Original Article

Frequency of HLA Alleles in a Group of Severe COVID‐19 Irani-an Patients

Abstract

Background: Human Leukocyte Antigen (HLA) system composed of a group of related proteins with important functions in the immune system. Several studies have reported that there is a significant association between specific HLA alleles and the susceptibility to different infectious diseases. This study aimed to detect the specific HLA alleles that cause higher susceptibility to COVID-19, we analyzed the HLA allele frequency distribution in Iranian patients with a severe form of COVID-19.

Methods: Overall, 48 severe cases of COVID-19 that were hospitalized and required intensive care unit (ICU) admission between Oct and Dec 2020 were included in this study. Genomic DNA was extracted from the peripheral blood samples and HLA typing (Locus A, B, and DR) was performed for the patients.

Results: After analyzing and comparing the results with a reference group of 500 Iranian individuals, a significant association was found for HLA-B*38, HLA-A*68, HLA-A*24, and HLA-DRB1*01.

Conclusion: These results may be valuable for studying the potential association of specific HLA alleles with susceptibility to COVID-19 and mortality due to the disease.

1. Chowdhury MA, Hossain N, Kashem MA, et al (2020). Immune response in COVID-19: A review. J Infect Public Health, 13(11):1619-1629.
2. Shiina T, Hosomichi K, Inoko H, et al (2009). The HLA genomic loci map: expression, interaction, diversity and disease. J Hum Genet, 54(1):15-39.
3. Meyer D, Aguiar VR, Bitarello BD, et al (2018). A genomic perspective on HLA evolution. Immunogenetics, 70(1):5-27.
4. Nejentsev S, Howson JM, Walker NM, et al (2007). Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A . Nature, 450(7171):887-92.
5. Kiepiela P, Leslie AJ, Honeyborne I, et al (2004). Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature, 432(7018):769-75.
6. Kamatani Y, Wattanapokayakit S, Ochi H, et al (2009). A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet, 41(5):591-5.
7. Sveinbjornsson G, Gudbjartsson DF, Halldorsson BV, et al (2016). HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nat Genet, 48(3):318-22.
8. Thomas GP, Brown MA (2010). Genetics and genomics of ankylosing spondylitis. Immunol Rev, 233(1):162-80.
9. Novelli A, Andreani M, Biancolella M, et al (2020). HLA allele frequencies and susceptibility to COVID‐19 in a group of 99 Italian patients. HLA, 96(5):610-614.
10. ShekarkarAzgomi M, Mohammadnezhad L, La Manna MP, (2020). Natural Selection Footprint in Novel Coronavirus: A Genomic Perspective of SARS-COV2 Pandemic and Hypothesis for Peptide-Based Vaccine. Available at SSRN 3681983.
11. Group SC-G (2020). Genomewide association study of severe Covid-19 with respiratory failure. N Engl J Med, 383:1522-1534.
12. Esmaeili A, Rabe SZT, Mahmoudi M, et al (2017). Frequencies of HLA-A, B and DRB1 alleles in a large normal population living in the city of Mashhad, Northeastern Iran. Iran J Basic Med Sci, 20(8):940-943.
13. Pairo-Castineira E, Clohisey S, Klaric L, et al (2020). Genetic mechanisms of critical illness in Covid-19. Nature: 591(7848):92-98.
14. Pisanti S, Deelen J, Gallina AM, et al (2020). Correlation of the two most frequent HLA haplotypes in the Italian population to the differential regional incidence of Covid-19. J Transl Med, 18:1-16.
15. Tomita Y, Ikeda T, Sato R, et al (2020). Association between HLA gene polymorphisms and mortality of COVID‐19: An in silico analysis. Immunity, inflammation and disease, 8:684-694.
16. Wang W, Zhang W, Zhang J, et al (2020). Distribution of HLA allele frequencies in 82 Chinese individuals with coronavirus disease‐2019 (COVID‐19). HLA, 96:194-196.
17. Pareek M, Bangash MN, Pareek N, et al (2020). Ethnicity and COVID-19: an urgent public health research priority. Lancet, 95(10234):1421-1422.
Files
IssueVol 50 No 9 (2021) QRcode
SectionOriginal Article(s)
Published2021-09-02
DOI https://doi.org/10.18502/ijph.v50i9.7061
Keywords
Human leukocyte antigen (HLA) COVID-19; Iran

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Hamidi Farahani R, Esmaeilzadeh E, Nezami Asl A, Heidari MF, Hazrati E. Frequency of HLA Alleles in a Group of Severe COVID‐19 Irani-an Patients. Iran J Public Health. 2021;50(9):1882-1886.