Prevalence and Distribution of Osteopenia in Chinese Population: A System Review and Meta-Analysis
-
Yanpeng Wang
,
Yinzhen Zhang
,
Lanbo Zhao
,
Guochen Wang
,
Chengan Yang
,
Changwei Zhao
,
Wenhai Zhao
Abstract
Background: The number of patients with osteoporosis ranks first in the world in China and as a precursor state of osteoporosis, the number and incidence of osteopenia are much higher than that of osteoporosis. This meta-analysis was conducted to evaluate the incidence and distribution of osteopenia in adults in mainland of China over 10 years to provides reference for the early prevention of osteoporosis and policymaking.
Methods: Relevant data were extracted from the databases including CNKI, Wanfang, VIP, Web of Science, PubMed, EMBASE, and Medline about the surveys on osteoporosis and bone loss from 2010 to 2021 by searching. The random effects model was adopted for Meta-analysis, and the funnel plot was used to test publication bias.
Results: Forty-seven literatures were included in this study, covering 27 provinces and 38 regions in the mainland of China, with the study of 135,688 cases, showing that the prevalence of osteopenia in adults in the past decade was 28.3%(95% CI 24-33%), aged 40~60 yr old , reaching the highest level. The incidence of osteopenia in males was higher than that in females (P<0.05), without significant difference in south and north China.
Conclusion: There is a large population with osteopenia in China, especially middle-aged population, both men and women should pay attention to osteopenia to delay its further progression.
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29. Huiwen C, Jinyong C, Guohua Z, et al (2011).A cross-sectional survey of bone mass and a analysis of risk factors for osteoporosis in 4000 healthy adults in Shaoyang region of Hunan Province. Chin J Osteoporosis,17(12):1087-91.
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50. Yongqin Z. Research on the related influ-encing factors of bone mineral density of adults in some urban areas of Taiyuan [MD thesis].Shanxi Medical Universi-ty,2017.
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55. Veiga SA, Da RM, Fernandes B, et al (2015).Factors associated with osteopenia and osteoporosis in women undergoing bone mineral density test. Rev Bras Reu-matol,55(3):223-8.
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59. Bonnick SL (2006). Osteoporosis in men and women. Clin Cornerstone,8(1):28-39.
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61. Chen JH, Chen YC, Tsai MK, et al (2017). Predicting the risk of osteopenia for women aged 40-55 years. J Formos Med Assoc,116(11):888-896.
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63. Zeng Q, Li N, Wang Q, et al (2019). The Prevalence of Osteoporosis in China, a Nationwide, Multicenter DXA Survey. J Bone Miner Res,34(10):1789-1797.
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2. 2. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy 2001).Osteoporosis preven-tion, diagnosis, and therapy. JAMA, 285(6):785-95.
3. Hernlund E, Svedbom A, Ivergard M, et al (2013).Osteoporosis in the European Union: medical management, epidemiol-ogy and economic burden. A report pre-pared in collaboration with the Interna-tional Osteoporosis Foundation (IOF) and the European Federation of Pharma-ceutical Industry Associations (EFPIA). Arch Osteoporos, 8(1):136.
4. Khambalia AZ, Seen LS (2010).Trends in overweight and obese adults in Malaysia (1996-2009): a systematic review. Obes Rev,11(6):403-12.
5. Meiling L, Hongzhuan T, Quan Z, et al (2013). Realizing the Meta-Analysis of Single Rate in R Software. J Evidence-Based Med,13(03):181-4.
6. Caihua P, Qiaoyun T, Weifeng L, et al (2011).Bone mineral density measurement and clinical analysis of osteoporosis prevalence in 1157 hospitalized elderly patients. Contemporary Medicine,17(15):81-2.
7. Jia Z, Hongqin L, Wei W (2020). Bone min-eral density in 1245 physical examination patients in Changsha area and analysis of its influencing factors. Clinical Research and Practice,5(12):9-11.
8. Xin L. Study on the influencing factors of osteoporosis among adult residents in Dalian city [MD thesis].Zunyi Medical University,2014.
9. Lin X, Jun W, Xiaohui Z, et al (2014). An analysis of detection of bone mineral density and prevalence of osteoporosis. Jinagsu Med J,40(20):2422-4.
