Original Article

Mortality Rate and Years of Life Lost Due to Breast and Gynecologic Cancers in Southern Iran 2004-2019: A Population-Based Study

Abstract

Background: There is an increase in the incidence of breast and gynecologic cancers in Iran during the last three decades. Literature is inadequate about the Years of Life Lost (YLL) attributed to these cancers in Iran.
Methods: Mortality data due to these cancers amongst females aged >20 yr from 2004 to 2019 was acquired from “Electronic Death Registry System”, Fars Province, Iran. Using local health centers’ databases and national census reports from 1996 to 2016, the age-standardized incidence rate (ASR) per 100,000 people were estimated. YLLs were calculated using the WHO’s 2015 “YLL template”.
Results: During 2004–2019, 1886 and 829 deaths occurred due to breast and gynecologic cancers, respectively. The ASR due to breast and gynecologic cancers showed a significant increasing trend (P<0.001 for each). The total YLL due to breast, cervical/uterine/vaginal/vulvar, and ovary cancers’ deaths in the 16-year period were 33,077, 7,172 and 6,584 yr, respectively. The highest YLLs were observed in 50-59-year-old females, followed by 40-49- and 60-69-year-old females. The 16- year trend of YLL rate due to premature mortality in breast cancer, ovary cancer and cervix cancer was increasing: annual percent change (APC) was 7.6% (95% CI: 5.5-9.7, P<0.001), 19.0% (95% CI: 12.2-26.1, P<0.001) and 9.2% (95% CI: -9.2 to 31.3, P>0.05, respectively.
Conclusion: Mortality rate and YLLs due to breast and gynecologic cancers have been increased in southern Iran during the last twenty years. Early detection programs and allocating treatments at early stages should be prioritized.

