Ante-, Peri-, and Neonatal Factors Associated with Autism Spectrum Disorders in Vietnam: A Population-Based Cross-Sectional Survey
-
Le Thi Vui
,
Duong Minh Duc
,
Chu Thi Thuy Quynh
,
Duong Kim Tuan
,
Nguyen Mai Huong
,
Nguyen Thi Minh Thanh
,
Nguyen Minh Hung
,
Hoang Van Minh
,
Bui Thi Thu Ha
Abstract
Background: Autism Spectrum Disorders (ASDs) are common behavioral syndromes but limited critical evidence in Vietnam. This study aimed to identify ante-, peri- and neonatal factors for ASDs amongst children in Vietnam.
Methods: This population-based study applied the cross-sectional design with a multistage sampling in 21 urban and rural districts in seven cities/provinces in Vietnam during 2017-2018. Overall, 42,551 children age 18 to 30 months were enrolled in the study. Two phases of assessment using Modified Checklist for Autism in Toddlers (M-CHAT) for screening and diagnostic assessment using Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for confirmation. We employed univariate and binary logistic regression to identify.
Results: Our study showed a fast-growing trend of ASDs amongst children age 18 and 30 months (75.8 per 10,000 individuals). Nine ante-, peri-, and neonatal factors were associated with ASDs: five factors of antenatal period (history of miscarriage/abortion or stillbirth, children conceived by assisted reproduction technologies, having cold, flu or acquiring virus during pregnancy, having gestational diabetes, toxemia, high blood pressure or pre-eclampsia during pregnancy, and having stress or mental disorders during pregnancy); one factors of perinatal period (mode of delivery); and three factors of neonatal period (jaundice, respiratory distress, and newborn seizures)
Conclusion: This first large-scale survey in Vietnam confirms some prenatal, perinatal, and postnatal factors with ASDs amongst children age 18 and 30 months. Future interventions should focus on these factors to early diagnosis and intervention to improve functional outcomes for risky children.
1. World Health Organization (2021) Autism spectrum disorders. (https://www.who.int/news-room/fact-sheets/detail/autism-spectrum-disorders).
2. Ozonoff S, Heung K, Byrd R, et al (2008). The onset of autism: patterns of symptom emergence in the first years of life. Autism Res, 1:320-8.
3. Elsabbagh M, Divan G, Koh YJ, et al (2012). Global prevalence of autism and other pervasive developmental disorders. Autism Res, 5:160-79.
4. Chiarotti F, Venerosi A (2020). Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014. Brain Sci, 10:274.
5. Yen NTH (2014). Early intervention for autism spectrum disorder and inclusive education for children with Autism in Vietnam for the period 2011-2020. ed. Hanoi National University of Education, Hanoi.
6. Kien PT, Dung LTK, Dung DV, Yen PT (2014) Prevalence and Treatment Results of Children with Autism Spectrum Disorder in Thai Nguyen Province, Vietnam. (ed)^(eds),
7. Bertrand J, Mars A, Boyle C, et al (2001). Prevalence of autism in a United States population: the Brick Township, New Jersey, investigation. Pediatrics, 108:1155-61.
8. Wang C, Geng H, Liu W, Zhang G (2017). Prenatal, perinatal, and postnatal factors associated with autism: A meta-analysis. Medicine (Baltimore), 96:e6696.
9. Hadjkacem I, Ayadi H, Turki M, et al (2016). Prenatal, perinatal and postnatal factors associated with autism spectrum disorder. J Pediatr (Rio J), 92:595-601.
10. Roberts AL, Lyall K, Hart JE, et al (2013). Perinatal air pollutant exposures and autism spectrum disorder in the children of Nurses' Health Study II participants. Environ Health Perspect, 121:978-84.
11. Bilder D, Pinborough-Zimmerman J, Miller J, McMahon W (2009). Prenatal, perinatal, and neonatal factors associated with autism spectrum disorders. Pediatrics, 123:1293-300.
12. Williams K, Helmer M, Duncan GW, Peat JK, Mellis CM (2008). Perinatal and maternal risk factors for autism spectrum disorders in New South Wales, Australia. Child Care Health Dev, 34:249-56.
