The Association between Four Common Polymorphisms in microRNA and Risk of Hepatocellular Carcinoma: An Updated Meta-Analysis
-
Mingxing Chen
,
Yu Lu
,
Xinyang Wang
,
Simeng Qin
,
Huaping Chen
,
Liuyi Lu
,
Xue Qin
Abstract
Background: Many epidemiological studies have explored the relationship between single-nucleotide polymorphism and hepatocellular carcinoma (HCC). However, the results remain controversial. We performed a large-scale meta-analysis to draw a more precise estimation of the aforementioned association.
Methods: Studies on the association between microRNA (MIR) polymorphisms and HCC risk that had been published up to Sep 30, 2021 were identified by searching the PubMed, Cochrane Library, Google Scholar, Web of Science, and Chinese Biomedical Literature electronic databases and the Excerpta Medical Database. The association between MIR polymorphisms and HCC risk was assessed using odds ratios (ORs) and their 95% confidence intervals (CIs).
Results: Overall, 29 studies, with a total of 9,263 cases and 10,875 controls, were included in our meta-analysis. MicroRNA149 (MIR149) significantly decreased the risk of developing HCC on the overall population (homozygous model CC vs. TT: OR = 0.703, 95% CI = 0.549-0.899, P = 0.005), and microRNA 196 (MIR196) significantly decreased the risk of developing HCC on the overall population (recessive model TT vs. CT+CC: OR = 0.864, 95% CI = 0.751-0.993, P = 0.04) and on Caucasians (OR = 0.613, 95% CI = 0.414-0.907, P = 0.014).
Conclusion: The MIR149 and MIR196 polymorphisms are the protect factors of developing HCC. The conduct of multi-center and multi-region studies with gene-gene, gene-environment should be considered.
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11. Hao Y, Wang J, Zhao L (2015). The effect and mechanism of miR196a in HepG2 cell. Biomed Pharmacother, 72:1-5.
12. Dong J, Teng F, Guo W, et al (2018). lncRNA SNHG8 Promotes the Tumorigenesis and Metastasis by Sponging miR-149-5p and Predicts Tumor Recurrence in Hepatocellular Carcinoma. Cell Physiol Biochem, 51:2262-2274.
13. Liu Z, Qin Q, Wu C, et al (2018). Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun, 9:2789.
14. Lu Y, Hippen KL, Lemire AL, et al (2016). miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency. Blood, 128:1424-35.
15. Farokhizadeh Z, Dehbidi S, Geramizadeh B, et al (2019). Association of MicroRNA Polymorphisms With Hepatocellular Carcinoma in an Iranian Population. Ann Lab Med, 39:58-66.
16. Kim WH, Min KT, Jeon YJ, et al (2012). Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population. Gene, 504:92-7.
17. Shan YF, Huang YH, Chen ZK, et al (2013). miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population. Genet Mol Res, 12:5365-71.
18. Xiang Y, Fan S, Cao J, et al (2012). Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population. Mol Biol Rep, 39:7019-23.
19. Xu T, Zhu Y, Wei QK, et al (2008). A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis, 29:2126-31.
20. Fteah AM, Ahmed AI, Mosaad NA, et al (2019). Association of MicroRNA 196a and 499 Polymorphisms with Development of Cirrhosis and Hepatocellular Carcinoma Post-HCV Infection in Egyptian Patients. Asian Pac J Cancer Prev, 20:3479-3485.
21. Qi P, Dou TH, Geng L, et al (2010). Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection. Hum Immunol, 71:621-6.
22. Yan P, Xia M, Gao F, et al (2015). Predictive role of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) in the development of hepatocellular carcinoma. Int J Clin Exp Pathol, 8:15177-83.
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25. Chen ZY, Chen X, Wang ZX (2016). The role of microRNA-196a in tumorigenesis, tumor progression, and prognosis. Tumour Biol, doi: 10.1007/s13277-016-5430-2.
26. Kim HY, Yoon JH, Lee HS, et al (2014). MicroRNA-196A-2 polymorphisms and hepatocellular carcinoma in patients with chronic hepatitis B. J Med Virol, 86:446-53.
27. Parlayan C, Ikeda S, Sato N, et al (2014). Association analysis of single nucleotide polymorphisms in miR-146a and miR-196a2 on the prevalence of cancer in elderly Japanese: a case-control study. Asian Pac J Cancer Prev, 15:2101-7.
