Oxidative Stress and DNA Damages Induced by Occupational Exposure to Asbestos: A Systematic Review
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Abstract
Background: Asbestos is one of the most important environmental and occupational carcinogens. Nevertheless, the mechanisms by which asbestos fiber exposure causes chronic diseases are not fully understood. We performed the first systematic review on the epidemiological evidence to examine the association between occupational exposure to asbestos and oxidative stress and DNA damage.
Methods: In this systematic review study, the PubMed and Scopus databases were searched for English-language publications. Eleven cross-sectional studies were included in the systematic review. A literature search was conducted by the main keywords including "Asbestos", "crocidolite", "chrysotile", "amphibole", "amosite", "Oxidative Stress", "DNA Damage", and "DNA injury". To evaluate the quality of studies, the "Newcastle-Ottawa Quality Assessment Scale" (NOS) was used.
Results: Overall, 1235 articles were achieved by searching in databases. Finally, by considering the inclusion, and exclusion criteria, 11 articles were conducted for this study. These studies were published between 1986 and 2020. Oxidative stress and DNA damage can occur in exposure to asbestos. Among various biomarkers, 8-OHdG is the best. The analysis of 8-oxodG in asbestos workers can help identify subjects with a higher level of genotoxic damage.
Conclusion: This systematic review suggests that oxidative stress and DNA damage are two main outputs of asbestos exposure. Therefore, oxidative stress and DNA damage biomarkers can be used for identifying subjects at higher risk of cancer. These findings support policy initiatives aimed at detecting and eliminating asbestos fiber exposure and preventing potential health hazards in occupational settings.
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2. Cheng YY, Rath EM, Linton A, Yuen ML, Takahashi K, Lee K (2020). The Current Understanding of Asbestos-Induced Ep-igenetic Changes Associated With Lung Cancer. Lung Cancer (Auckl), 11: 1-11.
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12. Norbet C, Joseph A, Rossi SS, Bhalla S, Gutierrez FR (2015). Asbestos-related lung disease: a pictorial review. Curr Probl Diagn Radiol, 44(4): 371-382.
13. Ospina D, Villegas VE, Rodríguez-Leguizamón G, Rondón-Lagos M (2019). Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos. Cancer Manag Res, 11: 4997-5012.
14. International Agency for Research on Cancer (2012). Biological agents. IARC monographs on the evaluation of carcinogenic risks to humans.
15. Afaghi A, Oryan S, Rahzani K, Abdollahi M (2015). Study on genotoxicity, oxidative stress biomarkers and clinical symptoms in workers of an asbestos-cement factory. EXCLI J, 14: 1067-1077.
16. Nagai H, Ishihara T, Lee WH, et al (2011). Asbestos surface provides a niche for oxidative modification. Cancer Sci, 102(12): 2118-2125.
17. Henderson LK, Craig JC, Willis NS, Tovey D, Webster AC (2010). How to write a Cochrane systematic review. Nephrology (Carlton), 15(6): 617-624.
18. Peterson J, Welch V, Losos M, Tugwell PJ (2011). The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa: Ottawa Hospital Research Institute, 2(1): 1-12.
19. Marczynski B, Kraus T, Rozynek P, Schlösser S, Raithel HJ, Baur X (2001). Changes in low molecular weight DNA fragmentation in white blood cells of workers highly exposed to asbestos. Int Arch Occup Environ Health, 74(5): 315-324.
20. Marczynski B, Rozynek P, Kraus T, Schlösser S, Raithel HJ, Baur X (2000). Levels of 8-hydroxy-2'-deoxyguanosine in DNA of white blood cells from workers highly exposed to asbestos in Germany. Mutat Res, 468(2): 195-202.
21. Dušinská M, Collins A, Kažimı́rová A, et al (2004). Genotoxic effects of asbestos in humans. Mutat Res, 553(1-2): 91-102.
22. Pelclova D, Fenclova Z, Kačer P, Kuzma M, Navrátil T, Lebedová J (2008). Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure. Ind Health, 46(5): 484-489.
