Effect of Self-Controlled Exercise on Antioxidant Activity of Red Blood Cells and Functional Recovery of Limbs in Patients with Breast Cancer after Rehabilitation
-
Feifei LI
,
Wei LIU
,
Fei HUO
,
Weifang HE
,
Fan YANG
,
Jiabin WEI
,
Jing WANG
Abstract
Background: We aimed to investigate the effect of self-controlled exercise on the antioxidant activity of red blood cells and the recovery of limb function in patients with breast cancer after rehabilitation.
Methods: Overall 130 breast cancer patients admitted to the First Affiliated Hospital of Zhengzhou University, China from Feb 2018 to Jan 2019 were divided into intervention group and control group. The control group received perioperative care and chemotherapy, the intervention group implemented a self-controlled exercise program. Indexes were compared between the two groups before intervention, 3 months and 6 months after intervention.
Results: The activity of erythrocyte superoxide dismutase (SOD in the intervention group was significantly increased in the first 3 months (P=0.030), and decreased from 3rd to 6th month (P=0.033). The glutathione peroxidase (GSH-Px) activity in the intervention group increased through the whole intervention period. The plasma malondialdehyde (MDA) in the intervention group was significantly decreased (P=0.029, 0.012). After intervention for 3 months and 6 months, the 6MND distances in the intervention group were significantly longer (P=0.001, 0.045). The average exercise time in the intervention group were significantly increased (P=0.004, 0.000).
Conclusion: Self-controlled exercise can effectively improve the antioxidant ability of red blood cells in patients with breast cancer, improve the mobility of shoulder joints of the affected side and increase their exercise capacity, with good sustainability. It has positive effect on postoperative rehabilitation, could be used in long-term regular clinical work.
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15. McCarroll ML, Armbruster S, Frasure HE, et al (2014). Self-efficacy, quality of life, and weight loss in overweight/obese en-dometrial cancer survivors (SUCCEED): A randomized controlled trial. Gynecol On-col, 132(2): 397-402.
16. Hoffman AJ, Brintnall RA, Brown JK, et al (2013). Too sick not to exercise: Using a 6-week, home-based exercise intervention for cancer-related fatigue self-management for postsurgical non-small cell lung cancer patients. Cancer Nurs, 36(3): 175-188.
17. Nyrop KA, Callahan LF, Cleveland RJ, et al (2017). Randomized Controlled Trial of a Home-Based Walking Program to Re-duce Moderate to Severe Aromatase In-hibitor-Associated Arthralgia in Breast Cancer Survivors. Oncologist, 22(10): 1238-1249.
18. Rogers LQ, Courneya KS, Anton PM, et al (2015). Effects of the BEAT Cancer physical activity behavior change inter-vention on physical activity, aerobic fit-ness, and quality of life in breast cancer survivors: a multicenter randomized con-trolled trial. Breast Cancer Res Treat, 149(1): 109-119.
19. Livingston PM, Craike MJ, Salmon J, et al (2015). Effects of a clinician referral and exercise program for men who have completed active treatment for prostate cancer: A multicenter cluster randomized controlled trial (ENGAGE). Cancer, 121(15): 2646-2654.
20. Galvão DA, Spry N, Denham J, et al (2014). Amulticentre year-long randomised con-trolled trial of exercise training targeting physical functioning in men with prostate cancer previously treated with androgen suppression and radiation from TROG 03.04 radar. Eur Urol, 65(5): 856-864.
21. Zhang AY, Bodner DR, Fu AZ, et al (2015). Effects of Patient Centered Interventions on Persistent Urinary Incontinence after Prostate Cancer Treatment: A Random-ized, Controlled Trial. J Urol, 194(6): 1675-1681.
22. Broderick JM, Guinan E, Kennedy MJ, et al (2013). Feasibility and efficacy of a super-vised exercise intervention in de-conditioned cancer survivors during the early survivorship phase: The PEACH trial. J Cancer Surviv, 7(4): 551-562.
23. Duijts SF, van Beurden M, Oldenburg HS, et al (2012). Efficacy of cognitive behav-ioral therapy and physical exercise in alle-viating treatment-induced menopausal symptoms in patients with breast cancer: Results of a randomized, controlled, mul-ticenter trial. J Clin Oncol, 30(33): 4124-4133.
24. Chung OK, Li HC, Chiu SY, et al (2015). Sustainability of an Integrated Adventure-Based Training and Health Education Program to Enhance Quality of Life Among Chinese Childhood Cancer Sur-vivors: A Randomized Controlled Trial. Cancer Nurs, 38(5): 366-374.