28. Al-Qahtani AA, Al-Anazi MR, Nazir N,et al (2017). Association of single nucleotide polymorphisms in microRNAs with susceptibility to hepatitis B virus infection and HBV-related liver complications: A study in a Saudi Arabian population. J Viral Hepat, 24:1132-1142.
29. Xu X, Ling Q, Wang J, et al (2016). Donor miR-196a-2 polymorphism is associated with hepatocellular carcinoma recurrence after liver transplantation in a Han Chinese population. Int J Cancer, 138:620-9.
30. Zhu X, Hou R, Ma A, Yang S, Pan X (2018). Associations of miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms with Ischemic Stroke in the Northern Chinese Han Population. Med Sci Monit, 24:7366-7374.
31. Khanizadeh S, Hasanvand B, Nikoo HR, et al (2019). Association between miRNA-146a rs2910164 (G/C) polymorphism with the susceptibility to chronic HBV infection and spontaneous viral clearance in an Iranian population. J Med Virol, 91:1063-1068.
32. Akkiz H, Bayram S, Bekar A, et al (2011). A functional polymorphism in pre-microRNA-196a-2 contributes to the susceptibility of hepatocellular carcinoma in a Turkish population: a case-control study. J Viral Hepat, 18:e399-407.
33. Akkiz H, Bayram S, Bekar A, et al (2011). Genetic variation in the microRNA-499 gene and hepatocellular carcinoma risk in a Turkish population: lack of any association in a case-control study. Asian Pac J Cancer Prev, 12:3107-12.
34. Akkiz H, Bayram S, Bekar A, et al (2011). No association of pre-microRNA-146a rs2910164 polymorphism and risk of hepatocellular carcinoma development in Turkish population: a case-control study. Gene, 486:104-9.
35. Chu YH, Hsieh MJ, Chiou HL, et al (2014). MicroRNA gene polymorphisms and environmental factors increase patient susceptibility to hepatocellular carcinoma. PLoS One, 9:e89930.
36. Han Y, Pu R, Han X, et al (2013). Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk. PLoS One, 8:e58564.
37. Li D, Peng JJ, Tan Y, et al (2015). Genetic variations in microRNA genes and susceptibility to hepatocellular carcinoma. Genet Mol Res, 14:1926-31.
38. Li J, Cheng G, Wang S (2016). A Single-Nucleotide Polymorphism of miR-196a2T>C rs11614913 Is Associated with Hepatocellular Carcinoma in the Chinese Population. Genet Test Mol Biomarkers, 20:213-5.
39. Li X, Li K, Wu Z (2015). Association of four common SNPs in microRNA polymorphisms with the risk of hepatocellular carcinoma. Int J Clin Exp Pathol, 8:9560-6.
40. Li XD, Li ZG, Song XX, Liu CF (2010). A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis. Pathology, 42:669-73.
41. Ma Y, Wang R, Zhang J, et al (2014). Identification of miR-423 and miR-499 polymorphisms on affecting the risk of hepatocellular carcinoma in a large-scale population. Genet Test Mol Biomarkers, 18:516-24.
42. Qi JH, Wang J, Chen J, et al (2014). High-resolution melting analysis reveals genetic polymorphisms in microRNAs confer hepatocellular carcinoma risk in Chinese patients. BMC Cancer, 14:643.
43. Riazalhosseini B, Mohamed Z, Apalasamy YD, et al (2016). Association between microRNA-196A2 and microRNA-146A polymorphisms and progression to cirrhosis and hepatocellular carcinoma in patients with viral hepatitis B. Pharmacogenet Genomics, 26:74-9.
44. Toraih EA, Fawzy MS, Elgazzaz MG, et al (2016). Combined Genotype Analyses of Precursor miRNA196a2 and 499a Variants With Hepatic and Renal Cancer Susceptibility a Preliminary Study. Asian Pac J Cancer Prev, 17:3369-3375.
45. Wang XH, Wang FR, Tang YF, et al (2014). Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population. Genet Mol Res, 13:5048-54.
46. Zhang J, Wang R, Ma YY, et al (2013). Association between single nucleotide polymorphisms in miRNA196a-2 and miRNA146a and susceptibility to hepatocellular carcinoma in a Chinese population. Asian Pac J Cancer Prev, 14:6427-31.
