Allium Vegetables Intake and Risk of Breast Cancer: A Meta-Analysis
Abstract
Abstract
Background: Intake of allium vegetables may modify the risk of breast cancer. The aim of this study was to examine the association between allium vegetables intake and breast cancer risk via a meta-analysis.
Methods: PubMed, Web of Knowledge, Scopus and Chinese National Knowledge Infrastructure (CNKI) were electronically searched up to June 2021 to identify relevant studies. We used random-effect models to calculate pooled risk estimates and their 95% confidence intervals (CIs) for risk of breast cancer with allium vegetables intake.
Results: A total of 17 studies were included in this meta-analysis on the association of total allium vegetables, garlic and onion intake with breast cancer risk. The combined risk estimate of breast cancer for the highest vs lowest category of total allium vegetables, garlic and onion intake was 0.70 (95% CI: 0.49-0.91, P < 0.001), 0.77 (95% CI: 0.61-0.93, P = 0.016) and 0.75 (95% CI: 0.53-0.98, P < 0.001), respectively. A significant heterogeneity was found among studies for all three pooled analyses.
Conclusion: High intake of allium vegetables may be protective against the development of breast cancer. Further well-designed prospective studies are needed to confirm the results.
Keywords: ; ; ; ;
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6. Challier B, Perarnau JM, Viel JF (1998). Gar-lic, onion and cereal fibre as protective factors for breast cancer: a French case-control study. Eur J Epidemiol, 14(8): 737-747.
7. Dorant E, van den Brandt PA, Goldbohm RA (1995). Allium vegetable consump-tion, garlic supplement intake, and female breast carcinoma incidence. Breast Cancer Res Treat, 33(2): 163-170.
8. Franceschi S, Parpinel M, La Vecchia C, et al (1998). Role of different types of vegeta-bles and fruit in the prevention of cancer of the colon, rectum, and breast. Epidemi-ology, 9(3): 338-341.
9. Lee MM, Chang IY, Horng CF, et al (2005). Breast cancer and dietary factors in Tai-wanese women. Cancer Causes Control, 16(8): 929-937.
10. Pourzand A, Tajaddini A, Pirouzpanah S, et al (2016). Associations between Dietary Allium Vegetables and Risk of Breast Cancer: A Hospital-Based Matched Case-Control Study. J Breast Cancer, 19(3): 292-300.
11. Torres-Sanchez L, Lopez-Carrillo L, Lopez-Cervantes M, et al (2000). Food sources of phytoestrogens and breast cancer risk in Mexican women. Nutr Cancer, 37(2): 134-139.
12. Zhang CX, Ho SC, Chen YM, et al (2009). Greater vegetable and fruit intake is asso-ciated with a lower risk of breast cancer among Chinese women. Int J Cancer, 125(1): 181-188.
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14. Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327(7414): 557-560.
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16. Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50(4): 1088-1101.
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20. van Gils CH, Peeters PH, Bueno-de-Mesquita HB, et al (2005). Consumption of vegetables and fruits and risk of breast cancer. JAMA, 293(2): 183-193.
21. Galeone C, Pelucchi C, Levi F, et al (2006). Onion and garlic use and human cancer. Am J Clin Nutr, 84(5): 1027-1032.
22. Chen QL, Song CY, Wang JH (2011). Risk factors of breast cancer in females in Pinghu, Zhejiang province. Disease Surveil-lance, 26(6): 496-498.
23. Lv S, Mao J, Luo T, et al (2015). Case-control study for risk factors of breast cancer in women living in a district of Shanghai. Chinese Primary Health Care, 29(3): 36-38.
24. Farvid MS, Chen WY, Michels KB, et al (2016). Fruit and vegetable consumption in adolescence and early adulthood and risk of breast cancer: population based cohort study. BMJ, 353:i2343.
25. Desai G, Schelske-Santos M, Nazario CM, et al (2020). Onion and Garlic Intake and Breast Cancer, a Case-Control Study in Puerto Rico. Nutr Cancer, 72(5): 791-800.
26. Guercio V, Turati F, La Vecchia C, et al (2016). Allium vegetables and upper aer-odigestive tract cancers: a meta-analysis of observational studies. Mol Nutr Food Res, 60(1): 212-222.
27. Turati F, Pelucchi C, Guercio V, et al (2015). Allium vegetable intake and gastric cancer: a case-control study and meta-analysis. Mol Nutr Food Res, 59(1): 171-179.
28. Zhou XF, Ding ZS, Liu NB (2013). Allium vegetables and risk of prostate cancer: ev-idence from 132,192 subjects. Asian Pac J Cancer Prev, 14(7): 4131-4134.
