Original Article

Dietary Factors and the Risk of Gastric Cancer in Hanzhong Area of China

Abstract

Background: Dietary factors play an important role in gastric cancer risk. They have not been investigated extensively in Hanzhong area, China.

Methods: We conducted a population-based case-control study of gastric cancer in Hanzhong area, China in 2018-2020. A total of 121 patients with historically confirmed gastric adenocarcinomas were interviewed. Controls were an age-stratified random sample of residents of Hanzhong area. The dietary questionnaire was a 70-item semiquantitative food frequency adapted for the Hanzhong diet. Odds ratios were calculated for quartiles of consumption of food groups and were adjusted for age, gender, calories, chili pepper intake, cigarette smoking, socioeconomic status, added salt, and history of peptic ulcer disease.

Results: There was approximately a threefold increased risk of gastric cancer for frequent consumption (highest quartile) of both fresh meat (odds ratio (OR) = 3.0) and processed meat (OR = 3.3). Odds ratios were also significantly elevated for frequent consumption of dairy products (OR = 3.1) and fish (OR = 3.1). The authors observed a decreasing gradient of risk with increasing frequency of vegetable consumption due to a significant inverse trend for the yellow and orange vegetables.

Conclusion: High intake of citrus fruits showed a slight inverse association. These findings are consistent with many studies around the world that indicate important roles for salt, processed meats, and vegetable consumption in gastric cancer risk.

1. Chen W, Zheng R, Baade P D, et al (2016). Cancer statistics in China, 2015. CA Can-cer J Clin, 66(2): 115-132.
2. Ferreira R M, Pereira-Marques J, Pinto-Ribeiro I, et al (2018). Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota. Gut, 67(2): 226-236.
3. Kamangar F, Dores GM, Anderson WF (2006). Patterns of cancer incidence, mor-tality, and prevalence across five conti-nents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 24(14): 2137-2150.
4. Gonzalez C A, Lopez-Carrillo L (2010). Heli-cobacter pylori, nutrition and smoking inter-actions: their impact in gastric carcino-genesis. Scand J Gastroenterol, 45(1): 6-14.
5. Wang X, Terry P, Yan H (2008). Stomach cancer in 67 Chinese counties: evidence of interaction between salt consumption and helicobacter pylori infection. Asia Pac J Clin Nutr, 17(4): 644-650.
6. Nouraie M, Pietinen P, Kamangar F, et al (2005). Fruits, vegetables, and antioxi-dants and risk of gastric cancer among male smokers. Cancer Epidemiol Biomarkers Prev, 14(9): 2087-2092.
7. Brenner H, Rothenbacher D, Arndt V (2009). Epidemiology of stomach cancer. Methods Mol Biol, 472: 467-477.
8. Lewandowska A M, Rudzki M, Rudzki S, et al (2019). Environmental risk factors for cancer - review paper. Ann Agric Environ Med, 26(1): 1-7.
9. Ferro A, Morais S, Pelucchi C, et al (2019). Smoking and Helicobacter pylori infection: an individual participant pooled analysis (Stomach Cancer Pooling- StoP Project). Eur J Cancer Prev, 28(5): 390-396.
10. Vanamala J (2017). Food systems approach to cancer prevention. Crit Rev Food Sci Nutr, 57(12): 2573-2588.
11. Venerito M, Link A, Rokkas T, et al (2016). Gastric cancer - clinical and epidemiolog-ical aspects. Helicobacter, 21 Suppl 1: 39-44.
12. Kim S R, Kim K, Lee S A, et al (2019). Ef-fect of Red, Processed, and White Meat Consumption on the Risk of Gastric Cancer: An Overall and Dose(-)Response Meta-Analysis. Nutrients, 11(4):826.
13. Balakrishnan M, George R, Sharma A, et al (2017). Changing Trends in Stomach Cancer throughout the World. Curr Gas-troenterol Rep, 19(8): 36.
14. Fang X, Wei J, He X, et al (2015). Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospec-tive cohort studies. Eur J Cancer, 51(18): 2820-2832.
15. Yoo J Y, Cho H J, Moon S, et al (2020). Pickled Vegetable and Salted Fish Intake and the Risk of Gastric Cancer: Two Prospective Cohort Studies and a Meta-Analysis. Cancers (Basel), 12(4):996.
16. Wu S, Liang J, Zhang L, et al (2011). Fish consumption and the risk of gastric can-cer: systematic review and meta-analysis. BMC Cancer, 11: 26.
17. Thorning T K, Raben A, Tholstrup T, et al (2016). Milk and dairy products: good or bad for human health? An assessment of the totality of scientific evidence. Food Nutr Res, 60: 32527.
18. Wang S, Zhou M, Ji A, et al (2018). Milk/dairy products consumption and gastric cancer: an update meta-analysis of epidemiological studies. Oncotarget, 9(6): 7126-7135.
19. Castello A, Amiano P, Fernandez D L N, et al (2019). Low adherence to the western and high adherence to the mediterranean dietary patterns could prevent colorectal cancer. Eur J Nutr, 58(4): 1495-1505.
20. Venerito M, Link A, Rokkas T, et al (2016). Gastric cancer - clinical and epidemiolog-ical aspects. Helicobacter, 21 Suppl 1: 39-44.
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IssueVol 51 No 8 (2022) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijph.v51i8.10263
Keywords
Dietary Gastric cancer China
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Wang C, He S, Jin W, Zheng L, Jin R, Feng S, Zhou Y, Tang H, Liu H, Si Y. Dietary Factors and the Risk of Gastric Cancer in Hanzhong Area of China. Iran J Public Health. 2022;51(8):1790-1797.