Which Individuals with Positive Family History of Gastric Can-cer Urgently Need Intensive Screening and Eradication of Heli-cobacter Pylori? A Systematic Review and Meta-Analysis
-
Gui He
,
Xuanke Ji
,
Yali Yan
,
Kunyan Wang
,
Chunhua Song
,
Peng Wang
,
Hua Ye
,
Liping Dai
,
Jianying Zhang
,
Kaijuan Wang
Abstract
Background: Family history may inform individuals that they are at risk of gastric cancer (GC). However, it is too extensive to conduct intensive screening strategies for all individuals with family history of GC instead of average-risk screening. To establish more precise prevention strategies, accurate risk estimates are necessary for individuals with family history of GC.
Methods: We searched PubMed, EMBASE and Cochrane for all relevant studies from their inception to May 21, 2020, for cohort and case-control studies investigating the association between family history of GC and its risk. Relative risk (RR) and 95% confidence interval (CI) were pooled from studies using random-effects or fixed effects.
Results: The RR of GC was 2.08 (95% CI=1.86-2.34) in individuals with family history of GC according to twenty-nine case-control studies and 1.83 (95%CI=1.67-2.01) from six cohort studies. The increased risk was higher in individuals with sibling history of GC than those with parental history of GC (RR=3.18, 95% CI=2.12-4.79 vs. RR=1.66, 95% CI=1.46-1.89, P=0.021). For individuals with 2 or more first-degree relatives (FDRs) with GC, the RR was 2.81(95% CI=1.89-3.99). Subjects with both family history and Helicobacter pylori (H. pylori) infection confer a higher risk of GC (RR = 4.03, 95%CI=2.46-6.59).
Conclusion: The RR of GC among FDRs is lower than in previous studies. However, the risk of GC is markedly increased in individuals having a sibling with GC, more than 2 FDRs with GC. Intensified screening and eradication therapy for H. pylori could be considered for these individuals.
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2. Bray F, Ferlay J, Soerjomataram I, et al (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 68(6):394-424.
3. Cai Q, Zhu C, Yuan Y, et al (2019). Development and validation of a prediction rule for estimating gastric cancer risk in the Chinese high-risk population: a nationwide multicentre study. Gut, 68(9):1576-87.
4. Lin Y, Wu C, Yan W, et al (2020). Sociodemographic and Lifestyle Factors in Relation to Gastric Cancer in a High-Risk Region of China: A Matched Case-Control Study. Nutr Cancer, 72(3):421-30.
5. Song M, Camargo MC, Weinstein SJ, et al (2018). Family history of cancer in first-degree relatives and risk of gastric cancer and its precursors in a Western population. Gastric Cancer, 21(5):729-37.
6. Gao S, Zhang X, Wang P, et al (2011). Genetic epidemiological analysis reveals a multi-gene additive model for gastric cancer. Fam Cancer, 10(1):119-25.
7. Duan F, Song C, Zhang J, et al. (2019). Evaluation of the Epidemiologic Efficacy of Eradicating Helicobacter pylori on Development of Gastric Cancer. Epidemiol Rev, 41(1):97-108.
8. Liberati A, Altman DG, Tetzlaff J, et al (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ, 339:b2700.
9. Greenland S (1987). Quantitative methods in the review of epidemiologic literature. Epidemiol Rev, 9:1-30.
10. McKenzie JE, Beller EM, Forbes AB (2016). Introduction to systematic reviews and meta-analysis. Respirology, 21(4):626-37.
11. Shen J, Xing H, Wang L (2001). [Studies on the spatial and familial aggregation of double Y nuclear family in gastric cancer pedigree]. Chinese Journal of Preventive Medicine, 35(1):33-6.
12. Wang GP, Han XY, Ding T, et al. (2012). [Studies on the risks of cardia neoplasm among immediate relatives of the patients in Shanxi province]. Chinese Journal of Epidemiology , 33(11):1123-6.
13. Shin CM, Kim N, Yang HJ, et al. (2010). Stomach cancer risk in gastric cancer relatives: interaction between Helicobacter pylori infection and family history of gastric cancer for the risk of stomach cancer. J Clin Gastroenterol, 44(2):e34-9.
14. Bakir T, Can G, Erkul S, et al. (2000). Stomach cancer history in the siblings of patients with gastric carcinoma. Eur J Cancer Prev, 9(6):401-8.
