Side Effects after mRNA COVID-19 Vaccine as a Booster in Health Workers

Background: In Indonesia, around 400 health workers died due to Covid-19 between June-July 2021, therefore the health workers need to be given further immunity. Health workers were among the first to get a booster shoot. However, they may experience side effects after vaccination. We aimed to describe side effects of Moderna vaccine as a booster in health workers.

Methods: A cross sectional study was conducted on health workers who received mRNA Covid-19 vaccine booster (Moderna) at Sulianti Saroso Infectious Disease Hospital, Indonesia and had filled the questionnaire assessing side effects form. We associated the form of the questionnaire assessing side effects from the originating source of hospital immunization unit in September 2021.

Results: A total of 101 health workers who received mRNA Covid-19 vaccine booster in Jul-Aug 2021 were included. Most of health worker experienced more than 3 side effects. The side effects were sore arm (100%); chills (72%); fatigue (57%); headache (53%) and fever (51%), other symptoms (28%). The side effects mostly happened a day of receiving a booster shot (61.4%). There was no association between age, gender, comorbid to amount of side effects (P>0.05).

Conclusion: Since the public must fulfil the immunization program during pandemic, it is the responsibility of the healthcare provider to inform about the potential side effects and benefits of a new Covid-19 vaccine.

1. Ershkov SV, Rachinskaya A (2021). A new approximation of mean-time trends for the second wave of COVID-19 pandem-ic evolving in key six countries. Nonlinear Dyn, 106(2): 1433–52. doi: 10.1007/s11071-021-06244-2.
2. Hendra Permana Y, Sahadewo GA (2020). A Tale of Two Peaks: Predicting the Peak of Covid-19 Infections in Indonesia. Pre-print, doi: 10.13140/RG.2.2.29574.80966
3. Nugraha DNS, Fridiana SW, Listiani N, et al (2021). A Critical Discourse Analysis to Prevent the Second Wave of COVID-19 Pandemic in Indonesia. Rev Int Geogr Educ Online, 11(5):906–12.
4. Widianto S (2021). Indonesia considers COVID-19 booster shots for wider use -govt official. Reuters. Available from: https://www.reuters.com/business/healthcare-pharmaceuticals
5. Barda N, Dagan N, Cohen C, et al (2021). Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study. Lancet, 398(10316):2093–100.
6. Cohen DA, Greenberg P, Formanowski B, Parikh PD (2022). Are COVID-19 mRNA vaccine side effects severe enough to cause missed work? Cross-sectional study of health care-associated workers. Medicine (Baltimore), 101(7):e28839.
7. Arbel R, Hammerman A, Sergienko R, et al (2021). BNT162b2 Vaccine Booster and Mortality Due to Covid-19. N Engl J Med, 385(26):2413–20.
8. Riad A, Schünemann H, Attia S, et al (2021). Covid-19 vaccines safety tracking (Co-vast): Protocol of a multi-center prospec-tive cohort study for active surveillance of covid-19 vaccines’ side effects. Int J Envi-ron Res Public Health, 18(15): 7859.
9. Baden LR, el Sahly HM, Essink B, et al (2021). Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med, 384(5):403–16.
10. Centers for diseases control and prevention (2021). Vaccine safety. Available from: https://www.cdc.gov/vaccinesafety/ensuringsafety/sideeffects/index.html
11. Rutkowski K, Mirakian R, Till S, Rutkowski R, Wagner A (2021). Adverse reactions to COVID-19 vaccines: A practical ap-proach. Clin Exp Allergy, 51(6):770-777.
12. Idayanti N, Sutiningsih D, Hadi M, Abrori I (2021). Adverse effects Associated with Third-Booster COVID-19 Vaccine (Het-erologous Vaccines by Sinovac-Moderna) among Health Care Workers. Int J Engl Lang Lit Stud, 6(6): 250-2.
13. Ramos CL, Kelso JM (2021). Clinical Communications “COVID Arm”: Very delayed large injection site reactions to mRNA COVID-19 vaccines. J Allergy Clin Immunol Pract , 9:2480–1.
14. Annisa D (2021). Current situation of Coronavirus Disease (COVID-19) 5 Aug. 2021. Ministry of health of Indonesia. Available from: https://infeksiemerging.kemkes.go.id/laporan-harian-covid-19
15. Jacobson MA, Zakaria A, Maung Z, et al (2022). Incidence and Characteristics of Delayed Injection Site Reaction to the mRNA-1273 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine (Moderna) in a Cohort of Hos-pital Employees. Clin Infect Dis, 74(4):591-596.
16. Papadimitriou I, Bakirtzi K, Sotiriou E, Va-kirlis E, Hatzibougias D, Ioannides D (2022). Delayed localized hypersensitivity reactions to COVID-19 mRNA vaccines: a 6-month retrospective study. Clin Exp Dermatol, 47(1): 157–8.
17. Wei N, Fishman M, Wattenberg D, Gordon M, Lebwohl M (2021). “COVID arm”: A reaction to the Moderna vaccine. JAAD Case Rep, 10:92–5.
18. Suehiro M, Okubo S, Nakajima K, et al (2022). Adverse events following COVID-19 virus vaccination in Japanese young population: The first cross-sectional study conducted by a question-naire survey after the first-time-injection. Arch Clin Biomed Res, 6(1): 9-29.

Files	XML PDF (923KB)
Issue	Vol 51 No 11 (2022)
Section	Original Article(s)
DOI	https://doi.org/10.18502/ijph.v51i11.11167
Keywords
Moderna Booster vaccine Side effects Indonesia

Rights and permissions
	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Pakki T, Mariana N, Lawrensia Tampubolon M, Rusli A, Romadhona S, Intan A, Chohan Z, Dinar Widiantari A, Herlina H, Puspitasari A, Mahardika M, Suliati S, Maemun S, Murtiani F, Syahril M. Side Effects after mRNA COVID-19 Vaccine as a Booster in Health Workers. Iran J Public Health. 2022;51(11):2504-2509.

Vancouver

Download Citation