25. Trinh L, Plotnikoff RC, Rhodes RE, et al (2014). Feasibility and Preliminary Effica-cy of Adding Behavioral Counseling to Supervised Physical Activity in Kidney Cancer Survivors: A Randomized Con-trolled Trial. Cancer Nurs, 37(5): E8-E22.
26. McGowan EL, North S, Courneya KS (2013). Randomized controlled trial of a behavior change intervention to increase physical activity and quality of life in pros-tate cancer survivors. Ann Behav Med, 46(3): 382-393.
27. Winters-Stone KM, Dobek J, Bennett JA, et al (2012). The effect of resistance training on muscle strength and physical function in older, postmenopausal breast cancer survivors: A randomized controlled trial. J Cancer Surviv, 6(2): 189-199.
28. Reif K, de Vries U, Petermann F, et al (2013). A patient education program is ef-fective in reducing cancer-related fatigue: A multi-centrerandomised two-group waiting-list controlled intervention trial. Eur J Oncol Nurs, 17(2): 204-213.
2. Mina DS, Cutrono SE, Laura Q (2018). Rogers. Integrating Exercise into the Electronic Medical Record: A Case Series in Oncology. Translational Journal of the ACSM, 3: 181-189.
3. Hoffman AJ, Brintnall RA, Given BA, et al (2017). Using Perceived Self-efficacy to Improve Fatigue and Fatigability In Postsurgical Lung Cancer Patients A Pilot Randomized Controlled Trial. Cancer Nurs, 40(1): 1-12.
4. Wiggins JM, Opoku-Acheampong AB, Baumfalk DR, et al (2018). Exercise and the Tumor Microenvironment: Potential Therapeutic Implications. Exerc Sport Sci Rev, 46(1): 56-64.
5. Winters-Stone KM, Moe EL, Perry CK, et al (2018). Enhancing an oncologist's rec-ommendation to exercise to manage fa-tigue levels in breast cancer patients: a randomized controlled trial. Support Care Cancer, 26(3): 905-912.
6. Moe E, Chadd J, McDonagh M, et al (2017). Exercise Interventions for Pros-tate Cancer Survivors Receiving Hor-mone Therapy: Systematic Review. TJACSM, 2: 1-9.
7. Lee MK, Yun YH, Park HA, et al (2014). A Web-based self-management exercise and diet intervention for breast cancer survivors: Pilot randomized controlled trial. Int J Nurs Stud, 51(12): 1557-1567.
8. Hanai A, Ishiguro H, Sozu T, et al (2016). Effects of a self-management program on antiemetic-induced constipation dur-ing chemotherapy among breast cancer patients: a randomized controlled clinical trial. Breast Cancer Res Treat, 155(1): 99-107.
9. Aycinena AC, Valdovinos C, Crew KD, et al (2017). Barriers to Recruitment and Ad-herence in a Randomized Controlled Diet and Exercise Weight Loss Intervention Among Minority Breast Cancer Survi-vors. J Immigr Minor Health, 19(1): 120-129.
10. Lindquist H, Enblom A, Dunberger G, et al (2015). Water Exercise Compared To Land Exercise Or Standard Care In Fe-male Cancer Survivors With Secondary Lymphedema. Lymphology, 48(2): 64-79.
11. Gaskin CJ, Craike M, Mohebbi M, et al (2017). A Clinician Referral and 12-Week Exercise Training Program for Men With Prostate Cancer: Outcomes to 12 Months of the ENGAGE Cluster Ran-domized Controlled Trial. J Phys Act Health, 14(5): 353-359.
12. Gokal K, Wallis D, Ahmed S, et al (2016). Effects of a self-managed home-based walking intervention on psychosocial health outcomes for breast cancer pa-tients receiving chemotherapy: a random-ised controlled trial. Support Care Cancer, 24(3): 1139-1166.
13. Juvet LK, Thune I, Elvsaas IKØ, et al (2017). The effect of exercise on fatigue and physical functioning in breast cancer patients during and after treatment and at 6 months follow-up: A meta-analysis. Breast, 33: 166-177.
14. Jeffs E, Wiseman T (2013). Randomised controlled trial to determine the benefit of daily home-based exercise in addition to self-care in the management of breast cancer-related lymphoedema: a feasibility study. Support Care Cancer, 21(4): 1013-1023.