15. Luo H, Mi D, Jing T, et al. (2005). [Risk factors of gastric cancer in Wuwei City---an endemic region of gastric cancer]. Chinese journal of cancer, 24(5):563-6.
16. Gong EJ, Ahn JY, Jung HY, et al. (2014). Risk factors and clinical outcomes of gastric cancer identified by screening endoscopy: a case-control study. J Gastroenterol Hepatol, 29(2):301-9.
17. Chen MJ, Wu DC, Ko YC, et al. (2004). Personal history and family history as a predictor of gastric cardiac adenocarcinoma risk: a case-control study in Taiwan. Am J Gastroenterol, 99(7):1250-7.
18. Behnampour N, Hajizadeh E, Zayeri F, et al. (2014). Modeling of influential predictors of gastric cancer incidence rates in Golestan province, North Iran. Asian Pac J Cancer Prev, 15(3):1111-7.
19. Zhao J, Wu M, Kim C, et al. (2017). Jiangsu Four Cancers Study: a large case-control study of lung, liver, stomach, and esophageal cancers in Jiangsu Province, China. Eur J Cancer Prev, 26(4):357-64.
20. Yatsuya H, Toyoshima H, Tamakoshi A, et al. (2004). Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study. Br J Cancer, 91(5):929-34.
21. Brenner H, Arndt V, Stürmer T, et al. (2000). Individual and joint contribution of family history and Helicobacter pylori infection to the risk of gastric carcinoma. Cancer, 88(2):274-9.
22. Wang N, Song G, Jin G, et al. (2010). A genetic epidemiological study on esophageal and cardia cancers in Ci County of Hebei Province. Chinese Journal of Clinical Oncology, 37:970-73.
23. García-González MA, Lanas A, Quintero E, et al. (2007). Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. Am J Gastroenterol, 102(9):1878-92.
24. Nagase H, Ogino K, Yoshida I, et al. (1996). Family history-related risk of gastric cancer in Japan: a hospital-based case-control study. Jpn J Cancer Res, 87(10):1025-8.
25. Song H, Ekheden I, Ploner A, et al. (2018). Family history of gastric mucosal abnormality and the risk of gastric cancer: a population-based observational study. Int J Epidemiol, 47(2):440-9.
26. Foschi R, Lucenteforte E, Bosetti C, et al. (2008). Family history of cancer and stomach cancer risk. Int J Cancer, 123(6):1429-32.
27. Dhillon P, Farrow D, Vaughan T, et al. (2001). Family history of cancer and risk of esophageal and gastric cancers in the United States. Int J Cancer, 93(1):148-52.
28. Hassan M, Phan A, Li D, et al. (2008). Family history of cancer and associated risk of developing neuroendocrine tumors: a case-control study. Biomarkers Prev, 17(4):959-65.
29. Safaee A, Moghimi Dehkordi B, Fatemi S, et al. (2011). Family History as a Risk for Upper Gastrointestinal Tract Cancer: A Case Control Study. Iran J Cancer Prev, 4(3):114-8.
30. La Vecchia C, Negri E, Franceschi S, et al. (1992). Family history and the risk of stomach and colorectal cancer. Cancer, 70(1):50-5.
31. Lissowska J, Groves F, Sobin L, et al. (1999). Family history and risk of stomach cancer in Warsaw, Poland. Eur J Cancer Prev, 8(3):223-7.
32. Hagy GW (1954). A familial study of gastric carcinoma. Am J Hum Genet, 6(4):434-47.
33. Zanghieri G, Di Gregorio C, Sacchetti C, et al. (1990). Familial occurrence of gastric cancer in the 2-year experience of a population-based registry. Cancer, 66(9):2047-51.
34. Toyoshima H, Hayashi S, Hashimoto S, et al. (1997). Familial aggregation and covariation of diseases in a Japanese rural community: comparison of stomach cancer with other diseases. Ann Epidemiol, 7(7):446-51.
35. Huang X, Tajima K, Hamajima N, et al. (1999). Effect of life styles on the risk of subsite-specific gastric cancer in those with and without family history. J Epidemiol, 9(1):40-5.