13. Kolevzon A, Gross R, Reichenberg A (2007). Prenatal and perinatal risk factors for autism: a review and integration of findings. Arch Pediatr Adolesc Med, 161:326-33.
14. Hoang VM, Le TV, Chu TTQ, et al (2019). Prevalence of autism spectrum disorders and their relation to selected socio-demographic factors among children aged 18-30 months in northern Vietnam, 2017. Int J Ment Health Syst, 13:29.
15. Binu VS, Mayya SS, Dhar M (2014). Some basic aspects of statistical methods and sample size determination in health science research. Ayu, 35:119-123.
16. Giang NTH (2012) Study of early detection of autism with M-CHAT23, epidemiological-clinical characteristics and early intervention with rehabilitation for autistic children. Thesis for Doctor of Medicine. Hanoi Medical University.
17. Kleinman JM, Robins DL, Ventola PE, et al (2008). The modified checklist for autism in toddlers: a follow-up study investigating the early detection of autism spectrum disorders. J Autism Dev Disord, 38:827-839.
18. Canal-Bedia R, Garcia-Primo P, Martin-Cilleros MV, et al (2011). Modified checklist for autism in toddlers: cross-cultural adaptation and validation in Spain. J Autism Dev Disord, 41:1342-51.
19. Johnson CP, Myers SM, American Academy of Pediatrics Council on Children With D (2007). Identification and evaluation of children with autism spectrum disorders. Pediatrics, 120:1183-215.
20. Hossain MD, Ahmed HU, Jalal Uddin MM, et al (2017). Autism Spectrum disorders (ASD) in South Asia: a systematic review. BMC Psychiatry, 17:281.
21. Bursac Z, Gauss CH, Williams DK, Hosmer DW (2008). Purposeful selection of variables in logistic regression. Source Code Biol Med, 3:17.
22. Sperandei S (2014). Understanding logistic regression analysis. Biochem Med (Zagreb), 24:12-18.
23. Eaton WW, Mortensen PB, Thomsen PH, Frydenberg M (2001). Obstetric complications and risk for severe psychopathology in childhood. J Autism Dev Disord, 31:279-85.
24. Glasson EJ, Bower C, Petterson B, et al (2004). Perinatal factors and the development of autism: a population study. Arch Gen Psychiatry, 61:618-27.
25. Liu L, Gao J, He X, Cai Y, Wang L, Fan X (2017). Association between assisted reproductive technology and the risk of autism spectrum disorders in the offspring: a meta-analysis. Sci Rep, 7:46207.
26. Hvidtjorn D, Schieve L, Schendel D, et al (2009). Cerebral palsy, autism spectrum disorders, and developmental delay in children born after assisted conception: a systematic review and meta-analysis. Arch Pediatr Adolesc Med, 163:72-83.
27. Brown MA, Lindheimer MD, de Swiet M, et al (2001). The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy, 20:IX-XIV.
28. Xu RT, Chang QX, Wang QQ, et al (2017). Association between hypertensive disorders of pregnancy and risk of autism in offspring: a systematic review and meta-analysis of observational studies. Oncotarget, 9:1291-1301.
29. Wan H, Zhang C, Li H, Luan S, Liu C (2018). Association of maternal diabetes with autism spectrum disorders in offspring: A systemic review and meta-analysis. Medicine (Baltimore), 97:e9438.
30. Braunschweig D, Ashwood P, Krakowiak P, et al (2008). Autism: maternally derived antibodies specific for fetal brain proteins. Neurotoxicology, 29:226-31.
31. Hagberg KW, Robijn AL, Jick S (2018). Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring. Clin Epidemiol, 10:1599-1612.
32. Zhang T, Sidorchuk A, Sevilla-Cermeno L, et al (2019). Association of Cesarean Delivery With Risk of Neurodevelopmental and Psychiatric Disorders in the Offspring: A Systematic Review and Meta-analysis. JAMA Netw Open, 2:e1910236.
33. Curran EA, Dalman C, Kearney PM, et al (2015). Association Between Obstetric Mode of Delivery and Autism Spectrum Disorder: A Population-Based Sibling Design Study. JAMA Psychiatry, 72:935-42.
