Original Article

Evaluation of Associated Markers of Neonatal Pathological Jaundice Due to Bacterial Infection

Abstract

Background: To evaluate changes of associated markers in neonatal pathological jaundice due to bacterial infection in newborns, to provide an experimental basis for early diagnosis and treatment of neonatal pathological jaundice.

Methods: A total of 126 newborns with neonatal pathological jaundice in the Pediatrics Department of Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University from Jan 2016 to Jun 2018 were enrolled. The patients were divided into bacterial infection group (76 cases with combined bacterial infection) and non-infection group (50 cases without bacterial infection). Peripheral blood was drawn from patients, and levels of inflammatory factors, levels of indexes of liver function and levels of cardiac markers were detected. Correlation between inflammatory factors and neonatal pathological jaundice was assessed.

Results: The levels of WBC, hs-CRP and PCT in the bacterial infection group were significantly higher than those in the non-infected group (P<0.05). The level of TRF in the bacterial infection group was significantly lower than that in the non-infection group (P<0.01). In the bacterial infection group, the levels of WBC, hs-CRP, PCT, and TRF were positively correlated with the levels of CK, CKMB, LDH, and α-HBDB, respectively (all P<0.05). The TRF level after treatment was significantly higher than that before treatment (P<0.01).

Conclusion: Markers such as WBC, hs-CRP, PCT, and TRF can be used as effective indicators in diagnosis of pathological jaundice due to bacterial infection in newborns. The combined testing of WBC, hs-CRP, PCT, and TRF was helpful for early diagnosis and early clinical intervention of neonatal pathological jaundice, which can lower the risk of clinical complications.

1. Scrafford CG, Mullany LC, Katz J, et al (2013). Incidence of and risk factors for neonatal jaundice among newborns in southern Nepal. Trop Med Int Health, 18(11): 1317-1328.
2. Dong T, Chen T, White RA, et al (2018). Meconium microbiome associates with the development of neonatal jaundice. Clin Transl Gastroenterol, 9(9): 182.
3. Olusanya BO, Slusher TM, Imosemi DO, et al (2017). Maternal detection of neonatal jaundice during birth hospitalization using a novel two-coloricterometer. PLoS One, 12(8): e0183882.
4. Jiao Y, Jin Y, Meng H, et al (2018). An anal-ysis on treatment effect of blue light pho-totherapy combined with Bifico in treat-ingneonatal hemolytic jaundice. Exp Ther Med, 16(2): 1360-1364.
5. Wan A, Mat Daud S, Teh SH, et al (2016). Management of neonatal jaundice in pri-mary care. Malays Fam Physician, 11(2-3): 16-19.
6. Bassari R, Koea JB (2015). Jaundice associat-ed pruritis: a review of pathophysiology and treatment. World J Gastroenterol, 21(5): 1404-1413.
7. Panahi R, Jafari Z, Sheibanizade A, et al (2013). The Relationship between the Be-havioral Hearing Thresholds and Maxi-mum Bilirubin Levels at Birth in Children with a History of Neonatal Hyperbiliru-binemia. Iran J Otorhinolaryngol, 25(72): 127-134.
8. Siu SL, Chan LW, Kwong AN (2018). Clini-cal and biochemical characteristics of in-fants with prolonged neonatal jaundice. Hong Kong Med J, 24(3): 270-276.
9. Llorente AM, Castillo CL (2012). Congenital cytomegalovirus infection in fraternal twins: a longitudinal case study examin-ingneurocognitive and neurobehavioral correlates. Appl Neuropsychol Child, 1(1): 63-73.
10. Volanakis JE (2001). Human C-reactive pro-tein: expression, structure, and function. Mol Immunol, 38(2-3): 189-197.
11. Yang C, Yang Y, Li B, et al (2016). The di-agnostic value of high-sensitivity C-reactive protein/albumin ratio in evaluat-ing early-onsetinfection in premature. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 28(2): 173-177.
12. Li Y, Zhong X, Cheng G, et al (2017). Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: A meta-analysis. Atherosclerosis, 259: 75-82.
13. Kosińska-Kaczyńska K, Szymusik I, Ka-czyński B, et al (2013). Iatrogenic and spontaneous late preterm twins--which are at higher risk of neonatalcomplica-tions. Ginekol Pol, 84(6): 430-435.
14. Lencot S, Cabaret B, Sauvage G, et al (2014). A new procalcitonin cord-based algo-rithm in early-onset neonatal infection: for a change ofparadigm. Eur J Clin Mi-crobiol Infect Dis, 33(7): 1229-1238.
15. Cottineau M, Launay E, Branger B, et al (2014). Diagnostic value of suspicion cri-teria for early-onset neonatal bacterial in-fection: report tenyears after the Anaes recommendations. Arch Pediatr, 21(2): 187-193.
16. Lee BK, Le Ray I, Sun JY, et al (2016). Hae-molytic and nonhaemolytic neonatal jaundice have different risk factor pro-files. Acta Paediatr, 105(12): 1444-1450.
17. Christensen RD, Yaish HM, Lemons RS (2014). Neonatal hemolytic jaundice: morphologic features of erythrocytes that will help you diagnosethe underlying condition. Neonatology, 105(4): 243-249.
18. Lamola AA, Bhutani VK, Wong RJ, et al (2013). The effect of hematocrit on the efficacy of phototherapy for neonatal jaundice. Pediatr Res, 74(1): 54-60.
19. Bhutani VK (2001). Neonatal hyperbiliru-binemia and the potential risk of subtle neurological dysfunction. PediatrRes, 50(6): 679-680.
20. Wang XF, Hong JG (2011). Management of severe asthma exacerbation in children. World J Pediatr, 7(4): 293-301.
21. Ricci F, De Caterina R (2011). Isolated crea-tine kinase-MB rise with normal cardiac troponins: a strange occurrence withdiffi-cult interpretation. J Cardiovasc Med (Hager-stown), 12(10): 736-740.
Files
IssueVol 50 No 2 (2021) QRcode
SectionOriginal Article(s)
Published2021-02-01
DOI https://doi.org/10.18502/ijph.v50i2.5394
Keywords
Pathological jaundice Newborn Bacterial infection Inflammatory factors Combined testing

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
LIU Y, SUN X, WANG Y, XING C, LI L, ZHOU S. Evaluation of Associated Markers of Neonatal Pathological Jaundice Due to Bacterial Infection. Iran J Public Health. 50(2):333-340.