10. Zhaolian Y, Longying Z, Yun W, et al (2017). A status investigation and related facters analysis on osteoporosis among health checkup crowd of Hainan Gen-eral Hospital. Chin J Frontiers of Med Science, 9(06):51-4.
11. Jia Z. Analysis of the influencing factors and TCM constitution of osteoporosis in the physical examination population in Yuhua District, Changsha city, Hunan Province [MD thesis].Hunan University Of Chinese Medicine,2020.
12. Chunyan H, Guangxia X, Pan W, et al (2015).Changes of lumbar vertebrae bone density in different age groups in Shanxi Province. J Chin Physician,17(S1):69-71.
13. Yueqi W. Clinical characteristics and risk fac-tors of 167 cases of elderly over 80 years old with osteoporosis [MD thesis].The first hospital of Jilin University, Jilin Uni-versity, China;2017.
14. Shujin W, Danhui K, Jianhong C, et al (2016). Analysis of bone mineral density in 1123 middle-aged and elderly patients. Jinagsu Med J, 42(14):1608-10.
15. Dengfa G, Meng L, Yanming Z, et al (2019). The bone density test data analy-sis of 2198 cases with middle-aged and elderly adults patients. Chin J Health Care Med, 21(03):220-2.
16. Yahui Z, Qiuyan X, Jie G, et al (2020). Prevalence and Related Risk Factors of Osteoporosis in Partial Population of Beijing. Progress in Modern Biomedicine, 20(13):2545-50.
17. Hongbing Y, Zhenfu Q, Qiang L, et al (2011).Investigation of bone mineral den-sity in the distal forearm and analysis of prevalence of osteoporosis in 19609 healthy people in Miyun county of Bei-jing. Chin J Osteoporosis,17(01):51-5.
18. Ying L (2019). An epidemiological survey of bone mineral density in 821 physical ex-amination subjects in Beijing. Journal of Qi-qihar Medical University,40(04):473-4.
19. Jiyuan H, Wenzhong S, Hongyin Z, et al (2016). Changes of the bone mineral density and effects of different T•score cut-Off on the diagnosis of osteoporosis in healthy people in Chengdu. Chin J Oste-oporosis, 22(11):1425-9.
20. Suqing Y, Baocheng M, Xiaoyun L, et al (2012).Prevalence of osteoporosis in 4633 adults in Chifeng area. Inner Mongolia Med J, 44(07):834-6.
21. Ruifei Y. Prevalence of Osteoporosis and Related Factors of Adults in Gansu prov-ince [MD thesis].Ning Xia Medical Uni-versity, 2017.
22. Hong H, Zhongyou Z, Jian Y, et al (2012). Preliminary survey on morbidity rate of osteoporosis and bone mineral density of elderly people in Zhanjiang area. Clin Med,32(07):29-31.
23. Yongsheng Y, Lanying S (2013). Study on the prevalence of osteopenia and osteo-porosis in middle-aged and old people in Guiyang. China Health Care & Nutrition, 23(8):4679-80.
24. Ying Z, Weimin P, Xin X, et al (2020).Changes of bone mineral density and prevalence of osteoporosis in mid-dle-aged and elderly people in Haikou ar-ea. Chin J Osteoporosis, 26(07):1054-8.
25. Wenyuan C, Shou Z, Xiaoli D (2010).A sur-vey on the prevalence of osteoporosis and fracture in the elderly in Haikou area. Chin J Gerontol,30(06):824-6.
26. Ping L. Study on lumber bone mineral den-sity and osteoporosis prevalence in mid-dle-aged and aged people in Huhhot [MD thesis]. Inner Mongolia Medical University, 2011.
27. Xiuwen L, Chunyan Z, Guiqing W, et al (2016). Investigation and analysis on the prevalence of osteoporosis among physi-cal examination population in Hulun Buir city. J Inner Mongolia Med Universi-ty,38(04):341-5.
28. Xiaping C, Gang W, Chao W, et al (2010). Study on bone mineral density of normal bodies in Shiyan. Chin J Osteoporo-sis,16(03):210-2.
29. Huiwen C, Jinyong C, Guohua Z, et al (2011).A cross-sectional survey of bone mass and a analysis of risk factors for osteoporosis in 4000 healthy adults in Shaoyang region of Hunan Province. Chin J Osteoporosis,17(12):1087-91.
