Original Article

Drug-Related Poisonings among Chilean Adult Population

Abstract

Background: Poisonings is a preventable public health problem that globally affects the population. We aimed to characterize drug-related acute poisonings occurred in Chile between the years of 2016 and 2020.

Methods: A retrospective study of poisonings among hospitalized patients was carried out. Data were obtained from the Medical Outcome Statistical Report database. Inclusion criteria were cases of patients admitted into either public or private healthcare settings with diagnosis of drug-related poisoning according to the WHO ICD-10 codes T30-T50. Statistical analyses were run to establish either significant associations or differences between variables selected in the study.

Results: Overall, 12,975 poisonings were identified during the 2016-2020 period. These events corresponded to 0.16% of all national hospital admissions in the study period. Women represented 71.1% of the cases. 76.7% of events were related to intentional poisonings while 7.3% and 16% were accidental and undetermined poisonings respectively. 44.6% of accidental and intentional poisonings occurred at the age of 18-29 yr old. Benzodiazepines (22.8%), antidepressants (11.2%), and acetaminophen (5.1) were the most common drugs associated with poisonings. Average length of hospitalization was between 3.3 and 8.2 days. 0.6% of poisonings resulted in deaths.    

Conclusion: Poisonings were characterized by patients’ sex and age, circumstance of exposure, length of hospitalization, and outcome. Poisoning rates were stable along the years with a slight decrease in 2020. Intentional poisonings among young women and men were more common. Most of the cases had favorable outcome for patients.

 

1. Frithsen IL, Simpson WM (2010). Recognition and management of acute medication poisoning. Am Fam Physician, 81(3): 316-23.
2. Ham S, Min YG, Chae MK, Kim HH (2020). Epidemiology and regional differences of acute poisonings of eight cities in Gyeonggi-do province in Korea using data from the National Emergency Department Information System of Korea. Clin Exp Emerg Med, 7(1): 43-51.
3. Kouli M, Al Houri HN, Jomaa S, et al(2023). Epidemiology of poisoning in Syria (1999 through 2020). Clin Toxicol (Phila), 61(2):116-122.
4. Zhang Y, Yu B, Wang N, et al (2018). Acute poisoning in Shenyang, China: a retrospective and descriptive study from 2012 to 2016. BMJ Open, 8: e021881.
5. Mehrpour O, Akbari A, Jahani F, et al (2018). Epidemiological and clinical profiles of acute poisoning in patients admitted to the intensive care unit in eastern Iran (2010 to 2017). BMC Emerg Med, 18: 30.
6. Mathias TL, Guidoni CM, Girotto E (2019). Trends of drug-related poisoning cases attended to at a poison control center. Rev Bras Epidemiol, 22: e190018
7. Gonzalez F, Retamal C, Silva L et al (2019). Characterization of the phone-calls made to a poison center related to household and cosmetics products exposition in pediatrics. Rev Chil Pediatr, 90(5): 500-7.
8. Aguilera P, Garrido M, Lessard E, et al (2016). Medication Overdoses at a Public Emergency Department in Santiago, Chile. West J Emerg Med, 17(1): 75-80.
9. Araneda N, Sanhueza P, Pacheco G, et al (2021). Suicidio en adolescentes y jóvenes en Chile: riesgos relativos, tendencias y desigualdades. Rev Panam Salud Publica, 45: e4
10. Hitti E, El Zahran T, Hamade H, et al (2020). Toxicological exposures reported to a telephonic consultation service at a tertiary care hospital in Lebanon. Clin Toxicol (Phila), 58(9): 886-92.
11. World Health Organization. ICD-10 (2016) Available from: https://icd.who.int/browse10/2016/en
12. Pholmoo N, Bunchorntavakul C (2019). Characteristics and Outcomes of Acetaminophen Overdose and Hepatotoxicity in Thailand. J Clin Transl Hepatol, 7(2): 132-9.
13. Beaune S, Juvin P, Beauchet A, et al (2016). Deliberate drug poisonings admitted to an emergency department in Paris area-a descriptive study and assessment of risk factors for intensive care admission. Eur Rev Med Pharmacol Sci, 20(6): 1174-9.
14. Spiller HA, Ackerman JP, Smith GA, Kistamgari S, et al (2020). Suicide attempts by self-poisoning in the United States among 10–25 year olds from 2000 to 2018: substances used, temporal changes and demographics. Clin Toxicol (Phila), 58(7): 676-87.
15. Fayed MM, Sharif AF (2021). Impact of lockdown due to COVID-19 on the modalities of intoxicated patients presenting to the emergency room. Prehosp Disaster Med, 36(2): 145-62.
16. World Health Organization (2022). Mental health and COVID-19: early evidence of the pandemic’s impact: scientific brief. Available from: https://apps.who.int/iris/handle/10665/352189
17. Dos Santos BP, de Gouveia GC, Eller S, et al (2021). Is COVID-19 the current world-wide pandemic having effects on the profile of psychoactive substance poisonings? Forensic Toxicol, 39(1): 282-5.
18. Bravo V, Roman M, Bettini M, et al (2012). Characterization of paracetamol overdose: report of a poison information center in Chile. Rev Med Chil, 140(3): 313-8.
19. Sanhueza-Aroca T, Verdugo-Silva S, Olate-Fica E, et al (2021). Acetaminophen poisonings in Chilean healthcare settings: a 20-year story that does not end. Nepal J Epidemiol, 11(4): 1086-94.
20. Gummin DD, Mowry JB, Beuhler MC, et al (2019). Annual report of the American association of poison control centers’ National Poison Data System (NPDS): 37th annual report. Clin Toxicol (Phila), 58(12): 1360-541.
21. Friedman N, Shoshani-Levy M, Brent J, et al (2020). Fatalities in poisoned patients managed by medical toxicologists. Clin Toxicol (Phila), 58(7): 688-91.
Files
IssueVol 52 No 5 (2023) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijph.v52i5.12714
Keywords
Drug-related poisoning Epidemiology Poisoning intent Chile

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Schulz-Bañares B, González-Norambuena C, Muller-Ramirez C. Drug-Related Poisonings among Chilean Adult Population. Iran J Public Health. 2023;52(5):978-985.