47. Zhang LH, Hao BB, Zhang CY, et al (2016). Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma. Genet Mol Res, 15: 10.4238/gmr.15038582.
48. Zhang S, Chen L, Wang Y, et al (2020). Investigation of the Association of miRNA-499, miRNA-146a, miRNA-196a2 Loci with Hepatocellular Carcinoma Risk: A Case-Control Study Involving 1507 Subjects. DNA Cell Biol, 39:379-388.
49. Zhou B, Dong LP, Jing XY, et al (2014). Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population. Tumour Biol, 35:7775-80.
50. Zhou J, Lv R, Song X, et al (2012). Association between two genetic variants in miRNA and primary liver cancer risk in the Chinese population. DNA Cell Biol, 31:524-30.
51. Zou HZ, Zhao YQ (2013). Positive association between miR-499A>G and hepatocellular carcinoma risk in a Chinese population. Asian Pac J Cancer Prev, 14:1769-72.
52. Zhang XW, Pan SD, Feng YL, et al (2011). [Relationship between genetic polymorphism in microRNAs precursor and genetic predisposition of hepatocellular carcinoma]. Zhonghua Yu Fang Yi Xue Za Zhi, 45:239-43.
53. Zheng L, Zhuang C, Zhao J, Ming L (2017). Functional miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms and the susceptibility to hepatocellular carcinoma: An updated meta-analysis. Clin Res Hepatol Gastroenterol, 41:664-676.
54. Dong S, Miao AY, Lei W, et al (2017). miR-146a rs2910164 and hepatocellular carcinoma: a meta-analysis. Minerva Med, 108:287-292.
55. Tian T, Wang M, Zhu W, et al (2017). MiR-146a and miR-196a-2 polymorphisms are associated with hepatitis virus-related hepatocellular cancer risk: a meta-analysis. Aging (Albany NY), 9:381-392.
2. Chen W, Zheng R, Baade PD, et al (2016). Cancer statistics in China, 2015. CA Cancer J Clin, 66:115-32.
3. Singal AG, El-Serag HB (2015). Hepatocellular Carcinoma From Epidemiology to Prevention: Translating Knowledge into Practice. Clin Gastroenterol Hepatol, 13:2140-2151.
4. El-Serag HB (2011). CURRENT CONCEPTS Hepatocellular Carcinoma. N Engl J Med, 365:1118-1127.
5. Dyson J, Jaques B, Chattopadyhay D, et al (2014). Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team. J Hepatol, 60:110-117.
6. Asrani SK, Devarbhavi H, Eaton J, Kamath PS (2019). Burden of liver diseases in the world. J Hepatol, 70:151-171.
7. Tam WL, Weinberg RA (2013). The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med, 19:1438-49.
8. Saliminejad K, Khorram Khorshid HR, Soleymani Fard S, Ghaffari SH (2019). An overview of microRNAs: Biology, functions, therapeutics, and analysis methods. J Cell Physiol, 234:5451-5465.
9. Iorio MV, Croce CM (2017). MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med, 9:852.
10. Dhanasekaran R, Bandoh S, Roberts LR (2016). Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances. F1000Res, 5:F1000 Faculty Rev-879.
11. Hao Y, Wang J, Zhao L (2015). The effect and mechanism of miR196a in HepG2 cell. Biomed Pharmacother, 72:1-5.
12. Dong J, Teng F, Guo W, et al (2018). lncRNA SNHG8 Promotes the Tumorigenesis and Metastasis by Sponging miR-149-5p and Predicts Tumor Recurrence in Hepatocellular Carcinoma. Cell Physiol Biochem, 51:2262-2274.
13. Liu Z, Qin Q, Wu C, et al (2018). Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun, 9:2789.
14. Lu Y, Hippen KL, Lemire AL, et al (2016). miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency. Blood, 128:1424-35.
15. Farokhizadeh Z, Dehbidi S, Geramizadeh B, et al (2019). Association of MicroRNA Polymorphisms With Hepatocellular Carcinoma in an Iranian Population. Ann Lab Med, 39:58-66.
16. Kim WH, Min KT, Jeon YJ, et al (2012). Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population. Gene, 504:92-7.