29. Thomson M, Ali M (2003). Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent. Curr Cancer Drug Targets, 3(1): 67-81.
30. Puccinelli MT, Stan SD (2017). Dietary Bio-active Diallyl Trisulfide in Cancer Preven-tion and Treatment. Int J Mol Sci, 18(8):1645.
31. Na HK, Kim EH, Choi MA, et al (2012). Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1. Bi-ochem Pharmacol, 84(10): 1241-1250.
32. Kiesel VA, Stan SD (2017). Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells. Biochem Biophys Res Commun, 484(4): 833-838.
33. Li X, Meng Y, Xie C, et al (2018). Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/beta-catenin pathway. J Cell Biochem, 119(5): 4134-4141.
34. Gapter LA, Yuin OZ, Ng KY (2008). S-Allylcysteine reduces breast tumor cell adhesion and invasion. Biochem Biophys Res Commun, 367(2): 446-451.
35. Ezzati M, Yousefi B, Velaei K, et al (2020). A review on anti-cancer properties of Quer-cetin in breast cancer. Life Sci, 248:117463.
36. Ghodrati Azadi H, Ghaffari SM, Riazi GH, et al (2008). Antiproliferative activity of chloroformic extract of Persian Shallot, Allium hirtifolium, on tumor cell lines. Cy-totechnology, 56(3): 179-185.
37. Antony ML, Singh SV (2011). Molecular mechanisms and targets of cancer chem-oprevention by garlic-derived bioactive compound diallyl trisulfide. Indian J Exp Biol, 49(11): 805-816.
38. Song K, Milner JA (2001). The influence of heating on the anticancer properties of garlic. J Nutr, 131(3s): 1054S-1057S.
39. Shang A, Cao SY, Xu XY, et al (2019). Bio-active Compounds and Biological Func-tions of Garlic (Allium sativum L.). Foods, 8(7):246.
2. DeSantis CE, Ma J, Gaudet MM, et al (2019). Breast cancer statistics, 2019. CA Cancer J Clin, 69(6): 438-451.
3. Mourouti N, Kontogianni MD, Papavagelis C, et al (2015). Diet and breast cancer: a systematic review. Int J Food Sci Nutr, 66(1): 1-42.
4. Emaus MJ, Peeters PH, Bakker MF, et al (2016). Vegetable and fruit consumption and the risk of hormone receptor-defined breast cancer in the EPIC cohort. Am J Clin Nutr, 103(1): 168-177.
5. Bao PP, Shu XO, Zheng Y, et al (2012). Fruit, vegetable, and animal food intake and breast cancer risk by hormone recep-tor status. Nutr Cancer, 64(6): 806-819.
6. Challier B, Perarnau JM, Viel JF (1998). Gar-lic, onion and cereal fibre as protective factors for breast cancer: a French case-control study. Eur J Epidemiol, 14(8): 737-747.
7. Dorant E, van den Brandt PA, Goldbohm RA (1995). Allium vegetable consump-tion, garlic supplement intake, and female breast carcinoma incidence. Breast Cancer Res Treat, 33(2): 163-170.
8. Franceschi S, Parpinel M, La Vecchia C, et al (1998). Role of different types of vegeta-bles and fruit in the prevention of cancer of the colon, rectum, and breast. Epidemi-ology, 9(3): 338-341.
9. Lee MM, Chang IY, Horng CF, et al (2005). Breast cancer and dietary factors in Tai-wanese women. Cancer Causes Control, 16(8): 929-937.
10. Pourzand A, Tajaddini A, Pirouzpanah S, et al (2016). Associations between Dietary Allium Vegetables and Risk of Breast Cancer: A Hospital-Based Matched Case-Control Study. J Breast Cancer, 19(3): 292-300.
11. Torres-Sanchez L, Lopez-Carrillo L, Lopez-Cervantes M, et al (2000). Food sources of phytoestrogens and breast cancer risk in Mexican women. Nutr Cancer, 37(2): 134-139.
12. Zhang CX, Ho SC, Chen YM, et al (2009). Greater vegetable and fruit intake is asso-ciated with a lower risk of breast cancer among Chinese women. Int J Cancer, 125(1): 181-188.
13. Moher D, Liberati A, Tetzlaff J, et al (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med, 6(7): e1000097.
14. Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327(7414): 557-560.
15. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315(7109): 629-634.
16. Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50(4): 1088-1101.