36. Palli D, Russo A, Saieva C, et al. (2000). Dietary and familial determinants of 10-year survival among patients with gastric carcinoma. Cancer, 89(6):1205-13.
37. Huang X, Hirose K, Wakai K, et al. (2004). Comparison of lifestyle risk factors by family history for gastric, breast, lung and colorectal cancer. Asian Pac J Cancer Prev, 5(4):419-27.
38. Ikeguchi M, Fukuda K, Oka S, et al. (2001). Clinicopathological findings in patients with gastric adenocarcinoma with familial aggregation. Dig Surg, 18(6):439-43.
39. Ihamäki T, Sipponen P, Varis K, et al. (1991). Characteristics of gastric mucosa which precede occurrence of gastric malignancy: results of long-term follow-up of three family samples. Scand J Gastroenterol Suppl, 186:16-23.
40. Muñoz N, Plummer M, Vivas J, et al. (2001). A case-control study of gastric cancer in Venezuela. Int J Cancer, 93(3):417-23.
41. Palli D, Bianchi S, Decarli A, et al. (1992). A case-control study of cancers of the gastric cardia in Italy. Br J Cancer, 65(2):263-6.
42. Minami Y, Tateno HJCs (2003). Associations between cigarette smoking and the risk of four leading cancers in Miyagi Prefecture, Japan: a multi-site case-control study. Cancer Sci, 94(6):540-7.
43. Group HaCC (2001). Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut, 49(3):347-53.
44. Sung JJY (2020). Population-based screening and mass eradication of Helicobacter pylori infection to prevent gastric cancer: There are more questions than answers. J Gastroenterol Hepatol, 35(4):521-2.
45. Choi IJ, Kim CG, Lee JY, et al (2020). Helicobacter pylori Family History of Gastric Cancer and Treatment. N Engl J Med, 382(5):427-36.
46. Yaghoobi M, McNabb-Baltar J, Bijarchi R, et al (2017). What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis. World J Gastroenterol, 23(13):2435-42.
47. Kim N (2019). Chemoprevention of gastric cancer by Helicobacter pylori eradication and its underlying mechanism. J Gastroenterol Hepatol, 34(8):1287-95.
48. Li H, Zang J, Wang P, et al (2012). Gastric cancer susceptibility in gastric cancer relatives: attributable risks of Macrophage migration inhibitory factor promoter polymorphism and Helicobacter pylori. Cytokine, 60(2):346-51.
49. Weyermann M, Rothenbacher D, Brenner H (2009). Acquisition of Helicobacter pylori infection in early childhood: independent contributions of infected mothers, fathers, and siblings. Am J Gastroenterol, 104(1):182-9.
50. Imsland AK, Eldon BJ, Arinbjarnarson S, et al (2002). Genetic epidemiologic aspects of gastric cancer in Iceland. J Am Coll Surg, 195(2):181-6; discussion 6-7.
2. Bray F, Ferlay J, Soerjomataram I, et al (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 68(6):394-424.
3. Cai Q, Zhu C, Yuan Y, et al (2019). Development and validation of a prediction rule for estimating gastric cancer risk in the Chinese high-risk population: a nationwide multicentre study. Gut, 68(9):1576-87.
4. Lin Y, Wu C, Yan W, et al (2020). Sociodemographic and Lifestyle Factors in Relation to Gastric Cancer in a High-Risk Region of China: A Matched Case-Control Study. Nutr Cancer, 72(3):421-30.
5. Song M, Camargo MC, Weinstein SJ, et al (2018). Family history of cancer in first-degree relatives and risk of gastric cancer and its precursors in a Western population. Gastric Cancer, 21(5):729-37.
6. Gao S, Zhang X, Wang P, et al (2011). Genetic epidemiological analysis reveals a multi-gene additive model for gastric cancer. Fam Cancer, 10(1):119-25.
7. Duan F, Song C, Zhang J, et al. (2019). Evaluation of the Epidemiologic Efficacy of Eradicating Helicobacter pylori on Development of Gastric Cancer. Epidemiol Rev, 41(1):97-108.
8. Liberati A, Altman DG, Tetzlaff J, et al (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ, 339:b2700.
9. Greenland S (1987). Quantitative methods in the review of epidemiologic literature. Epidemiol Rev, 9:1-30.
10. McKenzie JE, Beller EM, Forbes AB (2016). Introduction to systematic reviews and meta-analysis. Respirology, 21(4):626-37.