17. Shan YF, Huang YH, Chen ZK, et al (2013). miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population. Genet Mol Res, 12:5365-71.
18. Xiang Y, Fan S, Cao J, et al (2012). Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population. Mol Biol Rep, 39:7019-23.
19. Xu T, Zhu Y, Wei QK, et al (2008). A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis, 29:2126-31.
20. Fteah AM, Ahmed AI, Mosaad NA, et al (2019). Association of MicroRNA 196a and 499 Polymorphisms with Development of Cirrhosis and Hepatocellular Carcinoma Post-HCV Infection in Egyptian Patients. Asian Pac J Cancer Prev, 20:3479-3485.
21. Qi P, Dou TH, Geng L, et al (2010). Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection. Hum Immunol, 71:621-6.
22. Yan P, Xia M, Gao F, et al (2015). Predictive role of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) in the development of hepatocellular carcinoma. Int J Clin Exp Pathol, 8:15177-83.
23. Page MJ, McKenzie JE, Bossuyt PM, et al (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372:n71.
24. Wells G, Shea B, O'Connell J (2014). The Newcastle-Ottawa Scale (NOS) for Assessing The Quality of Nonrandomised Studies in Meta-analyses. Ottawa Health Research Institute Web site, 7.
25. Chen ZY, Chen X, Wang ZX (2016). The role of microRNA-196a in tumorigenesis, tumor progression, and prognosis. Tumour Biol, doi: 10.1007/s13277-016-5430-2.
26. Kim HY, Yoon JH, Lee HS, et al (2014). MicroRNA-196A-2 polymorphisms and hepatocellular carcinoma in patients with chronic hepatitis B. J Med Virol, 86:446-53.
27. Parlayan C, Ikeda S, Sato N, et al (2014). Association analysis of single nucleotide polymorphisms in miR-146a and miR-196a2 on the prevalence of cancer in elderly Japanese: a case-control study. Asian Pac J Cancer Prev, 15:2101-7.
28. Al-Qahtani AA, Al-Anazi MR, Nazir N,et al (2017). Association of single nucleotide polymorphisms in microRNAs with susceptibility to hepatitis B virus infection and HBV-related liver complications: A study in a Saudi Arabian population. J Viral Hepat, 24:1132-1142.
29. Xu X, Ling Q, Wang J, et al (2016). Donor miR-196a-2 polymorphism is associated with hepatocellular carcinoma recurrence after liver transplantation in a Han Chinese population. Int J Cancer, 138:620-9.
30. Zhu X, Hou R, Ma A, Yang S, Pan X (2018). Associations of miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms with Ischemic Stroke in the Northern Chinese Han Population. Med Sci Monit, 24:7366-7374.
31. Khanizadeh S, Hasanvand B, Nikoo HR, et al (2019). Association between miRNA-146a rs2910164 (G/C) polymorphism with the susceptibility to chronic HBV infection and spontaneous viral clearance in an Iranian population. J Med Virol, 91:1063-1068.
32. Akkiz H, Bayram S, Bekar A, et al (2011). A functional polymorphism in pre-microRNA-196a-2 contributes to the susceptibility of hepatocellular carcinoma in a Turkish population: a case-control study. J Viral Hepat, 18:e399-407.
33. Akkiz H, Bayram S, Bekar A, et al (2011). Genetic variation in the microRNA-499 gene and hepatocellular carcinoma risk in a Turkish population: lack of any association in a case-control study. Asian Pac J Cancer Prev, 12:3107-12.
34. Akkiz H, Bayram S, Bekar A, et al (2011). No association of pre-microRNA-146a rs2910164 polymorphism and risk of hepatocellular carcinoma development in Turkish population: a case-control study. Gene, 486:104-9.
35. Chu YH, Hsieh MJ, Chiou HL, et al (2014). MicroRNA gene polymorphisms and environmental factors increase patient susceptibility to hepatocellular carcinoma. PLoS One, 9:e89930.
36. Han Y, Pu R, Han X, et al (2013). Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk. PLoS One, 8:e58564.
37. Li D, Peng JJ, Tan Y, et al (2015). Genetic variations in microRNA genes and susceptibility to hepatocellular carcinoma. Genet Mol Res, 14:1926-31.
