Changes of Serum Adiponectin and Glycated Albumin Levels in Gestational Diabetes Mellitus Patients and Their Relationship with Insulin Resistance

  • Qingju WANG Department of General Medicine, Jinan City People's Hospital, Jinan, China
  • Juan DU Department of General Medicine, Jinan City People's Hospital, Jinan, China
  • Fenglian LIU Mail Department of General Medicine, Jinan City People's Hospital, Jinan, China
Keywords:
Gestational diabetes mellitus;, Serum adiponectin;, Insulin resistance

Abstract

Background: We aimed to investigate the changes of serum adiponectin and glycated albumin (GA) levels in gestational diabetes mellitus patients and their relationship with insulin resistance.

Methods: Overall, 137 pregnant women were enrolled from Jinan City People's Hospital, Laiwu District, China from Jan 2015 to Jun 2018. Among them, 71 pregnant women with gestational diabetes mellitus were examined as diabetes group, and 66 normal pregnant women as normal pregnant women group. In addition, 58 normal non-pregnant women of childbearing age who were examined in our hospital during the same period were selected as a control group. The serum adiponectin and GA levels of the three groups were compared, and the relationship between serum adiponectin, GA levels and insulin resistance was analyzed.

Results: The serum adiponectin level of pregnant women in gestational diabetes mellitus (GDM) group was significantly lower than that of normal pregnant women and control group (P=0.031, P=0.027). The serum GA level of pregnant women in GDM group was significantly higher than that of normal pregnant women and control group (P<0.001). Pearson correlation analysis showed that GA was positively correlated with Fasting plasma glucose (FPG), Fasting insulin (FINS) and Insulin resistance index(HOMA-IR) levels (P<0.001), while adiponectin was negatively correlated with FPG FINS and HOMA-IR levels (P<0.001).

Conclusion: Abnormal levels of serum GA and adiponectin are closely related to insulin resistance in patients with gestational diabetes mellitus. Detection of serum GA and adiponectin levels can diagnose gestational diabetes mellitus quickly and effectively.