11. Shen J, Xing H, Wang L (2001). [Studies on the spatial and familial aggregation of double Y nuclear family in gastric cancer pedigree]. Chinese Journal of Preventive Medicine, 35(1):33-6.
12. Wang GP, Han XY, Ding T, et al. (2012). [Studies on the risks of cardia neoplasm among immediate relatives of the patients in Shanxi province]. Chinese Journal of Epidemiology , 33(11):1123-6.
13. Shin CM, Kim N, Yang HJ, et al. (2010). Stomach cancer risk in gastric cancer relatives: interaction between Helicobacter pylori infection and family history of gastric cancer for the risk of stomach cancer. J Clin Gastroenterol, 44(2):e34-9.
14. Bakir T, Can G, Erkul S, et al. (2000). Stomach cancer history in the siblings of patients with gastric carcinoma. Eur J Cancer Prev, 9(6):401-8.
15. Luo H, Mi D, Jing T, et al. (2005). [Risk factors of gastric cancer in Wuwei City---an endemic region of gastric cancer]. Chinese journal of cancer, 24(5):563-6.
16. Gong EJ, Ahn JY, Jung HY, et al. (2014). Risk factors and clinical outcomes of gastric cancer identified by screening endoscopy: a case-control study. J Gastroenterol Hepatol, 29(2):301-9.
17. Chen MJ, Wu DC, Ko YC, et al. (2004). Personal history and family history as a predictor of gastric cardiac adenocarcinoma risk: a case-control study in Taiwan. Am J Gastroenterol, 99(7):1250-7.
18. Behnampour N, Hajizadeh E, Zayeri F, et al. (2014). Modeling of influential predictors of gastric cancer incidence rates in Golestan province, North Iran. Asian Pac J Cancer Prev, 15(3):1111-7.
19. Zhao J, Wu M, Kim C, et al. (2017). Jiangsu Four Cancers Study: a large case-control study of lung, liver, stomach, and esophageal cancers in Jiangsu Province, China. Eur J Cancer Prev, 26(4):357-64.
20. Yatsuya H, Toyoshima H, Tamakoshi A, et al. (2004). Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study. Br J Cancer, 91(5):929-34.
21. Brenner H, Arndt V, Stürmer T, et al. (2000). Individual and joint contribution of family history and Helicobacter pylori infection to the risk of gastric carcinoma. Cancer, 88(2):274-9.
22. Wang N, Song G, Jin G, et al. (2010). A genetic epidemiological study on esophageal and cardia cancers in Ci County of Hebei Province. Chinese Journal of Clinical Oncology, 37:970-73.
23. García-González MA, Lanas A, Quintero E, et al. (2007). Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. Am J Gastroenterol, 102(9):1878-92.
24. Nagase H, Ogino K, Yoshida I, et al. (1996). Family history-related risk of gastric cancer in Japan: a hospital-based case-control study. Jpn J Cancer Res, 87(10):1025-8.
25. Song H, Ekheden I, Ploner A, et al. (2018). Family history of gastric mucosal abnormality and the risk of gastric cancer: a population-based observational study. Int J Epidemiol, 47(2):440-9.
26. Foschi R, Lucenteforte E, Bosetti C, et al. (2008). Family history of cancer and stomach cancer risk. Int J Cancer, 123(6):1429-32.
27. Dhillon P, Farrow D, Vaughan T, et al. (2001). Family history of cancer and risk of esophageal and gastric cancers in the United States. Int J Cancer, 93(1):148-52.
28. Hassan M, Phan A, Li D, et al. (2008). Family history of cancer and associated risk of developing neuroendocrine tumors: a case-control study. Biomarkers Prev, 17(4):959-65.
29. Safaee A, Moghimi Dehkordi B, Fatemi S, et al. (2011). Family History as a Risk for Upper Gastrointestinal Tract Cancer: A Case Control Study. Iran J Cancer Prev, 4(3):114-8.
30. La Vecchia C, Negri E, Franceschi S, et al. (1992). Family history and the risk of stomach and colorectal cancer. Cancer, 70(1):50-5.
31. Lissowska J, Groves F, Sobin L, et al. (1999). Family history and risk of stomach cancer in Warsaw, Poland. Eur J Cancer Prev, 8(3):223-7.
