Determination of Drug Resistance Pattern of Prevalent Bacteria Isolated from Patients with UTI

Abstract

Background: Urinary tract infections are the most prevalent bacterial infections in the world and using empiric antibiotic therapy may increase the drug resistance. This cross- sectional study accomplished to determine the prevalence of UTI and related antibiotic resistance pattern. Methods: UTI suspected patients referred to Yazd central laboratory studied. The urine samples cultured colonies with colony count of > 105 cfu/ml identified, and antibiotic resistance patterns determined by the standard disk diffusion method (Kirby-Bauer). Results: Out of 17353 samples 1623 (9.35%) were positive culture. The most prevalent microorganisms were as follows: E.coli (47.07%). Enterobacter (12.07%). S. aureus (10.96%), Klebsiella pneumoniae (9.85%), CNS (8.37%), group B streptococci (4.86%). Enterococci (2.09%). Pseudomonas aeruginosa (1.54%). Proteus (1.17%). Nonhemolytic streptococci (0.86%), Citrobacter and α hemolytic Streptococci (0.55%). The antibiogram results showed that isolated strains had the most drug resistance as follows: to ampicillin (80%), SXT (53.66%), tetracycline (50.33%), cephalexin (22.92%), nalidixic acid (19.4%), nitrofruntain (17.12%), ceftizoxime (8.5%) and ciprofloxacin (8%). Gram (+) cocci strains were 100% sensitive to vancomycin. Conclusion: selection of proper antibiotic against isolated species though susceptibility testing decreases the dissemination of resistant strains.