References

1. Lu X, Wu F, Jiang M, et al (2019). Curcumin ameliorates gestational diabetes in mice partly through activating AMPK. Pharm Biol, 57(1): 250-254.
2. Kim D, Kim KJ, Huh JH, et al (2012). The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function. Clin Endocrinol (Oxf), 77(5): 679-683.
3. Nahavandi S, Price S, Sumithran P, et al (2019). Exploration of the shared pathophysiological mechanisms of gestational diabetes and large for gestationalage offspring. World J Diabetes, 10(6): 333-340.
4. Tumurbaatar B, Poole AT, Olson G, et al (2017). Adipose Tissue Insulin Resistance in Gestational Diabetes. Metab Syndr Relat Disord, 15(2): 86-92.
5. He Q, Zhu S, Lin M, et al (2019). Increased GPR120 level is associated with gestational diabetes mellitus. Biochem Biophys Res Commun, 512(2): 196-201.
6. Yudkin JS (2007). Insulin resistance and the metabolic syndrome—or the pitfalls of epidemiology. Diabetologia, 50(8): 1576-1586.
7. Heilbronn LK, Smith SR, Ravussin E (2003). The Insulin-sensitizing Role of the Fat Derived Hormone Adiponectin. Curr Pharm Des, 9(17): 1411-1418.
8. Vetterli L, Carobbio S, Frigerio F, et al (2016). The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity. J Biol Chem, 291(25): 13063-13075.
9. Wang X, Pu H, Ma C, et al (2014). Adiponectin abates atherosclerosis by reducing oxidative stress. Med Sci Monit, 20: 1792-1800.
10. Fantuzzi G (2008). Adiponectin and inflammation: consensus and controversy. J Allergy Clin Immunol, 121(2): 326-330.
11. Furusyo N, Koga T, Ai M, et al (2011). Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study: results from the Kyushu and Okinawa Population Study (KOPS). Diabetologia, 54(12): 3028-3036.
12. Cree-Green M, Newcomer BR, Brown MS, et al (2015). Delayed Skeletal Muscle Mitochondrial ADP Recovery in Youth With Type 1 Diabetes Relates to Muscle Insulin Resistance. Diabetes, 64(2): 383-392.
13. Imam K (2012). Clinical Features, Diagnostic Criteria and Pathogenesis of Diabetes Mellitus. Adv Exp Med Biol, 771: 340-355.
14. Benhalima K, Van Crombrugge P, Moyson C, et al (2019). Risk factor screening for gestational diabetes mellitus based on the 2013 WHO criteria. Eur J Endocrinol, 180(6): 353-363.
15. Gallo D, Diggs JL, Shell GR, et al (1986). Comparison of detection of antibody to the acquired immune deficiency syndrome virus by enzyme immunoassay, immunofluorescence, and Western blot methods. J Clin Microbiol, 23(6): 1049-1051.
16. Lotz TF, Chase JG, Mcauley KA, et al (2006). Transient and steady-state euglycemic clamp validation of a model for glycemic control and insulin sensitivity testing. Diabetes Technol Ther, 8(3): 338-346.
17. Dobrovolskaia E, Gam A, Slater JE (2006). Competition enzyme-linked immunosorbant assay (ELISA) can be a sensitive method for the specific detection of small quantities of allergen in a complex mixture. Clin Exp Allergy, 36(4): 525-530.
18. Metzger BE, Coustan DR, Trimble ER (2019). Hyperglycemia and Adverse Pregnancy Outcomes. Clin Chem, 65(7): 937-938.
19. Hamel MS, Kanno LM, Has P, et al (2019). Intrapartum Glucose Management in Women With Gestational Diabetes Mellitus: A Randomized Controlled Trial. Obstet Gynecol, 133(6): 1171-1177.
20. Lu J, Zhang S, Li W, et al (2019). Maternal Gestational Diabetes Is Associated With Offspring's Hypertension. Am J Hypertens, 32(4): 335-342.
21. Wang X, Zhang L, Ou G, et al (2019). Association of DUSP9 gene polymorphisms with gestational diabetes mellitus. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 36(3): 267-270.
22. Thyfault JP, Hedberg EM, Anchan RM, et al (2005). Gestational diabetes is associated with depressed adiponectin levels. J Soc Gynecol Investig, 12(1): 41-45.
23. Li H, Dong A, Lv X (2019). Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus. Exp Ther Med, 18(1): 685-691.
24. Khan R, Khan Z, Javed K, et al (2012). Effect of gestational diabetes on blood sugar, liver and renal function tests. J Ayub Med Coll Abbottabad, 24(2): 95-98.
25. Yuksel MA, Alici Davutoglu E, Temel Yuksel I, et al (2016). Maternal serum atrial natriuretic peptide (ANP) and brain-type natriuretic peptide (BNP) levels in gestational diabetes mellitus. J Matern Fetal Neonatal Med, 29(15): 2527-2530.
26. Pala HG, Ozalp Y, Yener AS, et al (2015). Adiponectinlevels in gestational diabetes mellitus and in pregnant women without glucose intolerance. Adv Clin Exp Med, 24(1): 85-92.
27. Hedderson M, Darbinian J, Ferrara A (2013). A3-3: Pre-Pregnancy Adiponectin Levels and Subsequent Risk of Gestational Diabetes Mellitus (GDM). Clin Med Res, 11(3): 145.
28. Maeda N, Shimomura I, Kishida K, et al (2002). Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med, 8(7): 731-737.
29. Sell H, Laurencikiene J, Taube A, et al (2009). Chemerin Is a Novel Adipocyte-Derived Factor Inducing Insulin Resistance in Primary Human Skeletal Muscle Cells. Diabetes, 58(12): 2731-40.
30. Sell H, Laurencikiene J, Taube A, et al (2009). Chemerin Is a Novel Adipocyte-Derived Factor Inducing Insulin Resistance in Primary Human Skeletal Muscle Cells. Diabetes, 58(12): 2731-2740.
31. Park KG, Park KS, Kim MJ, et al (2004). Relationship between serum adiponectin and leptin concentrations and body fat distribution. Diabetes Res Clin Pract, 63(2): 135-142.
32. Yamauchi T, Kamon J, Minokoshi Y, et al (2002). Adiponectin stimulates glucose utilization and fatty-acidoxidation by activating AMP-activated protein kinase. Nat Med, 8(11): 1288-1295.
Published
2020-06-30
How to Cite
1.
WANG Q, DU J, LIU F. Changes of Serum Adiponectin and Glycated Albumin Levels in Gestational Diabetes Mellitus Patients and Their Relationship with Insulin Resistance. Iran J Public Health. 49(7):1252-1261.
Section
Original Article(s)