SUPPRESSION OF MICE IMMUNE RESPONSE BY ANTIMACROPHAGE SERUM TREATEMENT AND ITS RECONSTITUATION BY MACROPHAGE TRANSPLANTATION

Abstract

The immunosuppressive effect of antimacrophage serum (AMS) on the primary immune response of mice to sheep red blood cells (SRBC) was studied. AMS, given before a small dose of antigen, abrogated the immune response. Transplantation of normal, galss-adherent macrophages enabled AMS-treated animals to respond to SRBC, while administration of lymph node lymphocytes did not reveres AMS - induced immunosuppression significantly.