34. Sandall J, Tribe RM, Avery L, et al (2018). Short-term and long-term effects of caesarean section on the health of women and children. Lancet, 392:1349-1357.
35. Gardener H, Spiegelman D, Buka SL (2011). Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis. Pediatrics, 128:344-55.
36. Amin SB, Smith T, Wang H (2011). Is neonatal jaundice associated with Autism Spectrum Disorders: a systematic review. J Autism Dev Disord, 41:1455-63.
37. Hartley-McAndrew M, Weinstock A (2010). Autism Spectrum Disorder: Correlation between aberrant behaviors, EEG abnormalities and seizures. Neurol Int, 2:e10.
2. Ozonoff S, Heung K, Byrd R, et al (2008). The onset of autism: patterns of symptom emergence in the first years of life. Autism Res, 1:320-8.
3. Elsabbagh M, Divan G, Koh YJ, et al (2012). Global prevalence of autism and other pervasive developmental disorders. Autism Res, 5:160-79.
4. Chiarotti F, Venerosi A (2020). Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014. Brain Sci, 10:274.
5. Yen NTH (2014). Early intervention for autism spectrum disorder and inclusive education for children with Autism in Vietnam for the period 2011-2020. ed. Hanoi National University of Education, Hanoi.
6. Kien PT, Dung LTK, Dung DV, Yen PT (2014) Prevalence and Treatment Results of Children with Autism Spectrum Disorder in Thai Nguyen Province, Vietnam. (ed)^(eds),
7. Bertrand J, Mars A, Boyle C, et al (2001). Prevalence of autism in a United States population: the Brick Township, New Jersey, investigation. Pediatrics, 108:1155-61.
8. Wang C, Geng H, Liu W, Zhang G (2017). Prenatal, perinatal, and postnatal factors associated with autism: A meta-analysis. Medicine (Baltimore), 96:e6696.
9. Hadjkacem I, Ayadi H, Turki M, et al (2016). Prenatal, perinatal and postnatal factors associated with autism spectrum disorder. J Pediatr (Rio J), 92:595-601.
10. Roberts AL, Lyall K, Hart JE, et al (2013). Perinatal air pollutant exposures and autism spectrum disorder in the children of Nurses' Health Study II participants. Environ Health Perspect, 121:978-84.
11. Bilder D, Pinborough-Zimmerman J, Miller J, McMahon W (2009). Prenatal, perinatal, and neonatal factors associated with autism spectrum disorders. Pediatrics, 123:1293-300.
12. Williams K, Helmer M, Duncan GW, Peat JK, Mellis CM (2008). Perinatal and maternal risk factors for autism spectrum disorders in New South Wales, Australia. Child Care Health Dev, 34:249-56.
13. Kolevzon A, Gross R, Reichenberg A (2007). Prenatal and perinatal risk factors for autism: a review and integration of findings. Arch Pediatr Adolesc Med, 161:326-33.
14. Hoang VM, Le TV, Chu TTQ, et al (2019). Prevalence of autism spectrum disorders and their relation to selected socio-demographic factors among children aged 18-30 months in northern Vietnam, 2017. Int J Ment Health Syst, 13:29.
15. Binu VS, Mayya SS, Dhar M (2014). Some basic aspects of statistical methods and sample size determination in health science research. Ayu, 35:119-123.
16. Giang NTH (2012) Study of early detection of autism with M-CHAT23, epidemiological-clinical characteristics and early intervention with rehabilitation for autistic children. Thesis for Doctor of Medicine. Hanoi Medical University.
17. Kleinman JM, Robins DL, Ventola PE, et al (2008). The modified checklist for autism in toddlers: a follow-up study investigating the early detection of autism spectrum disorders. J Autism Dev Disord, 38:827-839.
18. Canal-Bedia R, Garcia-Primo P, Martin-Cilleros MV, et al (2011). Modified checklist for autism in toddlers: cross-cultural adaptation and validation in Spain. J Autism Dev Disord, 41:1342-51.