30. Zhihong T, Weidong L, Xiankun L, et al (2013). Analysis of the lumbar apine bone mineral density of the elderly in Huizhou region. Hainan Med J, 24(14):2056-8.
31. Dongjun Z, Xinyu Z, Shibing T, et al (2016).Epidemiological investigation of lumbar vertebrae bone density in 4972 physical examination patients in southern Jiangsu province. Chin J Convalescent Med,25(11):1223-6.
32. Yanmin H, Hongxia W, Xiaobao L, et al (2019). Investigation of osteopenia preva-lence in populations of Kunshan area. Chin J Osteoporosis & Bone Miner Res,12(02):141-4.
33. Xin Z, Xiujuan S, Yanyan X, et al (2020). Prevalence and related factors of osteo-porosis among elderly patients in Cheng-yang District, Qingdao. J Applied Preventive Med, 26(03):227-9.
34. Dinggui H, Guoxiu H, Yingzhou B, et al (2017).Clinical significance of peak bone mass and rate of bone loss in 20899 normal pe ople of Zhuang and Han na-tionalitie s in Nanning area. Chin J Osteopo-rosis,23(11):1507-11.
35. Yuhong Z, Bin Z, Ming Q, et al (2012). Study on the prevalence of osteoporosis in general population in Xi 'an city. Chin J Clinicians,6(15):4449-50.
36. Caizhen B, Du Yingxin, Hongxia W, et al (2017).Bone mineral density and its rela-tionship with human body composition in 1925 normal subjects in Ningxia. Jour-nal of Ningxia Medical College,39(05):559-63.
37. Junjing S, Xue B, Hong X, et al (2020). Epi-demiological Study on Osteoporosis in Elderly Population in Agricultural and Pastoral Areas of Xinjiang. J Med Re-search,49(05):53-7.
38. Yan L, Bin P, Huifeng Q (2010). Survey of prevalence of primary osteoporosis in Kelamayi area of Xlnjiang. Chin J Osteopo-rosis,16(08):598-601.
39. Yan C, Tingxia S, Xiaofen H, et al (2020). Correlation analysis of bone mineral den-sity and BMI index in 1373 healthy sub-jects in Xining area. JHigh Altitude Med,30(01):39-41.
40. Lijing M, Jin D, Qishan X (2018). Epidemi-ological investigation and analysis of bone mineral density in 6 000 residents in Taiyuan, Shanxi Province. Chinese Remedies & Clinics,18(10):1708-9.
41. Xinyuan G, Xianzhang G (2016). A study on the prevalence of osteoporosis in middle-aged and old people in Chengguan District of Lanzhou city. Gan-su Med J, 35(01):14-6.
42. Li G (2017). Investigation and analysis of osteoporosis in yi Nationality group in Liangshan. Chin J Woman and Child Health Research, 28(S2):357-8.
43. Changquan H, You F, Yan C, et al (2016).Analysis of the prevalence of bone loss and osteoporosis in the middle-aged and elderly people in Mianyang region. Chin J Osteoporosis,22(08):1044-6.
44. Xiaomei Z, Ying L, Yaoqiang W, et al (2011). Investigation of bone mineral density and the Incidence of osteoporo-sis in different age groups in the Man-chus in Dandong. Chin J Osteoporo-sis,17(02):134-8.
45. Xuejun W, Jun W. Survey on the osteoporo-sis prevalence and comparision of the BMD detection results at different sites among the middle-aged and elderly. In: Editor, editor 2016, the second annual conference of Nutrition and Metabolism Branch of Zhejiang Medical Association and seminar on new Progress in diagno-sis and Treatment of nutrition and meta-bolic diseases in the elderly; 2016; Hang-zhou, Zhejiang, China. Pub Place; 2016. p. 6.
46. Chongchan Z, Xiangfeng J (2017). Study on the condition of bone mass reduction and osteoporosis in middle-aged and old people. Practi Clini J Integr Tradit Chin and West Med,17(08):69-71.
47. Qiaocong C, Huiling L, Cheng P, et al (2010). Analysis of bone mineral density change and prevalence of osteoporosis in middle-aged and elderly. Guangdong Medical Journal,32(05):620-2.
48. Ping L, Ping H, Fengxia X, et al (2017). Analysis of bone mineral density and prevalence of osteoporosis in middle-aged and elderly. Chin J Geron-tol,33(20):5139-40.