23. Tomasetti M, Amati M, Nocchi L, et al (2011). Asbestos exposure affects poly(ADP-ribose) polymerase-1 activity: role in asbestos-induced carcinogenesis. Mutagenesis, 26(5): 585-591.
24. Cellai F, Bonassi S, Cristaudo A, et al (2020). Chromatographic Detection of 8-Hydroxy-2'-Deoxyguanosine in Leukocytes of Asbestos Exposed Workers for Assessing Past and Recent Carcinogen Exposures. Diagnostics (Basel), 10(4):239.
25. Yoshida R, Ogawa Y, Shioji I, et al (2001). Urinary 8-oxo-7, 8-dihydro-2'-deoxyguanosine and biopyrrins levels among construction workers with asbestos exposure history. Ind Health, 39(2): 186-188.
26. Kelsey KT, Christiani DC, Little JB (1986). Enhancement of benzo [a] pyrene-induced sister chromatid exchanges in lymphocytes from cigarette smokers occupationally exposed to asbestos. J Natl Cancer Inst, 77(2): 321-327.
27. Scarselli A, Marinaccio A, Corfiati M, Di Marzio D, Iavicoli S (2020). Occupational asbestos exposure after the ban: a job exposure matrix developed in Italy. Eur J Public Health, 30(5): 936-941.
28. Stayner L, Welch LS, Lemen R (2013). The worldwide pandemic of asbestos-related diseases. Annu Rev Public Health, 34: 205-216
29. Neira M (2014). Chrysotile asbestos. World Health Organization. https://www.who.int/publications/i/item/9789241564816
30. Omari Shekaftik S, Nasirzadeh N (2021). 8-Hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage induced by occupational exposure to nanomaterials: a systematic review. Nanotoxicology, 15(6): 850-864.
31. Betteridge DJ (2000). What is oxidative stress? Metabolism, 49(2 Suppl 1): 3-8.
32. Ho E, Galougahi KK, Liu CC, Bhindi R, Figtree GA (2013). Biological markers of oxidative stress: Applications to cardiovascular research and practice. Redox Biol, 1(1): 483-491.
33. Svecova V, Topinka J, Solansky I, Sram RJ (2012). Personal exposure to volatile organic compounds in the Czech Republic. J Expo Sci Environ Epidemiol, 22(5): 455-460.
34. Peluso ME, Munnia A, Giese RW, et al (2015). Oxidatively damaged DNA in the nasal epithelium of workers occupationally exposed to silica dust in Tuscany region, Italy. Mutagenesis, 30(4): 519-525.
35. Marczynski B, Kraus T, Rozynek P, et al (2000). Association between 8-hydroxy-2'-deoxyguanosine levels in DNA of workers highly exposed to asbestos and their clinical data, occupational and non-occupational confounding factors, and cancer. Mutat Res, 468(2): 203-212.
36. Ghio AJ, Churg A, Roggli VL (2004). Ferruginous bodies: implications in the mechanism of fiber and particle toxicity. Toxicol Pathol, 32(6): 643-649.
37. Bernstein D, Dunnigan J, Hesterberg T (2013). Health risk of chrysotile revisited. Crit Rev Toxicol, 43(2): 154-183.
38. Li P, Liu T, Kamp DW, et al (2015). The c-Jun N-terminal kinase signaling pathway mediates chrysotile asbestos-induced alveolar epithelial cell apoptosis. Mol Med Rep, 11(5): 3626-3634.
2. Cheng YY, Rath EM, Linton A, Yuen ML, Takahashi K, Lee K (2020). The Current Understanding of Asbestos-Induced Ep-igenetic Changes Associated With Lung Cancer. Lung Cancer (Auckl), 11: 1-11.
3. Bonassi S, Cellai F, Munnia A, et al (2017). 3-(2-deoxy-β-d-erythro-pentafuranosyl) pyrimido [1, 2-α] purin-10 (3H)-one de-oxyguanosine adducts of workers ex-posed to asbestos fibers. Toxicol Lett, 270: 1-7.