1. Ferlay J, Soerjomataram I, Dikshit R, et al (2015). Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 136(5): E359-86.
2. Global Cancer Observatory. Cancer Inci-dence and Mortality Worldwide: IARC CancerBase No. 11 (2013). Lyon, France: International Agency for Research on Cancer.
3. Winters S, Martin C, Murphy D, et al (2017). Breast Cancer Epidemiology, Preven-tion, and Screening. Prog Mol Biol Transl Sci, 151: 1-32.
4. Forbes JF (1997). The incidence of breast cancer: the global burden, public health considerations. Semin Oncol, 24 (1 Suppl 1): S1-20-S1-35.
5. Bray F, Ferlay J, Laversanne M, et al (2015). Cancer Incidence in Five Continents: Inclusion criteria, highlights from Vol-ume X and the global status of cancer registration. Int J Cancer, 137(9): 2060-71.
6. World health Organization. Breast Cancer Awareness Month 2021 (2021). Interna-tional Agency for Research on Cancer. 2021. Available from: https://www.iarc.who.int/featured-news/breast-cancer-awareness-month-2021/
7. Mousavi SM, Montazeri A, Mohagheghi MA, et al (2007). Breast cancer in Iran: an epidemiological review. Breast J, 13(4): 383-91.
8. Ataeinia B, Saeedi Moghaddam S, Shabani M, et al (2021). National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990. Front Oncol, 11: 561376.
9. Sargazi N, Daroudi R, Zendehdel K, et al (2022). Economic Burden of Gynecolog-ical Cancers in Iran. Value Health Reg Is-sues, 28: 1-6.
10. Cho KR, Shih IeM (2009). Ovarian cancer. Annu Rev Pathol, 4: 287-313.
11. Sharifian A, Pourhoseingholi MA, No-rouzinia M, et al (2014). Ovarian cancer in Iranian women, a trend analysis of mortality and incidence. Asian Pac J Cancer Prev, 15 (24): 10787-90.
12. Waggoner SE (2003). Cervical cancer. Lan-cet, 361 (9376): 2217-25.
13. Arbyn M, Weiderpass E, Bruni L, et al (2020). Estimates of incidence and mor-tality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health, 8 (2): e191-e203.
14. Sankoh O, Sharrow D, Herbst K, et al (2014). The INDEPTH standard popula-tion for low-and middle-income coun-tries, 2013. Glob Health Action, 7: 23286.
15. World Health Organization (2001). Nation-al Burden of Disease Studies: A Practical Guide. 2nd ed. WHO, Geneva.
16. S Sharifian A, Pourhoseingholi MA, Emadedin M, et al (2015). Burden of Breast Cancer in Iranian Women is In-creasing. Asian Pac J Cancer Prev, 16 (12): 5049-52.
17. National Institutes of Health: SEER*Explorer Application (2022). Available from: https://seer.cancer.gov/statistics-network/explorer/application.html
18. Mobarakeh ZS, Mirzaei K, Hatmi N, et al (2014). Dietary habits contributing to breast cancer risk among Iranian wom-en. Asian Pac J Cancer Prev, 15 (21): 9543-7.
19. Harirchi I, Karbakhsh M, Kashefi A, et al (2004). Breast cancer in Iran: results of a multi-center study. Asian Pac J Cancer Prev, 5 (1): 24-27.
20. Abedi G, Janbabai G, Moosazadeh M, et al (2016). Survival Rate of Breast Cancer in Iran: A Meta-Analysis. Asian Pac J Cancer Prev, 17 (10): 4615-21.
21. Movahedi M, Haghighat S, Khayamzadeh M, et al (2012). Survival rate of breast cancer based on geographical variation in Iran, a national study. Iran Red Crescent Med J, 14 (12): 798-804.
22. Baghestani AR, Zayeri F, Akbari ME, et al (2015). Fitting Cure Rate Model to Breast Cancer Data of Cancer Research Cen-ter. Asian Pac J Cancer Prev, 16 (17): 7923-7.
23. Stewart C, Ralyea C, Lockwood S (2019). Ovarian Cancer: An Integrated Review. Semin Oncol Nurs, 35 (2): 151-156.
24. Financial Tribune. Daily and Contributors (2016). Available from: https://financialtribune.com/articles/people/53113/dietary-fiber-intake-low
25. Safaeian F, Ghaemimood S, El-Khatib Z, et al (2021). Burden of Cervical Cancer in the Eastern Mediterranean Region Dur-ing the Years 2000 and 2017: Retrospec-tive Data Analysis of the Global Burden of Disease Study. JMIR Public Health Sur-veill, 7 (5): e22160.
26. IHME GHDx. GBD results (2019). Availa-ble from: https://vizhub.healthdata.org/gbd-results/
27. Eftekharzadeh S, Ebrahimi N, Samaei M, et al (2020). National and Subnational Trends of Incidence and Mortality of Female Genital Cancers in Iran; 1990-2016. Arch Iran Med, 23 (7): 434-44.
28. Khorasanizadeh F, Hassanloo J, Khaksar N, et al (2013). Epidemiology of cervical cancer and human papilloma virus in-fection among Iranian women - anal-yses of national data and systematic re-view of the literature. Gynecol Oncol, 128 (2): 277-81.
29. Yip CH, Taib NA, Mohamed I (2006). Epi-demiology of breast cancer in Malaysia. Asian Pac J Cancer Prev, 7 (3): 369-74.
30. Remennick L (2006). The challenge of early breast cancer detection among immi-grant and minority women in multicul-tural societies. Breast J, 12 Suppl 1: S103-10.
31. Nafissi N, Khayamzadeh M, Zeinali Z, et al (2018). Epidemiology and histo-pathology of breast cancer in Iran ver-sus other Middle Eastern countries. Mid-dle East J Cancer, 9(3): 243-51.
32. Vostakolaei FA, Broeders MJ, Rostami N, et al (2012). Age at Diagnosis and Breast Cancer Survival in Iran. Int J Breast Can-cer, 2012:517976.
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IssueVol 53 No 8 (2024) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijph.v53i8.16295
Keywords
Years of life lost Mortality Breast cancer Gynecologic cancer Cervical cancer Ovarian cancer Iran
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How to Cite
1.
Azarbakhsh H, Heiran A, Askarinejad A, Hassanzadeh J, Janfada M, Mirahmadizadeh A. Mortality Rate and Years of Life Lost Due to Breast and Gynecologic Cancers in Southern Iran 2004-2019: A Population-Based Study. Iran J Public Health. 2024;53(8):1890-1897.