Factors Associated with Infant Mortality due to Congenital Anomalies: A Population-Based Case-Control Study
-
Fatemeh Zolfizadeh
,
Maryam ghorbani
,
Maryam Soltani
,
Shahab Rezaeian
,
Abdolhalim Rajabi
,
Koorosh Etemad
,
Mahmoud Hajipour
,
Ali Ghasemi
,
Halimeh Yaghoobi
Abstract
Background: Congenital anomalies are one of the major public health problems and one of the leading cause of infant mortality and morbidity. We aimed to investigate some factors associated with infant mortality due to congenital anomalies in several provinces of Iran.
Methods: This case-control study was conducted on 2199 women referring health centers of nine provinces of Iran 2015-2018. Cases were defined as mothers with infant death due to congenital anomalies, and control group comprised of mothers with live birth or infant deaths due to other causes (n=1986). The descriptive data were expressed as percentage and frequency. Factors associated with infant death due to congenital anomalies were evaluated and analyzed at 95% confidence level by logistic regression analysis.
Results: The multiple logistic regression analysis reveal that history of cesarean delivery [OR:2.13 ;95%CI (1.58-2.87)], maternal age [OR:1.94 ;95%CI (1.31-2.86)])], area of living [OR: 1.69;95%CI (1.22-2.33)], maternal smoking during pregnancy [OR: 1.41; 95%CI (1.02-1.95)], consanguineous marriage [OR:1.53;95%CI (1.12-2.08)], also low birth weight [OR: 3.09; 95%CI (2.23-4.30)] were significantly associated with infant death due to congenital anomalies.
Conclusion: Identification of factors associated with congenital anomalies has been shown to reduce treatment costs and medical complications of neonates. Therefore, genetic counseling and educational programs for high-risk women, and prenatal screening are essential to identify and prevent factors contributing to congenital abnormalities.
2. Irani M, Khadivzadeh T, Nekah A, et al (2018). The prevalence of congenital anomalies in Iran: A Systematic Review and Meta-analysis. The Iranian Journal of Obstetrics, Gynecology and Infertility, 21:29-41.
3. Luz GdS, Karam SdM, Dumith SC (2019). Congenital anomalies in Rio Grande do Sul State: a time series analysis. Rev Bras Epidemiol, 22:e190040.
4. Mashuda F, Zuechner A, Chalya PL, et al (2014). Pattern and factors associated with congenital anomalies among young infants admitted at Bugando medical centre, Mwanza, Tanzania. BMC Res Notes, 7:195.
5. WHO (2016). Available from: https://www.who.int/en/news-room/fact-sheets/detail/congenital-anomalies
6. Costa CMdS, Gama SGNd, Leal MdC (2006). Congenital malformations in Rio de Janeiro, Brazil: prevalence and associated factors. Cad Saude Publica, 22:2423-2431.
7. Bhide P, Kar A (2018). A national estimate of the birth prevalence of congenital anomalies in India: systematic review and meta-analysis. BMC Pediatr, 18(1):175.
8. Amini Nasab Z, Aminshokravi F, et al (2014). Demographical condition of neonates with congenital abnormalities under Birjand city health centers during 2007-2012. J Birjand Univ Med Sci, 21:96-103.
9. Karbasi SA, Golestan M, Fallah R, et al (2009). Prevalence of congenital malformations. Acta Medica Iranica,149-153.
10. Mashhadi Abdolahi H, Kargar Maher MH, Afsharnia F, et al (2014). Prevalence of congenital anomalies: a community-based study in the Northwest of Iran. ISRN Pediatr, 2014:920940.
11. Dastgiri S, Sheikhzadeh Y, Dastgiri A (2011). Monitoring of congenital anomalies in developing countries: a pilot model in Iran. Stud Health Technol Inform, pp. 157-161.
12. Nhoncanse GC, Germano CMR, Avó LRdSd, et al (2014). Maternal and perinatal aspects of birth defects: a case-control study. Rev Paul Pediatr, 32(1):24-31.
13. Alijahan R, Mirzarahimi M, Ahmadi Hadi P, et al (2013). Prevalence of congenital abnormalities and its related risk factors in Ardabil, Iran, 2011. Iranian Journal of Obstetrics, Gynecology and Infertility, 16(54):16-25.
14. Roncancio CP, Misnaza SP, Peña IC, et al (2018). Trends and characteristics of fetal and neonatal mortality due to congenital anomalies, Colombia 1999–2008. J Matern Fetal Neonatal Med, 31(13):1748-1755.
15. Căpățînă D, Cozaru GC (2015). Risk factors associated with congenital anomalies in children. ARS Medica Tomitana, 21:105-111.
16. Ebela I, Zile I, Zakis A, et al (2011). Mortality of children under five and prevalence of newborn congenital anomalies in relation to macroeconomic and socioeconomic factors in Latvia. Medicina (Kaunas), 47(12):667-74.
17. Cui H, He C, Kang L, et al (2016). Under-5-Years Child Mortality Due to Congenital Anomalies: A Retrospective Study in Urban and Rural China in 1996− 2013. Am J Prev Med , 50:663-671.
18. Mehrabi Kuski A, Zeyghami B (2005). The effect of consanguineous marriages on congenital malformation. J Res Med Sci, 10(5): 298-301.
19. Movafagh A, Haji Sjm, Hashemi S, et al (2007). Prevalence of congenital abnormalities in familial and non-familial marriage. Pajoohande, 12 (56): 129-134.
20. Morales-Suárez-Varela MM, Bille C, Christensen K, Olsen J (2006). Smoking habits, nicotine use, and congenital malformations. Obstet Gynecol, 107(1):51-7.
21. Parmar A, Rathod S, Patel S, et al (2010). A study of congenital anomalies in newborn. NJIRM, 1:13-17.
22. Louis B, Steven B, Margret N, et al (2016). Prevalence and factors associated with low birth weight among teenage mothers in new Mulago Hospital: A cross sectional study. J Health Sci (El Monte), 4:192.
23. Fredell L, Kockum I, Hansson E, et al (2002). Heredity of hypospadias and the significance of low birth weight. J Urol, 167(3):1423-7.
24. Fallah R, Islami Z, Mosavian T (2011). Developmental status of NICU admited low birth weight preterm neonates at 6 and 12 months of age using Ages and Stages Questionaire. Iran J Child Neurol, 5:21-28.
| Files | ||
| Issue | Vol 51 No 5 (2022) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v51i5.9411 | |
| Keywords | ||
| Congenital abnormalities Infant mortality Iran | ||
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