Hypothetical Strategies of Gene and Environmental Influence on Life Expectancy: A Brief Review
Abstract
Almost all diseases have a genetic basis. However, several disorders stem from a combination of genes and environmental conditions. In the present study, databases including PubMed, Scopus and Google scholar were searched and reviewed and those relevant studies that investigated the association between environmental and genetic factors with the incidence of diseases were extracted and used. At the final step, it is concluded that in many cases, disorders have a multifactorial etiology. Having a gene related to a specific disorder is not the only reason for contracting the disease. Both genes and environmental factors play a role in human disease etiology. Everything outside of DNA, may affect health and even in many people with a positive family history of a specific disorder, environmental factors can facilitate or prevent the occurrence of the disease. Therefore, living a healthy lifestyle is important in reducing exposure to diseases, and long-life expectancy.
2. Hernandez LM, Blazer DG (2006). Genes, Behavior, and the Social Environment: Moving Beyond the Nature/Nurture Debate. The National Academies Collection: Reports funded by National Institutes of Health. DOI: 10.17226/11693
3. Farhud DD (2017). Life Style and Sustaina-ble Development. Iran J Public Health, 46(1):1-3.
4. Becker F, Van EC, Ibarreta, D, et al (2011). Genetic testing and common disorders in a public health framework: how to as-sess relevance and possibilities. Eur J Hum Genet, 19 Suppl 1(Suppl 1):S6-44.
5. Horton RH, Lucassen AM. Recent devel-opments in genetic/genomic medicine (2019). Clin Sci (Lond), 133(5):697-708.
6. Farhud DD (2015). Impact of Lifestyle on Health, Iran J Public Health, 44(11):1442-4.
7. Tengilimoğlu D, Gönüllü U, Işık Q, et al (2022). The Problems Experienced by Employees with Chronic Disease during the COVID-19 Pandemic. Int J Environ Res Public Health, 19(1): 578.
8. WHO (2022). Noncommunicable diseases. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases
9. Holman HR (2020). The Relation of the Chronic Disease Epidemic to the Health Care Crisis. ACR Open Rheumatol, 2(3):167-173.
10. Ng R, Sutradhar R, Yao Z, et al (2020). Smoking, drinking, diet and physical ac-tivity-modifiable lifestyle risk factors and their associations with age to first chronic disease. Int J Epidemiol, 49(1):113-130.
11. Vrablik M, Dlouha D, Todorovova V, et al (2021). Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management? Int J Mol Sci, 22(8):4182.
12. North BJ, Sinclair DA (2012). The intersection between aging and cardiovascular disease. Circ Res, 110(8):1097-108.
13. Bhatnagar A (2017). Environmental Determinants of Cardiovascular Disease. Circ Res, 121(2):162-80.
14. Martino E, Smith L, Bradley SH, et al (2022). Incidence trends for twelve cancers in younger adults—a rapid review. Br J Cancer, 126(10):1374-86.
15. White MC, Holman DM, Boehm JE, et al (2014). Age and cancer risk: a potentially modifiable relationship. Am J Prev Med, 46(3 Suppl 1):S7-15.
16. Rani J, Mittal I, Pramanik A, et al (2017). T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders. Sci Rep, 7(1):6892.
17. Ali O (2013). Genetics of type 2 diabetes. World J Diabetes, 4(4):114-23.
18. Choquet H, Meyre D (2011). Genetics of Obesity: What have we Learned? Curr Genomics, 12(3):169-79.
19. Walley AJ, Asher JE, Froguel P (2009). The genetic contribution to non-syndromic human obesity. Nat Rev Genet, 10(7):431-42.
20. Reitz C (2015). Genetic diagnosis and prog-nosis of Alzheimer's disease: challenges and opportunities. Expert Rev Mol Diagn, 15(3):339-48.
21. Serrano-Pozo A, Das S, Hyman BT (2021). APOE and Alzheimer's disease: advances in genetics, pathophysiology, and thera-peutic approaches. Lancet Neurol, 20(1):68-80.
22. Cacace R, Sleegers K, Van Broeckhoven C (2016). Molecular genetics of early-onset Alzheimer's disease revisited. Alzheimers Dement, 12(6):733-48.
23. Killin LO, Starr JM, Shiue IJ, et al (2016). Environmental risk factors for dementia: a systematic review. BMC Geriatr, 16(1):175.
24. James M (2018). Rippe. Lifestyle Medicine: The Health Promoting Power of Daily Habits and Practices. Am J Lifestyle Med, 12(6): 499-512.
25. WHO (2010). A healthy lifestyle - WHO recommendations. https://www.who.int/europe/news-room/fact-sheets/item/a-healthy-lifestyle---who-recommendations
26. CDC (2020). Data and Statistics on Down Syndrome. https://www.cdc.gov/ncbddd/birthdefects/downsyndrome/data.html
27. Wu J, Springett A, Morris JK (2013). Survival of trisomy 18 (Edwards syndrome) and trisomy 13 (Patau Syndrome) in England and Wales: 2004-2011. Am J Med Genet A, 161A(10):2512-8.
28. Herbert L. Muncie, James S. Campbell (2009). Alpha and Beta Thalassemia. Am Fam Physician, 80(4):339-344.
29. Peroos S, Forsythe E, Pugh JH, et al (2012). Longevity and Patau syndrome: what de-termines survival? BMJ Case Rep, 2012:bcr0620114381.
30. Durda-Masny M, Goździk-Spychalska J, John A, et al (2021). The determinants of survival among adults with cystic fibro-sis—a cohort study. J Physiol Anthropol, 40(1):19.
31. Crimmins EM, Hayward MD, Ueda H, et al (2008). Life with and without heart dis-ease among women and men over 50. J Women Aging, 20(1-2):5-19.
32. Cleveland Clinic (2020). Tay-Sachs Disease. https://my.clevelandclinic.org/health/diseases/14348-tay-sachs-disease
33. Holm KE, Plaufcan MR, Ford DW, et al (2014). The impact of age on outcomes in chronic obstructive pulmonary disease differs by relationship status. J Behav Med, 37(4):654-63.
34. Stephen Fitzmaurice (2016). Rare Patients With Sickle Cell Disease Live Nearly Twice as Long as Average. https://www.hematology.org/newsroom/press-releases/2016/rare-patients-with-sickle-cell-disease-live-nearly-twice-as-long-as-average
35. Sattar N, Rawshani A, Franzén S, et al (2019). Age at diagnosis of type 2 diabe-tes mellitus and associations with cardio-vascular and mortality risks: findings from the Swedish National Diabetes Reg-istry. Circulation, 139(19):2228-2237.
36. Zanetti O, Solerte SB, Cantoni F (2009). Life expectancy in Alzheimer's disease (AD). Arch Gerontol Geriatr, 49 Suppl 1:237-43.
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Issue | Vol 51 No 11 (2022) | |
Section | Review Article(s) | |
DOI | https://doi.org/10.18502/ijph.v51i11.11156 | |
Keywords | ||
Genetic disorders Lifestyle Life expectancy Environmental factors |
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