4. Panou V, Røe OD (2020). Inherited Genet-ic Mutations and Polymorphisms in Ma-lignant Mesothelioma: A Comprehen-sive Review. Int J Mol Sci, 21(12):4327.
5. Takahashi K, Landrigan PJ, Ramazzini C (2016). The Global Health Dimensions of Asbestos and Asbestos-Related Diseases. Ann Glob Health, 82(1): 209-213.
6. International Agency for Research on Cancer (2012). Asbestos (chrysotile, amosite, crocidolite, tremolite, actino-lite, and anthophyllite). IARC mono-graphs on the evaluation of carcinogen-ic risks to humans. A review of human carcinogens; part C: arsenic, metals, fi-bres, and dusts. 219-309.
7. Marini V, Michelazzi L, Cioé A, Fucile C, Spigno F, Robbiano L (2011). Exposure to asbestos: correlation between blood levels of mesothelin and frequency of micronuclei in peripheral blood lym-phocytes. Mutat Res, 721(1): 114-117.
8. Pang CC, Phan K, Karim MN, Afroz A, Winter M, Glass DC (2021). Occupational Asbestos Exposure and Kidney Cancer: Systematic Review and Meta-analysis of Cohort Studies. Ann Work Expo Health, 65(3): 255-265.
9. Landrigan PJ, Lemen RA (2018). Asbestos related diseases in the united states: historical trends and current situation. Occup Environ Med, 75(Suppl 2):A1–A650.
10. Ruff K (2017). How Canada Changed from Exporting Asbestos to Banning Asbestos: The Challenges That Had to Be Overcome. Int J Environ Res Public Health, 14(10):1135.
11. Hashim D, Boffetta P (2014). Occupational and environmental exposures and cancers in developing countries. Ann Glob Health, 80(5): 393-411.
12. Norbet C, Joseph A, Rossi SS, Bhalla S, Gutierrez FR (2015). Asbestos-related lung disease: a pictorial review. Curr Probl Diagn Radiol, 44(4): 371-382.
13. Ospina D, Villegas VE, Rodríguez-Leguizamón G, Rondón-Lagos M (2019). Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos. Cancer Manag Res, 11: 4997-5012.
14. International Agency for Research on Cancer (2012). Biological agents. IARC monographs on the evaluation of carcinogenic risks to humans.
15. Afaghi A, Oryan S, Rahzani K, Abdollahi M (2015). Study on genotoxicity, oxidative stress biomarkers and clinical symptoms in workers of an asbestos-cement factory. EXCLI J, 14: 1067-1077.
16. Nagai H, Ishihara T, Lee WH, et al (2011). Asbestos surface provides a niche for oxidative modification. Cancer Sci, 102(12): 2118-2125.
17. Henderson LK, Craig JC, Willis NS, Tovey D, Webster AC (2010). How to write a Cochrane systematic review. Nephrology (Carlton), 15(6): 617-624.
18. Peterson J, Welch V, Losos M, Tugwell PJ (2011). The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa: Ottawa Hospital Research Institute, 2(1): 1-12.
19. Marczynski B, Kraus T, Rozynek P, Schlösser S, Raithel HJ, Baur X (2001). Changes in low molecular weight DNA fragmentation in white blood cells of workers highly exposed to asbestos. Int Arch Occup Environ Health, 74(5): 315-324.
20. Marczynski B, Rozynek P, Kraus T, Schlösser S, Raithel HJ, Baur X (2000). Levels of 8-hydroxy-2'-deoxyguanosine in DNA of white blood cells from workers highly exposed to asbestos in Germany. Mutat Res, 468(2): 195-202.
21. Dušinská M, Collins A, Kažimı́rová A, et al (2004). Genotoxic effects of asbestos in humans. Mutat Res, 553(1-2): 91-102.
22. Pelclova D, Fenclova Z, Kačer P, Kuzma M, Navrátil T, Lebedová J (2008). Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure. Ind Health, 46(5): 484-489.
