Analysis of Plasmodium vivax Merozoite Surface Protein-1 Gene Sequences

Abstract

The emergence of Plasmodium vivax in Dashte Moghan in northwestern Iran has become a major concern for Iranian's health officials. Knowledge of genetic make up of the P. vivax populations in this area would give us an insight into the origin of the prevalent infections and the possible routes they are introduced. This paper reports the analysis of a variable region between the two interspecies conserved blocks (ICBs) of 5 and 6 of MSP-1 gene in 18 isolates from Dashte Moghan. The results revealed that all the 18 isolates were similar to an Azari Belem-like type with 21 glutamine (Q) in the repeated residues. Our results may give a clue that the resurgent malaria in Dashteh Moghan might have primarily been introduced from Azerbaijan. However, much more molecular and epidemiological evidence are needed to confirm this hypothesis.