19. Johnson CP, Myers SM, American Academy of Pediatrics Council on Children With D (2007). Identification and evaluation of children with autism spectrum disorders. Pediatrics, 120:1183-215.
20. Hossain MD, Ahmed HU, Jalal Uddin MM, et al (2017). Autism Spectrum disorders (ASD) in South Asia: a systematic review. BMC Psychiatry, 17:281.
21. Bursac Z, Gauss CH, Williams DK, Hosmer DW (2008). Purposeful selection of variables in logistic regression. Source Code Biol Med, 3:17.
22. Sperandei S (2014). Understanding logistic regression analysis. Biochem Med (Zagreb), 24:12-18.
23. Eaton WW, Mortensen PB, Thomsen PH, Frydenberg M (2001). Obstetric complications and risk for severe psychopathology in childhood. J Autism Dev Disord, 31:279-85.
24. Glasson EJ, Bower C, Petterson B, et al (2004). Perinatal factors and the development of autism: a population study. Arch Gen Psychiatry, 61:618-27.
25. Liu L, Gao J, He X, Cai Y, Wang L, Fan X (2017). Association between assisted reproductive technology and the risk of autism spectrum disorders in the offspring: a meta-analysis. Sci Rep, 7:46207.
26. Hvidtjorn D, Schieve L, Schendel D, et al (2009). Cerebral palsy, autism spectrum disorders, and developmental delay in children born after assisted conception: a systematic review and meta-analysis. Arch Pediatr Adolesc Med, 163:72-83.
27. Brown MA, Lindheimer MD, de Swiet M, et al (2001). The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy, 20:IX-XIV.
28. Xu RT, Chang QX, Wang QQ, et al (2017). Association between hypertensive disorders of pregnancy and risk of autism in offspring: a systematic review and meta-analysis of observational studies. Oncotarget, 9:1291-1301.
29. Wan H, Zhang C, Li H, Luan S, Liu C (2018). Association of maternal diabetes with autism spectrum disorders in offspring: A systemic review and meta-analysis. Medicine (Baltimore), 97:e9438.
30. Braunschweig D, Ashwood P, Krakowiak P, et al (2008). Autism: maternally derived antibodies specific for fetal brain proteins. Neurotoxicology, 29:226-31.
31. Hagberg KW, Robijn AL, Jick S (2018). Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring. Clin Epidemiol, 10:1599-1612.
32. Zhang T, Sidorchuk A, Sevilla-Cermeno L, et al (2019). Association of Cesarean Delivery With Risk of Neurodevelopmental and Psychiatric Disorders in the Offspring: A Systematic Review and Meta-analysis. JAMA Netw Open, 2:e1910236.
33. Curran EA, Dalman C, Kearney PM, et al (2015). Association Between Obstetric Mode of Delivery and Autism Spectrum Disorder: A Population-Based Sibling Design Study. JAMA Psychiatry, 72:935-42.
34. Sandall J, Tribe RM, Avery L, et al (2018). Short-term and long-term effects of caesarean section on the health of women and children. Lancet, 392:1349-1357.
35. Gardener H, Spiegelman D, Buka SL (2011). Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis. Pediatrics, 128:344-55.
36. Amin SB, Smith T, Wang H (2011). Is neonatal jaundice associated with Autism Spectrum Disorders: a systematic review. J Autism Dev Disord, 41:1455-63.
37. Hartley-McAndrew M, Weinstock A (2010). Autism Spectrum Disorder: Correlation between aberrant behaviors, EEG abnormalities and seizures. Neurol Int, 2:e10.
| Files | ||
| Issue | Vol 52 No 5 (2023) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v52i5.12711 | |
| Keywords | ||
| Autism spectrum disorder (ASD) Population-based survey Vietnam | ||
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How to Cite
1.
Vui LT, Duc DM, Quynh CTT, Tuan DK, Huong NM, Thanh NTM, Hung NM, Minh HV, Ha BTT. Ante-, Peri-, and Neonatal Factors Associated with Autism Spectrum Disorders in Vietnam: A Population-Based Cross-Sectional Survey. Iran J Public Health. 2023;52(5):950-959.