32. Hagy GW (1954). A familial study of gastric carcinoma. Am J Hum Genet, 6(4):434-47.
33. Zanghieri G, Di Gregorio C, Sacchetti C, et al. (1990). Familial occurrence of gastric cancer in the 2-year experience of a population-based registry. Cancer, 66(9):2047-51.
34. Toyoshima H, Hayashi S, Hashimoto S, et al. (1997). Familial aggregation and covariation of diseases in a Japanese rural community: comparison of stomach cancer with other diseases. Ann Epidemiol, 7(7):446-51.
35. Huang X, Tajima K, Hamajima N, et al. (1999). Effect of life styles on the risk of subsite-specific gastric cancer in those with and without family history. J Epidemiol, 9(1):40-5.
36. Palli D, Russo A, Saieva C, et al. (2000). Dietary and familial determinants of 10-year survival among patients with gastric carcinoma. Cancer, 89(6):1205-13.
37. Huang X, Hirose K, Wakai K, et al. (2004). Comparison of lifestyle risk factors by family history for gastric, breast, lung and colorectal cancer. Asian Pac J Cancer Prev, 5(4):419-27.
38. Ikeguchi M, Fukuda K, Oka S, et al. (2001). Clinicopathological findings in patients with gastric adenocarcinoma with familial aggregation. Dig Surg, 18(6):439-43.
39. Ihamäki T, Sipponen P, Varis K, et al. (1991). Characteristics of gastric mucosa which precede occurrence of gastric malignancy: results of long-term follow-up of three family samples. Scand J Gastroenterol Suppl, 186:16-23.
40. Muñoz N, Plummer M, Vivas J, et al. (2001). A case-control study of gastric cancer in Venezuela. Int J Cancer, 93(3):417-23.
41. Palli D, Bianchi S, Decarli A, et al. (1992). A case-control study of cancers of the gastric cardia in Italy. Br J Cancer, 65(2):263-6.
42. Minami Y, Tateno HJCs (2003). Associations between cigarette smoking and the risk of four leading cancers in Miyagi Prefecture, Japan: a multi-site case-control study. Cancer Sci, 94(6):540-7.
43. Group HaCC (2001). Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut, 49(3):347-53.
44. Sung JJY (2020). Population-based screening and mass eradication of Helicobacter pylori infection to prevent gastric cancer: There are more questions than answers. J Gastroenterol Hepatol, 35(4):521-2.
45. Choi IJ, Kim CG, Lee JY, et al (2020). Helicobacter pylori Family History of Gastric Cancer and Treatment. N Engl J Med, 382(5):427-36.
46. Yaghoobi M, McNabb-Baltar J, Bijarchi R, et al (2017). What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis. World J Gastroenterol, 23(13):2435-42.
47. Kim N (2019). Chemoprevention of gastric cancer by Helicobacter pylori eradication and its underlying mechanism. J Gastroenterol Hepatol, 34(8):1287-95.
48. Li H, Zang J, Wang P, et al (2012). Gastric cancer susceptibility in gastric cancer relatives: attributable risks of Macrophage migration inhibitory factor promoter polymorphism and Helicobacter pylori. Cytokine, 60(2):346-51.
49. Weyermann M, Rothenbacher D, Brenner H (2009). Acquisition of Helicobacter pylori infection in early childhood: independent contributions of infected mothers, fathers, and siblings. Am J Gastroenterol, 104(1):182-9.
50. Imsland AK, Eldon BJ, Arinbjarnarson S, et al (2002). Genetic epidemiologic aspects of gastric cancer in Iceland. J Am Coll Surg, 195(2):181-6; discussion 6-7.
| Files | ||
| Issue | Vol 50 No 12 (2021) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v50i12.7922 | |
| Keywords | ||
| Family history Gastric cancer Risk Meta-analysis Helicobacter pylori infection | ||
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How to Cite
1.
He G, Ji X, Yan Y, Wang K, Song C, Wang P, Ye H, Dai L, Zhang J, Wang K. Which Individuals with Positive Family History of Gastric Can-cer Urgently Need Intensive Screening and Eradication of Heli-cobacter Pylori? A Systematic Review and Meta-Analysis. Iran J Public Health. 2021;50(12):2384-2396.