49. Jun Z. Study on the changes of bone densi-ty in middle-aged and old people and the correlation between bone density and TCM syndromes in primary osteoporo-sis patients [MD thesis].Chengdu Uni-versity of Traditional Chinese Medi-cine,2014.
50. Yongqin Z. Research on the related influ-encing factors of bone mineral density of adults in some urban areas of Taiyuan [MD thesis].Shanxi Medical Universi-ty,2017.
51. Lingyun W, Hongmei M, Shiqi T (2013). Prevalence and influencing factors of os-teoporosis in older people in Wuhan ar-ea. Occupation & Health,29(22):2892-3057.
52. Peipei L, Yuhua W, Yali Z, et al (2021). Cross-sectional study on prevalence and treatment of osteoporosis among mid-dle-aged and elderly people in Putuo Dis-trict of Shanghai. J Tongji University (Med Science) ,42(01):35-41.
53. Foundation CHP (2009). Chinese White Pa-per on Osteoporosis. Chin J Health Man-age,03):148-9.
54. Kaushal N, Vohora D, Jalali RK, et al (2018).Prevalence of osteoporosis and osteopenia in an apparently healthy Indi-an population - a cross-sectional retro-spective study. Osteoporos Sarcopenia,4(2):53-60.
55. Veiga SA, Da RM, Fernandes B, et al (2015).Factors associated with osteopenia and osteoporosis in women undergoing bone mineral density test. Rev Bras Reu-matol,55(3):223-8.
56. Wright NC, Looker AC, Saag KG, et al (2014).The recent prevalence of osteopo-rosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J Bone Miner Res,29(11):2520-6.
57. Sharma S, Tandon VR, Mahajan A, et al (2006). Preliminary screening of osteopo-rosis and osteopenia in urban women from Jammu using calcaneal QUS. Indian J Med Sci,60(5):183-9.
58. Limpaphayom KK, Taechakraichana N, Jaisamrarn U, et al (2001). Prevalence of osteopenia and osteoporosis in Thai women. Menopause,8(1):65-9.
59. Bonnick SL (2006). Osteoporosis in men and women. Clin Cornerstone,8(1):28-39.
60. Donescu OS, Battie MC, Videman T, et al (2006).The predictive role of bone turno-ver markers for BMD in middle-aged men. Aging Male,9(2):97-102.
61. Chen JH, Chen YC, Tsai MK, et al (2017). Predicting the risk of osteopenia for women aged 40-55 years. J Formos Med Assoc,116(11):888-896.
62. Nayak S, Roberts MS, Greenspan SL (2011). Cost-effectiveness of different screening strategies for osteoporosis in postmeno-pausal women. Ann Intern Med,155(11):751-61.
63. Zeng Q, Li N, Wang Q, et al (2019). The Prevalence of Osteoporosis in China, a Nationwide, Multicenter DXA Survey. J Bone Miner Res,34(10):1789-1797.
64. Chitten JJ, James B (2018). Prevalence of Osteopenia and Osteoporosis in Ortho-paedic Outpatients in Southern India. Journal of Clinical & Diagnostic Research, 12(3):14-17
65. McGuigan F, Murray L, Gallagher A, et al (2002). Genetic and environmental de-terminants of peak bone mass in young men and women. J Bone Miner Res,17(7):1273-9.
66. Armstrong VJ, Muzylak M, Sunters A, et al (2007). Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem, 282(28):20715-27.
67. Drake MT, Khosla S (2012). Male Osteopo-rosis. Endocrinol Metab Clin North Am,41(3):629-41.
68. Kim JG, Kim MH, Kim IS, et al (2000). De-creased expression of mac25 mRNA in uterine leiomyomata compared with adja-cent myometrium. Am J Reprod Immunol, 43(1):53-7.
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| Files | ||
| Issue | Vol 51 No 11 (2022) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v51i11.11161 | |
| Keywords | ||
| Osteopenia Meta-analysis Prevalence China Osteoporosis | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Wang Y, Zhang Y, Zhao L, Wang G, Yang C, Zhao C, Zhao W. Prevalence and Distribution of Osteopenia in Chinese Population: A System Review and Meta-Analysis. Iran J Public Health. 2022;51(11):2435-2448.