17. Levi F, La Vecchia C, Gulie C, et al (1993). Dietary factors and breast cancer risk in Vaud, Switzerland. Nutr Cancer, 19(3): 327-335.
18. Cao KJ, Wu YL, Ma GS, et al (2001). A case-control study on risk factors of fe-male breast cancer in Guangzhou. China Cancer, 10(12): 702-704.
19. Malin AS, Qi D, Shu XO, et al (2003). Intake of fruits, vegetables and selected micro-nutrients in relation to the risk of breast cancer. Int J Cancer, 105(3): 413-418.
20. van Gils CH, Peeters PH, Bueno-de-Mesquita HB, et al (2005). Consumption of vegetables and fruits and risk of breast cancer. JAMA, 293(2): 183-193.
21. Galeone C, Pelucchi C, Levi F, et al (2006). Onion and garlic use and human cancer. Am J Clin Nutr, 84(5): 1027-1032.
22. Chen QL, Song CY, Wang JH (2011). Risk factors of breast cancer in females in Pinghu, Zhejiang province. Disease Surveil-lance, 26(6): 496-498.
23. Lv S, Mao J, Luo T, et al (2015). Case-control study for risk factors of breast cancer in women living in a district of Shanghai. Chinese Primary Health Care, 29(3): 36-38.
24. Farvid MS, Chen WY, Michels KB, et al (2016). Fruit and vegetable consumption in adolescence and early adulthood and risk of breast cancer: population based cohort study. BMJ, 353:i2343.
25. Desai G, Schelske-Santos M, Nazario CM, et al (2020). Onion and Garlic Intake and Breast Cancer, a Case-Control Study in Puerto Rico. Nutr Cancer, 72(5): 791-800.
26. Guercio V, Turati F, La Vecchia C, et al (2016). Allium vegetables and upper aer-odigestive tract cancers: a meta-analysis of observational studies. Mol Nutr Food Res, 60(1): 212-222.
27. Turati F, Pelucchi C, Guercio V, et al (2015). Allium vegetable intake and gastric cancer: a case-control study and meta-analysis. Mol Nutr Food Res, 59(1): 171-179.
28. Zhou XF, Ding ZS, Liu NB (2013). Allium vegetables and risk of prostate cancer: ev-idence from 132,192 subjects. Asian Pac J Cancer Prev, 14(7): 4131-4134.
29. Thomson M, Ali M (2003). Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent. Curr Cancer Drug Targets, 3(1): 67-81.
30. Puccinelli MT, Stan SD (2017). Dietary Bio-active Diallyl Trisulfide in Cancer Preven-tion and Treatment. Int J Mol Sci, 18(8):1645.
31. Na HK, Kim EH, Choi MA, et al (2012). Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1. Bi-ochem Pharmacol, 84(10): 1241-1250.
32. Kiesel VA, Stan SD (2017). Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells. Biochem Biophys Res Commun, 484(4): 833-838.
33. Li X, Meng Y, Xie C, et al (2018). Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/beta-catenin pathway. J Cell Biochem, 119(5): 4134-4141.
34. Gapter LA, Yuin OZ, Ng KY (2008). S-Allylcysteine reduces breast tumor cell adhesion and invasion. Biochem Biophys Res Commun, 367(2): 446-451.
35. Ezzati M, Yousefi B, Velaei K, et al (2020). A review on anti-cancer properties of Quer-cetin in breast cancer. Life Sci, 248:117463.
36. Ghodrati Azadi H, Ghaffari SM, Riazi GH, et al (2008). Antiproliferative activity of chloroformic extract of Persian Shallot, Allium hirtifolium, on tumor cell lines. Cy-totechnology, 56(3): 179-185.
37. Antony ML, Singh SV (2011). Molecular mechanisms and targets of cancer chem-oprevention by garlic-derived bioactive compound diallyl trisulfide. Indian J Exp Biol, 49(11): 805-816.
38. Song K, Milner JA (2001). The influence of heating on the anticancer properties of garlic. J Nutr, 131(3s): 1054S-1057S.
39. Shang A, Cao SY, Xu XY, et al (2019). Bio-active Compounds and Biological Func-tions of Garlic (Allium sativum L.). Foods, 8(7):246.
| Files | ||
| Issue | Vol 51 No 4 (2022) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v51i4.9235 | |
| Keywords | ||
| Allium vegetables Breast cancer Garlic Meta-analysis Onion | ||
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How to Cite
1.
Zhang J, Yang J. Allium Vegetables Intake and Risk of Breast Cancer: A Meta-Analysis. Iran J Public Health. 2022;51(4):746-757.