38. Li J, Cheng G, Wang S (2016). A Single-Nucleotide Polymorphism of miR-196a2T>C rs11614913 Is Associated with Hepatocellular Carcinoma in the Chinese Population. Genet Test Mol Biomarkers, 20:213-5.
39. Li X, Li K, Wu Z (2015). Association of four common SNPs in microRNA polymorphisms with the risk of hepatocellular carcinoma. Int J Clin Exp Pathol, 8:9560-6.
40. Li XD, Li ZG, Song XX, Liu CF (2010). A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis. Pathology, 42:669-73.
41. Ma Y, Wang R, Zhang J, et al (2014). Identification of miR-423 and miR-499 polymorphisms on affecting the risk of hepatocellular carcinoma in a large-scale population. Genet Test Mol Biomarkers, 18:516-24.
42. Qi JH, Wang J, Chen J, et al (2014). High-resolution melting analysis reveals genetic polymorphisms in microRNAs confer hepatocellular carcinoma risk in Chinese patients. BMC Cancer, 14:643.
43. Riazalhosseini B, Mohamed Z, Apalasamy YD, et al (2016). Association between microRNA-196A2 and microRNA-146A polymorphisms and progression to cirrhosis and hepatocellular carcinoma in patients with viral hepatitis B. Pharmacogenet Genomics, 26:74-9.
44. Toraih EA, Fawzy MS, Elgazzaz MG, et al (2016). Combined Genotype Analyses of Precursor miRNA196a2 and 499a Variants With Hepatic and Renal Cancer Susceptibility a Preliminary Study. Asian Pac J Cancer Prev, 17:3369-3375.
45. Wang XH, Wang FR, Tang YF, et al (2014). Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population. Genet Mol Res, 13:5048-54.
46. Zhang J, Wang R, Ma YY, et al (2013). Association between single nucleotide polymorphisms in miRNA196a-2 and miRNA146a and susceptibility to hepatocellular carcinoma in a Chinese population. Asian Pac J Cancer Prev, 14:6427-31.
47. Zhang LH, Hao BB, Zhang CY, et al (2016). Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma. Genet Mol Res, 15: 10.4238/gmr.15038582.
48. Zhang S, Chen L, Wang Y, et al (2020). Investigation of the Association of miRNA-499, miRNA-146a, miRNA-196a2 Loci with Hepatocellular Carcinoma Risk: A Case-Control Study Involving 1507 Subjects. DNA Cell Biol, 39:379-388.
49. Zhou B, Dong LP, Jing XY, et al (2014). Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population. Tumour Biol, 35:7775-80.
50. Zhou J, Lv R, Song X, et al (2012). Association between two genetic variants in miRNA and primary liver cancer risk in the Chinese population. DNA Cell Biol, 31:524-30.
51. Zou HZ, Zhao YQ (2013). Positive association between miR-499A>G and hepatocellular carcinoma risk in a Chinese population. Asian Pac J Cancer Prev, 14:1769-72.
52. Zhang XW, Pan SD, Feng YL, et al (2011). [Relationship between genetic polymorphism in microRNAs precursor and genetic predisposition of hepatocellular carcinoma]. Zhonghua Yu Fang Yi Xue Za Zhi, 45:239-43.
53. Zheng L, Zhuang C, Zhao J, Ming L (2017). Functional miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms and the susceptibility to hepatocellular carcinoma: An updated meta-analysis. Clin Res Hepatol Gastroenterol, 41:664-676.
54. Dong S, Miao AY, Lei W, et al (2017). miR-146a rs2910164 and hepatocellular carcinoma: a meta-analysis. Minerva Med, 108:287-292.
55. Tian T, Wang M, Zhu W, et al (2017). MiR-146a and miR-196a-2 polymorphisms are associated with hepatitis virus-related hepatocellular cancer risk: a meta-analysis. Aging (Albany NY), 9:381-392.
| Files | ||
| Issue | Vol 52 No 11 (2023) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v52i11.14027 | |
| Keywords | ||
| Hepatocellular carcinoma MicroRNA Polymorphism Susceptibility Meta-analysis | ||
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How to Cite
1.
Chen M, Lu Y, Wang X, Qin S, Chen H, Lu L, Qin X. The Association between Four Common Polymorphisms in microRNA and Risk of Hepatocellular Carcinoma: An Updated Meta-Analysis. Iran J Public Health. 2023;52(11):2272-2285.