15. McCarroll ML, Armbruster S, Frasure HE, et al (2014). Self-efficacy, quality of life, and weight loss in overweight/obese en-dometrial cancer survivors (SUCCEED): A randomized controlled trial. Gynecol On-col, 132(2): 397-402.
16. Hoffman AJ, Brintnall RA, Brown JK, et al (2013). Too sick not to exercise: Using a 6-week, home-based exercise intervention for cancer-related fatigue self-management for postsurgical non-small cell lung cancer patients. Cancer Nurs, 36(3): 175-188.
17. Nyrop KA, Callahan LF, Cleveland RJ, et al (2017). Randomized Controlled Trial of a Home-Based Walking Program to Re-duce Moderate to Severe Aromatase In-hibitor-Associated Arthralgia in Breast Cancer Survivors. Oncologist, 22(10): 1238-1249.
18. Rogers LQ, Courneya KS, Anton PM, et al (2015). Effects of the BEAT Cancer physical activity behavior change inter-vention on physical activity, aerobic fit-ness, and quality of life in breast cancer survivors: a multicenter randomized con-trolled trial. Breast Cancer Res Treat, 149(1): 109-119.
19. Livingston PM, Craike MJ, Salmon J, et al (2015). Effects of a clinician referral and exercise program for men who have completed active treatment for prostate cancer: A multicenter cluster randomized controlled trial (ENGAGE). Cancer, 121(15): 2646-2654.
20. Galvão DA, Spry N, Denham J, et al (2014). Amulticentre year-long randomised con-trolled trial of exercise training targeting physical functioning in men with prostate cancer previously treated with androgen suppression and radiation from TROG 03.04 radar. Eur Urol, 65(5): 856-864.
21. Zhang AY, Bodner DR, Fu AZ, et al (2015). Effects of Patient Centered Interventions on Persistent Urinary Incontinence after Prostate Cancer Treatment: A Random-ized, Controlled Trial. J Urol, 194(6): 1675-1681.
22. Broderick JM, Guinan E, Kennedy MJ, et al (2013). Feasibility and efficacy of a super-vised exercise intervention in de-conditioned cancer survivors during the early survivorship phase: The PEACH trial. J Cancer Surviv, 7(4): 551-562.
23. Duijts SF, van Beurden M, Oldenburg HS, et al (2012). Efficacy of cognitive behav-ioral therapy and physical exercise in alle-viating treatment-induced menopausal symptoms in patients with breast cancer: Results of a randomized, controlled, mul-ticenter trial. J Clin Oncol, 30(33): 4124-4133.
24. Chung OK, Li HC, Chiu SY, et al (2015). Sustainability of an Integrated Adventure-Based Training and Health Education Program to Enhance Quality of Life Among Chinese Childhood Cancer Sur-vivors: A Randomized Controlled Trial. Cancer Nurs, 38(5): 366-374.
25. Trinh L, Plotnikoff RC, Rhodes RE, et al (2014). Feasibility and Preliminary Effica-cy of Adding Behavioral Counseling to Supervised Physical Activity in Kidney Cancer Survivors: A Randomized Con-trolled Trial. Cancer Nurs, 37(5): E8-E22.
26. McGowan EL, North S, Courneya KS (2013). Randomized controlled trial of a behavior change intervention to increase physical activity and quality of life in pros-tate cancer survivors. Ann Behav Med, 46(3): 382-393.
27. Winters-Stone KM, Dobek J, Bennett JA, et al (2012). The effect of resistance training on muscle strength and physical function in older, postmenopausal breast cancer survivors: A randomized controlled trial. J Cancer Surviv, 6(2): 189-199.
28. Reif K, de Vries U, Petermann F, et al (2013). A patient education program is ef-fective in reducing cancer-related fatigue: A multi-centrerandomised two-group waiting-list controlled intervention trial. Eur J Oncol Nurs, 17(2): 204-213.
| Files | ||
| Issue | Vol 50 No 2 (2021) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v50i2.5345 | |
| PMCID | PMC7956092 | |
| PMID | 33747994 | |
| Keywords | ||
| Self-controlled exercise Breast cancer Rehabilitation Antioxidant Red blood cells | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
LI F, LIU W, HUO F, HE W, YANG F, WEI J, WANG J. Effect of Self-Controlled Exercise on Antioxidant Activity of Red Blood Cells and Functional Recovery of Limbs in Patients with Breast Cancer after Rehabilitation. Iran J Public Health. 2021;50(2):306-314.
