Comparison of Efficacy between Clopidogrel and Ticagrelor in Patients with Acute Coronary Syndrome after Interventional Treatment and Their Effects on IL-6

  • Bin YANG Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China
  • Chunyan ZHENG Medical Consultation Center, The Affiliated Hospital of Qingdao University, Qingdao, China
  • Haichu YU Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China
  • Rui ZHANG Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China
  • Shan LI Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China
  • Min LEN Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China
  • Shanglang CAI Mail Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China
Keywords:
Clopidogrel;, Ticagrelor;, Acute coronary syndrome;, Interleukin-6;, Platelet aggregation

Abstract

Background: We aimed to compare the efficacy between clopidogrel and ticagrelor in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) and their effects on IL-6.

Methods: A retrospective analysis and collection of 200 ACS patients diagnosed by the Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, China in 2016 were performed. Patients were randomly divided into clopidogrel group and ticagrelor group. Data of left ventricular ejection fraction and ACS clinical classification before PCI, PCI treatment, IL-6, platelet aggregation status, maximum platelet aggregation rate (MPAR), P2Y12 response unit (PRU) and adverse reaction of patients were collected. After PCI, patients were followed up for 1 year to compare the ischemia after treatment between clopidogrel group and tigravilol group.

Results: MPAR and PRU after PCI of clopidogrel group were significantly higher than those of ticagrelor group (P<0.05). The expression of IL-6 in two groups peaked at 1 day after PCI and then decreased. That of ticagrelor group was consistently lower than that of clopidogrel group (P<0.05). The incidence of ischemic events after treatment in clopidogrel group was significantly higher than that in ticagrelor group (P<0.001).

Conclusion: Compared with clopidogrel, tigerrilol had more significant inhibition of platelet aggregation after PCI in ACS patients, and tigerrilol had better effect after interventional treatment in ACS patients. In addition, compared with clopidogrel, tegrel can significantly inhibit the expression of IL-6 in patients with ACS and better alleviate the inflammatory response after PCI.

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Published
2020-02-01
How to Cite
1.
YANG B, ZHENG C, YU H, ZHANG R, LI S, LEN M, CAI S. Comparison of Efficacy between Clopidogrel and Ticagrelor in Patients with Acute Coronary Syndrome after Interventional Treatment and Their Effects on IL-6. Iran J Public Health. 49(2):240-248.
Section
Original Article(s)