23. Tomasetti M, Amati M, Nocchi L, et al (2011). Asbestos exposure affects poly(ADP-ribose) polymerase-1 activity: role in asbestos-induced carcinogenesis. Mutagenesis, 26(5): 585-591.
24. Cellai F, Bonassi S, Cristaudo A, et al (2020). Chromatographic Detection of 8-Hydroxy-2'-Deoxyguanosine in Leukocytes of Asbestos Exposed Workers for Assessing Past and Recent Carcinogen Exposures. Diagnostics (Basel), 10(4):239.
25. Yoshida R, Ogawa Y, Shioji I, et al (2001). Urinary 8-oxo-7, 8-dihydro-2'-deoxyguanosine and biopyrrins levels among construction workers with asbestos exposure history. Ind Health, 39(2): 186-188.
26. Kelsey KT, Christiani DC, Little JB (1986). Enhancement of benzo [a] pyrene-induced sister chromatid exchanges in lymphocytes from cigarette smokers occupationally exposed to asbestos. J Natl Cancer Inst, 77(2): 321-327.
27. Scarselli A, Marinaccio A, Corfiati M, Di Marzio D, Iavicoli S (2020). Occupational asbestos exposure after the ban: a job exposure matrix developed in Italy. Eur J Public Health, 30(5): 936-941.
28. Stayner L, Welch LS, Lemen R (2013). The worldwide pandemic of asbestos-related diseases. Annu Rev Public Health, 34: 205-216
29. Neira M (2014). Chrysotile asbestos. World Health Organization. https://www.who.int/publications/i/item/9789241564816
30. Omari Shekaftik S, Nasirzadeh N (2021). 8-Hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage induced by occupational exposure to nanomaterials: a systematic review. Nanotoxicology, 15(6): 850-864.
31. Betteridge DJ (2000). What is oxidative stress? Metabolism, 49(2 Suppl 1): 3-8.
32. Ho E, Galougahi KK, Liu CC, Bhindi R, Figtree GA (2013). Biological markers of oxidative stress: Applications to cardiovascular research and practice. Redox Biol, 1(1): 483-491.
33. Svecova V, Topinka J, Solansky I, Sram RJ (2012). Personal exposure to volatile organic compounds in the Czech Republic. J Expo Sci Environ Epidemiol, 22(5): 455-460.
34. Peluso ME, Munnia A, Giese RW, et al (2015). Oxidatively damaged DNA in the nasal epithelium of workers occupationally exposed to silica dust in Tuscany region, Italy. Mutagenesis, 30(4): 519-525.
35. Marczynski B, Kraus T, Rozynek P, et al (2000). Association between 8-hydroxy-2'-deoxyguanosine levels in DNA of workers highly exposed to asbestos and their clinical data, occupational and non-occupational confounding factors, and cancer. Mutat Res, 468(2): 203-212.
36. Ghio AJ, Churg A, Roggli VL (2004). Ferruginous bodies: implications in the mechanism of fiber and particle toxicity. Toxicol Pathol, 32(6): 643-649.
37. Bernstein D, Dunnigan J, Hesterberg T (2013). Health risk of chrysotile revisited. Crit Rev Toxicol, 43(2): 154-183.
38. Li P, Liu T, Kamp DW, et al (2015). The c-Jun N-terminal kinase signaling pathway mediates chrysotile asbestos-induced alveolar epithelial cell apoptosis. Mol Med Rep, 11(5): 3626-3634.
| Files | ||
| Issue | Vol 52 No 8 (2023) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v52i8.13400 | |
| Keywords | ||
| Systematic review Occupational exposure Oxidative stress DNA damage | ||
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How to Cite
1.
Seyed Someah M, Golbabaei F, Arjomandi R, Babaei Semiromi F, Mohammadi A. Oxidative Stress and DNA Damages Induced by Occupational Exposure to Asbestos: A Systematic Review. Iran J Public Health. 2023;52(8):1613-1625.
