoreto R, Murphy CT (2015). The cell biology of aging. Mol Biol Cell, 26(25) :4524–31.
5. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013). The Hallmarks of Aging. Cell, 153(6):1194–217.
6. Mundstock E, Sarria EE, Zatti H, et al (2015). Effect of obesity on telomere length: Systematic review and meta-analysis. Obesity (Silver Spring), 23(11):2165–74.
7. Aravinthan A (2023). Cellular senescence: a hitchhiker’s guide. Hum Cel, 28(2):51–64.
8. Bitto A, Crowe EP, Lerner C, Torres C, Sell C (2014). The senescence arrest program and the cell cycle. Methods Mol Biol, 1170:145–54.
9. Page MJ, McKenzie JE, Bossuyt PM, et al (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372: n71
10. GA Wells D O’Connell, J Peterson, V Welch, M Losos, P Tugwell BS (2014). Newcastle-Ottawa quality assessment scale. Ottawa Hosp Res Institute, (3):2–4.
11. Puzianowska-Kuznicka M, Kuryłowicz A, Walkiewicz D, et al (2019). Obesity Paradox in Caucasian Seniors: Results of the PolSenior Study. J Nutr Health Aging, 23(9):796–804.
12. Bowman K, Atkins JL, Delgado J, et al (2017). Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants. Am J Clin Nutr,106(1):130–5.
13. Apalasamy YD, Awang H, Mansor N, AbRashid N, Kamarulzaman ND, Lih Yoong T (2021). Factors Associated With Obesity and Abdominal Obesity Among Malaysian Older Adults. Asia-Pacific J Public Heal,33(5):547–54.
14. Romano E, Ma R, Vancampfort D, et al (2021). Multimorbidity and obesity in older adults from six low- and middle-income countries. Prev Med,153: 106816.
15. Choi S, Chon J, Lee SA, et al (2022). Central obesity is associated with lower prevalence of sarcopenia in older women, but not in men: a cross-sectional study. BMC Geriatr, 22(1):406.
16. Muhammad T, Boro B, Kumar M, Srivastava S (2022). Gender differences in the association of obesity-related measures with multi-morbidity among older adults in India: evidence from LASI, Wave-1. BMC Geriatr,22(1):171.
17. Muhammad T, Balachandran A, Kumar P, Srivastava S (2022). Obesity-related measures and successful ageing among community-dwelling older adults in India: a cross-sectional study. Sci Rep, 12(1):17186.
18. Santamaría-Ulloa C, Chinnock A, Montero-López M (2022). Association between obesity and mortality in the Costa Rican elderly: a cohort study. BMC Public Health , 22(1):1007.
19. Svärd A, Lahti J, Roos E, et al (2017). Obesity, change of body mass index and subsequent physical and mental health functioning: A 12-year follow-up study among ageing employees. BMC Public Health, 17(1):744.
20. Han TS, Correa E, Lean MEJ, et al (2017). Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS). Endocrine,55(2):456-69.
21. Brunelli DT, Boldrini VO, Bonfante ILP, et al (2022). Obesity Increases Gene Expression of Markers Associated With Immunosenescence in Obese Middle-Aged Individuals. Front Immunol, 12:806400.
22. Espinosa De Ycaza AE, Søndergaard E, Morgan-Bathke M, et al (2021). Senescent cells in human adipose tissue: A cross-sectional study. Obesity (Silver Spring),29(8):1320–7.
23. Rabhi N, Desevin K, Belkina AC, et al (2022). Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors. Life Sci Alliance, 5(5): e202101286.
24. Iizuka Y, Kim H, Nakasatomi M, Matsumoto A, Shimizu J (2021). Phenotypic and genotypic changes in obesity and type 2 diabetes of male KK mice with aging. Exp Anim, 71(1):71–81.
25. Frasca D, Romero M, Diaz A, Garcia D, Thaller S, Blomberg BB (2021). B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity. Int J Mol Sci, 22(4):1839.
26. Garawi F, Devries K, Thorogood N, Uauy R (2014). Global differences between women and men in the prevalence of obesity: is there an association with gender inequality? Eur J Clin Nutr, 68(10):1101–6.
27. Case A, Menendez A (2009). Sex differences in obesity rates in poor countries: Evidence from South Africa. Economics and Human Biology, 7(3): 271-82.
28. Yount KM, Li L (2011). Domestic violence and obesity in Egyptian women. J Biosoc Sci, 43(1):85–99.
29. Af El-Hazmi M, Warsy AS (2002). Relationship between Age and the Prevalence of Obesity and Overweight in Saudi Population. Bahrain Med Bull, 24(2):1-7.
30. Bakhshi E, Seifi B, Biglarian A, Mohammad K (2011). Factors associated with obesity in Iranian elderly people: Results from the national health survey. BMC Res Notes, 4:538.
31. Wang R, Zhang P, Gao C, et al (2016). Prevalence of overweight and obesity and some associated factors among adult residents of northeast China: a cross-sectional study. BMJ Open, 6(7):e010828.
32. Toth MJ, Tchernof A, Sites CK, Poehlman ET (2000). Effect of menopausal status on body composition and abdominal fat distribution. Int J Obes Relat Metab Disord , 24(2):226–31.
33. Ruan XY, Gallagher D, Harris T, et al (2007). Estimating whole body intermuscular adipose tissue from single cross-sectional magnetic resonance images. J Appl Physiol (1985), 102(2):748–54.
34. Lemieux I, Pascot A, Couillard C, et al (2000). Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation , 102(2):179–84.
35. Tchernof A, Lamarche B, Prud’homme D, et al (1996). The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care, 19(6):629–37.
36. Couillard C, Bergeron N, Prud’Homme D, et al (1998). Postprandial triglyceride response in visceral obesity in men. Diabetes , 47(6):953–60.
37. Thorpe RJ, Ferraro KF (2004). Aging, Obesity, and Mortality: Misplaced Concern About Obese Older People? Res Aging, 26(1):108–29.
38. Barbé-Tuana F, Funchal G, Schmitz CRR, Maurmann RM, Bauer ME (2020). The interplay between immunosenescence and age-related diseases. Semin Immunopathol , 42(5):545-57.
39. Rouault C, Marcelin G, Adriouch S, et al (2020). Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity. Diabetologia 54(1):240-254.
40. Fuente M, Miquel J (2009). An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging. Curr Pharm Des, 15(26):3003–26.
41. Solana R, Pawelec G, Tarazona R (2006). Aging and innate immunity. Immunity, 24(5):491–4.
42. Bastard J-P, Maachi M, Lagathu C, et al (2006). Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw, 17(1):4–12.
| Files | ||
| Issue | Vol 53 No 1 (2024) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v53i1.14679 | |
| Keywords | ||
| Obesity Aging Senescence Meta-analysis | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Widjaja SS, Rusdiana R, Helvi TM, Simanullang R, Jayalie VF, Amelia R, Arisa J. Finding a Link between Obesity and Senescence: A Systematic Review and Meta-Analysis. Iran J Public Health. 2023;53(1):12-24.
